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MA30985B1 - Compose heteromonocyclique et ses utilisations - Google Patents

Compose heteromonocyclique et ses utilisations

Info

Publication number
MA30985B1
MA30985B1 MA31977A MA31977A MA30985B1 MA 30985 B1 MA30985 B1 MA 30985B1 MA 31977 A MA31977 A MA 31977A MA 31977 A MA31977 A MA 31977A MA 30985 B1 MA30985 B1 MA 30985B1
Authority
MA
Morocco
Prior art keywords
group
formula
compound
alkylamino
alkyl
Prior art date
Application number
MA31977A
Other languages
English (en)
Inventor
Takanobu Kuroita
Hiroki Sakamoto
Hideyuki Igawa
Minoru Sasaki
Kouhei Asano
Tsuyoshi Maekawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA30985B1 publication Critical patent/MA30985B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION PORTE SUR UN COMPOSÉ DE FORMULE (I): OÙ R1 EST UN GROUPE OXO, =N-R OU ANALOGUE OU UN GROUPE DE FORMULE (I); R2 EST UN GROUPE DE FORMULE (I); R3 ET R4 SONT CHACUN H, OU C1-C6 ALKYLE, C3-C6 CYCLOALKYLE, C1-C6 ALKOXY, C1-C6 ALKYLAMINO, DI (C1-C6) ALKYLAMINO OU C1-C6 ALKYLTHIO, TOUS FACULTATIVEMENT SUBSTITUÉS; ET R5 EST H, OU C1-C6 ALKYLE, C2-C6 ALCÉNYLE, UN GROUPE CYCLIQUE, TOUS FACULTATIVEMENT SUBSTITUÉ, -CO-R8 OU -O-R8', OU UN DE LEURS SELS. LEDIT COMPOSÉ S'AVÈRE UTILE COMME MÉDICAMENT POUR LA PROPHYLAXIE OU LE TRAITEMENT DE MALADIES CIRCULATOIRES, DE TROUBLES DU MÉTABOLISME ET/OU DE MALADIES DU SNC.
MA31977A 2006-11-24 2009-06-10 Compose heteromonocyclique et ses utilisations MA30985B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006317839 2006-11-24
JP2007232106 2007-09-06

Publications (1)

Publication Number Publication Date
MA30985B1 true MA30985B1 (fr) 2009-12-01

Family

ID=39205144

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31977A MA30985B1 (fr) 2006-11-24 2009-06-10 Compose heteromonocyclique et ses utilisations

Country Status (21)

Country Link
US (2) US20080207654A1 (fr)
EP (2) EP2256115A1 (fr)
JP (1) JP2010510962A (fr)
KR (1) KR20090085117A (fr)
AR (1) AR063912A1 (fr)
AU (1) AU2007322608A1 (fr)
BR (1) BRPI0719060A2 (fr)
CA (1) CA2670404A1 (fr)
CL (1) CL2007003352A1 (fr)
CO (1) CO6231035A2 (fr)
CR (1) CR10847A (fr)
EA (1) EA200970510A1 (fr)
EC (1) ECSP099461A (fr)
IL (1) IL198819A0 (fr)
MA (1) MA30985B1 (fr)
MX (1) MX2009005449A (fr)
NO (1) NO20092415L (fr)
PE (1) PE20081228A1 (fr)
TN (1) TN2009000199A1 (fr)
TW (1) TW200829581A (fr)
WO (1) WO2008062905A2 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7103906B1 (en) 2000-09-29 2006-09-05 International Business Machines Corporation User controlled multi-device media-on-demand system
DE60135567D1 (de) 2000-10-11 2008-10-09 United Video Properties Inc Systeme und verfahren zur bereitstellung von datenspeichern in servern in einem medien-auf-anfrage liefersystem
US8086575B2 (en) 2004-09-23 2011-12-27 Rovi Solutions Corporation Methods and apparatus for integrating disparate media formats in a networked media system
US9681105B2 (en) 2005-12-29 2017-06-13 Rovi Guides, Inc. Interactive media guidance system having multiple devices
US8607287B2 (en) 2005-12-29 2013-12-10 United Video Properties, Inc. Interactive media guidance system having multiple devices
US7803940B2 (en) * 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
EA200970510A1 (ru) * 2006-11-24 2009-12-30 Такеда Фармасьютикал Компани Лимитед Гетеромоноциклическое соединение и его применение
US20090019492A1 (en) 2007-07-11 2009-01-15 United Video Properties, Inc. Systems and methods for mirroring and transcoding media content
AR075344A1 (es) * 2009-01-30 2011-03-23 Takeda Pharmaceutical Derivados heterociclicos nitrogenados fusionados, medicamentos que los contienen y uso de los mismos en el tratamiento de enfermedades cardiacas, renales y metabolicas, entre otras
JPWO2010095462A1 (ja) 2009-02-23 2012-08-23 興和株式会社 新規な３−（５−アルコキシピリミジン−２−イル）ピリミジン−４（３ｈ）−オン構造を有する化合物及びこれを含有する医薬
US8664226B2 (en) 2009-04-17 2014-03-04 Kowa Company, Ltd. Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same
US20120046308A1 (en) 2009-05-29 2012-02-23 Kowa Company, Ltd. Novel alpha-phenoxybenzeneacetic acid derivative and pharmaceutical preparation comprising same
WO2011024468A1 (fr) 2009-08-27 2011-03-03 興和株式会社 Nouveau dérivé de sulfonamide et composition pharmaceutique le contenant
US9014546B2 (en) 2009-09-23 2015-04-21 Rovi Guides, Inc. Systems and methods for automatically detecting users within detection regions of media devices
EP2484675B1 (fr) * 2009-09-29 2014-11-05 Kowa Company, Ltd. Nouveau dérivé de phénylpyridine et agent médicinal le comprenant
US20120225896A1 (en) * 2009-12-22 2012-09-06 Kowa Company, Ltd. Novel 2-pyridone derivative and pharmaceutical product containing same
JPWO2011105099A1 (ja) * 2010-02-25 2013-06-20 興和株式会社 新規な４−アルコキシピリミジン構造を有する化合物及びこれを含有する医薬
AU2011251302A1 (en) * 2010-05-11 2013-01-10 8337187 Canada, Inc. Benzo- or pyrido-imidazole derivative
WO2012011592A1 (fr) * 2010-07-23 2012-01-26 武田薬品工業株式会社 Composé hétérocyclique et application de celui-ci
UY33650A (es) 2010-10-07 2012-04-30 Takeda Pharmaceutical Compuestos heterocíclicos
US9359300B2 (en) 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
WO2012078673A1 (fr) 2010-12-06 2012-06-14 Confluence Life Sciences, Inc. Composés urée-pyridine substitués
EP2648516B1 (fr) 2010-12-06 2018-09-05 Aclaris Therapeutics, Inc. Composés pyridinone-pyridinyle substitués
US8507499B2 (en) 2010-12-06 2013-08-13 Confluence Life Sciences, Inc. Substituted indole/indazole-pyrimidinyl compounds
KR101559307B1 (ko) * 2011-03-14 2015-10-12 교와 가부시키가이샤 신규 페닐피리딘 유도체 및 이를 함유하는 의약
EP2567959B1 (fr) 2011-09-12 2014-04-16 Sanofi Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013086208A1 (fr) 2011-12-06 2013-06-13 Confluence Life Sciences, Inc. Composés de pyrimidinone-phényl-pyrimidinyle substitués
EP3290413B9 (fr) * 2011-12-21 2020-04-29 ONO Pharmaceutical Co., Ltd. Dérivés de pyridinone et de pyrimidinone en tant qu'inhibiteurs du facteur xia
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
JP6699909B2 (ja) 2013-06-07 2020-05-27 アクラリス セラピューティクス，インコーポレイテッド メチル／フルオロ−ピリジニル−メトキシ置換ピリジノン−ピリジニル化合物及びフルオロ−ピリミジニル−メトキシ置換ピリジノン−ピリジニル化合物
WO2014202510A1 (fr) 2013-06-20 2014-12-24 Bayer Cropscience Ag Dérivés d'arylsulfure et d'arylsulfoxyde utilisés comme acaricides et insecticides
BR112015031155A2 (pt) 2013-06-20 2017-07-25 Bayer Cropscience Ag derivados de sulfureto de arila e derivados de aril sulfóxido como acaricidas e inseticidas
US9674563B2 (en) 2013-11-04 2017-06-06 Rovi Guides, Inc. Systems and methods for recommending content
ES2663806T3 (es) 2013-12-19 2018-04-17 unshine Lake Pharma Co., Ltd. Derivados heterocíclicos nitrogenados y su aplicación en el tratamiento de la fibrosis tisular
RS61016B1 (sr) 2014-04-01 2020-12-31 Merck Sharp & Dohme Prolekovi inhibitora hiv reverzne transkriptaze
ES2927307T3 (es) 2014-12-10 2022-11-04 Ono Pharmaceutical Co Derivado de dihidroindolizinona
AU2017295745A1 (en) 2016-07-12 2019-01-31 Bayer Cropscience Aktiengesellschaft Bicyclic compounds as pest control agents
KR101984121B1 (ko) * 2017-08-21 2019-05-30 보령제약 주식회사 피리미디논 유도체 화합물 및 이의 용도
PH12022552263A1 (en) 2020-03-27 2023-11-13 Aclaris Therapeutics Inc Oral compositions of mk2 pathway inhibitor for treatment of immune conditions
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411980A (en) * 1989-07-28 1995-05-02 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
ATE113281T1 (de) * 1989-08-02 1994-11-15 Takeda Chemical Industries Ltd Pyrazol-derivate, verfahren zu deren herstellung und anwendung.
JPH03218371A (ja) 1989-08-02 1991-09-25 Takeda Chem Ind Ltd ピラゾール誘導体
JP3032844B2 (ja) 1990-02-15 2000-04-17 武田薬品工業株式会社 ピリミジンジオン誘導体
DE69129998T2 (de) * 1990-02-15 1998-12-24 Takeda Chemical Industries, Ltd., Osaka Pyrimidindionderivate, deren Herstellung und Verwendung
CA2037630C (fr) * 1990-03-07 2001-07-03 Akira Morimoto Composes heterocycliques renfermant de l'azote, methode de production et applications correspondantes
JP3114073B2 (ja) 1990-03-07 2000-12-04 武田薬品工業株式会社 アンジオテンシンｉｉ拮抗薬−含窒素異項環化合物
US5166206A (en) * 1990-03-30 1992-11-24 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
US5472967A (en) * 1991-02-20 1995-12-05 Synthelabo 4-pyrimidinone derivatives their preparation and their application in therapy
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
IT1250749B (it) * 1991-08-02 1995-04-21 Luso Farmaco Inst Composti eterociclici ad attivita' a ii antagonista
ATE264323T1 (de) 1992-09-14 2004-04-15 Takeda Chemical Industries Ltd Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten
JPH06239859A (ja) 1992-09-14 1994-08-30 Takeda Chem Ind Ltd アンギオテンシンｉｉ拮抗作用を有する環状化合物およびその用途
JP3412887B2 (ja) 1992-12-22 2003-06-03 武田薬品工業株式会社 アンギオテンシンｉｉ拮抗作用を有する複素環化合物およびその用途
EP0603712B1 (fr) 1992-12-22 2001-08-16 Takeda Chemical Industries, Ltd. Composés hétérocycliques avec une activité angiotensine II antagonistique et leur utilisation
US20010020100A1 (en) * 1994-06-14 2001-09-06 G.D. Searle & Co. N-substituted-1, 2, 4-triazolone compounds for treatment of cardiovascular disorders
US6057338A (en) 1997-04-04 2000-05-02 Merck & Co., Inc. Somatostatin agonists
US6025372A (en) 1997-04-04 2000-02-15 Merck & Co., Inc. Somatostatin agonists
AU1285499A (en) 1997-10-30 1999-05-24 Merck & Co., Inc. Somatostatin agonists
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
EP1227090A4 (fr) 1999-10-07 2002-11-20 Tadeka Chemical Ind Ltd Derives d'amines
JP3723071B2 (ja) 1999-11-10 2005-12-07 武田薬品工業株式会社 含窒素５員複素環化合物
WO2001082925A1 (fr) 2000-04-28 2001-11-08 Takeda Chemical Industries, Ltd. Antagonistes de l'hormone concentrant la melanine
EP1283199A4 (fr) 2000-05-16 2003-12-17 Takeda Chemical Industries Ltd Antagoniste de l'hormone de concentration de la melanine
PL360398A1 (en) 2000-07-13 2004-09-06 Takeda Chemical Industries, Ltd. Lipid-rich plaque inhibitors
US20050245571A1 (en) 2001-10-19 2005-11-03 Hidenori Abe Amine derivative
NZ533893A (en) 2002-01-11 2006-06-30 Takeda Pharmaceutical Coumarin derivatives, process for their production and use thereof
CA2507026A1 (fr) 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited Derives d'imidazole, leur procede de production et d'utilisation
US7803940B2 (en) * 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
EA200970510A1 (ru) * 2006-11-24 2009-12-30 Такеда Фармасьютикал Компани Лимитед Гетеромоноциклическое соединение и его применение

Also Published As

Publication number Publication date
CL2007003352A1 (es) 2008-07-04
AU2007322608A2 (en) 2009-07-16
MX2009005449A (es) 2009-06-02
NO20092415L (no) 2009-08-17
TN2009000199A1 (en) 2010-10-18
BRPI0719060A2 (pt) 2014-02-04
WO2008062905A2 (fr) 2008-05-29
PE20081228A1 (es) 2008-10-29
KR20090085117A (ko) 2009-08-06
US20100056526A1 (en) 2010-03-04
TW200829581A (en) 2008-07-16
CO6231035A2 (es) 2010-12-20
JP2010510962A (ja) 2010-04-08
WO2008062905A3 (fr) 2008-12-04
EA200970510A1 (ru) 2009-12-30
ECSP099461A (es) 2009-11-30
AU2007322608A1 (en) 2008-05-29
AR063912A1 (es) 2009-02-25
CA2670404A1 (fr) 2008-05-29
US20080207654A1 (en) 2008-08-28
IL198819A0 (en) 2010-02-17
EP2074117A2 (fr) 2009-07-01
EP2256115A1 (fr) 2010-12-01
CR10847A (es) 2009-07-13

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