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MX2008016423A - Arilamidas sustituidas con tetrazol. - Google Patents

Arilamidas sustituidas con tetrazol.

Info

Publication number
MX2008016423A
MX2008016423A MX2008016423A MX2008016423A MX2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A MX 2008016423 A MX2008016423 A MX 2008016423A
Authority
MX
Mexico
Prior art keywords
sub
optionally substituted
compounds
tetrazole
methods
Prior art date
Application number
MX2008016423A
Other languages
English (en)
Inventor
Li Chen
Michael Patrick Dillon
Ronald Charles Hawley
Minmin Yang
Lichun Feng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2008016423A publication Critical patent/MX2008016423A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuestos de la fórmula I: (ver fórmula (I)) o su sal farmacéuticamente aceptable, en donde R1 es tetrazolilo opcionalmente sustituido, R2 es fenilo opcionalmente sustituido, piridilo opcionalmente sustituido o tienilo opcionalmente sustituido, y R3, R4, R5 y R6 son como se definen en la presente. También se proporcionan métodos para utilizar los compuestos para tratar enfermedades mediadas por un antagonista del receptor P2X3 y/o P2X2/3 y métodos para hacer los compuestos.
MX2008016423A 2006-06-29 2007-06-18 Arilamidas sustituidas con tetrazol. MX2008016423A (es)

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