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MX2009003129A - Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras. - Google Patents

Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras.

Info

Publication number
MX2009003129A
MX2009003129A MX2009003129A MX2009003129A MX2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A
Authority
MX
Mexico
Prior art keywords
inflammatory
oxadiazole derivatives
immunosuppressive properties
immunosuppressive
properties
Prior art date
Application number
MX2009003129A
Other languages
English (en)
Inventor
Sven Weiler
Frederic Zecri
Rainer Albert
Nigel Graham Cooke
Ian Lewis
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009003129A publication Critical patent/MX2009003129A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se dan a conocer compuestos policíclicos de la siguiente fórmula I: (ver fórmula (I)) y su uso como agentes anti-inflamatorios e inmunosupresores.
MX2009003129A 2006-09-29 2007-09-27 Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras. MX2009003129A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06121495 2006-09-29
PCT/EP2007/008431 WO2008037476A1 (en) 2006-09-29 2007-09-27 Oxadiazole derivatives with anti-inflammatory and immunosuppressive properties

Publications (1)

Publication Number Publication Date
MX2009003129A true MX2009003129A (es) 2009-04-06

Family

ID=37771076

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003129A MX2009003129A (es) 2006-09-29 2007-09-27 Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras.

Country Status (11)

Country Link
US (1) US20100087491A1 (es)
EP (1) EP2081916A1 (es)
JP (1) JP2010504932A (es)
KR (1) KR20090057070A (es)
CN (1) CN101522646A (es)
AU (1) AU2007302262A1 (es)
BR (1) BRPI0717656A2 (es)
CA (1) CA2664268A1 (es)
MX (1) MX2009003129A (es)
RU (1) RU2009115963A (es)
WO (1) WO2008037476A1 (es)

Families Citing this family (27)

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AR062683A1 (es) 2006-09-07 2008-11-26 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-4-ilo, composicion farmaceutica que los contiene, y uso de los mismos en la preparacion de medicamentos
DK2069335T3 (da) 2006-09-08 2013-02-18 Actelion Pharmaceuticals Ltd Pyridin-3-ylderivater som immunomoduleringsmidler
EP2069318B1 (en) 2006-09-21 2012-09-12 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
AU2007334436A1 (en) 2006-12-15 2008-06-26 Abbott Laboratories Novel oxadiazole compounds
EP2125797B1 (en) 2007-03-16 2014-01-15 Actelion Pharmaceuticals Ltd. Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
WO2009043889A2 (en) 2007-10-04 2009-04-09 Merck Serono S.A. Oxadiazole derivatives
BRPI0817597A2 (pt) 2007-10-04 2015-04-07 Merck Serono Sa Compostos de diarila de oxadiazol, processo para sua preparação, composições farmacêuticas e kit compreendendo os mesmos, bem como seus usos
EP2252609B1 (en) * 2008-03-07 2013-04-17 Actelion Pharmaceuticals Ltd. Pyridin-2-yl derivatives as immunomodulating agents
AU2009220893A1 (en) 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Novel aminomethyl benzene derivatives
HUE025984T2 (hu) 2008-05-14 2016-05-30 Scripps Research Inst Szfingozin foszfát receptor új modulátorai
EP2241558A1 (en) * 2009-04-03 2010-10-20 Merck Serono SA Oxadiazole derivatives
SG178042A1 (en) 2009-07-16 2012-03-29 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
WO2011056916A1 (en) * 2009-11-05 2011-05-12 Lexicon Pharmaceuticals, Inc. Tryptophan hydroxylase inhibitors for the treatment of cancer
CN103119038B (zh) 2010-04-23 2016-05-04 百时美施贵宝公司 作为1-磷酸鞘氨醇1受体激动剂的4-(5-异噁唑基或5-吡唑基-1，2，4-噁二唑基-3-基)扁桃酰胺
US8318783B2 (en) 2010-04-27 2012-11-27 Allergan, Inc. 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators
TW201206429A (en) * 2010-07-08 2012-02-16 Merck Serono Sa Substituted oxadiazole derivatives
JP5869579B2 (ja) 2010-09-24 2016-02-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 置換オキサジアゾール化合物およびそれらのｓ１ｐ１アゴニストとしての使用
KR101317492B1 (ko) * 2010-09-29 2013-10-15 가톨릭대학교 산학협력단 Ａｇ490을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물
SI2665720T1 (sl) 2011-01-19 2015-08-31 Actelion Pharmaceuticals Ltd. Derivati 2-metoksi-piridin-4-ila
US10385043B2 (en) 2015-05-20 2019-08-20 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
US11278526B2 (en) 2016-09-29 2022-03-22 Receptos Llc Compounds and methods for treating lupus
US10676467B2 (en) * 2017-06-30 2020-06-09 Washington University Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
CN107827837B (zh) * 2017-11-21 2021-09-24 苏州朗科生物技术股份有限公司 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用
KR102830313B1 (ko) * 2021-01-08 2025-07-09 광주과학기술원 신규한 트립토판 수산화효소 저해제 및 이의 용도
WO2024029638A1 (ko) * 2022-08-01 2024-02-08 한국과학기술연구원 신규한 헤테로사이클릴-페닐-메틸아민 유도체, 이의 제조방법 및 이의 다발성 경화증 예방, 개선, 또는 치료 용도
CN115974807B (zh) * 2023-01-18 2024-05-31 中国药科大学 2-苯基-5-联苯基-1,3,4-噁二唑类化合物及其制备方法、药物组合物和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010113820A (ko) * 1999-04-19 2001-12-28 시오노 요시히코 옥사디아졸 고리를 갖는 술폰아미드 유도체
WO2003035610A1 (en) * 2001-10-26 2003-05-01 Shionogi & Co., Ltd. Sulfonamide derivative having mmp inhibitory activity
AU2003276043A1 (en) * 2002-06-17 2003-12-31 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
US20070043014A1 (en) * 2003-10-01 2007-02-22 Merck & Co., Inc. 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
EP1760071A4 (en) * 2004-06-23 2008-03-05 Ono Pharmaceutical Co COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
AU2005299851B2 (en) * 2004-10-22 2011-03-17 Merck Sharp & Dohme Corp. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists
CA2591399C (en) * 2004-12-13 2014-05-20 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof
EP1893591A1 (en) * 2005-06-08 2008-03-05 Novartis AG POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
WO2007043400A1 (ja) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. 含窒素芳香族複素環化合物およびそれを含有する医薬組成物
JP2009269819A (ja) * 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk アミン化合物

Also Published As

Publication number Publication date
CN101522646A (zh) 2009-09-02
RU2009115963A (ru) 2010-11-10
WO2008037476A1 (en) 2008-04-03
CA2664268A1 (en) 2008-04-03
AU2007302262A1 (en) 2008-04-03
KR20090057070A (ko) 2009-06-03
BRPI0717656A2 (pt) 2014-04-29
JP2010504932A (ja) 2010-02-18
US20100087491A1 (en) 2010-04-08
EP2081916A1 (en) 2009-07-29

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