MX2009011253A - Proceso de fabricacion de agentes anti-inflamatorios no esteroides e intermediarios de los mismos. - Google Patents
Proceso de fabricacion de agentes anti-inflamatorios no esteroides e intermediarios de los mismos.Info
- Publication number
- MX2009011253A MX2009011253A MX2009011253A MX2009011253A MX2009011253A MX 2009011253 A MX2009011253 A MX 2009011253A MX 2009011253 A MX2009011253 A MX 2009011253A MX 2009011253 A MX2009011253 A MX 2009011253A MX 2009011253 A MX2009011253 A MX 2009011253A
- Authority
- MX
- Mexico
- Prior art keywords
- groups
- intermediates
- manufacture
- inflammatory agents
- steroidal anti
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 title 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- -1 chloro, bromo, hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
- C07D317/06—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invención describe nuevas rutas de síntesis quiral e intermediarios para la elaboración de agentes anti-inflamatorios quirales de la fórmula general VIII, en la cual al menos uno de los grupos X1, X2, X3 se selecciona entre flúor, cloro, bromo, hidroxi, metoxi, etoxi, trifluorometilo, amino, en tanto los otros grupos X1, X2, X3 significan un átomo de hidrógeno, en la cual al menos uno de los grupos Z1, Z2, Z3 se selecciona entre -O-, -S-, -NH-, -N(-CH3)-, en tanto los otros grupos Z1, Z2, Z3 significan un grupo -CH2-, y en la cual Ar es un grupo aromático.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91259607P | 2007-04-18 | 2007-04-18 | |
| EP07090075A EP1982976A1 (en) | 2007-04-18 | 2007-04-18 | Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof |
| EP07008931 | 2007-05-03 | ||
| PCT/EP2008/003202 WO2008128750A2 (en) | 2007-04-18 | 2008-04-17 | Process for the manufacture for non-steroidal anti-inflammatory agents and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009011253A true MX2009011253A (es) | 2009-12-02 |
Family
ID=39744996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009011253A MX2009011253A (es) | 2007-04-18 | 2008-04-17 | Proceso de fabricacion de agentes anti-inflamatorios no esteroides e intermediarios de los mismos. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8071796B2 (es) |
| EP (1) | EP2142503A2 (es) |
| JP (1) | JP5725539B2 (es) |
| KR (1) | KR20090129480A (es) |
| CN (1) | CN101679247B (es) |
| AR (1) | AR066216A1 (es) |
| AU (1) | AU2008240936B8 (es) |
| BR (1) | BRPI0810448A2 (es) |
| CA (1) | CA2683512C (es) |
| IL (2) | IL200970A (es) |
| MX (1) | MX2009011253A (es) |
| SG (1) | SG182950A1 (es) |
| TW (2) | TWI356057B (es) |
| WO (1) | WO2008128750A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5725539B2 (ja) * | 2007-04-18 | 2015-05-27 | インテンディス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非ステロイド抗炎症剤及びその中間体の製造方法 |
| CN108430385A (zh) | 2015-10-19 | 2018-08-21 | 拉奥·维沙尔·尤齐拉·晒舍儿 | 气管食管语音假体装置 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1175889A (ja) * | 1997-07-15 | 1999-03-23 | Mitsubishi Rayon Co Ltd | 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法 |
| JP2000014397A (ja) * | 1998-07-01 | 2000-01-18 | Sumitomo Chem Co Ltd | 光学活性２−ヒドロキシ−２−トリフルオロメチル酢酸類の製造方法 |
| RU2005124558A (ru) * | 2003-01-03 | 2006-04-10 | Берингер Ингельхайм Фармасьютиклз, Инк. (Us) | Производные 1-пропанола и 1-пропиламина и их применение в качестве глюкокортикоидных лигандов |
| US7417056B2 (en) * | 2004-11-12 | 2008-08-26 | Schering Ag | 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents |
| DE102004055633A1 (de) * | 2004-11-12 | 2006-05-18 | Schering Ag | 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| JP5725539B2 (ja) * | 2007-04-18 | 2015-05-27 | インテンディス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非ステロイド抗炎症剤及びその中間体の製造方法 |
-
2008
- 2008-04-17 JP JP2010503427A patent/JP5725539B2/ja not_active Expired - Fee Related
- 2008-04-17 WO PCT/EP2008/003202 patent/WO2008128750A2/en not_active Ceased
- 2008-04-17 MX MX2009011253A patent/MX2009011253A/es active IP Right Grant
- 2008-04-17 KR KR1020097021654A patent/KR20090129480A/ko not_active Abandoned
- 2008-04-17 EP EP08735344A patent/EP2142503A2/en not_active Withdrawn
- 2008-04-17 SG SG2012028296A patent/SG182950A1/en unknown
- 2008-04-17 AU AU2008240936A patent/AU2008240936B8/en not_active Ceased
- 2008-04-17 BR BRPI0810448-4A2A patent/BRPI0810448A2/pt not_active IP Right Cessation
- 2008-04-17 CA CA2683512A patent/CA2683512C/en not_active Expired - Fee Related
- 2008-04-17 US US12/104,772 patent/US8071796B2/en not_active Expired - Fee Related
- 2008-04-17 CN CN200880012255.2A patent/CN101679247B/zh not_active Expired - Fee Related
- 2008-04-18 TW TW097114364A patent/TWI356057B/zh not_active IP Right Cessation
- 2008-04-18 TW TW100126242A patent/TWI409260B/zh not_active IP Right Cessation
- 2008-04-18 AR ARP080101593A patent/AR066216A1/es unknown
-
2009
- 2009-09-16 IL IL200970A patent/IL200970A/en not_active IP Right Cessation
-
2011
- 2011-10-14 US US13/273,472 patent/US20120035371A1/en not_active Abandoned
-
2012
- 2012-11-29 IL IL223343A patent/IL223343A0/en unknown
-
2014
- 2014-03-14 US US14/212,422 patent/US20140200354A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2683512A1 (en) | 2008-10-30 |
| TW201139423A (en) | 2011-11-16 |
| EP2142503A2 (en) | 2010-01-13 |
| CN101679247B (zh) | 2014-02-19 |
| HK1141525A1 (en) | 2010-11-12 |
| WO2008128750A3 (en) | 2009-01-08 |
| IL200970A0 (en) | 2010-05-17 |
| SG182950A1 (en) | 2012-08-30 |
| AU2008240936A1 (en) | 2008-10-30 |
| CA2683512C (en) | 2014-12-02 |
| US20120035371A1 (en) | 2012-02-09 |
| CN101679247A (zh) | 2010-03-24 |
| WO2008128750A2 (en) | 2008-10-30 |
| JP2010524878A (ja) | 2010-07-22 |
| AR066216A1 (es) | 2009-08-05 |
| BRPI0810448A2 (pt) | 2014-10-14 |
| IL200970A (en) | 2015-02-26 |
| AU2008240936B2 (en) | 2014-04-10 |
| TWI409260B (zh) | 2013-09-21 |
| JP5725539B2 (ja) | 2015-05-27 |
| US20080274517A1 (en) | 2008-11-06 |
| IL223343A0 (en) | 2013-02-03 |
| TW200911791A (en) | 2009-03-16 |
| AU2008240936B8 (en) | 2014-08-14 |
| US8071796B2 (en) | 2011-12-06 |
| TWI356057B (en) | 2012-01-11 |
| US20140200354A1 (en) | 2014-07-17 |
| KR20090129480A (ko) | 2009-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX339476B (es) | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. | |
| UA94833C2 (en) | Substituted bicyclolactams | |
| MX2010003614A (es) | Compuestos de diarilo oxadiazol. | |
| WO2010044981A3 (en) | Benzoquinoline inhibitors of vesicular monoamine transporter 2 | |
| SG161302A1 (en) | DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE ss2 ADRENERGIC RECEPTOR | |
| MX2009005217A (es) | Compuestos heterociclicos que contienen nitrogeno y metodos de uso de los mismos. | |
| NO20080784L (no) | Histondeacetylaseinhibitorer | |
| MY149296A (en) | INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11-ß-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS | |
| MX2010009184A (es) | Proceso para la yodacion de compuestos aromaticos. | |
| MX2009005813A (es) | Procedimiento para la preparacion de betamimeticos. | |
| IL183064A0 (en) | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition | |
| UY32343A (es) | Compuestos de oxadiazol que inhiben dgat1 | |
| CR10671A (es) | Compuestos azabiciclicos como inhibidores de la recaptacion de monoaminas | |
| TW200745173A (en) | Fluoropolymer for chromatic aberration correction lens, and chromatic aberration correction lens | |
| MX2007005936A (es) | Una sintesis asimetrica del acido (s)-(+)-3-(aminometil)-5- metilhexanoico. | |
| UA86119C2 (ru) | Амидные пролекарства гемцитабина, их композиции и применение | |
| MX2009011253A (es) | Proceso de fabricacion de agentes anti-inflamatorios no esteroides e intermediarios de los mismos. | |
| EA014665B3 (ru) | Соединения и их соли, специфичные к ppar рецепторам и egf рецепторам, и их применение в области медицины | |
| IL188927A0 (en) | Aryloxy quinolines and uses thereof as 5-ht6 modulators | |
| NO20081947L (no) | Kjolesammensetning | |
| MX2012005596A (es) | Derivados de difenil azepano como inhibidores de reabsorcion de monoaminas. | |
| NZ615733A (en) | Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof | |
| WO2007004041A3 (en) | New compounds and their pharmaceutical use | |
| ATE539762T1 (de) | Aminosäureersatz für peptidkonstruktionen | |
| WO2006133339A3 (en) | Monoamine re-uptake inhibitors and methods relating thereto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |