MX2010002242A - Estimulación de ruta wnt en reprogramacion de celulas somaticas. - Google Patents
Estimulación de ruta wnt en reprogramacion de celulas somaticas.Info
- Publication number
- MX2010002242A MX2010002242A MX2010002242A MX2010002242A MX2010002242A MX 2010002242 A MX2010002242 A MX 2010002242A MX 2010002242 A MX2010002242 A MX 2010002242A MX 2010002242 A MX2010002242 A MX 2010002242A MX 2010002242 A MX2010002242 A MX 2010002242A
- Authority
- MX
- Mexico
- Prior art keywords
- somatic cells
- methods
- reprogramming
- reprogramming somatic
- wnt pathway
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/45—Artificially induced pluripotent stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
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- C12N2510/00—Genetically modified cells
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
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- Reproductive Health (AREA)
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Abstract
La invención proporciona composiciones y métodos de uso en la reprogramación de células somáticas. Las composiciones y métodos de la invención son de uso, por ejemplo para generar o modular (por ejemplo, para mejorar) la generación de células madre pluripotentes inducidas al reprogramar células somáticas. Las células somáticas reprogramadas son útiles para varios propósitos, que incluyen tratar o prevenir una afección médica en un individuo. La invención proporciona además métodos para identificar un agente que reprograma células somáticas a un estado pluripotente y/o mejora la velocidad y/o eficiencia de la reprogramación. Ciertas composiciones y métodos se refieren a modular la ruta de Wnt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96702807P | 2007-08-31 | 2007-08-31 | |
| US18819008P | 2008-08-06 | 2008-08-06 | |
| PCT/US2008/010249 WO2009032194A1 (en) | 2007-08-31 | 2008-08-29 | Wnt pathway stimulation in reprogramming somatic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002242A true MX2010002242A (es) | 2010-06-01 |
Family
ID=40429192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002242A MX2010002242A (es) | 2007-08-31 | 2008-08-29 | Estimulación de ruta wnt en reprogramacion de celulas somaticas. |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US9102919B2 (es) |
| EP (2) | EP2198011B1 (es) |
| JP (8) | JP6151879B2 (es) |
| CN (1) | CN101855338B (es) |
| AU (5) | AU2008297011B2 (es) |
| CA (2) | CA2698091C (es) |
| ES (2) | ES2799897T3 (es) |
| MX (1) | MX2010002242A (es) |
| RU (1) | RU2492232C2 (es) |
| WO (1) | WO2009032194A1 (es) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| EP4223769A3 (en) | 2005-12-13 | 2023-11-01 | Kyoto University | Nuclear reprogramming factor |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| JP5813321B2 (ja) | 2007-03-23 | 2015-11-17 | ウィスコンシン アラムニ リサーチ ファンデーション | 体細胞の再プログラム化 |
| EP3878949B1 (en) | 2007-04-07 | 2025-06-04 | Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| EP2198011B1 (en) | 2007-08-31 | 2016-06-08 | Whitehead Institute for Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| EP2090649A1 (en) * | 2008-02-13 | 2009-08-19 | Fondazione Telethon | Method for reprogramming differentiated cells |
| WO2009102983A2 (en) * | 2008-02-15 | 2009-08-20 | President And Fellows Of Harvard College | Efficient induction of pluripotent stem cells using small molecule compounds |
| SG10201808863UA (en) | 2008-03-17 | 2018-11-29 | Scripps Research Inst | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| SG10201400329YA (en) | 2008-05-02 | 2014-05-29 | Univ Kyoto | Method of nuclear reprogramming |
| DK2297307T3 (en) | 2008-06-04 | 2016-07-25 | Cellular Dynamics Int Inc | PROCEDURES FOR THE MANUFACTURE OF IPS CELLS USING NON-VIRAL METHODS |
| CA2727681C (en) | 2008-06-13 | 2017-07-25 | Whitehead Institute For Biomedical Research | Programming and reprogramming of cells |
| CN107988261A (zh) | 2008-08-12 | 2018-05-04 | 细胞动力国际有限公司 | 产生ips细胞的方法 |
| WO2010068955A2 (en) * | 2008-12-13 | 2010-06-17 | Dna Microarray | MICROENVIRONMENT NICHE ASSAY FOR CiPS SCREENING |
| EP2373784B1 (en) | 2008-12-17 | 2017-10-25 | The Scripps Research Institute | Generation and maintenance of stem cells |
| DK2432881T3 (en) | 2009-05-18 | 2018-02-26 | Curna Inc | TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR |
| EP3150701B1 (en) * | 2009-06-05 | 2018-10-03 | FUJIFILM Cellular Dynamics, Inc. | Reprogramming t cells and hematopoietic cells |
| JP2011004674A (ja) * | 2009-06-26 | 2011-01-13 | Fujitsu Ltd | 誘導多能性幹細胞(iPS細胞)の製造方法 |
| SG177552A1 (en) | 2009-07-08 | 2012-03-29 | Inst Nat Sante Rech Med | A method for inducing extended self-renewal of functionally differentiated somatic cells |
| JP5886195B2 (ja) | 2009-07-09 | 2016-03-16 | ホワイトヘッド・インスティチュート・フォア・バイオメディカル・リサーチ | 哺乳動物遺伝学のための組成物および方法、ならびにその使用 |
| JP5751548B2 (ja) * | 2009-08-07 | 2015-07-22 | 国立大学法人京都大学 | イヌiPS細胞及びその製造方法 |
| CN102741394B (zh) | 2009-10-16 | 2016-05-04 | 斯克里普斯研究所 | 多能细胞的诱导 |
| KR102014977B1 (ko) | 2009-10-31 | 2019-08-27 | 뉴 월드 레보러토리즈 인코포레이티드. | 세포의 재프로그램화 방법 및 이의 용도 |
| US9453205B2 (en) | 2009-10-31 | 2016-09-27 | Genesis Technologies Limited | Methods for reprogramming cells and uses thereof |
| US20140038291A1 (en) | 2009-10-31 | 2014-02-06 | New World Laboratories Inc. | Methods for reprogramming cells and uses thereof |
| JP5898086B2 (ja) * | 2009-11-04 | 2016-04-06 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 化学物質を用いるエピソームリプログラミング |
| JP2013510563A (ja) * | 2009-11-13 | 2013-03-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 操作された微小胞を用いた真核細胞のリプログラミング |
| CN105176930B (zh) | 2010-03-31 | 2021-05-04 | 斯克里普斯研究所 | 重编程细胞 |
| ES2986590T3 (es) | 2010-06-14 | 2024-11-12 | Scripps Research Inst | Reprogramación de células hacia un nuevo destino |
| JPWO2011158852A1 (ja) * | 2010-06-15 | 2013-08-19 | 国立大学法人 東京大学 | 誘導型多能性幹細胞の製造方法 |
| KR101975688B1 (ko) | 2010-12-22 | 2019-05-07 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| US9926532B2 (en) | 2010-12-31 | 2018-03-27 | Guangzhou Institute Of Biomedicine And Health | Method of generating induced pluripotent stem cells and differentiated cells |
| CN107988381B (zh) | 2011-07-25 | 2021-05-28 | 国立大学法人京都大学 | 筛选诱导的多能干细胞的方法 |
| EP2763670B1 (en) * | 2011-10-03 | 2018-12-05 | Universite Libre De Bruxelles | Reactivation of hiv-1 gene expression to treat persistent hiv infection |
| JP6162604B2 (ja) | 2011-10-21 | 2017-07-12 | 国立大学法人京都大学 | 層流による多能性維持単一分散細胞培養法 |
| JP5999658B2 (ja) | 2011-11-25 | 2016-09-28 | 国立大学法人京都大学 | 多能性幹細胞の培養方法 |
| RU2477314C1 (ru) * | 2011-12-07 | 2013-03-10 | Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт патологии кровообращения имени академика Е.Н. Мешалкина" Минздравсоцразвития РФ, (ФГБУ "ННИИПК им. акад. Е.Н. Мешалкина" Минздравсоцразвития России) | РЕКОМБИНАНТНАЯ ПЛАЗМИДА pSM-ZsGreen, КОДИРУЮЩАЯ БЕЛКИ SOX2 И С-MYC ЧЕЛОВЕКА И ФЛУОРЕСЦЕНТНЫЙ БЕЛОК ZsGreen, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ПОЛУЧЕНИЯ ИНДУЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ СТВОЛОВЫХ КЛЕТОК ЧЕЛОВЕКА |
| WO2013159103A1 (en) * | 2012-04-20 | 2013-10-24 | Whitehead Institute For Biomedical Research | Programming and reprogramming of cells |
| US10077429B2 (en) | 2012-10-23 | 2018-09-18 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| WO2014123242A1 (ja) | 2013-02-08 | 2014-08-14 | 国立大学法人京都大学 | 巨核球及び血小板の製造方法 |
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| CA2909230C (en) | 2013-04-12 | 2021-06-15 | Kyoto University | Method for inducing alveolar epithelial progenitor cells |
| JP6429280B2 (ja) | 2013-05-14 | 2018-11-28 | 国立大学法人京都大学 | 効率的な心筋細胞の誘導方法 |
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| US9796962B2 (en) | 2013-08-07 | 2017-10-24 | Kyoto University | Method for generating pancreatic hormone-producing cells |
| US11473058B2 (en) | 2013-09-05 | 2022-10-18 | Kyoto University | Method for inducing dopaminergic neuron progenitor cells |
| KR102219743B1 (ko) | 2013-11-01 | 2021-02-23 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 신규 연골 세포 유도 방법 |
| ES2966757T3 (es) | 2014-03-04 | 2024-04-24 | Fate Therapeutics Inc | Métodos de reprogramación mejorados y plataformas de cultivo celular |
| WO2015140257A1 (en) | 2014-03-19 | 2015-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for inducing human cholangiocyte differentiation |
| EP3929302A1 (en) | 2014-07-14 | 2021-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method for identifying epitope on protein |
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