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MX2009004947A - Arilsulfonil-pirrolidinas como inhibidores 5-hidroxitriptaminas6 (5-ht6). - Google Patents

Arilsulfonil-pirrolidinas como inhibidores 5-hidroxitriptaminas6 (5-ht6).

Info

Publication number
MX2009004947A
MX2009004947A MX2009004947A MX2009004947A MX2009004947A MX 2009004947 A MX2009004947 A MX 2009004947A MX 2009004947 A MX2009004947 A MX 2009004947A MX 2009004947 A MX2009004947 A MX 2009004947A MX 2009004947 A MX2009004947 A MX 2009004947A
Authority
MX
Mexico
Prior art keywords
pyrrolidines
arylsulfonyl
inhibitors
compounds
formula
Prior art date
Application number
MX2009004947A
Other languages
English (en)
Inventor
Francisco Javier Lopez-Tapia
Dov Nitzan
Lee Edwin Lowrie Jr
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009004947A publication Critical patent/MX2009004947A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Esta invención se refiere a compuestos de pirrolidina sustituida de la fórmula I: (ver fórmula (I)) en la que m, n, Ar, R1 y R2 tienen los significados definidos en esta solicitud. Se describen métodos para la obtención de los compuestos y la utilización de los compuestos.
MX2009004947A 2006-11-09 2007-11-02 Arilsulfonil-pirrolidinas como inhibidores 5-hidroxitriptaminas6 (5-ht6). MX2009004947A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85810606P 2006-11-09 2006-11-09
PCT/EP2007/061813 WO2008055847A1 (en) 2006-11-09 2007-11-02 Arylsulfonyl pyrrolidines as 5-ht6 inhibitors

Publications (1)

Publication Number Publication Date
MX2009004947A true MX2009004947A (es) 2009-05-19

Family

ID=39023536

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004947A MX2009004947A (es) 2006-11-09 2007-11-02 Arilsulfonil-pirrolidinas como inhibidores 5-hidroxitriptaminas6 (5-ht6).

Country Status (18)

Country Link
US (1) US7776910B2 (es)
EP (1) EP2081890B1 (es)
JP (1) JP2010509266A (es)
KR (1) KR20090079259A (es)
CN (1) CN101573332A (es)
AR (1) AR063576A1 (es)
AT (1) ATE495153T1 (es)
AU (1) AU2007316688A1 (es)
BR (1) BRPI0718584A2 (es)
CA (1) CA2667710A1 (es)
CL (1) CL2007003190A1 (es)
DE (1) DE602007011962D1 (es)
ES (1) ES2358549T3 (es)
IL (1) IL198322A0 (es)
MX (1) MX2009004947A (es)
PE (1) PE20081160A1 (es)
TW (1) TW200827337A (es)
WO (1) WO2008055847A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8987307B2 (en) 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
JP2015512431A (ja) 2012-04-04 2015-04-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｇｐｂａｒ１モジュレーターとしての１，２−ピリダジン、１，６−ピリダジン又はピリミジン−ベンズアミド誘導体
CN104557726B (zh) * 2013-10-19 2019-05-24 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
CN105566182B (zh) * 2016-02-24 2018-02-13 苏州天马精细化学品股份有限公司 一种2‑氨基‑4‑（乙磺酰基）苯酚的合成方法
CN108689904B (zh) * 2017-04-12 2022-06-17 轩竹生物科技股份有限公司 手性杂环叔醇中间体的制备方法及其应用
CN109232362B (zh) * 2017-07-10 2022-12-27 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
AU2018359224B2 (en) * 2017-10-30 2023-10-05 Neuropore Therapies, Inc. Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
CN109912487B (zh) * 2019-03-25 2023-01-10 山东理工大学 一种合成1-对甲苯磺酰基-2-乙烯基-1氢-吡咯的方法
AU2020365108A1 (en) 2019-10-18 2022-04-21 Atengen, Inc. 3-phenylsulphonyl-quinoline derivatives as agents for treating pathogenic blood vessels disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0930302T1 (en) * 1998-01-16 2003-10-31 F. Hoffmann-La Roche Ag Benzosulfone derivatives
US20040014966A1 (en) * 2000-06-20 2004-01-22 Jacobsen Eric Jon Bis-arylsulfones
PE20020063A1 (es) 2000-06-20 2002-01-30 Upjohn Co Bis-arilsulfonas como ligandos del receptor de 5-ht
PL376479A1 (en) 2002-10-18 2005-12-27 F.Hoffmann-La Roche Ag 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity
BRPI0407618A (pt) * 2003-02-21 2006-02-21 Pfizer derivados de tiazole amino substituidos com cicloalquilo contendo n e composições farmacêuticas para inibição da proliferação celular e métodos para a sua utilização
WO2005014578A1 (en) 2003-08-08 2005-02-17 Glaxo Group Limited Phenylsulfonyl compounds as antipsychotic agents
RU2008103700A (ru) * 2005-08-15 2009-09-27 Вайет (Us) Производные азинил-3-сульфонилиндазола в качестве лиганд 5ов 5-гидрокситриптамина-6
CN101421234A (zh) * 2006-04-19 2009-04-29 艾博特股份有限两合公司 适于治疗对5-羟色胺5ht6受体调节有反应的病症的杂环芳基砜

Also Published As

Publication number Publication date
CA2667710A1 (en) 2008-05-15
EP2081890B1 (en) 2011-01-12
TW200827337A (en) 2008-07-01
CL2007003190A1 (es) 2008-06-27
PE20081160A1 (es) 2008-08-15
IL198322A0 (en) 2010-02-17
US20080167361A1 (en) 2008-07-10
KR20090079259A (ko) 2009-07-21
WO2008055847A1 (en) 2008-05-15
BRPI0718584A2 (pt) 2014-03-11
AR063576A1 (es) 2009-02-04
JP2010509266A (ja) 2010-03-25
AU2007316688A1 (en) 2008-05-15
ATE495153T1 (de) 2011-01-15
DE602007011962D1 (en) 2011-02-24
CN101573332A (zh) 2009-11-04
US7776910B2 (en) 2010-08-17
ES2358549T3 (es) 2011-05-11
EP2081890A1 (en) 2009-07-29

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