MX2009013340A - Mutante de cadena pesada que lleva a produccion de inmunoglobulina mejorada. - Google Patents
Mutante de cadena pesada que lleva a produccion de inmunoglobulina mejorada.Info
- Publication number
- MX2009013340A MX2009013340A MX2009013340A MX2009013340A MX2009013340A MX 2009013340 A MX2009013340 A MX 2009013340A MX 2009013340 A MX2009013340 A MX 2009013340A MX 2009013340 A MX2009013340 A MX 2009013340A MX 2009013340 A MX2009013340 A MX 2009013340A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- heavy chain
- immunoglobulin production
- domain
- terminal part
- Prior art date
Links
- 230000016784 immunoglobulin production Effects 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 7
- 102000039446 nucleic acids Human genes 0.000 abstract 7
- 108020004707 nucleic acids Proteins 0.000 abstract 7
- 210000004899 c-terminal region Anatomy 0.000 abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- IKAIKUBBJHFNBZ-UHFFFAOYSA-N glycyl-lysine Chemical compound NCCCCC(C(O)=O)NC(=O)CN IKAIKUBBJHFNBZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención describe un ácido nucleico que codifica para la secuencia de aminoácidos de la parte C-terminal del dominio CH3 de una inmunoglobulina de la clase IgA o IgG, o la parte C-terminal del dominio CH4 de una inmunoglobulina de la clase IgE o IgM, en donde el dipéptido de glicina-lisina comprendido en la secuencia de aminoácido de la parte C-terminal del dominio CH3 o CH4 es codificado por el ácido nucleico donde ggaaaa, o el ácido nucleico ggcaaa, o el ácido nucleico gggaaa, o el ácido nucleico gggaag, o el ácido nucleico ggcaag, o el ácido nucleico ggaaag.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07012774 | 2007-06-29 | ||
| PCT/EP2008/005136 WO2009003623A1 (en) | 2007-06-29 | 2008-06-25 | Heavy chain mutant leading to improved immunoglobulin production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009013340A true MX2009013340A (es) | 2010-01-18 |
Family
ID=38649939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009013340A MX2009013340A (es) | 2007-06-29 | 2008-06-25 | Mutante de cadena pesada que lleva a produccion de inmunoglobulina mejorada. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8314225B2 (es) |
| EP (2) | EP2167540B1 (es) |
| JP (1) | JP5512514B2 (es) |
| KR (1) | KR101163295B1 (es) |
| CN (1) | CN101687920B (es) |
| CA (1) | CA2689125C (es) |
| DK (1) | DK2167540T3 (es) |
| ES (1) | ES2665920T3 (es) |
| HR (1) | HRP20180565T1 (es) |
| HU (1) | HUE037060T2 (es) |
| IL (1) | IL201919A (es) |
| LT (1) | LT2167540T (es) |
| MX (1) | MX2009013340A (es) |
| NO (1) | NO2167540T3 (es) |
| PL (1) | PL2167540T3 (es) |
| PT (1) | PT2167540T (es) |
| RU (1) | RU2522481C2 (es) |
| SI (1) | SI2167540T1 (es) |
| TW (2) | TWI457441B (es) |
| WO (1) | WO2009003623A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017205270B2 (en) | 2016-01-08 | 2024-01-18 | Nykode Therapeutics ASA | Therapeutic anticancer neoepitope vaccine |
| MX2021015193A (es) * | 2019-06-28 | 2022-01-18 | Hoffmann La Roche | Metodo para la produccion de un anticuerpo. |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204244A (en) * | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) * | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| JP3150340B2 (ja) | 1990-11-13 | 2001-03-26 | イムネクス コーポレイション | 二機能選択可能融合遺伝子 |
| CA2163427A1 (en) | 1993-05-21 | 1994-12-08 | Stephen D. Lupton | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5888809A (en) * | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| US20020146750A1 (en) | 2000-03-30 | 2002-10-10 | Hoogenboom Hendricus R.J.M. | Mucin-1 specific binding members and methods of use thereof |
| US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| WO2004024915A1 (en) | 2002-09-13 | 2004-03-25 | The University Of Queensland | Gene expression system based on codon translation efficiency |
| KR20050119120A (ko) | 2003-03-14 | 2005-12-20 | 와이어쓰 | 인간 ⅰｌ-21 수용체에 대한 항체 및 그것의 용도 |
| AR046071A1 (es) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
| US7696322B2 (en) * | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
| EP1508576A1 (en) * | 2003-08-20 | 2005-02-23 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
| HRP20130440T1 (en) | 2004-04-13 | 2013-06-30 | F. Hoffmann - La Roche Ag | Anti-p-selectin antibodies |
| EP1797182A2 (en) * | 2004-10-05 | 2007-06-20 | Wyeth a Corporation of the State of Delaware | Methods and compositions for improving recombinant protein production |
| CA2606576A1 (en) * | 2005-05-20 | 2006-11-23 | Lonza Biologics Plc. | High-level expression of recombinant antibody in a mammalian host cell |
| KR20080039844A (ko) * | 2005-05-24 | 2008-05-07 | 아베스타 겐그레인 테크놀로지스 피브이티 리미티드 | Ｂ―세포 림프종 치료를 위한 ｃｄ20에 대한 모노클로날항체의 제조 방법 |
| WO2006126068A2 (en) * | 2005-05-24 | 2006-11-30 | Avestha Gengraine Technologies Pvt Ltd | Recombinant method for the production of a monoclonal antibody to cd52 for the treatment of chronic lymphocytic leukemia |
| WO2007068429A1 (en) * | 2005-12-12 | 2007-06-21 | F. Hoffmann-La Roche Ag | Antibodies against amyloid beta 4 with glycosylated in the variable region |
| EA019517B1 (ru) * | 2008-03-12 | 2014-04-30 | Имклоун Элэлси | Антитела к tyrp1 и их применение |
-
2008
- 2008-06-25 HR HRP20180565TT patent/HRP20180565T1/hr unknown
- 2008-06-25 DK DK08773643.5T patent/DK2167540T3/en active
- 2008-06-25 KR KR1020107002053A patent/KR101163295B1/ko active Active
- 2008-06-25 SI SI200831942T patent/SI2167540T1/en unknown
- 2008-06-25 JP JP2010513747A patent/JP5512514B2/ja active Active
- 2008-06-25 NO NO08773643A patent/NO2167540T3/no unknown
- 2008-06-25 HU HUE08773643A patent/HUE037060T2/hu unknown
- 2008-06-25 ES ES08773643.5T patent/ES2665920T3/es active Active
- 2008-06-25 WO PCT/EP2008/005136 patent/WO2009003623A1/en not_active Ceased
- 2008-06-25 US US12/664,401 patent/US8314225B2/en active Active
- 2008-06-25 PT PT87736435T patent/PT2167540T/pt unknown
- 2008-06-25 EP EP08773643.5A patent/EP2167540B1/en active Active
- 2008-06-25 CA CA2689125A patent/CA2689125C/en active Active
- 2008-06-25 PL PL08773643T patent/PL2167540T3/pl unknown
- 2008-06-25 LT LTEP08773643.5T patent/LT2167540T/lt unknown
- 2008-06-25 EP EP18154012.1A patent/EP3351557A1/en active Pending
- 2008-06-25 CN CN2008800227713A patent/CN101687920B/zh not_active Ceased
- 2008-06-25 RU RU2010102811/10A patent/RU2522481C2/ru active
- 2008-06-25 MX MX2009013340A patent/MX2009013340A/es active IP Right Grant
- 2008-06-27 TW TW100130177A patent/TWI457441B/zh active
- 2008-06-27 TW TW097124423A patent/TWI361221B/zh active
-
2009
- 2009-11-04 IL IL201919A patent/IL201919A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PT2167540T (pt) | 2018-04-04 |
| US20100184144A1 (en) | 2010-07-22 |
| IL201919A0 (en) | 2010-06-16 |
| RU2010102811A (ru) | 2011-08-10 |
| CA2689125C (en) | 2015-10-20 |
| TWI361221B (en) | 2012-04-01 |
| TWI457441B (zh) | 2014-10-21 |
| PL2167540T3 (pl) | 2018-07-31 |
| LT2167540T (lt) | 2018-04-25 |
| KR101163295B1 (ko) | 2012-07-05 |
| EP2167540B1 (en) | 2018-02-14 |
| CN101687920B (zh) | 2013-06-19 |
| HRP20180565T1 (hr) | 2018-05-04 |
| WO2009003623A1 (en) | 2009-01-08 |
| RU2522481C2 (ru) | 2014-07-20 |
| JP2010531648A (ja) | 2010-09-30 |
| KR20100038409A (ko) | 2010-04-14 |
| TW200914609A (en) | 2009-04-01 |
| CN101687920A (zh) | 2010-03-31 |
| NO2167540T3 (es) | 2018-07-14 |
| ES2665920T3 (es) | 2018-04-30 |
| SI2167540T1 (en) | 2018-05-31 |
| CA2689125A1 (en) | 2009-01-08 |
| EP2167540A1 (en) | 2010-03-31 |
| HUE037060T2 (hu) | 2018-08-28 |
| JP5512514B2 (ja) | 2014-06-04 |
| AU2008271659A1 (en) | 2009-01-08 |
| EP3351557A1 (en) | 2018-07-25 |
| US8314225B2 (en) | 2012-11-20 |
| TW201142025A (en) | 2011-12-01 |
| DK2167540T3 (en) | 2018-04-30 |
| BRPI0813963A2 (pt) | 2015-01-06 |
| IL201919A (en) | 2015-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |