[go: up one dir, main page]

MX2009006444A - Metodo para producir derivado de c-glucosido e intermediario sintetico del mismo. - Google Patents

Metodo para producir derivado de c-glucosido e intermediario sintetico del mismo.

Info

Publication number
MX2009006444A
MX2009006444A MX2009006444A MX2009006444A MX2009006444A MX 2009006444 A MX2009006444 A MX 2009006444A MX 2009006444 A MX2009006444 A MX 2009006444A MX 2009006444 A MX2009006444 A MX 2009006444A MX 2009006444 A MX2009006444 A MX 2009006444A
Authority
MX
Mexico
Prior art keywords
glycoside derivative
producing
diabetes
insulin
synthetic intermediate
Prior art date
Application number
MX2009006444A
Other languages
English (en)
Inventor
Ryota Shiraki
Atsushi Nakamura
Masakazu Imamura
Keita Nakanishi
Kousuke Komenoi
Makoto Kasai
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2009006444A publication Critical patent/MX2009006444A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se pretende proporcionar un método para producir un derivado de C-glucósido con un alto rendimiento y bajo costo, el cual cumple con las regulaciones de protección ambiental y es aplicable industrialmente. El derivado de C-glucósido es útil para tratar y evitar diabetes mellitus tal como diabetes mellitus dependiente de insulina (diabetes tipo 1) y diabetes mellitus no dependiente de insulina (diabetes tipo 2) y también diversas enfermedades relacionadas con diabetes que incluyen enfermedades resistentes a insulina y obesidad.
MX2009006444A 2006-12-21 2007-12-20 Metodo para producir derivado de c-glucosido e intermediario sintetico del mismo. MX2009006444A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006344360 2006-12-21
PCT/JP2007/074516 WO2008075736A1 (ja) 2006-12-21 2007-12-20 Ｃ－グリコシド誘導体の製造方法及びその合成中間体

Publications (1)

Publication Number Publication Date
MX2009006444A true MX2009006444A (es) 2009-06-26

Family

ID=39536363

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006444A MX2009006444A (es) 2006-12-21 2007-12-20 Metodo para producir derivado de c-glucosido e intermediario sintetico del mismo.

Country Status (8)

Country Link
US (1) US8198464B2 (es)
EP (1) EP2105442A4 (es)
JP (1) JPWO2008075736A1 (es)
KR (1) KR101100072B1 (es)
CN (1) CN101568537A (es)
CA (1) CA2673498C (es)
MX (1) MX2009006444A (es)
WO (1) WO2008075736A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101001848B1 (ko) * 2003-03-14 2010-12-17 고토부키 세이야쿠 가부시키가이샤 Ｃ-글리코시드 유도체 또는 이의 염, 및 이를 포함하는 의약 조성물
TWI370818B (en) 2006-04-05 2012-08-21 Astellas Pharma Inc Cocrystal of c-glycoside derivative and l-proline
US8198464B2 (en) 2006-12-21 2012-06-12 Astellas Pharma Inc. Method for producing C-glycoside derivative and intermediate for synthesis thereof
JP5302900B2 (ja) * 2008-01-31 2013-10-02 アステラス製薬株式会社 脂肪性肝疾患の治療用医薬組成物
JP5646706B2 (ja) * 2013-07-24 2014-12-24 壽製薬株式会社 Ｃ−グリコシド誘導体の製造方法
WO2016016852A1 (en) * 2014-07-31 2016-02-04 Sun Pharmaceutical Industries Limited Process for the purification of canagliflozin
CN106188022A (zh) * 2015-04-30 2016-12-07 上海医药工业研究院 伊格列净的制备方法
CN105541816A (zh) * 2016-01-20 2016-05-04 大连理工大学 一种伊格列净的合成方法
CN107540706A (zh) * 2016-06-28 2018-01-05 山东诚创医药技术开发有限公司 伊格列净中间体的制备方法
US11312740B2 (en) 2017-05-09 2022-04-26 Piramal Pharma Limited Process for the preparation of SGLT2 inhibitors and intermediates thereof
CN108276396A (zh) * 2018-02-11 2018-07-13 安庆奇创药业有限公司 一种合成伊格列净的方法
CN108623558A (zh) * 2018-04-20 2018-10-09 瑞孚信江苏药业股份有限公司 一种2-(5-溴-2-氟苄基)苯并噻吩的合成方法
KR102097250B1 (ko) * 2019-11-09 2020-04-03 유니셀랩 주식회사 신규한 이프라글리플로진의 결정형, 이의 제조방법 또는 용도

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2027796A1 (en) 1970-06-05 1971-12-16 Sterlon Co , Gross, Arthur, Stock holm Enema additive - in liquid form obtained by irradiation of ingredient
CN1020944C (zh) * 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
JPH06199695A (ja) 1992-03-06 1994-07-19 Yunie:Kk 糖尿病改善治療剤
WO1998031697A1 (en) 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6627611B2 (en) * 2000-02-02 2003-09-30 Kotobuki Pharmaceutical Co Ltd C-glycosides and preparation of thereof as antidiabetic agents
JP4456768B2 (ja) 2000-02-02 2010-04-28 壽製薬株式会社 Ｃ−配糖体を含有する薬剤
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
JP2004536047A (ja) 2001-04-11 2004-12-02 ブリストル−マイヤーズ　スクイブ　カンパニー 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法
US6617313B1 (en) * 2002-03-13 2003-09-09 Council Of Scientific And Industrial Research Glucopyranoside and process of isolation thereof from pterocarpus marsupium pharmaceutical composition containing the same and use thereof
WO2003082887A1 (en) 2002-03-28 2003-10-09 Council Of Scientific And Industrial Research 8-(c-beta-d-glucopyranosyl)-7,3',4'-trihydroxyflavone, process of isolation from pterocarpus marsupium and pharmaceutical composition for the treatment of diabetes
WO2003087093A1 (en) 2002-04-08 2003-10-23 Council Of Scientific And Industrial Research Novel glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof
EP1501520A1 (en) 2002-05-06 2005-02-02 Diakron Pharmaceuticals, Inc. Pharmaceutical compositions for lowering blood glucose and blood cholesterol levels
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
TWI254635B (en) 2002-08-05 2006-05-11 Yamanouchi Pharma Co Ltd Azulene derivative and salt thereof
BR0317929A (pt) 2003-01-03 2006-04-11 Bristol Myers Squibb Co métodos de produzir inibidores de sglt2 de glicosìdeo de c-arila
KR101001848B1 (ko) 2003-03-14 2010-12-17 고토부키 세이야쿠 가부시키가이샤 Ｃ-글리코시드 유도체 또는 이의 염, 및 이를 포함하는 의약 조성물
JP2004359630A (ja) 2003-06-06 2004-12-24 Yamanouchi Pharmaceut Co Ltd ジフルオロジフェニルメタン誘導体及びその塩
EP1679966A4 (en) * 2003-08-01 2009-05-27 Janssen Pharmaceutica Nv SUBSTITUTED BENZIMIDAZOLE, BENZOTRIAZOL AND BENZIMIDAZOLON-O-GLUCOSIDES
EA010655B1 (ru) 2003-08-01 2008-10-30 Янссен Фармацевтика Н.В. Замещенные индазол-о-глюкозиды
CN103214471B (zh) * 2003-08-01 2018-02-06 田边三菱制药株式会社 具有钠依赖型葡萄糖转运体抑制活性的化合物的制备方法
WO2005012318A2 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica Nv Substituted fused heterocyclic c-glycosides
TW200526678A (en) 2003-08-01 2005-08-16 Janssen Pharmaceutica Nv Substituted indole-O-glucosides
KR101184797B1 (ko) 2003-09-04 2012-09-20 세파론, 인코포레이티드 모다피닐 조성물
US7566805B2 (en) * 2003-09-04 2009-07-28 Cephalon, Inc. Modafinil compositions
US20090018202A1 (en) * 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
IL218714A (en) 2004-03-16 2013-02-28 Boehringer Ingelheim Int Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
JPWO2006006496A1 (ja) 2004-07-08 2008-04-24 アステラス製薬株式会社 アズレン誘導体の製造方法及びその合成中間体
DE102004034690A1 (de) 2004-07-17 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
AR051446A1 (es) 2004-09-23 2007-01-17 Bristol Myers Squibb Co Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
DE102004048388A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
TW200637839A (en) * 2005-01-07 2006-11-01 Taisho Pharmaceutical Co Ltd 1-thio-d-glucitol derivatives
DE602006009772D1 (de) 2005-02-23 2009-11-26 Boehringer Ingelheim Int Glucopyranosylsubstituierte ((hetero)arylethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters typ 2 (sglt2)
CA2605245A1 (en) * 2005-04-15 2006-10-19 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors
US7723309B2 (en) 2005-05-03 2010-05-25 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
UA91546C2 (uk) 2005-05-03 2010-08-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
WO2007000445A1 (en) * 2005-06-29 2007-01-04 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200726755A (en) 2005-07-07 2007-07-16 Astellas Pharma Inc A crystalline choline salt of an azulene derivative
EP1910390B1 (en) * 2005-07-27 2010-05-19 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted ((hetero)cycloalyklethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter (sglt) inhibitors
ATE484499T1 (de) * 2005-08-30 2010-10-15 Boehringer Ingelheim Int Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
AR056195A1 (es) 2005-09-15 2007-09-26 Boehringer Ingelheim Int Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
BRPI0707849A2 (pt) * 2006-02-15 2011-05-10 Boehringer Ingelheim Int derivados de benzonitrila substituÍdos por glicopiranosila, composiÇÕes farmacÊuticas contendo tais compostos, seu uso e processo para sua fabricaÇço
TWI370818B (en) 2006-04-05 2012-08-21 Astellas Pharma Inc Cocrystal of c-glycoside derivative and l-proline
PE20080697A1 (es) 2006-05-03 2008-08-05 Boehringer Ingelheim Int Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
RU2437876C2 (ru) 2006-05-19 2011-12-27 Тайсо Фармасьютикал Ко., Лтд. Соединение с-фенилглицитола для лечения диабета
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
US20080027014A1 (en) * 2006-07-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Novel SGLT inhibitors
CA2656847A1 (en) 2006-08-15 2008-02-21 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture
WO2008034859A1 (en) 2006-09-21 2008-03-27 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted difluorobenzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US8198464B2 (en) 2006-12-21 2012-06-12 Astellas Pharma Inc. Method for producing C-glycoside derivative and intermediate for synthesis thereof
TW200904454A (en) 2007-03-22 2009-02-01 Bristol Myers Squibb Co Methods for treating obesity employing an SGLT2 inhibitor and compositions thereof
PE20090185A1 (es) * 2007-03-22 2009-02-28 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2

Also Published As

Publication number Publication date
WO2008075736A1 (ja) 2008-06-26
EP2105442A4 (en) 2013-01-23
KR101100072B1 (ko) 2011-12-29
EP2105442A1 (en) 2009-09-30
US8198464B2 (en) 2012-06-12
CA2673498A1 (en) 2008-06-26
CA2673498C (en) 2012-04-24
CN101568537A (zh) 2009-10-28
JPWO2008075736A1 (ja) 2010-04-15
KR20090090374A (ko) 2009-08-25
US20100094025A1 (en) 2010-04-15

Similar Documents

Publication Publication Date Title
MX2009006444A (es) Metodo para producir derivado de c-glucosido e intermediario sintetico del mismo.
MXPA05009356A (es) Derivados de c-glicosido y sales de los mismos.
WO2007009656A3 (de) Neues 1,4-benzothiazepin-1,1-dioxidderivat mit verbesserten eigenschaften, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung
WO2009051244A1 (ja) 複素環化合物
WO2009048101A1 (ja) アミド化合物
WO2007125547A3 (en) Novel process for statins and its pharmaceutically acceptable salts thereof
WO2008128639A8 (de) Thiadiazolyloxyphenylamidine und deren verwendung als fungizide
WO2006112549A8 (ja) 縮合複素環化合物
WO2006135640A3 (en) Process for the synthesis of organic compounds
EA017861B9 (ru) Способ получения 4-оксохинолинового соединения
WO2009028655A1 (ja) 複素環化合物およびその用途
GEP20105033B (en) Therapeutic agent for diabetes
WO2008153154A1 (ja) 環状化合物、フォトレジスト基材及びフォトレジスト組成物
WO2007099548A3 (en) Novel 11 beta - hydroxyandrosta-4-ene-3-ones
WO2009068463A9 (en) Process for the preparation of isoindole derivatives as well as a process for the preparation of their intermediates
MX2009003713A (es) Inhibidor de progresion de enfermedad de alzheimer que contiene un compuesto heterociclico con estructura especifica.
WO2004071445A3 (en) 2-(aminomethyl)arylamide analgesics
WO2008136385A1 (ja) アミド化合物およびその用途
WO2009066735A1 (ja) ２－アザアダマンタン類の製造方法
WO2009011305A1 (ja) アミド化合物とその植物病害防除方法
WO2007115968A3 (en) Process for the preparation of a glucokinase activator
WO2005121078A3 (de) Substituierte cyclopenten-verbindungen
WO2006058628A3 (en) Substituted benzoquinolizines as dpp-iv inhibitors for the treatment of diabetes
ZA200801577B (en) Method for preparing 4ß-Amino-4'-demethyl-4-desoxy-podophyllotoxin
WO2009121507A3 (de) Substituierte enaminothiocarbonylverbindungen

Legal Events

Date Code Title Description
FG Grant or registration