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MX2010003450A - Region constante de anticuerpo modificada. - Google Patents

Region constante de anticuerpo modificada.

Info

Publication number
MX2010003450A
MX2010003450A MX2010003450A MX2010003450A MX2010003450A MX 2010003450 A MX2010003450 A MX 2010003450A MX 2010003450 A MX2010003450 A MX 2010003450A MX 2010003450 A MX2010003450 A MX 2010003450A MX 2010003450 A MX2010003450 A MX 2010003450A
Authority
MX
Mexico
Prior art keywords
constant region
reduced
present inventors
stability
discovered
Prior art date
Application number
MX2010003450A
Other languages
English (en)
Inventor
Tomoyuki Igawa
Hirotake Shiraiwa
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40511493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010003450(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2010003450A publication Critical patent/MX2010003450A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Los presentes inventores tuvieron ?xito en mejorar la regi?n constante de un anticuerpo para obtener una estabilidad incrementada bajo condiciones ?cidas, una heterogeneidad originada en los enlaces disulfuro en la regi?n bisagra reducida, una heterogeneidad originada en el extremo C de la cadena H reducida, y una mayor estabilidad en concentraciones elevadas, y tambi?n descubrieron nuevas secuencias de la regi?n constante que tienen una actividad de uni?n al receptor Fcy reducida, y que simult?neamente permiten minimizar la generaci?n de nuevos ep?topos pept?dicos de las c?lulas T. Como resultado, los presentes inventores descubrieron exitosamente regiones constantes de anticuerpos con propiedades f?sicoqu?micas (estabilidad y homogeneidad), inmunogenicidad, seguridad y farmacocin?tica mejoradas.
MX2010003450A 2007-09-26 2008-09-26 Region constante de anticuerpo modificada. MX2010003450A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007250147 2007-09-26
PCT/JP2008/067483 WO2009041613A1 (ja) 2007-09-26 2008-09-26 抗体定常領域改変体

Publications (1)

Publication Number Publication Date
MX2010003450A true MX2010003450A (es) 2010-04-27

Family

ID=40511493

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010003450A MX2010003450A (es) 2007-09-26 2008-09-26 Region constante de anticuerpo modificada.
MX2013009569A MX342551B (es) 2007-09-26 2008-09-26 Region constante de anticuerpo modificada.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2013009569A MX342551B (es) 2007-09-26 2008-09-26 Region constante de anticuerpo modificada.

Country Status (22)

Country Link
US (3) US9688762B2 (es)
EP (4) EP3415529B1 (es)
JP (9) JP5484060B2 (es)
KR (6) KR101922788B1 (es)
CN (1) CN101874041B (es)
AR (4) AR068563A1 (es)
AU (1) AU2008304748C1 (es)
CA (5) CA3139492C (es)
CL (1) CL2008002886A1 (es)
DK (2) DK3059246T3 (es)
ES (2) ES2566957T3 (es)
IL (1) IL204537A0 (es)
MX (2) MX2010003450A (es)
MY (3) MY180713A (es)
PE (1) PE20090711A1 (es)
PH (3) PH12018501459B1 (es)
PL (1) PL3059246T3 (es)
RU (2) RU2526512C2 (es)
SG (2) SG10201605394SA (es)
TW (2) TWI464262B (es)
WO (1) WO2009041613A1 (es)
ZA (1) ZA201002422B (es)

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