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MX2008012576A - Pirimidinas 5-amido sustituidas inhibidoras del virus de inmunodeficiencia humana. - Google Patents

Pirimidinas 5-amido sustituidas inhibidoras del virus de inmunodeficiencia humana.

Info

Publication number
MX2008012576A
MX2008012576A MX2008012576A MX2008012576A MX2008012576A MX 2008012576 A MX2008012576 A MX 2008012576A MX 2008012576 A MX2008012576 A MX 2008012576A MX 2008012576 A MX2008012576 A MX 2008012576A MX 2008012576 A MX2008012576 A MX 2008012576A
Authority
MX
Mexico
Prior art keywords
substituted pyrimidines
amido substituted
hiv inhibiting
hiv
inhibiting
Prior art date
Application number
MX2008012576A
Other languages
English (en)
Inventor
Jerome Emile Georges Guillemont
Mikael Paugam
Bruno Francois Marie Delest
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MX2008012576A publication Critical patent/MX2008012576A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a derivados de pirimidina de la fórmula: (ver formula (I)) que tienen propiedades de inhibición de la duplicación del virus de inmunodeficiencia humana VIH;: la preparación de los mismos y composiciones farmacéuticas que comprenden estos compuestos.
MX2008012576A 2006-03-30 2007-03-30 Pirimidinas 5-amido sustituidas inhibidoras del virus de inmunodeficiencia humana. MX2008012576A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112044 2006-03-30
PCT/EP2007/053111 WO2007113254A1 (en) 2006-03-30 2007-03-30 Hiv inhibiting 5-amido substituted pyrimidines

Publications (1)

Publication Number Publication Date
MX2008012576A true MX2008012576A (es) 2008-10-10

Family

ID=36791649

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008012576A MX2008012576A (es) 2006-03-30 2007-03-30 Pirimidinas 5-amido sustituidas inhibidoras del virus de inmunodeficiencia humana.

Country Status (14)

Country Link
US (2) US8933089B2 (es)
EP (1) EP2004632B1 (es)
JP (1) JP5078986B2 (es)
KR (1) KR20080114741A (es)
CN (1) CN101405283B (es)
AU (1) AU2007233737B2 (es)
BR (1) BRPI0709690B8 (es)
CA (1) CA2645958C (es)
DK (1) DK2004632T3 (es)
ES (1) ES2465666T3 (es)
IL (1) IL193610A (es)
MX (1) MX2008012576A (es)
RU (1) RU2480464C2 (es)
WO (1) WO2007113254A1 (es)

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Also Published As

Publication number Publication date
US20100168104A1 (en) 2010-07-01
EP2004632A1 (en) 2008-12-24
US8933089B2 (en) 2015-01-13
US20150099749A1 (en) 2015-04-09
CA2645958A1 (en) 2007-10-11
CN101405283A (zh) 2009-04-08
EP2004632B1 (en) 2014-03-12
IL193610A0 (en) 2009-05-04
CA2645958C (en) 2014-11-04
AU2007233737B2 (en) 2012-11-29
BRPI0709690B1 (pt) 2020-09-29
ES2465666T3 (es) 2014-06-06
BRPI0709690B8 (pt) 2021-05-25
WO2007113254A1 (en) 2007-10-11
RU2008143001A (ru) 2010-05-10
BRPI0709690A2 (pt) 2011-07-19
KR20080114741A (ko) 2008-12-31
JP2009531394A (ja) 2009-09-03
JP5078986B2 (ja) 2012-11-21
AU2007233737A1 (en) 2007-10-11
IL193610A (en) 2014-01-30
US9573942B2 (en) 2017-02-21
RU2480464C2 (ru) 2013-04-27
CN101405283B (zh) 2014-06-18
DK2004632T3 (da) 2014-06-16

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