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MX2010003768A - Composicion para tratamiento de cancer de prostata (pca). - Google Patents

Composicion para tratamiento de cancer de prostata (pca).

Info

Publication number
MX2010003768A
MX2010003768A MX2010003768A MX2010003768A MX2010003768A MX 2010003768 A MX2010003768 A MX 2010003768A MX 2010003768 A MX2010003768 A MX 2010003768A MX 2010003768 A MX2010003768 A MX 2010003768A MX 2010003768 A MX2010003768 A MX 2010003768A
Authority
MX
Mexico
Prior art keywords
composition
prostate
immunostimulatory
vaccine
active
Prior art date
Application number
MX2010003768A
Other languages
English (en)
Inventor
Jochen Probst
Ingmar Hoerr
Thomas Lander
Original Assignee
Curevac Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac Gmbh filed Critical Curevac Gmbh
Publication of MX2010003768A publication Critical patent/MX2010003768A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001195—Prostate specific membrane antigen [PSMA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invenci?n se refiere a una composici?n (inmunoestimuladora) activa que comprende al menos un ARN, de preferencia un ARNm, que codifica para al menos dos ant?genos (de preferencia diferentes) capaces de desarrollar una respuesta inmune (adaptiva) en un mam?fero, en donde los ant?genos se seleccionan del grupo que consiste en PSA (Antigeno Especifico de Pr?stata), PSMA (Antigeno de Membrana Especifico de Pr?stata), PSCA (Antigeno de C?lulas Madre de Pr?stata) y STEAP (Antigeno Epitelial de Seis Transmembranas de la Pr?stata). La invenci?n se refiere adem?s a una vacuna que comprende la composici?n (inmunoestimuladora) activa, y el uso de la composici?n (inmunoestimuladora) activa (en la preparaci?n de una vacuna) y/o de la vacuna para provocar una respuesta inmune (adaptiva) en el tratamiento de c?ncer de pr?stata (PCa), de preferencia de c?nceres de pr?stata neoadyuvantes y/o refractarios a hormonas, y enfermedades o trastornos relacionados con los mismos Finalmente, la invenci?n se refiere a kits, particularmente a kits de partes, que contienen la composici?n (inmunoestimuladora) activa y/o la vacuna.
MX2010003768A 2007-10-09 2008-10-08 Composicion para tratamiento de cancer de prostata (pca). MX2010003768A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2007/008771 WO2009046739A1 (en) 2007-10-09 2007-10-09 Composition for treating prostate cancer (pca)
PCT/EP2008/008504 WO2009046975A1 (en) 2007-10-09 2008-10-08 COMPOSITION FOR TREATING PROSTATE CANCER (PCa)

Publications (1)

Publication Number Publication Date
MX2010003768A true MX2010003768A (es) 2010-04-30

Family

ID=39472544

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003768A MX2010003768A (es) 2007-10-09 2008-10-08 Composicion para tratamiento de cancer de prostata (pca).

Country Status (11)

Country Link
US (5) US20100305196A1 (es)
JP (2) JP5139530B2 (es)
CN (2) CN104840953A (es)
AU (1) AU2008309931B2 (es)
BR (1) BRPI0818320A2 (es)
CA (1) CA2696772C (es)
DK (1) DK2195015T3 (es)
ES (1) ES2633246T3 (es)
MX (1) MX2010003768A (es)
RU (2) RU2583004C2 (es)
WO (2) WO2009046739A1 (es)

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