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MX2009009176A - Inhibidores de serina-proteasas. - Google Patents

Inhibidores de serina-proteasas.

Info

Publication number
MX2009009176A
MX2009009176A MX2009009176A MX2009009176A MX2009009176A MX 2009009176 A MX2009009176 A MX 2009009176A MX 2009009176 A MX2009009176 A MX 2009009176A MX 2009009176 A MX2009009176 A MX 2009009176A MX 2009009176 A MX2009009176 A MX 2009009176A
Authority
MX
Mexico
Prior art keywords
relates
inhibitors
hepatitis
virus
compounds
Prior art date
Application number
MX2009009176A
Other languages
English (en)
Inventor
Luc Farmer
Robert B Perni
John Maxwell
Randy Scott Bethiel
Dylan Jacobs
Kevin Cottrell
Summer Halas
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2009009176A publication Critical patent/MX2009009176A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos que inhiben la actividad de serina-proteasas, particularmente la actividad de la proteasa NS3-NS4A del virus de hepatitis C. como tales, actúan al interferir con el ciclo de vida del virus de hepatitis C y también son útiles como agentes antivirales. La invención se refiere adicionalmente a composiciones que comprenden estos compuestos ya sea para el uso ex vivo o para la administración de un paciente que padece de infección de HCV. La invención también se refiere a métodos para tratar una infección de HCV en el paciente al administrar una composición que comprende un compuesto de esta invención.
MX2009009176A 2007-02-27 2008-02-20 Inhibidores de serina-proteasas. MX2009009176A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90381407P 2007-02-27 2007-02-27
PCT/US2008/002395 WO2008106058A2 (en) 2007-02-27 2008-02-20 Inhibitors of serine proteases

Publications (1)

Publication Number Publication Date
MX2009009176A true MX2009009176A (es) 2009-09-28

Family

ID=39721791

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009176A MX2009009176A (es) 2007-02-27 2008-02-20 Inhibidores de serina-proteasas.

Country Status (9)

Country Link
US (1) US8575208B2 (es)
EP (1) EP2134717A2 (es)
JP (1) JP2010519329A (es)
CN (1) CN101903392A (es)
AU (1) AU2008219704A1 (es)
CA (1) CA2679426A1 (es)
MX (1) MX2009009176A (es)
NZ (1) NZ579295A (es)
WO (1) WO2008106058A2 (es)

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