MX2009008413A - Tratamiento y prevencion de enfermedades neurodegenerativas usando terapia genica. - Google Patents
Tratamiento y prevencion de enfermedades neurodegenerativas usando terapia genica.Info
- Publication number
- MX2009008413A MX2009008413A MX2009008413A MX2009008413A MX2009008413A MX 2009008413 A MX2009008413 A MX 2009008413A MX 2009008413 A MX2009008413 A MX 2009008413A MX 2009008413 A MX2009008413 A MX 2009008413A MX 2009008413 A MX2009008413 A MX 2009008413A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- prevention
- treatment
- administered
- immune response
- Prior art date
Links
- 230000004770 neurodegeneration Effects 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 238000001415 gene therapy Methods 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- 108091027981 Response element Proteins 0.000 abstract 3
- 230000024932 T cell mediated immunity Effects 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
En este documento se proporcionan composiciones y métodos para tratar y/o prevenir una enfermedad neurodegenerativa, tal como enfermedad de Alzheimer. En aspectos particulares, las composiciones administradas en este documento codifican un elemento de respuesta inmune celular. Las composiciones pueden prepararse y administrarse de manera tal que la secuencia codificante del elemento de respuesta inmune celular se expresa en el sujeto al que se administra la composición. Las composiciones incluyen sistemas de expresión, sistemas de suministro, y ciertos genes de elementos de respuesta inmune celular.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90013807P | 2007-02-06 | 2007-02-06 | |
| PCT/US2008/052953 WO2008097927A2 (en) | 2007-02-06 | 2008-02-04 | Treatment and prevention of neurodegenerative diseases using gene therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009008413A true MX2009008413A (es) | 2009-11-02 |
Family
ID=39682371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009008413A MX2009008413A (es) | 2007-02-06 | 2008-02-04 | Tratamiento y prevencion de enfermedades neurodegenerativas usando terapia genica. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8247385B2 (es) |
| EP (1) | EP2114153B1 (es) |
| JP (1) | JP5829377B2 (es) |
| KR (2) | KR20140102327A (es) |
| CN (2) | CN101652063A (es) |
| AU (1) | AU2008213999B2 (es) |
| CA (1) | CA2677273A1 (es) |
| IL (1) | IL200151A (es) |
| MX (1) | MX2009008413A (es) |
| NZ (1) | NZ579050A (es) |
| RU (1) | RU2471487C2 (es) |
| WO (1) | WO2008097927A2 (es) |
| ZA (1) | ZA200906165B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010110408A1 (ja) * | 2009-03-26 | 2010-09-30 | 財団法人東京都医学研究機構 | アルツハイマー病に対するdnaワクチン |
| US9173928B2 (en) | 2009-03-26 | 2015-11-03 | Yoh Matsumoto | DNA vaccine for Alzheimer's disease |
| KR101367568B1 (ko) * | 2011-05-31 | 2014-02-27 | 임우석 | Abc 수송체 조절을 통한 퇴행성신경질환에서 이상단백질 조절 |
| US20160058889A1 (en) * | 2014-08-11 | 2016-03-03 | The Board Of Regents Of The University Of Texas System | Prevention of muscular dystrophy by crispr/cas9-mediated gene editing |
| RU2652312C2 (ru) * | 2016-01-20 | 2018-04-25 | Селл энд Джин Терапи Лтд | Линейка биологически активных генно-терапевтических субстанций на основе гена tgfb1 для коррекции патологических состояний клеток органов и тканей и органов и тканей человека, способ получения и использования |
| CN105748518B (zh) * | 2016-03-21 | 2019-06-07 | 大连大学 | 包含脂肪干细胞提取物的抗衰老组合物 |
| CA3031401A1 (en) * | 2016-07-20 | 2018-01-25 | Vib Vzw | Therapeutic agents for neurological and psychiatric disorders |
| CA3051583A1 (en) | 2017-01-25 | 2018-08-02 | Whitehead Institute For Biomedical Research | Methods for building genomic networks and uses thereof |
| WO2019147036A1 (ko) * | 2018-01-24 | 2019-08-01 | 주식회사 에스엘바이젠 | 뇌유래-신경영양인자를 발현하는 중간엽줄기세포 및 이의 용도 |
| WO2019162942A1 (en) * | 2018-02-20 | 2019-08-29 | Carmel Haifa University Economic Corporation Ltd. | Compositions and methods for delivery and expression of small inhibitory peptides and use thereof |
| IT201800003279A1 (it) * | 2018-03-05 | 2019-09-05 | Consiglio Nazionale Ricerche | Peptide neurotrofico per il trattamento terapeutico di patologie neurodegenerative e/o infiammatorie. |
| CN109942714B (zh) * | 2019-04-02 | 2022-07-08 | 中国药科大学 | 一种功能多肽及应用 |
| WO2020212598A1 (en) | 2019-04-19 | 2020-10-22 | Synerkine Pharma B.V. | A fusion protein comprising il13 |
| CN114761569A (zh) * | 2019-10-16 | 2022-07-15 | 康奈尔大学 | 阿尔茨海默氏病的基因疗法 |
| US20250270547A1 (en) * | 2020-02-28 | 2025-08-28 | Rznomics Inc. | Trans-splicing ribozyme specific to apoe4 rna and use thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
| JP2914692B2 (ja) | 1987-12-11 | 1999-07-05 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 内皮細胞の遺伝子修飾 |
| JPH04507041A (ja) | 1988-12-13 | 1992-12-10 | アメリカ合衆国 | 遺伝工学により修飾された内皮細胞およびその利用方法 |
| US5693622A (en) * | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| DK0737750T3 (da) | 1989-03-21 | 2003-09-01 | Vical Inc | Ekspression af exogene polynucleotidsekvenser i vertebrater |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US20030125519A1 (en) | 1990-08-27 | 2003-07-03 | Peter Besmer | Ligand for the c-kit receptor and methods of use thereof |
| JPH06500923A (ja) | 1990-09-21 | 1994-01-27 | カイロン コーポレイション | パッケージング細胞 |
| JP3418982B2 (ja) | 1990-10-31 | 2003-06-23 | ソマティクス セラピー コーポレイション | 内皮細胞の遺伝的変性 |
| WO1992014829A1 (en) | 1991-02-19 | 1992-09-03 | The Regents Of The University Of California | Viral particles having altered host range |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| AU6714094A (en) | 1993-04-28 | 1994-11-21 | Ribozyme Pharmaceuticals, Inc. | Ocular delivery of nucleic acid |
| US5910488A (en) | 1993-06-07 | 1999-06-08 | Vical Incorporated | Plasmids suitable for gene therapy |
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| US5763270A (en) | 1995-06-07 | 1998-06-09 | Genemedicine, Inc. | Plasmid for delivery of nucleic acids to cells and methods of use |
| US6911530B1 (en) | 1995-10-23 | 2005-06-28 | Amrad Operations, Pty., Ltd. | Haemopoietin receptor and genetic sequences encoding same |
| US6734014B1 (en) | 1996-02-08 | 2004-05-11 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating T cells |
| US6080728A (en) | 1996-07-16 | 2000-06-27 | Mixson; A. James | Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy |
| EP0961830A1 (en) * | 1997-01-29 | 1999-12-08 | Neurosearch A/S | EXPRESSION VECTORS AND METHODS FOR $i(IN VIVO) EXPRESSION OF THERAPEUTIC POLYPEPTIDES |
| US6034072A (en) | 1997-02-10 | 2000-03-07 | Genemedicine, Inc. | IL-2 gene expression and delivery systems and uses |
| AU8476698A (en) | 1997-07-03 | 1999-01-25 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| WO2002007774A2 (en) * | 2000-07-19 | 2002-01-31 | The Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
| WO2000004050A2 (en) | 1998-07-14 | 2000-01-27 | Janssen Pharmaceutica N.V. | Neurotrophic growth factor |
| RU2238947C2 (ru) | 1998-07-14 | 2004-10-27 | Янссен Фармацевтика Н.В. | Нейротрофический фактор роста человека (эновин), кодирующая его выделенная молекула нуклеиновой кислоты, вектор (варианты), фармацевтическая композиция (варианты), антитело, способ обнаружения фактора роста, набор, способ идентификации агониста или антагониста (варианты) |
| CA2407074A1 (en) | 2000-04-21 | 2001-11-01 | Jukka Hartikka | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics |
| EP2301552A1 (en) * | 2001-11-21 | 2011-03-30 | The Board Of Trustees Of The Leland Stanford Junior University | Polynucleotide therapy |
| GB0212648D0 (en) * | 2002-05-31 | 2002-07-10 | Immunoclin Lab Ltd | Treatment with cytokines |
| US20060073119A1 (en) * | 2004-09-01 | 2006-04-06 | Avigen, Inc. | Methods for treating neurodegenerative disorders |
| US20080025962A1 (en) * | 2004-11-30 | 2008-01-31 | Angesmg,Inc. | Remedy for Alzheimer's Disease |
| AU2006208226A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
| CA2654033A1 (en) * | 2006-05-31 | 2007-12-06 | Dnavec Corporation | Therapeutic agent for alzheimer's disease |
-
2008
- 2008-02-04 CN CN200880010918A patent/CN101652063A/zh active Pending
- 2008-02-04 KR KR1020147021915A patent/KR20140102327A/ko not_active Ceased
- 2008-02-04 AU AU2008213999A patent/AU2008213999B2/en not_active Ceased
- 2008-02-04 NZ NZ579050A patent/NZ579050A/xx not_active IP Right Cessation
- 2008-02-04 MX MX2009008413A patent/MX2009008413A/es active IP Right Grant
- 2008-02-04 JP JP2009549194A patent/JP5829377B2/ja not_active Expired - Fee Related
- 2008-02-04 WO PCT/US2008/052953 patent/WO2008097927A2/en not_active Ceased
- 2008-02-04 US US12/025,684 patent/US8247385B2/en not_active Expired - Fee Related
- 2008-02-04 EP EP08728962.5A patent/EP2114153B1/en active Active
- 2008-02-04 CA CA002677273A patent/CA2677273A1/en not_active Abandoned
- 2008-02-04 RU RU2009132196/15A patent/RU2471487C2/ru active
- 2008-02-04 CN CN201710045905.4A patent/CN106890342B/zh not_active Expired - Fee Related
- 2008-02-04 KR KR1020097018535A patent/KR101661356B1/ko not_active Expired - Fee Related
-
2009
- 2009-07-30 IL IL200151A patent/IL200151A/en active IP Right Grant
- 2009-09-04 ZA ZA2009/06165A patent/ZA200906165B/en unknown
-
2012
- 2012-07-17 US US13/551,495 patent/US20130231632A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101652063A (zh) | 2010-02-17 |
| CN106890342B (zh) | 2022-09-23 |
| EP2114153A2 (en) | 2009-11-11 |
| CA2677273A1 (en) | 2008-08-14 |
| RU2009132196A (ru) | 2011-03-20 |
| US20080292603A1 (en) | 2008-11-27 |
| EP2114153A4 (en) | 2011-05-11 |
| KR20140102327A (ko) | 2014-08-21 |
| RU2471487C2 (ru) | 2013-01-10 |
| WO2008097927A3 (en) | 2008-12-18 |
| AU2008213999A1 (en) | 2008-08-14 |
| JP5829377B2 (ja) | 2015-12-09 |
| NZ579050A (en) | 2012-10-26 |
| US20130231632A1 (en) | 2013-09-05 |
| ZA200906165B (en) | 2012-02-29 |
| KR20090118956A (ko) | 2009-11-18 |
| JP2010518105A (ja) | 2010-05-27 |
| AU2008213999B2 (en) | 2014-04-17 |
| IL200151A (en) | 2015-06-30 |
| CN106890342A (zh) | 2017-06-27 |
| IL200151A0 (en) | 2010-04-15 |
| EP2114153B1 (en) | 2016-11-23 |
| WO2008097927A2 (en) | 2008-08-14 |
| KR101661356B1 (ko) | 2016-09-30 |
| US8247385B2 (en) | 2012-08-21 |
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