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MX2010000162A - Conversion de tebaina a la morfina derivados. - Google Patents

Conversion de tebaina a la morfina derivados.

Info

Publication number
MX2010000162A
MX2010000162A MX2010000162A MX2010000162A MX2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A
Authority
MX
Mexico
Prior art keywords
conversion
thebaine
morphine derivatives
morphine
hydrocodone
Prior art date
Application number
MX2010000162A
Other languages
English (en)
Inventor
Robert Carroll
Hannes Leisch
Tomas Hudlicky
Cox D Phillip
Original Assignee
Univ Brock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brock filed Critical Univ Brock
Publication of MX2010000162A publication Critical patent/MX2010000162A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención proporciona métodos para la conversión de la tebaína a un derivado de morfina, tales como hidrocodona. Se proporcionan intermediarios de cetal nuevos. Un procedimiento de un solo paso para la conversión que se compone del tratamiento de la tebaína con un ácido en la presencia de un catalizador metal.
MX2010000162A 2007-06-29 2008-06-30 Conversion de tebaina a la morfina derivados. MX2010000162A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/771,259 US7928234B2 (en) 2007-06-29 2007-06-29 Conversion of thebaine to morphine derivatives
PCT/CA2008/001178 WO2009003271A1 (en) 2007-06-29 2008-06-30 Conversion of thebaine to morphine derivatives

Publications (1)

Publication Number Publication Date
MX2010000162A true MX2010000162A (es) 2010-03-22

Family

ID=40161386

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010000162A MX2010000162A (es) 2007-06-29 2008-06-30 Conversion de tebaina a la morfina derivados.

Country Status (9)

Country Link
US (1) US7928234B2 (es)
EP (1) EP2173754A1 (es)
JP (1) JP2010531813A (es)
KR (1) KR20100055393A (es)
CN (1) CN101801976A (es)
AU (1) AU2008271863A1 (es)
CA (1) CA2692429C (es)
MX (1) MX2010000162A (es)
WO (1) WO2009003271A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2763996T (pt) * 2011-10-03 2018-11-09 Johnson Matthey Plc Processo para preparar buprenorfina
EP2970320B1 (en) 2013-03-15 2020-10-28 Johnson Matthey Public Limited Company Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain
US9120800B2 (en) * 2013-08-02 2015-09-01 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone alkaloid and oxymorphone salts
MX2016005187A (es) 2013-11-07 2016-08-08 Mallinckrodt Llc Produccion de 6-hidroxi morfinanos sin el aislamiento de intermediarios.
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
CA2881229C (en) 2014-02-07 2022-04-05 Tomas Hudlicky Methods for the preparation of hydromorphone
WO2018009856A1 (en) 2016-07-08 2018-01-11 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone and other opiates
CN113845526B (zh) * 2021-01-18 2022-11-08 四川大学 一种蒂巴因衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277604A (en) 1980-01-25 1981-07-07 The United States Of America As Represented By The Department Of Health And Human Services Facile synthesis of codeine precursors from thebaine
US5668285A (en) 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US8067597B2 (en) 2005-06-16 2011-11-29 Mallinckrodt Llc Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs

Also Published As

Publication number Publication date
US7928234B2 (en) 2011-04-19
CA2692429A1 (en) 2009-01-08
KR20100055393A (ko) 2010-05-26
WO2009003271A1 (en) 2009-01-08
JP2010531813A (ja) 2010-09-30
US20090005563A1 (en) 2009-01-01
AU2008271863A1 (en) 2009-01-08
CA2692429C (en) 2017-03-21
CN101801976A (zh) 2010-08-11
EP2173754A1 (en) 2010-04-14

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal