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MX2009004900A - Arilamidas sustituidas por tiazol u oxazol. - Google Patents

Arilamidas sustituidas por tiazol u oxazol.

Info

Publication number
MX2009004900A
MX2009004900A MX2009004900A MX2009004900A MX2009004900A MX 2009004900 A MX2009004900 A MX 2009004900A MX 2009004900 A MX2009004900 A MX 2009004900A MX 2009004900 A MX2009004900 A MX 2009004900A MX 2009004900 A MX2009004900 A MX 2009004900A
Authority
MX
Mexico
Prior art keywords
oxazole
thiazole
formula
compounds
substituted arylamides
Prior art date
Application number
MX2009004900A
Other languages
English (en)
Inventor
Li Chen
Michael Patrick Dillon
Ronald Charles Hawley
Minmin Yang
Lichun Feng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009004900A publication Critical patent/MX2009004900A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se descripen compuestos de la fórmula I: (ver fórmula (I)) o sales farmacéuticamente aceptables de los mismos, en la que R1 es un grupo de la fórmula A o de la fórmula B; (ver fórmulas (A y B)) y X, R2, R3, R4, R5, R6, Ra y Rb tienen los significados aquí definidos. Se proporcionan también métodos para utilizar los compuestos en el tratamiento de enfermedades, en ellas los compuestos actúan como antagonistas de receptores P2X3 y/o P2X2/3 y métodos para la obtención de los compuestos de interés.
MX2009004900A 2006-11-09 2007-10-31 Arilamidas sustituidas por tiazol u oxazol. MX2009004900A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85828306P 2006-11-09 2006-11-09
PCT/EP2007/061771 WO2008055840A1 (en) 2006-11-09 2007-10-31 Thiazole and oxazole-substituted arylamides

Publications (1)

Publication Number Publication Date
MX2009004900A true MX2009004900A (es) 2009-05-19

Family

ID=39149180

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004900A MX2009004900A (es) 2006-11-09 2007-10-31 Arilamidas sustituidas por tiazol u oxazol.

Country Status (17)

Country Link
US (1) US7786110B2 (es)
EP (1) EP2091927B1 (es)
JP (1) JP5084839B2 (es)
KR (2) KR101165936B1 (es)
CN (1) CN101528717B (es)
AR (1) AR063601A1 (es)
AT (1) ATE517097T1 (es)
AU (1) AU2007316681B2 (es)
BR (1) BRPI0718714B8 (es)
CA (1) CA2668399C (es)
CL (1) CL2007003192A1 (es)
ES (1) ES2367455T3 (es)
IL (1) IL198301A (es)
MX (1) MX2009004900A (es)
PE (1) PE20081475A1 (es)
TW (1) TW200829584A (es)
WO (1) WO2008055840A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009004900A (es) 2006-11-09 2009-05-19 Hoffmann La Roche Arilamidas sustituidas por tiazol u oxazol.
US8501933B2 (en) 2006-11-09 2013-08-06 Roche Palo Alto Llc Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
JP5552430B2 (ja) * 2007-10-31 2014-07-16 メルク・シャープ・アンド・ドーム・コーポレーション 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト
JP2011502148A (ja) * 2007-10-31 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト
BRPI0821266B8 (pt) * 2007-12-17 2023-02-07 Hoffmann La Roche Derivados de arilamida triazol-substituída e seu uso e composição farmacêutica
JP5301561B2 (ja) * 2007-12-17 2013-09-25 エフ．ホフマン−ラ ロシュ アーゲー 新規なピラゾール置換アリールアミド
EP2234989B1 (en) * 2007-12-17 2014-08-13 F. Hoffmann-La Roche AG Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists
EP2234981B1 (en) * 2007-12-17 2016-03-30 F. Hoffmann-La Roche AG Novel imidazole-substituted arylamides
EP2262766B1 (en) 2008-02-29 2015-11-11 Evotec AG Amide compounds, compositions and uses thereof
JP5608655B2 (ja) * 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
EP2379518B1 (en) * 2008-12-16 2014-05-07 F. Hoffmann-La Roche AG Thiadiazole-substituted arylamides
CA2764956A1 (en) 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel biphenyl and phenyl-pyridine amides
CA2754654A1 (en) * 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel oxazolone and pyrrolidinone-substituted arylamides
JP5813101B2 (ja) * 2010-06-04 2015-11-17 アルバニー モレキュラー リサーチ， インコーポレイテッド グリシントランスポーター−１阻害剤、その作製方法および使用方法
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EP2928874B1 (de) * 2012-12-07 2017-02-01 Bayer CropScience AG N-(isoxazol-3-yl)-arylcarbonsäureamide und ihre verwendung als herbizide
EP2905282A1 (en) * 2014-02-05 2015-08-12 AXXAM S.p.A. Substituted thiazole or oxazole as P2X7 receptor antagonists
CN110256418B (zh) 2014-12-09 2023-01-20 拜耳公司 1，3-噻唑-2-基取代的苯甲酰胺
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
KR20160138877A (ko) 2015-05-26 2016-12-06 (주)펠리테크 마이크로파를 이용한 세라믹 발열 하이브리드 건조기
DK3512833T3 (da) 2016-09-15 2020-10-12 Boehringer Ingelheim Int Heteroarylcarboxamidforbindelser som inhibitorer af ripk2
CN109996546B (zh) * 2016-09-30 2023-06-27 阿沙纳生物科学公司 P2x3和/或p2x2/3化合物及方法
WO2020002090A1 (de) 2018-06-25 2020-01-02 Bayer Aktiengesellschaft Substituierte thiazolylpyrrolone sowie deren salze und ihre verwendung als herbizide wirkstoffe
EP3757103A1 (en) * 2019-06-27 2020-12-30 Bayer AG Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases
WO2022063205A1 (zh) * 2020-09-24 2022-03-31 中国医药研究开发中心有限公司 芳基甲酰胺类化合物及其制备方法和医药用途

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MX2009004900A (es) 2006-11-09 2009-05-19 Hoffmann La Roche Arilamidas sustituidas por tiazol u oxazol.
JP2011502148A (ja) 2007-10-31 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト

Also Published As

Publication number Publication date
JP5084839B2 (ja) 2012-11-28
AR063601A1 (es) 2009-02-04
EP2091927A1 (en) 2009-08-26
CL2007003192A1 (es) 2008-06-20
CN101528717A (zh) 2009-09-09
KR20120034766A (ko) 2012-04-12
AU2007316681B2 (en) 2013-01-24
CN101528717B (zh) 2013-04-24
WO2008055840A1 (en) 2008-05-15
BRPI0718714A2 (pt) 2013-11-26
IL198301A0 (en) 2010-02-17
AU2007316681A1 (en) 2008-05-15
ATE517097T1 (de) 2011-08-15
EP2091927B1 (en) 2011-07-20
PE20081475A1 (es) 2008-10-18
BRPI0718714B8 (pt) 2021-05-25
CA2668399C (en) 2015-01-27
JP2010509264A (ja) 2010-03-25
KR101165936B1 (ko) 2012-07-19
ES2367455T3 (es) 2011-11-03
KR20090086073A (ko) 2009-08-10
US7786110B2 (en) 2010-08-31
CA2668399A1 (en) 2008-05-15
TW200829584A (en) 2008-07-16
BRPI0718714B1 (pt) 2020-09-29
US20080132494A1 (en) 2008-06-05
KR101152714B1 (ko) 2012-06-18
IL198301A (en) 2013-06-27

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