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MX2009002258A - Procedimiento para producir 1-(3,4-diclorobencil)-5-octilbiguanida o una sal de la misma. - Google Patents

Procedimiento para producir 1-(3,4-diclorobencil)-5-octilbiguanida o una sal de la misma.

Info

Publication number
MX2009002258A
MX2009002258A MX2009002258A MX2009002258A MX2009002258A MX 2009002258 A MX2009002258 A MX 2009002258A MX 2009002258 A MX2009002258 A MX 2009002258A MX 2009002258 A MX2009002258 A MX 2009002258A MX 2009002258 A MX2009002258 A MX 2009002258A
Authority
MX
Mexico
Prior art keywords
salt
octylbiguanide
dichlorobenzyl
producing
present
Prior art date
Application number
MX2009002258A
Other languages
English (en)
Inventor
Yoshihiko Okaichi
Nobuhito Tada
Daisuke Nomi
Nobuhisa Fujita
Koichi Tsuji
Taizo Yamaguchi
Yasuaki Muguruma
Hisayuki Tsujimori
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of MX2009002258A publication Critical patent/MX2009002258A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/02—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención provee un procedimiento para producir 1-(3,4-diclorobencil)-5-octilbiguanida o una sal de la misma, el procedimiento comprende hacer reaccionar 1-ciano-3-octilguanidina o una sal de la misma, con 3,4-diclorobencilamina o una sal de la misma, en un solvente orgánico a base de éster; de acuerdo con la presente invención, la reacción se puede llevar a cabo a una temperatura baja usando equipo de propósitos generales, y 1-(3,4-diclorobencil)-5-octilbiguanida o una sal de la misma se puede producir en un rendimiento alto mediante un procedimiento seguro y fácil.
MX2009002258A 2006-08-30 2007-08-28 Procedimiento para producir 1-(3,4-diclorobencil)-5-octilbiguanida o una sal de la misma. MX2009002258A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006232922 2006-08-30
PCT/JP2007/067107 WO2008026757A1 (en) 2006-08-30 2007-08-28 Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof

Publications (1)

Publication Number Publication Date
MX2009002258A true MX2009002258A (es) 2009-03-20

Family

ID=38871529

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002258A MX2009002258A (es) 2006-08-30 2007-08-28 Procedimiento para producir 1-(3,4-diclorobencil)-5-octilbiguanida o una sal de la misma.

Country Status (17)

Country Link
US (1) US7868207B2 (es)
EP (1) EP2066623B1 (es)
JP (1) JP5078993B2 (es)
KR (1) KR101087454B1 (es)
CN (1) CN101506152B (es)
AR (1) AR062576A1 (es)
AU (1) AU2007289597B2 (es)
BR (1) BRPI0715831A2 (es)
CA (1) CA2661272C (es)
ES (1) ES2422161T3 (es)
IL (1) IL196982A (es)
MX (1) MX2009002258A (es)
MY (1) MY146360A (es)
RU (1) RU2440978C2 (es)
TW (1) TWI385143B (es)
WO (1) WO2008026757A1 (es)
ZA (1) ZA200900838B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007062222A2 (en) 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
WO2010025448A2 (en) * 2008-08-29 2010-03-04 University Of South Florida Inhibition of cell proliferation
ES2734299T3 (es) * 2015-09-11 2019-12-05 Bayer Cropscience Ag Procedimiento para producir sales de biguanida y s-triazinas
EP4083016B1 (en) * 2019-12-26 2025-03-12 Resonac Corporation Method for manufacturing highly polymerizable n-vinyl carboxylic acid amide monomer
CN113939496B (zh) * 2019-12-26 2024-10-29 株式会社力森诺科 高聚合性n-乙烯基羧酸酰胺单体的制造方法
US11718579B2 (en) 2019-12-26 2023-08-08 Showa Denko K.K. Method for producing highly polymerizable N-vinyl carboxylic acid amide monomer
JP7639706B2 (ja) * 2019-12-26 2025-03-05 株式会社レゾナック 高重合性ｎ－ビニルカルボン酸アミド単量体の製造方法
WO2021132365A1 (ja) * 2019-12-26 2021-07-01 昭和電工株式会社 高重合性ｎ－ビニルカルボン酸アミド単量体の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2455896A (en) * 1945-10-12 1948-12-07 American Cyanamid Co 1-aryl, 5-alkyl, biguanides
US5286905A (en) * 1990-12-28 1994-02-15 Idemitsu Kosan Company Limited Process for producing biguanide derivative
CA2064664C (en) * 1991-04-05 2000-01-11 Hiroshi Ishikawa Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives
JPH04308562A (ja) * 1991-04-05 1992-10-30 Otsuka Pharmaceut Co Ltd ビスビグアナイド誘導体とこの誘導体を含有した消毒薬
JP2662343B2 (ja) * 1991-06-19 1997-10-08 大塚製薬株式会社 モノビグアナイド誘導体とこの誘導体を含有した消毒薬
JP3493692B2 (ja) * 1993-09-09 2004-02-03 三菱マテリアル株式会社 ビスビグアナイド系化合物およびそれを含む殺菌剤
CN1794983B (zh) * 2003-05-28 2012-07-18 大塚制药株式会社 奥兰西丁水溶液及其制备方法和消毒剂

Also Published As

Publication number Publication date
KR101087454B1 (ko) 2011-11-25
CN101506152A (zh) 2009-08-12
TWI385143B (zh) 2013-02-11
IL196982A0 (en) 2009-11-18
IL196982A (en) 2013-03-24
EP2066623B1 (en) 2013-06-19
RU2009111276A (ru) 2010-10-10
JP2010502567A (ja) 2010-01-28
US20090270653A1 (en) 2009-10-29
JP5078993B2 (ja) 2012-11-21
BRPI0715831A2 (pt) 2013-07-23
AU2007289597B2 (en) 2011-03-03
US7868207B2 (en) 2011-01-11
CA2661272C (en) 2014-03-18
CA2661272A1 (en) 2008-03-06
WO2008026757A1 (en) 2008-03-06
KR20090045409A (ko) 2009-05-07
HK1130468A1 (en) 2009-12-31
EP2066623A1 (en) 2009-06-10
RU2440978C2 (ru) 2012-01-27
AR062576A1 (es) 2008-11-19
MY146360A (en) 2012-08-15
CN101506152B (zh) 2012-11-21
ZA200900838B (en) 2010-05-26
ES2422161T3 (es) 2013-09-09
AU2007289597A1 (en) 2008-03-06
TW200817316A (en) 2008-04-16

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