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MX2009006078A - Compuesto triciclico y su uso medico. - Google Patents

Compuesto triciclico y su uso medico.

Info

Publication number
MX2009006078A
MX2009006078A MX2009006078A MX2009006078A MX2009006078A MX 2009006078 A MX2009006078 A MX 2009006078A MX 2009006078 A MX2009006078 A MX 2009006078A MX 2009006078 A MX2009006078 A MX 2009006078A MX 2009006078 A MX2009006078 A MX 2009006078A
Authority
MX
Mexico
Prior art keywords
optionally substituted
ring
hydrocarbon group
atom
medical use
Prior art date
Application number
MX2009006078A
Other languages
English (en)
Inventor
Osamu Uchikawa
Tatsuki Koike
Takafumi Takai
Yasutaka Hoashi
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MX2009006078A publication Critical patent/MX2009006078A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describe un compuesto representado por la fórmula siguiente, el cual es útilo como agente preventivo/terapéutico para enfermedades asociadas con la actividad de melatoninaa, o una sal de él (En la fórmula, R1 representa n grupo hidrocarburo sustituido opcionalmente, un amino sustituido opcionalmente, un hidroxi sustituido opcionalmente o un grupo heterocíclico sustituido opcionalmente; R2 representa un átomo de hidrógeno o un grupo hidrocarburo sustituido opcionalmente; R3 representa un átomo de hidrógeno, un átomo de halógeno, un grupo hidrocarburo sustituido opcionalmente, un amino sustituido opcionalmente, un hidroxi sustituido opcionalmente o un mercapto sustituido opcionalmente; Xa-Xe representan respectivamente un átomo de carbono o un átomo de nitrógeno; m representa un número de 0 a 2; y el anillo A hasta el anillo C representan respectivamente un anillo sustituido opcionalmente).
MX2009006078A 2006-12-08 2007-12-07 Compuesto triciclico y su uso medico. MX2009006078A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006332647 2006-12-08
PCT/JP2007/073680 WO2008069311A1 (ja) 2006-12-08 2007-12-07 三環性化合物およびその医薬用途

Publications (1)

Publication Number Publication Date
MX2009006078A true MX2009006078A (es) 2009-09-18

Family

ID=39492186

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006078A MX2009006078A (es) 2006-12-08 2007-12-07 Compuesto triciclico y su uso medico.

Country Status (12)

Country Link
US (1) US8273761B2 (es)
EP (1) EP2100895B1 (es)
JP (1) JP5227806B2 (es)
KR (1) KR20090086641A (es)
CN (1) CN101605795A (es)
AT (1) ATE548371T1 (es)
AU (1) AU2007329879A1 (es)
BR (1) BRPI0719869A2 (es)
CA (1) CA2671354A1 (es)
EA (1) EA200970555A1 (es)
MX (1) MX2009006078A (es)
WO (1) WO2008069311A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090095666A (ko) 2006-12-28 2009-09-09 다케다 야쿠힌 고교 가부시키가이샤 삼환 화합물 및 이의 약학적 용도
EP2884275A4 (en) * 2012-07-10 2016-04-13 Astellas Pharma Inc PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF STRESS-RELATED HARNINE CONTINENCE OR MIXED INCONTINENCE AND METHOD FOR SCREENING COMPOUNDS FOR INTRODUCTION TO THIS PHARMACEUTICAL COMPOSITION
AR091699A1 (es) * 2012-07-10 2015-02-25 Astellas Pharma Inc Derivado de indol carboxamida
US10577591B2 (en) * 2015-06-12 2020-03-03 Mayo Foundation For Medical Education And Research Mumps virus as a potential oncolytic agent
JP6893476B2 (ja) 2016-01-08 2021-06-23 武田薬品工業株式会社 自閉症スペクトラム障害の予防または治療剤
KR20260008212A (ko) 2016-01-08 2026-01-15 다케다 야쿠힌 고교 가부시키가이샤 섬망의 예방 또는 치료제
KR20250073542A (ko) 2018-03-09 2025-05-27 리커리엄 아이피 홀딩스, 엘엘씨 치환된 1,2-다이하이드로-3H-피라졸로[3,4-d]피리미딘-3-온
US20250228798A1 (en) * 2024-01-17 2025-07-17 Rivo Bio, Inc. Indane-, indene-, azaindane-, and azaindene-amines as activators of serotonin receptors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326192D0 (en) * 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
US5998461A (en) 1994-10-21 1999-12-07 Adir Et Compagnie Tricyclic amide compounds
FR2725985B1 (fr) 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2732969B1 (fr) * 1995-04-14 1997-05-16 Adir Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SK283970B6 (sk) * 1996-03-08 2004-06-08 Takeda Chemical Industries, Ltd. Tricyklické zlúčeniny, spôsob výroby a farmaceutický prípravok ich obsahujúci
US6034239A (en) 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
US7592352B2 (en) 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
WO2006027424A1 (fr) * 2004-08-12 2006-03-16 Inria Institut National De Recherche En Informatique Et En Automatique Dispositif de contrôle de communications
FR2874611B1 (fr) * 2004-08-31 2006-11-17 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE381250T1 (de) 2005-05-13 2007-12-15 Sefar Ag Leiterplatte und verfahren zu deren herstellung

Also Published As

Publication number Publication date
JP5227806B2 (ja) 2013-07-03
US8273761B2 (en) 2012-09-25
WO2008069311A1 (ja) 2008-06-12
KR20090086641A (ko) 2009-08-13
EP2100895A4 (en) 2009-12-23
JPWO2008069311A1 (ja) 2010-03-25
EP2100895A1 (en) 2009-09-16
AU2007329879A1 (en) 2008-06-12
CN101605795A (zh) 2009-12-16
ATE548371T1 (de) 2012-03-15
EA200970555A1 (ru) 2010-02-26
US20100029707A1 (en) 2010-02-04
EP2100895B1 (en) 2012-03-07
CA2671354A1 (en) 2008-06-12
BRPI0719869A2 (pt) 2014-04-15

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal