MX2009005449A - Compuesto heteromonociclico y uso del mismo. - Google Patents
Compuesto heteromonociclico y uso del mismo.Info
- Publication number
- MX2009005449A MX2009005449A MX2009005449A MX2009005449A MX2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compound
- group
- group represented
- alkylamino
- Prior art date
Links
- -1 Heteromonocyclic compound Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de la presente invención representado por la fórmula (I): (ver fórmula (I)) en donde R1 es un grupo oxo, =N-R o similar; un grupo representado por la fórmula: (ver fórmula) es un grupo representado por la formula: (ver fórmulas) R2 es un grupo representado por la fórmula: (ver fórmula) R3 y R4 son cada uno H, o C1-C6 alquilo, C3-C6 cicloalquilo, C1-C6 alcoxi, C1-C6 alquilamino, di(C1-C6)alquilamino o C1-C6 alquiltio, cada uno de los cuales es opcionalmente substituido; y R5 es H, o un grupo C1-C6 alquilo, C2-C6 alquenilo, cíclico, cada uno de los cuales es opcionalmente substituido, -CO-R8 o -O-R8', o una sal del mismo. El compuesto de la presente invención es útil como un fármaco para la profilaxis o tratamiento de enfermedades circulatorias, enfermedades metabólicas y/o enfermedades del sistema nervioso central.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006317839 | 2006-11-24 | ||
| JP2007232106 | 2007-09-06 | ||
| PCT/JP2007/073004 WO2008062905A2 (en) | 2006-11-24 | 2007-11-21 | Heteromonocyclic compound and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009005449A true MX2009005449A (es) | 2009-06-02 |
Family
ID=39205144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009005449A MX2009005449A (es) | 2006-11-24 | 2007-11-21 | Compuesto heteromonociclico y uso del mismo. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20080207654A1 (es) |
| EP (2) | EP2256115A1 (es) |
| JP (1) | JP2010510962A (es) |
| KR (1) | KR20090085117A (es) |
| AR (1) | AR063912A1 (es) |
| AU (1) | AU2007322608A1 (es) |
| BR (1) | BRPI0719060A2 (es) |
| CA (1) | CA2670404A1 (es) |
| CL (1) | CL2007003352A1 (es) |
| CO (1) | CO6231035A2 (es) |
| CR (1) | CR10847A (es) |
| EA (1) | EA200970510A1 (es) |
| EC (1) | ECSP099461A (es) |
| IL (1) | IL198819A0 (es) |
| MA (1) | MA30985B1 (es) |
| MX (1) | MX2009005449A (es) |
| NO (1) | NO20092415L (es) |
| PE (1) | PE20081228A1 (es) |
| TN (1) | TN2009000199A1 (es) |
| TW (1) | TW200829581A (es) |
| WO (1) | WO2008062905A2 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7103906B1 (en) | 2000-09-29 | 2006-09-05 | International Business Machines Corporation | User controlled multi-device media-on-demand system |
| DE60135567D1 (de) | 2000-10-11 | 2008-10-09 | United Video Properties Inc | Systeme und verfahren zur bereitstellung von datenspeichern in servern in einem medien-auf-anfrage liefersystem |
| US8086575B2 (en) | 2004-09-23 | 2011-12-27 | Rovi Solutions Corporation | Methods and apparatus for integrating disparate media formats in a networked media system |
| US9681105B2 (en) | 2005-12-29 | 2017-06-13 | Rovi Guides, Inc. | Interactive media guidance system having multiple devices |
| US8607287B2 (en) | 2005-12-29 | 2013-12-10 | United Video Properties, Inc. | Interactive media guidance system having multiple devices |
| US7803940B2 (en) * | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| EA200970510A1 (ru) * | 2006-11-24 | 2009-12-30 | Такеда Фармасьютикал Компани Лимитед | Гетеромоноциклическое соединение и его применение |
| US20090019492A1 (en) | 2007-07-11 | 2009-01-15 | United Video Properties, Inc. | Systems and methods for mirroring and transcoding media content |
| AR075344A1 (es) * | 2009-01-30 | 2011-03-23 | Takeda Pharmaceutical | Derivados heterociclicos nitrogenados fusionados, medicamentos que los contienen y uso de los mismos en el tratamiento de enfermedades cardiacas, renales y metabolicas, entre otras |
| JPWO2010095462A1 (ja) | 2009-02-23 | 2012-08-23 | 興和株式会社 | 新規な３−（５−アルコキシピリミジン−２−イル）ピリミジン−４（３ｈ）−オン構造を有する化合物及びこれを含有する医薬 |
| US8664226B2 (en) | 2009-04-17 | 2014-03-04 | Kowa Company, Ltd. | Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same |
| US20120046308A1 (en) | 2009-05-29 | 2012-02-23 | Kowa Company, Ltd. | Novel alpha-phenoxybenzeneacetic acid derivative and pharmaceutical preparation comprising same |
| WO2011024468A1 (ja) | 2009-08-27 | 2011-03-03 | 興和株式会社 | 新規なスルホンアミド誘導体及びこれを含有する医薬 |
| US9014546B2 (en) | 2009-09-23 | 2015-04-21 | Rovi Guides, Inc. | Systems and methods for automatically detecting users within detection regions of media devices |
| EP2484675B1 (en) * | 2009-09-29 | 2014-11-05 | Kowa Company, Ltd. | Novel phenylpyridine derivative and medicinal agent comprising same |
| US20120225896A1 (en) * | 2009-12-22 | 2012-09-06 | Kowa Company, Ltd. | Novel 2-pyridone derivative and pharmaceutical product containing same |
| JPWO2011105099A1 (ja) * | 2010-02-25 | 2013-06-20 | 興和株式会社 | 新規な４−アルコキシピリミジン構造を有する化合物及びこれを含有する医薬 |
| AU2011251302A1 (en) * | 2010-05-11 | 2013-01-10 | 8337187 Canada, Inc. | Benzo- or pyrido-imidazole derivative |
| WO2012011592A1 (ja) * | 2010-07-23 | 2012-01-26 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| UY33650A (es) | 2010-10-07 | 2012-04-30 | Takeda Pharmaceutical | Compuestos heterocíclicos |
| US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| WO2012078673A1 (en) | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
| EP2648516B1 (en) | 2010-12-06 | 2018-09-05 | Aclaris Therapeutics, Inc. | Substituted pyridinone-pyridinyl compounds |
| US8507499B2 (en) | 2010-12-06 | 2013-08-13 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
| KR101559307B1 (ko) * | 2011-03-14 | 2015-10-12 | 교와 가부시키가이샤 | 신규 페닐피리딘 유도체 및 이를 함유하는 의약 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013086208A1 (en) | 2011-12-06 | 2013-06-13 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
| EP3290413B9 (en) * | 2011-12-21 | 2020-04-29 | ONO Pharmaceutical Co., Ltd. | Pyridinone and pyrimidinone derivatives as factor xia inhibitors |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| JP6699909B2 (ja) | 2013-06-07 | 2020-05-27 | アクラリス セラピューティクス，インコーポレイテッド | メチル／フルオロ−ピリジニル−メトキシ置換ピリジノン−ピリジニル化合物及びフルオロ−ピリミジニル−メトキシ置換ピリジノン−ピリジニル化合物 |
| WO2014202510A1 (de) | 2013-06-20 | 2014-12-24 | Bayer Cropscience Ag | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
| BR112015031155A2 (pt) | 2013-06-20 | 2017-07-25 | Bayer Cropscience Ag | derivados de sulfureto de arila e derivados de aril sulfóxido como acaricidas e inseticidas |
| US9674563B2 (en) | 2013-11-04 | 2017-06-06 | Rovi Guides, Inc. | Systems and methods for recommending content |
| ES2663806T3 (es) | 2013-12-19 | 2018-04-17 | unshine Lake Pharma Co., Ltd. | Derivados heterocíclicos nitrogenados y su aplicación en el tratamiento de la fibrosis tisular |
| RS61016B1 (sr) | 2014-04-01 | 2020-12-31 | Merck Sharp & Dohme | Prolekovi inhibitora hiv reverzne transkriptaze |
| ES2927307T3 (es) | 2014-12-10 | 2022-11-04 | Ono Pharmaceutical Co | Derivado de dihidroindolizinona |
| AU2017295745A1 (en) | 2016-07-12 | 2019-01-31 | Bayer Cropscience Aktiengesellschaft | Bicyclic compounds as pest control agents |
| KR101984121B1 (ko) * | 2017-08-21 | 2019-05-30 | 보령제약 주식회사 | 피리미디논 유도체 화합물 및 이의 용도 |
| PH12022552263A1 (en) | 2020-03-27 | 2023-11-13 | Aclaris Therapeutics Inc | Oral compositions of mk2 pathway inhibitor for treatment of immune conditions |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
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| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| EP1227090A4 (en) | 1999-10-07 | 2002-11-20 | Tadeka Chemical Ind Ltd | AMINE DERIVATIVES |
| JP3723071B2 (ja) | 1999-11-10 | 2005-12-07 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
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| US7803940B2 (en) * | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| EA200970510A1 (ru) * | 2006-11-24 | 2009-12-30 | Такеда Фармасьютикал Компани Лимитед | Гетеромоноциклическое соединение и его применение |
-
2007
- 2007-11-21 EA EA200970510A patent/EA200970510A1/ru unknown
- 2007-11-21 EP EP10173592A patent/EP2256115A1/en not_active Withdrawn
- 2007-11-21 MX MX2009005449A patent/MX2009005449A/es not_active Application Discontinuation
- 2007-11-21 JP JP2009521472A patent/JP2010510962A/ja not_active Abandoned
- 2007-11-21 AU AU2007322608A patent/AU2007322608A1/en not_active Abandoned
- 2007-11-21 KR KR1020097012959A patent/KR20090085117A/ko not_active Withdrawn
- 2007-11-21 WO PCT/JP2007/073004 patent/WO2008062905A2/en not_active Ceased
- 2007-11-21 CA CA002670404A patent/CA2670404A1/en not_active Abandoned
- 2007-11-21 US US11/943,910 patent/US20080207654A1/en not_active Abandoned
- 2007-11-21 EP EP07832719A patent/EP2074117A2/en not_active Withdrawn
- 2007-11-21 BR BRPI0719060-3A2A patent/BRPI0719060A2/pt not_active IP Right Cessation
- 2007-11-21 US US12/516,099 patent/US20100056526A1/en not_active Abandoned
- 2007-11-23 AR ARP070105204A patent/AR063912A1/es not_active Application Discontinuation
- 2007-11-23 CL CL200703352A patent/CL2007003352A1/es unknown
- 2007-11-23 TW TW096144409A patent/TW200829581A/zh unknown
- 2007-11-23 PE PE2007001629A patent/PE20081228A1/es not_active Application Discontinuation
-
2009
- 2009-05-19 IL IL198819A patent/IL198819A0/en unknown
- 2009-05-20 TN TNP2009000199A patent/TN2009000199A1/fr unknown
- 2009-06-09 CR CR10847A patent/CR10847A/es unknown
- 2009-06-10 MA MA31977A patent/MA30985B1/fr unknown
- 2009-06-23 EC EC2009009461A patent/ECSP099461A/es unknown
- 2009-06-24 NO NO20092415A patent/NO20092415L/no not_active Application Discontinuation
- 2009-06-24 CO CO09065607A patent/CO6231035A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CL2007003352A1 (es) | 2008-07-04 |
| AU2007322608A2 (en) | 2009-07-16 |
| NO20092415L (no) | 2009-08-17 |
| TN2009000199A1 (en) | 2010-10-18 |
| BRPI0719060A2 (pt) | 2014-02-04 |
| WO2008062905A2 (en) | 2008-05-29 |
| PE20081228A1 (es) | 2008-10-29 |
| KR20090085117A (ko) | 2009-08-06 |
| US20100056526A1 (en) | 2010-03-04 |
| TW200829581A (en) | 2008-07-16 |
| CO6231035A2 (es) | 2010-12-20 |
| JP2010510962A (ja) | 2010-04-08 |
| WO2008062905A3 (en) | 2008-12-04 |
| EA200970510A1 (ru) | 2009-12-30 |
| ECSP099461A (es) | 2009-11-30 |
| AU2007322608A1 (en) | 2008-05-29 |
| AR063912A1 (es) | 2009-02-25 |
| CA2670404A1 (en) | 2008-05-29 |
| US20080207654A1 (en) | 2008-08-28 |
| IL198819A0 (en) | 2010-02-17 |
| EP2074117A2 (en) | 2009-07-01 |
| EP2256115A1 (en) | 2010-12-01 |
| CR10847A (es) | 2009-07-13 |
| MA30985B1 (fr) | 2009-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |