[go: up one dir, main page]

MX2009004649A - Metodo para preparar medetomidina y sus sales. - Google Patents

Metodo para preparar medetomidina y sus sales.

Info

Publication number
MX2009004649A
MX2009004649A MX2009004649A MX2009004649A MX2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A
Authority
MX
Mexico
Prior art keywords
salts
preparing medetomidine
medetomidine
preparing
transmetalation
Prior art date
Application number
MX2009004649A
Other languages
English (en)
Inventor
Inese Reine
Armands Zandersons
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Publication of MX2009004649A publication Critical patent/MX2009004649A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a un método mejorado altamente eficiente para preparar Medetomidina, y sus sales, en particular sus sales farmacéuticamente aceptables. El método utiliza la alta reactividad de imidazoles halogenados hacia la transmetalación con reactivos de Grignard y la reacción subsiguiente con 2,3-dimetilbenzaldehído.
MX2009004649A 2006-11-06 2007-11-02 Metodo para preparar medetomidina y sus sales. MX2009004649A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123548A EP1918282A1 (en) 2006-11-06 2006-11-06 Method for preparing medetomidine and its salts
PCT/EP2007/061822 WO2008055852A1 (en) 2006-11-06 2007-11-02 Method for preparing medetomidine and its salts

Publications (1)

Publication Number Publication Date
MX2009004649A true MX2009004649A (es) 2009-05-21

Family

ID=37770375

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004649A MX2009004649A (es) 2006-11-06 2007-11-02 Metodo para preparar medetomidina y sus sales.

Country Status (19)

Country Link
US (1) US7902377B2 (es)
EP (2) EP1918282A1 (es)
JP (1) JP2010508332A (es)
KR (1) KR20090052398A (es)
CN (1) CN101535272B (es)
AT (1) ATE517094T1 (es)
AU (1) AU2007316693B2 (es)
BR (1) BRPI0714992A2 (es)
CA (1) CA2660365C (es)
DK (1) DK2079706T3 (es)
EA (1) EA200900355A1 (es)
ES (1) ES2369746T3 (es)
MX (1) MX2009004649A (es)
NZ (1) NZ575125A (es)
PL (1) PL2079706T3 (es)
PT (1) PT2079706E (es)
SI (1) SI2079706T1 (es)
WO (1) WO2008055852A1 (es)
ZA (1) ZA200902607B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011070069A1 (en) 2009-12-09 2011-06-16 I-Tech Ab Process for preparation of medetomidine
CN102452984B (zh) * 2010-10-21 2013-10-23 桑迪亚医药技术（上海）有限责任公司 4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
HUE037591T2 (hu) 2011-07-22 2018-09-28 Cambrex Karlskoga Ab Új eljárások 4. szénatomon szubsztituált imidazolok elõállítására
WO2012172119A2 (en) 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
JP5777840B2 (ja) 2012-05-08 2015-09-09 ロンザ・リミテッド ２−（２，３−ジメチルフェニル）−１−プロパナールを調製するための方法
EP2847173B1 (en) * 2012-05-08 2015-12-30 Lonza Ltd Method for preparation of medetomidine
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
MY165218A (en) * 2012-06-28 2018-03-09 Lonza Ag Method for preparation of medetomidine with chloroacetone
CN104220408B (zh) 2012-06-28 2016-01-20 隆萨有限公司 用氯丙酮制备2-(2,3-二甲基苯基)-1-丙醛的方法
WO2012172122A2 (en) 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
CN103588711B (zh) * 2013-11-27 2015-04-08 天津炜捷制药有限公司 一种美托咪定中间体的制备方法
CN103664788B (zh) * 2013-12-04 2015-11-25 湖北生物医药产业技术研究院有限公司 制备美托咪啶的方法
CN104447562A (zh) * 2014-03-27 2015-03-25 宁波天衡药业股份有限公司 一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) * 2016-08-02 2018-06-26 江苏恒瑞医药股份有限公司 一种右美托咪定的制备方法
CN111269192A (zh) * 2020-02-25 2020-06-12 成都睿智化学研究有限公司 一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
JP2008514601A (ja) * 2004-09-24 2008-05-08 アラーガン、インコーポレイテッド 特異的α２アドレナリン作動剤としての４−（フェニルメチルおよび置換フェニルメチル）−イミダゾール−２−チオン
NZ553290A (en) * 2004-09-24 2010-11-26 Allergan Inc 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

Also Published As

Publication number Publication date
BRPI0714992A2 (pt) 2013-07-30
PL2079706T3 (pl) 2011-12-30
ES2369746T3 (es) 2011-12-05
CN101535272B (zh) 2011-10-05
CN101535272A (zh) 2009-09-16
PT2079706E (pt) 2011-10-19
WO2008055852A1 (en) 2008-05-15
EP2079706A1 (en) 2009-07-22
KR20090052398A (ko) 2009-05-25
ATE517094T1 (de) 2011-08-15
AU2007316693A1 (en) 2008-05-15
JP2010508332A (ja) 2010-03-18
DK2079706T3 (da) 2011-10-03
SI2079706T1 (sl) 2011-11-30
EP2079706B1 (en) 2011-07-20
EA200900355A1 (ru) 2009-10-30
ZA200902607B (en) 2010-04-28
WO2008055852A8 (en) 2009-05-22
NZ575125A (en) 2011-02-25
US7902377B2 (en) 2011-03-08
AU2007316693B2 (en) 2012-02-02
CA2660365A1 (en) 2008-05-15
EP1918282A1 (en) 2008-05-07
US20100048915A1 (en) 2010-02-25
CA2660365C (en) 2014-03-25

Similar Documents

Publication Publication Date Title
MX2009004649A (es) Metodo para preparar medetomidina y sus sales.
AU2016204376A1 (en) MicroRNA-based methods and compositions for the diagnosis and treatment of ovarian cancer
MX2010006395A (es) Formulacion de anticuerpos.
EP2214442B8 (en) Apparatus and method for coordinating the operations of discontinuous reception and the semi-persistent scheduling.
UA107443C2 (uk) Хімічний спосіб
IL243812A0 (en) Compounds of diarylhydantoin
TW201129938A (en) Personal mapping system
PL2124381T3 (pl) Sposób, system i urządzenie do generowania klucza grupowego
MX338561B (es) Un sistema para utilizarse en la reparacion de tejido.
MY150971A (en) Mineral amino acid polysaccharide complex
UA102250C2 (ru) Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
EP2347996A4 (en) PROCESS FOR PRODUCING CARBONITRIDE MIXTURE PARTICLE OR OXYCARBONITRIDE MIXTURE PARTICLE, AND USE THEREOF
TW200604843A (en) Location processing apparatus, systems, and methods
TN2011000166A1 (en) Disubstituted phthalazine hedgehog pathway antagonists
TW200617019A (en) A process for the preparation of 7α-alkylated 19-norsteroids
WO2010062742A3 (en) Methods for freparation and use of marrow infiltrating lymphocytes (mils)
EP1878714A4 (en) ORGANIC HYDRIDE SYNTHESIS DEVICE, ORGANIC HYDRIDE SYNTHESIS SYSTEM, AND HYDROGEN PRODUCTION DEVICE
MX349563B (es) Formulacion farmaceutica de fenofibrato nanonizado.
EP2029615B8 (en) A process for the preparation of an oxaliplatin
TW200722135A (en) System and method of generating contour structures using a dose volume histogram
GR1005773B (el) Διαταξη δια τη συλλογη καρπων
UA29548U (en) Method for treating osteoarthrosis
UA39992U (ru) Композиция для наполнения-гидрофобизации кожи
UA29385U (ru) Способ лечения персистирующего урогенитального хламидиоза
MX2009001158A (es) Sistema y metodo para la generacion automatica de un perfil de usuario a partir de informacion de localizacion.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal