MX2009010765A - Anticuerpos anti-ige. - Google Patents
Anticuerpos anti-ige.Info
- Publication number
- MX2009010765A MX2009010765A MX2009010765A MX2009010765A MX2009010765A MX 2009010765 A MX2009010765 A MX 2009010765A MX 2009010765 A MX2009010765 A MX 2009010765A MX 2009010765 A MX2009010765 A MX 2009010765A MX 2009010765 A MX2009010765 A MX 2009010765A
- Authority
- MX
- Mexico
- Prior art keywords
- ige
- relates
- present
- ige antibodies
- asthma
- Prior art date
Links
- 208000006673 asthma Diseases 0.000 abstract 2
- 208000004262 Food Hypersensitivity Diseases 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000020932 food allergy Nutrition 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/805—Drug, bio-affecting and body treating compositions involving IgE or IgD
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a anticuerpos de humanos novedosos especialmente dirigidos en contra de la inmunoglobulina de humano E (anti-IgE). La presente invención también se refiere a composiciones farmacológicas y métodos para tratar el asma, en particular asma alérgico, así como otras enfermedades mediadas por IgE, incluyendo rinitis alérgica y alergias alimenticias.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92154607P | 2007-04-02 | 2007-04-02 | |
| US875507P | 2007-12-20 | 2007-12-20 | |
| PCT/US2008/004286 WO2008123999A2 (en) | 2007-04-02 | 2008-04-01 | Anti-ige antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009010765A true MX2009010765A (es) | 2009-10-26 |
Family
ID=39831518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009010765A MX2009010765A (es) | 2007-04-02 | 2008-04-01 | Anticuerpos anti-ige. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7867494B2 (es) |
| EP (1) | EP2142214A4 (es) |
| JP (1) | JP2010532158A (es) |
| KR (1) | KR20100018499A (es) |
| CN (1) | CN101808661A (es) |
| AR (1) | AR065921A1 (es) |
| AU (1) | AU2008236765A1 (es) |
| BR (1) | BRPI0809677A2 (es) |
| CA (1) | CA2682927A1 (es) |
| CL (1) | CL2008000935A1 (es) |
| DO (1) | DOP2008000018A (es) |
| GT (1) | GT200800034A (es) |
| IL (1) | IL201156A0 (es) |
| MX (1) | MX2009010765A (es) |
| PA (1) | PA8775101A1 (es) |
| PE (1) | PE20081899A1 (es) |
| RU (1) | RU2009140313A (es) |
| SG (1) | SG182985A1 (es) |
| TW (1) | TW200904470A (es) |
| UY (1) | UY30994A1 (es) |
| WO (1) | WO2008123999A2 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006297304B2 (en) | 2005-09-29 | 2012-05-17 | Medimmune, Llc | Method of identifying membrane LG specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
| AU2009293143C1 (en) * | 2008-09-17 | 2015-07-23 | Xencor, Inc. | Novel compositons and methods for treating IgE-mediated disorders |
| CA2744754A1 (en) | 2008-12-09 | 2010-06-17 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
| WO2010122460A1 (en) * | 2009-04-20 | 2010-10-28 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| WO2010128265A2 (fr) | 2009-05-07 | 2010-11-11 | Stallergenes S.A. | Utilisation d'immunoglobulines igg1 et/ou de ligands du récepteur cd32 pour le traitement de maladies et manifestations inflammatoires par voie mucosale |
| CA2800774A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
| US10017762B2 (en) | 2010-11-24 | 2018-07-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for treating or preventing lupus |
| WO2012145469A1 (en) | 2011-04-19 | 2012-10-26 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
| US9546219B2 (en) | 2012-02-08 | 2017-01-17 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
| KR102102111B1 (ko) * | 2012-02-08 | 2020-04-20 | 아이쥐엠 바이오사이언스 인코포레이티드 | Cdim 결합 단백질 및 이의 용도 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| WO2014144817A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Inhibitory polypeptides specific to wnt inhibitors |
| MX2016002870A (es) | 2013-09-05 | 2017-02-23 | Amgen Inc | Moleculas que contienen fc que presentan perfiles de glicoforma predecibles, consistentes y reproducibles. |
| EP3143404B1 (en) | 2014-05-16 | 2018-08-29 | Amgen Inc. | Assay for detecting th1 and th2 cell populations |
| JP6519913B2 (ja) * | 2015-02-05 | 2019-05-29 | 国立大学法人名古屋大学 | IgE結合性エピトープペプチドの利用 |
| WO2016164920A1 (en) | 2015-04-09 | 2016-10-13 | Cornell University | Gene therapy to prevent reactions to allergens |
| WO2016191246A2 (en) * | 2015-05-22 | 2016-12-01 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for a prame peptide |
| GB201610198D0 (en) * | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
| CN107686521B (zh) * | 2016-08-04 | 2021-04-06 | 越海百奥药业(绍兴)有限公司 | 一种人源化抗IgE单克隆抗体 |
| JP7127859B2 (ja) | 2016-11-09 | 2022-08-30 | ノース カロライナ ステート ユニバーシティ | キメラタンパク質を用いたアレルギー疾患の治療 |
| WO2018129248A1 (en) * | 2017-01-06 | 2018-07-12 | The Regents Of The University Of California | Therapeutic anti-ige antibodies and methods and compositions thereof |
| AU2018235928B2 (en) | 2017-03-14 | 2023-09-21 | Amgen Inc. | Control of total afucosylated glycoforms of antibodies produced in cell culture |
| WO2019183437A1 (en) | 2018-03-23 | 2019-09-26 | North Carolina State University | Methods and compositions for antibody to high affinity receptor for ige |
| CA3093853A1 (en) | 2018-03-26 | 2019-10-03 | Amgen Inc. | Total afucosylated glycoforms of antibodies produced in cell culture |
| WO2021062372A1 (en) | 2019-09-26 | 2021-04-01 | Amgen Inc. | Methods of producing antibody compositions |
| CA3156740A1 (en) | 2019-11-01 | 2021-05-06 | Anthony Boitano | Anti-cd45 antibodies and conjugates thereof |
| CN113372450A (zh) * | 2020-03-10 | 2021-09-10 | 北京万华生物工程有限公司 | IgE嵌合性双特异性抗体制备及应用 |
| EP4162257A1 (en) | 2020-06-04 | 2023-04-12 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
| KR20230022231A (ko) * | 2020-06-15 | 2023-02-14 | 노파르티스 아게 | 항-ige 항체를 사용한 식품 알레르기 치료 |
| WO2022081824A1 (en) | 2020-10-15 | 2022-04-21 | Amgen Inc. | Relative unpaired glycans in antibody production methods |
| KR102545843B1 (ko) * | 2021-02-24 | 2023-06-20 | 주식회사 세바바이오텍 | 알러지, 아토피 및 가려움 개선용 기능성 소재의 스크리닝 방법 |
| CA3213283A1 (en) | 2021-03-11 | 2022-09-15 | IgGenix, Inc. | Methods and systems for predicting allergic response |
| AR126089A1 (es) | 2021-06-07 | 2023-09-13 | Amgen Inc | Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas |
| JP2024537100A (ja) | 2021-10-05 | 2024-10-10 | アムジエン・インコーポレーテツド | Fcガンマ受容体II結合、及びグリカン含量 |
| CN114504644B (zh) * | 2021-12-24 | 2024-02-13 | 北京大学第一医院 | 抗IgE抗体在用于治疗腺样体肥大中的应用 |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| AU2024256160A1 (en) | 2023-04-20 | 2025-10-02 | Amgen Inc. | Methods of determining relative unpaired glycan content |
| WO2025038600A1 (en) | 2023-08-14 | 2025-02-20 | Amgen Inc. | Methods for reducing yellow color |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449760A (en) * | 1987-12-31 | 1995-09-12 | Tanox Biosystems, Inc. | Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| WO1996033735A1 (en) | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) * | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6150584A (en) * | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ATE139258T1 (de) * | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
| WO1992015677A1 (en) | 1991-03-01 | 1992-09-17 | Protein Engineering Corporation | Process for the development of binding mini-proteins |
| WO1992017207A1 (en) * | 1991-03-26 | 1992-10-15 | Tanox Biosystems, Inc. | MONOCLONAL ANTIBODIES WHICH BIND TO SECRETED AND MEMBRANE-BOUND IgE, BUT NOT TO IgE ON BASOPHILS |
| ATE269401T1 (de) | 1991-04-10 | 2004-07-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| WO1992021031A1 (en) * | 1991-05-10 | 1992-11-26 | Alain De Weck | PROCEDURE FOR DETECTING AND PREPARING ANTI-IgE AUTOANTIBODIES AND USE OF THESE ANTIBODIES AS ACTIVE AGENTS IN DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US6699472B2 (en) * | 1991-08-14 | 2004-03-02 | Genentech, Inc. | Method of treating allergic disorders |
| ATE181571T1 (de) | 1991-09-23 | 1999-07-15 | Medical Res Council | Methoden zur herstellung humanisierter antikörper |
| WO1993019197A1 (en) * | 1992-03-20 | 1993-09-30 | Immunet | Human monoclonal antibodies and methods for human monoclonal antibody production |
| ATE381614T1 (de) | 1992-07-24 | 2008-01-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US5958708A (en) * | 1992-09-25 | 1999-09-28 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
| US6091001A (en) * | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6130364A (en) * | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| KR100479146B1 (ko) * | 1995-04-21 | 2005-05-16 | 셀 제네시스, 인코포레이티드 | 큰게놈dna결실유발법 |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5714352A (en) * | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US5994619A (en) * | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| JP4215172B2 (ja) | 1996-12-03 | 2009-01-28 | アムジェン フレモント インク. | 複数のV▲下H▼およびV▲下κ▼領域を含むヒトIg遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体 |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| US6172213B1 (en) * | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| EP1060193A2 (en) | 1998-03-03 | 2000-12-20 | Abgenix, Inc. | Cd147 binding molecules as therapeutics |
| US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
| WO2000009560A2 (en) | 1998-08-17 | 2000-02-24 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| CA2342967A1 (en) | 1998-12-08 | 2000-06-15 | Biovation Limited | Modifying protein immunogenicity |
| PL210435B1 (pl) | 1998-12-23 | 2012-01-31 | Amgen Fremont Inc | Ludzkie przeciwciała monoklonalne wiążące się z CTLA-4 |
| AU778551B2 (en) * | 2000-01-14 | 2004-12-09 | Daiichi Pharmaceutical Co., Ltd. | Novel peptide and screening method by using the same |
| EP1461423B1 (en) | 2001-12-03 | 2008-05-14 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| US20050169909A1 (en) * | 2004-02-02 | 2005-08-04 | Sanjaya Singh | Identification of novel IgE epitopes |
| DOP2006000195A (es) * | 2005-09-07 | 2017-08-15 | Amgen Fremont Inc | Anticuerpos monoclonales humanos para la quinasa-1 tipo receptor de activina |
-
2008
- 2008-04-01 SG SG2012048765A patent/SG182985A1/en unknown
- 2008-04-01 UY UY30994A patent/UY30994A1/es unknown
- 2008-04-01 GT GT200800034A patent/GT200800034A/es unknown
- 2008-04-01 RU RU2009140313/15A patent/RU2009140313A/ru not_active Application Discontinuation
- 2008-04-01 BR BRPI0809677-5A2A patent/BRPI0809677A2/pt not_active IP Right Cessation
- 2008-04-01 CA CA002682927A patent/CA2682927A1/en not_active Abandoned
- 2008-04-01 PE PE2008000595A patent/PE20081899A1/es not_active Application Discontinuation
- 2008-04-01 US US12/080,419 patent/US7867494B2/en not_active Expired - Fee Related
- 2008-04-01 JP JP2010502126A patent/JP2010532158A/ja not_active Withdrawn
- 2008-04-01 WO PCT/US2008/004286 patent/WO2008123999A2/en not_active Ceased
- 2008-04-01 KR KR1020097022898A patent/KR20100018499A/ko not_active Withdrawn
- 2008-04-01 AR ARP080101376A patent/AR065921A1/es not_active Application Discontinuation
- 2008-04-01 MX MX2009010765A patent/MX2009010765A/es not_active Application Discontinuation
- 2008-04-01 CN CN200880010487A patent/CN101808661A/zh active Pending
- 2008-04-01 EP EP08742484A patent/EP2142214A4/en not_active Withdrawn
- 2008-04-01 CL CL2008000935A patent/CL2008000935A1/es unknown
- 2008-04-01 PA PA20088775101A patent/PA8775101A1/es unknown
- 2008-04-01 DO DO2008000018A patent/DOP2008000018A/es unknown
- 2008-04-01 AU AU2008236765A patent/AU2008236765A1/en not_active Abandoned
- 2008-04-01 TW TW097111898A patent/TW200904470A/zh unknown
-
2009
- 2009-09-24 IL IL201156A patent/IL201156A0/en unknown
-
2010
- 2010-11-24 US US12/954,196 patent/US20110064726A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090117124A1 (en) | 2009-05-07 |
| DOP2008000018A (es) | 2008-10-15 |
| SG182985A1 (en) | 2012-08-30 |
| BRPI0809677A2 (pt) | 2014-10-07 |
| EP2142214A4 (en) | 2012-03-21 |
| US20110064726A1 (en) | 2011-03-17 |
| CA2682927A1 (en) | 2008-10-16 |
| TW200904470A (en) | 2009-02-01 |
| CL2008000935A1 (es) | 2008-11-07 |
| EP2142214A2 (en) | 2010-01-13 |
| AR065921A1 (es) | 2009-07-08 |
| US7867494B2 (en) | 2011-01-11 |
| GT200800034A (es) | 2010-03-16 |
| PE20081899A1 (es) | 2009-01-26 |
| UY30994A1 (es) | 2008-11-28 |
| WO2008123999A9 (en) | 2009-12-10 |
| PA8775101A1 (es) | 2008-11-19 |
| AU2008236765A1 (en) | 2008-10-16 |
| CN101808661A (zh) | 2010-08-18 |
| WO2008123999A2 (en) | 2008-10-16 |
| WO2008123999A3 (en) | 2010-06-24 |
| KR20100018499A (ko) | 2010-02-17 |
| RU2009140313A (ru) | 2011-05-10 |
| JP2010532158A (ja) | 2010-10-07 |
| IL201156A0 (en) | 2010-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009010765A (es) | Anticuerpos anti-ige. | |
| NZ599875A (en) | Human il-23 antigen binding proteins | |
| MX2009010092A (es) | Anticuerpos anti ige apoptoticos. | |
| WO2010032059A3 (en) | Antibodies directed to cd105 and uses thereof | |
| WO2006003388A3 (en) | Compositions and methods for treating inflammatory disorders | |
| PH12012500843A1 (en) | Engineered anti-tslp antibody | |
| WO2008097461A3 (en) | Hepcidin and hepcidin antibodies | |
| PH12013500356A1 (en) | Engineered anti-tslp antibody | |
| TN2010000126A1 (en) | Antibodies that bind il-4 and/or il-13 and their uses | |
| TNSN08333A1 (en) | Thymic stromal lymphopoietin (tslp) antibodies and uses thereof | |
| MY145349A (en) | Benzofuro- and benzothienopyrimidine modulators of the histamine h4 receptor | |
| MX2009012950A (es) | ANTICUERPOS HUMANIZADOS CONTRA EL GLOBULOMERO Aß (20-42) Y SUS USOS. | |
| MX2009008787A (es) | Moduladores 2-aminopirimidina del receptor de histamina h4. | |
| TW200736274A (en) | Immunoglobulins | |
| WO2009013543A3 (en) | Targeted binging agents directed to kdr and uses thereof - 035 | |
| MX2009008410A (es) | Elementos de aglutinacion para moleculas de ige. | |
| EP2772260A3 (en) | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment | |
| WO2010072740A3 (en) | TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF | |
| MY149492A (en) | Immunoglobulins directed against nogo | |
| WO2006109301A3 (en) | Molecules and methods of using same for treating mcp-1/ccr2 associated diseases | |
| WO2006135694A3 (en) | Uii-modulating compounds and their use | |
| ATE524463T1 (de) | 4-chromenonyl-1,4-dihydropyridincarbonitrile und ihre verwendung | |
| WO2010019565A3 (en) | Anti-ephrin b2 antibodies and their use in treatment of disease | |
| WO2011080050A3 (en) | Ccl21 binding molecules | |
| ATE496047T1 (de) | Phenylen-bis-oxazolidin-derivate und ihre verwendung als antikoagulantien |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |