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MX2009012567A - 3-(imidazolil)-pirazolo[3,4-b]piridinas. - Google Patents

3-(imidazolil)-pirazolo[3,4-b]piridinas.

Info

Publication number
MX2009012567A
MX2009012567A MX2009012567A MX2009012567A MX2009012567A MX 2009012567 A MX2009012567 A MX 2009012567A MX 2009012567 A MX2009012567 A MX 2009012567A MX 2009012567 A MX2009012567 A MX 2009012567A MX 2009012567 A MX2009012567 A MX 2009012567A
Authority
MX
Mexico
Prior art keywords
pyrazolo
ccr1
pyridines
imidazolyl
compounds
Prior art date
Application number
MX2009012567A
Other languages
English (en)
Inventor
Penglie Zhang
Lianfa Li
Andrew M K Pennell
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of MX2009012567A publication Critical patent/MX2009012567A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos que actúan como potentes antagonistas del receptor CCR1, y tienen actividad antiinflamatoria in vivo. Los compuestos son derivados 3-imidazolil-pirazoio[3,4-b]ipiridina y son útiles para composiciones farmacéuticas, métodos para tratar enfermedades mediadas por CCR1, y como controles en ensayos para la identificación de antagonistas competitivos de CCR1.
MX2009012567A 2007-05-22 2008-05-21 3-(imidazolil)-pirazolo[3,4-b]piridinas. MX2009012567A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93294807P 2007-05-22 2007-05-22
PCT/US2008/064374 WO2008147815A1 (en) 2007-05-22 2008-05-21 3-(imidazolyl)-pyrazolo[3,4-b]pyridines

Publications (1)

Publication Number Publication Date
MX2009012567A true MX2009012567A (es) 2010-02-17

Family

ID=40075474

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012567A MX2009012567A (es) 2007-05-22 2008-05-21 3-(imidazolil)-pirazolo[3,4-b]piridinas.

Country Status (26)

Country Link
US (4) US7629344B2 (es)
EP (1) EP2155712B1 (es)
JP (1) JP5457338B2 (es)
KR (1) KR101534661B1 (es)
CN (1) CN101743238B (es)
AR (2) AR066701A1 (es)
AU (1) AU2008256862B2 (es)
BR (1) BRPI0811849A8 (es)
CA (1) CA2687625C (es)
CL (1) CL2008001493A1 (es)
CO (1) CO6241152A2 (es)
DK (1) DK2155712T3 (es)
EA (1) EA015529B1 (es)
ES (1) ES2600477T3 (es)
HU (1) HUE032273T2 (es)
IL (1) IL202248A (es)
JO (1) JO3319B1 (es)
MA (1) MA31442B1 (es)
MX (1) MX2009012567A (es)
NZ (1) NZ581405A (es)
PE (1) PE20090293A1 (es)
PL (1) PL2155712T3 (es)
PT (1) PT2155712T (es)
TW (1) TWI418353B (es)
UA (1) UA99619C2 (es)
WO (1) WO2008147815A1 (es)

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ES2536884T3 (es) 2008-09-11 2015-05-29 Chemocentryx, Inc. 4-Amino-3-(imidazolil)pirazol[3,4-d]pirimidinas
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
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MX2015007051A (es) * 2012-12-07 2016-01-12 Chemocentryx Inc Diazol lactamas.
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US20170195506A1 (en) * 2015-12-30 2017-07-06 Kabushiki Kaisha Toshiba Image forming apparatus forming location free print system and print job retrieval method by the same
TWI808938B (zh) * 2016-04-07 2023-07-21 美商卡默森屈有限公司 藉由投予ccr1拮抗劑與pd-1抑制劑或pd-l1抑制劑之組合減少腫瘤負荷
KR102890201B1 (ko) 2019-07-10 2025-11-24 케모센트릭스, 인크. Pd-l1 억제제로서의 인단
CA3152714A1 (en) 2019-10-16 2021-04-22 Pingchen Fan Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases
PH12022550876A1 (en) 2019-10-16 2023-03-27 Chemocentryx Inc Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases

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Also Published As

Publication number Publication date
AU2008256862A8 (en) 2009-12-24
JP5457338B2 (ja) 2014-04-02
PE20090293A1 (es) 2009-04-04
HUE032273T2 (en) 2017-09-28
US8481545B2 (en) 2013-07-09
IL202248A0 (en) 2010-06-16
US20120010214A1 (en) 2012-01-12
AU2008256862A1 (en) 2008-12-04
DK2155712T3 (en) 2016-12-19
JP2010528038A (ja) 2010-08-19
AR110128A2 (es) 2019-02-27
CA2687625A1 (en) 2008-12-04
CN101743238A (zh) 2010-06-16
EP2155712A1 (en) 2010-02-24
NZ581405A (en) 2011-06-30
PT2155712T (pt) 2016-12-13
ES2600477T3 (es) 2017-02-09
CL2008001493A1 (es) 2008-08-29
CO6241152A2 (es) 2011-01-20
AU2008256862B2 (en) 2013-01-31
CA2687625C (en) 2015-12-22
TWI418353B (zh) 2013-12-11
US20100173911A1 (en) 2010-07-08
IL202248A (en) 2015-04-30
BRPI0811849A8 (pt) 2019-01-15
EP2155712B1 (en) 2016-09-07
TW200906402A (en) 2009-02-16
CN101743238B (zh) 2014-04-30
US7960388B2 (en) 2011-06-14
KR20100022998A (ko) 2010-03-03
KR101534661B1 (ko) 2015-07-09
AR066701A1 (es) 2009-09-09
HK1141524A1 (zh) 2010-11-12
EP2155712A4 (en) 2011-05-11
US20130184289A1 (en) 2013-07-18
US20080300257A1 (en) 2008-12-04
EA015529B1 (ru) 2011-08-30
PL2155712T3 (pl) 2017-02-28
UA99619C2 (en) 2012-09-10
EA200901572A1 (ru) 2010-04-30
JO3319B1 (ar) 2019-03-13
MA31442B1 (fr) 2010-06-01
US7629344B2 (en) 2009-12-08
BRPI0811849A2 (pt) 2014-11-18
WO2008147815A1 (en) 2008-12-04

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