[go: up one dir, main page]

MX2009008347A - Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso. - Google Patents

Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.

Info

Publication number
MX2009008347A
MX2009008347A MX2009008347A MX2009008347A MX2009008347A MX 2009008347 A MX2009008347 A MX 2009008347A MX 2009008347 A MX2009008347 A MX 2009008347A MX 2009008347 A MX2009008347 A MX 2009008347A MX 2009008347 A MX2009008347 A MX 2009008347A
Authority
MX
Mexico
Prior art keywords
oxabicycloheptenes
oxabicycloheptanes
preparation
tumors
treatment
Prior art date
Application number
MX2009008347A
Other languages
English (en)
Inventor
John S Kovach
Francis Johnson
Original Assignee
Lixte Biotechnology Holdings I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lixte Biotechnology Holdings I filed Critical Lixte Biotechnology Holdings I
Publication of MX2009008347A publication Critical patent/MX2009008347A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Oncology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Esta invención proporciona compuestos que tengan la estructura que se puede utilizar para el tratamiento de tumores.
MX2009008347A 2007-02-06 2008-02-06 Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso. MX2009008347A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89990307P 2007-02-06 2007-02-06
US96490407P 2007-08-14 2007-08-14
US1132308P 2008-01-15 2008-01-15
PCT/US2008/001549 WO2008097561A1 (en) 2007-02-06 2008-02-06 Oxabicycloheptanes and oxabicycloheptenes, their preparation and use

Publications (1)

Publication Number Publication Date
MX2009008347A true MX2009008347A (es) 2009-10-19

Family

ID=39682021

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008347A MX2009008347A (es) 2007-02-06 2008-02-06 Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.

Country Status (10)

Country Link
US (6) US7998957B2 (es)
EP (1) EP2124550B1 (es)
JP (1) JP5693850B2 (es)
CN (2) CN103788108B (es)
AU (1) AU2008214299B2 (es)
BR (1) BRPI0806365B8 (es)
CA (1) CA2676422C (es)
EA (1) EA023804B1 (es)
MX (1) MX2009008347A (es)
WO (1) WO2008097561A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
JP5693850B2 (ja) 2007-02-06 2015-04-01 リクスト・バイオテクノロジー，インコーポレイテッド オキサビシクロヘプタンおよびオキサビシクロヘプテン、それらの製造および使用
AU2008284364A1 (en) * 2007-08-03 2009-02-12 Lixte Biotechnology, Inc. Use of phosphatases to treat neuroblastomas and medulloblastomas
WO2009039407A1 (en) * 2007-09-19 2009-03-26 University Of Massachusetts Water-soluble and water-insoluble, ring opening metathesis polymerization products, monomers and related methods
EP2200439B1 (en) * 2007-10-01 2017-03-22 Lixte Biotechnology, Inc. Hdac inhibitors
US8227473B2 (en) * 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
US8058268B2 (en) * 2008-08-01 2011-11-15 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
AU2009277179A1 (en) * 2008-08-01 2010-02-04 Lixte Biotechnology, Inc. Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase
EP2870161B1 (en) 2012-06-29 2018-08-08 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes for the treatment of reperfusion injury
CA2877167A1 (en) 2012-06-29 2014-01-03 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes for the treatment of diabetes
CN105209036B (zh) * 2013-04-09 2018-10-26 莱克斯特生物技术公司 氧杂双环庚烷和氧杂双环庚烯的配制品
US20160264593A1 (en) * 2013-11-15 2016-09-15 John S. Kovach Protein phosphatase inhibitors that cross the blood brain barrier
CN103664978B (zh) * 2013-11-29 2016-06-22 西北农林科技大学 一种卤苯基芳香胺取代去甲斑蝥素及其制备方法和应用
TWI662039B (zh) 2014-05-13 2019-06-11 瑞士商諾華公司 用於誘發軟骨生成之化合物及組合物
EP3157336A4 (en) * 2014-06-20 2018-01-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes for the treatment of ovarian cancer
CN106572989B (zh) * 2014-07-24 2021-08-27 H·李·莫菲特癌症中心与研究所公司 用于治疗骨髓增生异常综合征的蛋白磷酸酶2a抑制剂
US20160074390A1 (en) * 2014-09-12 2016-03-17 Lixte Biotechnology, Inc. Human dosing of phosphatase inhibitor
US9994584B2 (en) 2014-10-15 2018-06-12 Lixte Biotechnology, Inc. Process of synthesizing 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1] heptane-2-carboxylic acid
US10266546B2 (en) 2014-12-19 2019-04-23 Avantium Knowledge Centre B.V. Process for the preparation of a benzene compound
MX382044B (es) 2015-02-19 2025-03-13 Lixte Biotechnology Inc Oxabicicloheptanos y oxabicicloheptenos para el tratamiento de trastornos depresivos y de estrés.
MX386975B (es) 2015-05-15 2025-03-19 Lixte Biotechnology Inc Fármacos precursores de oxabicicloheptanos.
CN109475543A (zh) * 2016-01-27 2019-03-15 利克斯特生物技术公司 用磷酸酶抑制剂治疗骨髓发育不良综合征的临床方案
CN106083877A (zh) * 2016-06-21 2016-11-09 遵义医学院附属医院 不饱和去甲斑蝥素甲酯钡盐及其抗肿瘤应用
CA3046515A1 (en) 2016-12-08 2018-06-14 Lixte Biotechnology, Inc. Oxabicycloheptanes for modulation of immune response
CA3208466A1 (en) * 2021-01-19 2022-07-28 Lixte Biotechnology, Inc. Oxabicycloheptanes for treatment of small cell lung cancer
WO2022204455A1 (en) 2021-03-26 2022-09-29 Alliance For Sustainable Energy, Llc Electrolyte components for charging of lithium-ion batteries
WO2024097784A2 (en) * 2022-11-03 2024-05-10 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes for treating refractory cancers
CN116531361B (zh) * 2022-12-01 2024-11-15 武汉大学 氧桥双环-[2.2.1]-庚烯类化合物在制备抗新型冠状病毒药物中的应用

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2957906A (en) 1955-10-25 1960-10-25 Monsanto Chemicals Ketones
JPS5752354B2 (es) * 1973-10-22 1982-11-06
US3980674A (en) * 1974-01-28 1976-09-14 Delmar Chemicals Limited 2,3-Disubstituted 7-oxabicyclo-[2.2.1]-5-heptene
JPS5132733A (en) * 1974-09-10 1976-03-19 Kyowa Hakko Kogyo Kk Josozai
US3954913A (en) * 1975-01-06 1976-05-04 The Standard Oil Company Stabilized nitrile polymers
JPS5188631A (en) * 1975-01-31 1976-08-03 Hiiryoyosatsukinzai oyobi sonoseizoho
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4218478A (en) 1979-01-05 1980-08-19 Ruiko Oiwa Trichostatin as an antiprotozoal agent
US4298752A (en) 1980-09-19 1981-11-03 Regents Of The University Of California Cycloadduct precursors of cantharidin and method
US4614825A (en) 1982-05-17 1986-09-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane and 7-oxabicycloheptene compounds
US4463015A (en) 1982-08-18 1984-07-31 E. R. Squibb & Sons, Inc. Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation
US4524151A (en) * 1983-11-14 1985-06-18 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane thio ethers useful as cardiovascular agents
JPS61176523A (ja) 1985-01-30 1986-08-08 Teruhiko Beppu 制癌剤
US4654355A (en) 1985-08-01 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs
US4851553A (en) 1986-06-04 1989-07-25 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane amido-carboxylic acids
US4816579A (en) 1986-06-04 1989-03-28 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
SU1553533A1 (ru) 1988-01-28 1990-03-30 Военная Краснознаменная академия химической защиты им.Маршала Советского Союза С.К.Тимошенко Способ получени 1,4-бисполифторалкил-7-оксбицикло [2.2.1]гептанов
JP2789365B2 (ja) * 1988-12-14 1998-08-20 塩野義製薬株式会社 ジカルボン酸モノエステルおよびその製造法
US5763647A (en) 1990-03-30 1998-06-09 Shionogi & Co., Ltd. Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
US5266710A (en) 1990-12-18 1993-11-30 Patel Ramesh N (Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl ester and diacyl ester
US5326898A (en) 1992-02-11 1994-07-05 Allergan, Inc. Substituted phenylethenyl compounds having retinoid-like biological activity
US6602713B1 (en) 2001-02-09 2003-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of protein phosphatase 2 catalytic subunit beta expression
US5518993A (en) * 1994-08-12 1996-05-21 Buckman Laboratories International, Inc. Pesticidal compositions containing ethoxylated fatty amines for increasing the effectiveness of endothal and salts thereof
US5770382A (en) 1994-12-30 1998-06-23 Ligand Pharmaceuticals, Inc. Tricyclic retinoids, methods for their production and use
US6222055B1 (en) * 1995-07-06 2001-04-24 Fraunhofer-Gesellschaft Zur Foerderung Der Angwandten Forschung E.V. Hydrolyzable and polymerizable and/or polyadditive silanes
DE19600707B4 (de) 1996-01-11 2004-02-19 Glüsenkamp, Karl-Heinz, Dr. Biyclische Anhydrid-Wirkstoff-Verbindungen, Verfahren zur Herstellung und Verwendung derselben
US5968965A (en) 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US5925651A (en) 1996-04-03 1999-07-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6387673B1 (en) 1997-05-01 2002-05-14 The Salk Institute For Biological Studies Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
EP1391206B1 (en) 1997-10-15 2008-07-02 Polarx Biopharmaceuticals, Inc. Pharmaceutical compositions comprising arsenic trioxide for the treatment of non-Hodgkin's lymphoma
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
AU762626B2 (en) 1998-06-05 2003-07-03 Nutrinia Ltd Insulin supplemented infant formula
US20040110822A1 (en) 1998-07-14 2004-06-10 The University Of Newcastle Research Associates Anhydride modified cantharidin analogues useful in the treatment of cancer
AUPP466598A0 (en) * 1998-07-14 1998-08-06 University Of Newcastle Research Associates Limited, The Product and process
PT1102763E (pt) 1998-08-07 2005-01-31 Applied Research Systems Mimeticos fsh para o tratamento da infertilidade
US20020151515A1 (en) 1999-06-18 2002-10-17 Roberts Bruce L. Preparation and use of superior vaccines
US6949624B1 (en) 1999-08-03 2005-09-27 The United States Of America As Represented By The Department Of Health And Human Services Cloning of the human nuclear receptor co-repressor gene
EA007649B1 (ru) 1999-09-08 2006-12-29 Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч Ингибиторы гистондеацетилазы, вызывающие дифференцировку клеток, и их применение
US7605185B2 (en) 1999-11-23 2009-10-20 Gerhart Graupner Treatment of arrhythmia by retinoids affecting signal transduction
JP4518627B2 (ja) * 2000-03-14 2010-08-04 旭化成イーマテリアルズ株式会社 ヒドロキシポリアミド
WO2001070675A2 (en) 2000-03-24 2001-09-27 Methylgene, Inc. Inhibitors of histone deacetylase
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
KR20030030027A (ko) 2000-09-21 2003-04-16 스미스클라인비이참피이엘시이 Ｒａｆ 키나제 저해제인 이미다졸 유도체
US6696483B2 (en) 2000-10-03 2004-02-24 Oncopharmaceutical, Inc. Inhibitors of angiogenesis and tumor growth for local and systemic administration
US7154022B2 (en) 2000-10-06 2006-12-26 Board Of Trustees Operating Michigan State University Divinyl ether synthase gene, and protein and uses thereof
CN1213050C (zh) 2000-11-23 2005-08-03 拜尔公司 氧杂双环[2.2.1]庚烷衍生物，其制备方法和作为农药的用途
US20020177692A1 (en) 2001-04-16 2002-11-28 Myriad Genetics, Incorporated BCL-XL-interacting protein and use thereof
AUPR392301A0 (en) * 2001-03-23 2001-04-26 University Of Newcastle Research Associates Limited, The Protein phosphatase inhibitors
US20040253637A1 (en) 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US20070015144A9 (en) 2001-05-25 2007-01-18 Genset, S.A. Human cDNAs and proteins and uses thereof
WO2003014062A1 (en) 2001-08-03 2003-02-20 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents
US20040010045A1 (en) 2001-09-07 2004-01-15 Taolin Yi Therapeutic compositions comprised of pentamidine and methods of using same to treat cancer
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
WO2003032921A2 (en) 2001-10-16 2003-04-24 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases and cancer of the brain
CA2461373A1 (en) 2001-11-06 2003-05-15 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
CN1646558B (zh) 2002-02-20 2010-05-12 国立大学法人九州工业大学 组蛋白脱乙酰酶抑制剂
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
US7148257B2 (en) 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
ATE414424T1 (de) 2002-03-08 2008-12-15 Basf Se Fungizide mischungen auf der basis von prothioconazol mit einem insektizid
US6809118B2 (en) * 2002-07-25 2004-10-26 Yih-Lin Chung Methods for therapy of radiation cutaneous syndrome
AU2003241346A1 (en) 2002-05-01 2003-11-17 The Cleveland Clinic Foundation Therapeutic compositions comprised of pentamidine and methods of using same to treat cancer
CA2499874A1 (en) 2002-09-23 2004-04-01 Schering Corporation Novel imidazopyrazines as cyclin dependent kinase inhibitors
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2004044218A2 (en) 2002-11-05 2004-05-27 The Regents Of The University Of California Methods and materials for examining pathways associated with glioblastoma progression
GB0226855D0 (en) 2002-11-18 2002-12-24 Queen Mary & Westfield College Histone deacetylase inhibitors
US20040197888A1 (en) 2002-12-31 2004-10-07 Armour Christopher D. Alternatively spliced isoforms of histone deacetylase 3 (HDAC3)
US20050222013A1 (en) 2003-01-16 2005-10-06 Georgetown University Methods for the use of inhibitors of histone deacetylase as synergistic agents in cancer therapy
US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
CN1781019A (zh) * 2003-03-12 2006-05-31 萨马里坦药品公司 模拟神经系统疾病的动物模型
EP2258365B1 (en) * 2003-03-28 2013-05-29 Novartis Vaccines and Diagnostics, Inc. Use of organic compounds for immunopotentiation
US7842835B2 (en) 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
JP2007502287A (ja) 2003-08-13 2007-02-08 アムジェン インコーポレイテッド メラニン凝集ホルモン受容体アンタゴニスト
WO2005025620A2 (en) 2003-08-13 2005-03-24 Pharmacia Corporation Combination therapy with inhibitors of inducible nitric oxide synthase and alkylating agents
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
US20070135365A1 (en) 2003-08-21 2007-06-14 Katsuyuki Tanizawa Pharmaceutical composition for preventing or remedying cardiac hypertrophy and cardiovascular disease caused thereby
US7094193B2 (en) 2003-08-28 2006-08-22 Philip Morris Usa Inc. High speed laser perforation of cigarette tipping paper
WO2005034866A2 (en) 2003-10-06 2005-04-21 Glaxo Group Limited Preparation of 1, 6, 7- trisubstituted azabenzimidazoles as kinase inhibitors
AU2004283313A1 (en) 2003-10-24 2005-05-06 Exelixis, Inc. TAO kinase modulators and methods of use
WO2005049084A2 (en) 2003-11-13 2005-06-02 Board Of Regents, The University Of Texas System Inhibition of trp channels as a treatment for cardiac hypertrophy and heart failure
GB0328157D0 (en) 2003-12-04 2004-01-07 Imp College Innovations Ltd Compounds
US20060018970A1 (en) 2003-12-12 2006-01-26 Myogen, Inc. Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
US8652502B2 (en) 2003-12-19 2014-02-18 Cordis Corporation Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury
US20050282893A1 (en) 2004-01-30 2005-12-22 Au Jessie L Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors
EP1715870A1 (en) 2004-02-02 2006-11-02 Myogen, Inc. Inhibition of protein kinase c-related kinase (prk) as a treatment for cardiac hypertrophy and heart failure
US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
FR2872704B1 (fr) 2004-07-12 2007-11-02 Laurent Schwartz Pluritherapie contre le cancer
US8299083B2 (en) 2004-08-17 2012-10-30 The Johns Hopkins University PDE5 inhibitor compositions and methods for treating cardiac indications
KR100677149B1 (ko) 2004-11-12 2007-02-02 삼성전자주식회사 잉크 조성물
EP1863804A1 (en) 2005-04-01 2007-12-12 Methylgene, Inc. Inhibitors of histone deacetylase
GB0511266D0 (en) 2005-06-02 2005-07-13 Trust Chemical compounds
WO2007014029A2 (en) 2005-07-22 2007-02-01 The Regents Of The University Of Colorado, A Body Corporate Yin yang 1 as a treatment for cardiac hypertrophy and heart failure
US20090012066A1 (en) 2005-08-10 2009-01-08 Novartis Ag Method of Use of Deacetylase Inhibitors
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
BRPI0620040A2 (pt) 2005-12-19 2011-10-25 Methylgene Inc inibidores de histona desacetilase para realçar a atividade de agentes antifúngicos
CA2641308A1 (en) * 2006-02-06 2007-08-16 Lixte Biotechnology Holdings, Inc. Use of phosphatases to treat tumors overexpressing n-cor
CN101466670B (zh) 2006-04-07 2013-04-17 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
US20090018142A9 (en) 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
TWI449524B (zh) 2006-09-07 2014-08-21 Stemline Therapeutics Inc 以斑螫酸酐（ｃａｎｔｈａｒｉｄｉｎ）及斑螫酸酐類似物進行之癌症治療
ES2423482T3 (es) 2006-09-08 2013-09-20 Institut Gustave Roussy (Igr) Inhibidores de proteína fosfatasa 1, de GADD34 y del complejo de proteína fosfatasa 1/GADD34, y usos de los mismos combinados con etopósido o mitomicina C
JP5198755B2 (ja) 2006-10-31 2013-05-15 日精株式会社 機械式駐車場装置
CA2670259A1 (en) * 2006-11-15 2008-05-22 Genetic Technologies Limited Compounds, compositions and methods for controlling invertebrate pests
JP5693850B2 (ja) 2007-02-06 2015-04-01 リクスト・バイオテクノロジー，インコーポレイテッド オキサビシクロヘプタンおよびオキサビシクロヘプテン、それらの製造および使用
AU2008284364A1 (en) 2007-08-03 2009-02-12 Lixte Biotechnology, Inc. Use of phosphatases to treat neuroblastomas and medulloblastomas
EP2200439B1 (en) 2007-10-01 2017-03-22 Lixte Biotechnology, Inc. Hdac inhibitors
JP5069091B2 (ja) 2007-12-12 2012-11-07 三菱電機株式会社 監視カメラおよび監視カメラシステム
US8058268B2 (en) 2008-08-01 2011-11-15 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
AU2009277179A1 (en) 2008-08-01 2010-02-04 Lixte Biotechnology, Inc. Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase
US8227473B2 (en) 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
US20120135522A1 (en) 2009-06-18 2012-05-31 Kovach John S Methods of modulating cell regulation by inhibiting p53

Also Published As

Publication number Publication date
WO2008097561A8 (en) 2009-10-01
US9079917B2 (en) 2015-07-14
US20170369503A1 (en) 2017-12-28
WO2008097561A1 (en) 2008-08-14
US20130302402A1 (en) 2013-11-14
BRPI0806365B8 (pt) 2021-05-25
CN103788108B (zh) 2017-04-12
EA200970737A1 (ru) 2010-02-26
EA023804B1 (ru) 2016-07-29
EP2124550A4 (en) 2011-04-06
CN103788108A (zh) 2014-05-14
CN101662939B (zh) 2015-11-25
JP2010518081A (ja) 2010-05-27
AU2008214299A1 (en) 2008-08-14
CN101662939A (zh) 2010-03-03
JP5693850B2 (ja) 2015-04-01
US10023587B2 (en) 2018-07-17
US10399993B2 (en) 2019-09-03
US7998957B2 (en) 2011-08-16
BRPI0806365A2 (pt) 2011-09-06
US8426444B2 (en) 2013-04-23
BRPI0806365B1 (pt) 2020-01-21
CA2676422C (en) 2018-10-16
CA2676422A1 (en) 2008-08-14
AU2008214299B2 (en) 2014-01-09
EP2124550B1 (en) 2017-04-19
US20120270736A1 (en) 2012-10-25
US8822461B2 (en) 2014-09-02
US20180370983A1 (en) 2018-12-27
EP2124550A1 (en) 2009-12-02
US20090036309A1 (en) 2009-02-05
US20150045373A1 (en) 2015-02-12

Similar Documents

Publication Publication Date Title
MX2009008347A (es) Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.
WO2008124660A3 (en) Methods and compositions for the treatment of cancer
MX2009008430A (es) Anticuerpos anti-robo4 y sus usos.
EA201171367A1 (ru) Винилиндазолильные соединения
MX2014011134A (es) Compuestos de carbamato y preparacion y uso de los mismos.
MX2009012625A (es) Metodos para el tratamiento, diagnostico y deteccion de trastornos asociados con el fgf21.
JO2788B1 (en) Amido phenoxyendazole compounds beneficial as C-MET inhibitors
UA104459C2 (uk) Антитіла проти fgfr3 і способи їх застосування
GB2453058A (en) Kinase antagonists
WO2011032169A3 (en) Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
WO2009129246A3 (en) Compositions and methods for preparing and using same
MX2011007930A (es) Conjugados de insulina cristalina.
MX354402B (es) Inhibidores de molecula pequeña del dominio de homologia de pleckstrin y metodos para usar los mismos.
WO2010083385A3 (en) Compounds for reducing drug resistance and uses thereof
WO2008120098A3 (en) Peptide prodrugs
WO2008112192A3 (en) Epha3 antibodies for the treatment of solid tumors
MX2009011346A (es) Tapentadol para tratamiento de dolor con artritis.
BRPI0818170A2 (pt) 5-cianotienopiridinas para o tratamento de tumores.
PH12013502194A1 (en) Antibodies to egfl7 and methods for their use
MX2008015775A (es) Compuestos y composiciones para tratamiento de cancer.
TW200738751A (en) Anti-EphrinB2 antibodies and methods using same
MX2009009693A (es) Metodos para activar irs-1 y akt.
EA200971067A1 (ru) Триазолиламинопиримидиновые соединения
IN2012DN05142A (es)

Legal Events

Date Code Title Description
GB Transfer or rights
FG Grant or registration