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MX2009010931A - Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno. - Google Patents

Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.

Info

Publication number
MX2009010931A
MX2009010931A MX2009010931A MX2009010931A MX2009010931A MX 2009010931 A MX2009010931 A MX 2009010931A MX 2009010931 A MX2009010931 A MX 2009010931A MX 2009010931 A MX2009010931 A MX 2009010931A MX 2009010931 A MX2009010931 A MX 2009010931A
Authority
MX
Mexico
Prior art keywords
hydrogen transfer
oxycodone
oripavine
transfer reaction
catalytic hydrogen
Prior art date
Application number
MX2009010931A
Other languages
English (en)
Inventor
Gary L Cantrell
Peter X Wang
Tao Jiang
David Wayne Berberich
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of MX2009010931A publication Critical patent/MX2009010931A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Se proporciona un esquema de síntesis mejorado de compuestos opiáceos. Un mejoramiento a la oxidación de oripavina y derivados de oripavina comprende la formación in situ de los peroxiácidos requeridos para oxidar la oripavina y derivados de oripavina para formar un intermediario. Un mejoramiento a la reducción del intermediario para formar una oxicodona y derivados de oxicodona comprende la reducción utilizando un reactivo de transferencia de hidrógeno. Estos mejoramientos permiten la producción de oxicodona y derivados de oxicodona sin el aislamiento del intermediario, proporcionando un método de síntesis en un crisol.
MX2009010931A 2007-04-16 2008-04-15 Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno. MX2009010931A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91195007P 2007-04-16 2007-04-16
PCT/US2008/004869 WO2008130553A1 (en) 2007-04-16 2008-04-15 Novel opiate reduction utilizing catalytic hydrogen transfer reaction

Publications (1)

Publication Number Publication Date
MX2009010931A true MX2009010931A (es) 2009-10-29

Family

ID=39560869

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010931A MX2009010931A (es) 2007-04-16 2008-04-15 Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.

Country Status (8)

Country Link
US (1) US8309727B2 (es)
EP (1) EP2137190B1 (es)
JP (2) JP5373764B2 (es)
AU (1) AU2008241528B2 (es)
CA (1) CA2684458A1 (es)
ES (1) ES2423180T3 (es)
MX (1) MX2009010931A (es)
WO (1) WO2008130553A1 (es)

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JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
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EP2877473B1 (en) 2012-07-16 2017-06-14 Rhodes Technologies Process for improved opioid synthesis
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AU2014346883B2 (en) * 2013-11-07 2018-07-19 SpecGx LLC Production of 6-hydroxy morphinans without the isolation of intermediates
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
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MX374394B (es) 2014-01-15 2025-03-06 Rhodes Tech Proceso para la sintesis mejorada de oxicodona.
AU2015207734B2 (en) 2014-01-15 2017-02-23 Rhodes Technologies Process for improved oxymorphone synthesis
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CN111205296B (zh) * 2018-11-22 2022-10-04 中国科学院上海有机化学研究所 羟考酮类化合物及其中间体和制备方法
CN114573508B (zh) * 2020-12-01 2024-07-23 绍兴赜军生物医药科技有限公司 羟考酮类化合物、其中间体及制备方法

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Also Published As

Publication number Publication date
JP2010524938A (ja) 2010-07-22
JP2013216696A (ja) 2013-10-24
JP5373764B2 (ja) 2013-12-18
AU2008241528B2 (en) 2013-07-04
CA2684458A1 (en) 2008-10-30
ES2423180T3 (es) 2013-09-18
WO2008130553A1 (en) 2008-10-30
AU2008241528A1 (en) 2008-10-30
EP2137190A1 (en) 2009-12-30
US8309727B2 (en) 2012-11-13
US20100048905A1 (en) 2010-02-25
EP2137190B1 (en) 2013-06-12

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