MX2009003188A - Polipeptidos hibridos inmunogenicos antiobesidad y composicion de vacuna antiobesidad que comprende los mismos. - Google Patents
Polipeptidos hibridos inmunogenicos antiobesidad y composicion de vacuna antiobesidad que comprende los mismos.Info
- Publication number
- MX2009003188A MX2009003188A MX2009003188A MX2009003188A MX2009003188A MX 2009003188 A MX2009003188 A MX 2009003188A MX 2009003188 A MX2009003188 A MX 2009003188A MX 2009003188 A MX2009003188 A MX 2009003188A MX 2009003188 A MX2009003188 A MX 2009003188A
- Authority
- MX
- Mexico
- Prior art keywords
- obese
- cell epitope
- immunogenic hybrid
- vaccine composition
- expression vector
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 230000002163 immunogen Effects 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 abstract 3
- 238000003259 recombinant expression Methods 0.000 abstract 3
- 102000007592 Apolipoproteins Human genes 0.000 abstract 2
- 108010071619 Apolipoproteins Proteins 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 102000006991 Apolipoprotein B-100 Human genes 0.000 abstract 1
- 108010008150 Apolipoprotein B-100 Proteins 0.000 abstract 1
- 101800001415 Bri23 peptide Proteins 0.000 abstract 1
- 102400000107 C-terminal peptide Human genes 0.000 abstract 1
- 101800000655 C-terminal peptide Proteins 0.000 abstract 1
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 241000711798 Rabies lyssavirus Species 0.000 abstract 1
- 238000004873 anchoring Methods 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describe un polipéptido híbrido inmunogénico para la prevención y el tratamiento de la obesidad, en el cual un péptido mimético de un epitopo del linfocito B de la apolipoproteína B-100; un epitopo del linfocito T auxiliar del virus de la rabia o un epitopo del linfocito T auxiliar del antígeno de la superficie del virus de la hepatitis B y un fragmento del péptido C terminal de la apolipoproteína CII de ratón o un péptido mimético de un epitopo del linfocito B de la apolipoproteína B-100 están fusionados unos con otros en ese orden, en la dirección del término N hacia el término C del mismo. También, se describe una composición de vacuna para la prevención y el tratamiento de la obesidad, que comprende el polipéptido híbrido inmunogénico, junto con un polinucleótido que codifica el polipéptido híbrido inmunogénico, un vector de expresión recombinante que porta el polinucleótido, una célula hospedera que ancla el vector de expresión recombinante y un método para producir el polipéptido híbrido inmunogénico, cultivando la célula hospedera transformada con el vector de expresión recombinante.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20060093130 | 2006-09-25 | ||
| PCT/KR2007/004692 WO2008038990A1 (en) | 2006-09-25 | 2007-09-21 | Anti-obese immunogenic hybrid polypeptides and anti-obese vaccine composition comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009003188A true MX2009003188A (es) | 2009-05-22 |
Family
ID=39230370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009003188A MX2009003188A (es) | 2006-09-25 | 2007-09-21 | Polipeptidos hibridos inmunogenicos antiobesidad y composicion de vacuna antiobesidad que comprende los mismos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110002955A1 (es) |
| EP (1) | EP2076544A4 (es) |
| JP (1) | JP2010504094A (es) |
| KR (2) | KR100956893B1 (es) |
| CN (1) | CN101516915A (es) |
| AU (1) | AU2007300842B2 (es) |
| BR (1) | BRPI0717223A2 (es) |
| CA (1) | CA2664529A1 (es) |
| MX (1) | MX2009003188A (es) |
| RU (1) | RU2418005C2 (es) |
| WO (1) | WO2008038990A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101476383B1 (ko) * | 2011-07-12 | 2014-12-24 | 한국생명공학연구원 | 단백질 분비융합인자를 포함하는 재조합 벡터 및 이를 이용한 비만백신 단백질의 대량생산 방법 |
| US10858422B2 (en) | 2016-05-31 | 2020-12-08 | Abcentra, Llc | Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody |
| EP3463416A1 (en) | 2016-05-31 | 2019-04-10 | CardioVax, LLC | Methods for diagnosing and treating systemic lupus erythematosus |
| KR20230042053A (ko) * | 2020-07-22 | 2023-03-27 | (주)쓰리에이치바이오 | 면역 치료제용 펩타이드 |
| KR102261457B1 (ko) * | 2020-07-22 | 2021-06-09 | (주)쓰리에이치바이오 | 면역 치료제용 펩타이드 |
| WO2024040025A2 (en) * | 2022-08-19 | 2024-02-22 | University Of Washington | Th2 vaccine-based prevention and treatment of inflammation in obesity |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60193926A (ja) | 1984-03-15 | 1985-10-02 | Tokyo Daigaku | 単クローン性抗ヒトアポリポ蛋白質ｂ１００抗体 |
| US5837249A (en) * | 1985-04-19 | 1998-11-17 | The Wistar Institute | Method for generating an immunogenic T cell response protective against a virus |
| US5693325A (en) * | 1994-03-15 | 1997-12-02 | Molecumetics, Ltd. | Peptide vaccines and methods relating thereto |
| KR0135708B1 (ko) * | 1994-05-31 | 1998-04-23 | 김은영 | 인간 혈중 아포지단백질 비-100(b-100)에 대한 신규 단일클론 항체 및 이들의 생산을 위한 재조합 하이브리도마 세포주 |
| GB0121171D0 (en) | 2001-08-31 | 2001-10-24 | Glaxosmithkline Biolog Sa | Vaccine |
| KR100472841B1 (ko) | 2000-09-04 | 2005-03-07 | (주)에스제이바이오메드 | 아포지단백질 비-100의 에피토프에 대한 모조 펩타이드,그들의 연쇄물 또는 변형체와 이들을 함유하는 백신 조성물 |
| CN1231262C (zh) * | 2000-09-04 | 2005-12-14 | 金晓骏 | 载脂蛋白b－100表位的模拟肽、其多联体和修饰肽,以及含有这些肽的疫苗组合物 |
| CN1312178C (zh) * | 2001-05-15 | 2007-04-25 | 株式会社Jimro | 高密度脂蛋白反应性肽 |
| US20060147417A1 (en) * | 2002-08-30 | 2006-07-06 | Claire Ashman | Immunogenic composition comprising an il-13 element and t cell epitopes, and its therapeutic use |
| MXPA06001326A (es) * | 2003-08-07 | 2006-05-04 | Hoffmann La Roche | Peptidos antigenicos de artritis reumatoide. |
| KR100639397B1 (ko) * | 2004-03-18 | 2006-10-26 | (주)에스제이바이오메드 | 항비만용 면역원성 하이브리드 폴리펩타이드 및 이를포함하는 항비만 백신 조성물 |
-
2007
- 2007-09-21 CA CA002664529A patent/CA2664529A1/en not_active Abandoned
- 2007-09-21 KR KR1020070097000A patent/KR100956893B1/ko not_active Expired - Fee Related
- 2007-09-21 RU RU2009115688/10A patent/RU2418005C2/ru not_active IP Right Cessation
- 2007-09-21 BR BRPI0717223-0A2A patent/BRPI0717223A2/pt not_active IP Right Cessation
- 2007-09-21 CN CNA2007800356531A patent/CN101516915A/zh active Pending
- 2007-09-21 WO PCT/KR2007/004692 patent/WO2008038990A1/en not_active Ceased
- 2007-09-21 JP JP2009529132A patent/JP2010504094A/ja not_active Ceased
- 2007-09-21 US US12/442,760 patent/US20110002955A1/en not_active Abandoned
- 2007-09-21 AU AU2007300842A patent/AU2007300842B2/en not_active Ceased
- 2007-09-21 EP EP07808454A patent/EP2076544A4/en not_active Withdrawn
- 2007-09-21 MX MX2009003188A patent/MX2009003188A/es not_active Application Discontinuation
-
2010
- 2010-02-25 KR KR1020100017360A patent/KR100970178B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2076544A4 (en) | 2009-11-11 |
| RU2418005C2 (ru) | 2011-05-10 |
| KR20100033395A (ko) | 2010-03-29 |
| US20110002955A1 (en) | 2011-01-06 |
| JP2010504094A (ja) | 2010-02-12 |
| EP2076544A1 (en) | 2009-07-08 |
| AU2007300842A1 (en) | 2008-04-03 |
| CN101516915A (zh) | 2009-08-26 |
| CA2664529A1 (en) | 2008-04-03 |
| RU2009115688A (ru) | 2010-11-10 |
| KR100956893B1 (ko) | 2010-05-11 |
| BRPI0717223A2 (pt) | 2013-09-24 |
| AU2007300842B2 (en) | 2011-01-27 |
| KR20080027753A (ko) | 2008-03-28 |
| WO2008038990A1 (en) | 2008-04-03 |
| KR100970178B1 (ko) | 2010-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |