MX2007010787A - Derivados de 1,2,4-triazinas, su preparacion y su aplicacion en terapia humana. - Google Patents
Derivados de 1,2,4-triazinas, su preparacion y su aplicacion en terapia humana.Info
- Publication number
- MX2007010787A MX2007010787A MX2007010787A MX2007010787A MX2007010787A MX 2007010787 A MX2007010787 A MX 2007010787A MX 2007010787 A MX2007010787 A MX 2007010787A MX 2007010787 A MX2007010787 A MX 2007010787A MX 2007010787 A MX2007010787 A MX 2007010787A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- trifluoromethyl
- groups
- alkyl
- phenyl
- Prior art date
Links
- 150000003920 1,2,4-triazines Chemical class 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- SSPYSWLZOPCOLO-UHFFFAOYSA-N 6-azauracil Chemical class O=C1C=NNC(=O)N1 SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- -1 hydroxycarbonylvinyl Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
La invencion se refiere a derivados de 3,5-dioxo-(2H,4H)-1,2,4- triazina de formula general I (ver formula (I)) en la cual R1 y R2pueden ser identicos o diferentes y representan un radical alquilo o alquenilo, lineal o ramificado de C1-C7, un radical alquilo de C1-C6 sustituido con grupos tales como trifluorometilo, cicloalquilo de C5-C6, nitrilo, alcoxicarbonilvinilo de C1-C4, carboxilato, benciloxi o fenilo (para el cual el nucleo fenilo esta posiblemente sustituido con uno o mas grupos tales como alquilo de C1-C4, alcoxi de C1-C4, nitro, halogeno o trifluorometilo), YR3 representa oxigeno o NR3 en el cual R3 representa hidrogeno, un radical alquilo o alquenilo, lineal o ramificado de C1-C7, un radical alquilo de C1-C6 sustituido con grupos tales como trifluorometilo o fenilo (para los cuales el nucleo fenilo esta posiblemente sustituido con uno o mas grupos tales como alquilo de C1-C4, alcoxi de C1-C4, nitro, halogeno o trifluorometilo), Z representa un atomo de oxigeno o un atomo de carbono que puede estar ligado en posicion orto, meta o para sobre el grupo fenilo de formula I, n puede ser igual a 0-5 cuando Z=C o de 2 a 4 cuando Z=O, X representa oxigeno o azufre, R4, R5, R6, R7 y R8 representan hidrogeno o fluor, R9, R10 y R11 representan hidrogeno o un grupo alquilo, lineal o ramificado de C1-C5, asi como tambien sales de adicion con bases farmaceuticamente aceptables, y los varios enantiomeros de compuestos que tienen carbonos asimetricos, asi como tambien sus mezclas en todas las proporciones, incluyendo mezclas racemicas en particular.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0502152A FR2882750B1 (fr) | 2005-03-03 | 2005-03-03 | Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine |
| PCT/FR2006/000469 WO2006092507A1 (fr) | 2005-03-03 | 2006-03-02 | Derives de 1 ,2,4-triazines, leur preparation et leur application en therapeutique humaine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007010787A true MX2007010787A (es) | 2007-09-25 |
Family
ID=35116027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007010787A MX2007010787A (es) | 2005-03-03 | 2006-03-02 | Derivados de 1,2,4-triazinas, su preparacion y su aplicacion en terapia humana. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7713971B2 (es) |
| EP (1) | EP1856065B1 (es) |
| JP (1) | JP5269420B2 (es) |
| KR (1) | KR20070112230A (es) |
| CN (1) | CN101155790A (es) |
| AR (1) | AR053155A1 (es) |
| AT (1) | ATE448211T1 (es) |
| AU (1) | AU2006219802A1 (es) |
| BR (1) | BRPI0607567A2 (es) |
| CA (1) | CA2599848A1 (es) |
| CR (1) | CR9366A (es) |
| DE (1) | DE602006010337D1 (es) |
| ES (1) | ES2336823T3 (es) |
| FR (1) | FR2882750B1 (es) |
| IL (1) | IL185586A0 (es) |
| MA (1) | MA29343B1 (es) |
| MX (1) | MX2007010787A (es) |
| MY (1) | MY140662A (es) |
| NI (1) | NI200700224A (es) |
| NO (1) | NO20074881L (es) |
| PL (1) | PL1856065T3 (es) |
| PT (1) | PT1856065E (es) |
| RU (1) | RU2007136027A (es) |
| TN (1) | TNSN07335A1 (es) |
| TW (1) | TW200643016A (es) |
| WO (1) | WO2006092507A1 (es) |
| ZA (1) | ZA200707730B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ592057A (en) | 2008-09-05 | 2013-01-25 | Acucela Inc | Sulfur-linked compounds for treating opthalmic diseases and disorders |
| JP2013538215A (ja) | 2010-08-31 | 2013-10-10 | エスエヌユー アールアンドディービー ファウンデーション | ＰＰＡＲδアゴニストの胎児再プログラミング用途 |
| CN107074823B (zh) * | 2014-09-05 | 2021-05-04 | 基因泰克公司 | 治疗性化合物及其用途 |
| TWI840423B (zh) | 2018-10-12 | 2024-05-01 | 美商拓臻股份有限公司 | 甲狀腺素受體β促效劑化合物 |
| CN121081472A (zh) | 2018-12-13 | 2025-12-09 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| AU2020336272A1 (en) | 2019-08-23 | 2022-04-14 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| EP4028008A4 (en) | 2019-09-12 | 2023-09-13 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| EP4568664A1 (en) | 2023-04-07 | 2025-06-18 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2707294B1 (fr) | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
| UA82048C2 (uk) * | 2000-11-10 | 2008-03-11 | Эли Лилли Энд Компани | Агоністи альфа-рецепторів, активованих проліфератором пероксисом |
| GB0113233D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
| FR2866339B1 (fr) * | 2004-02-18 | 2006-05-05 | Pf Medicament | Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine |
-
2005
- 2005-03-03 FR FR0502152A patent/FR2882750B1/fr not_active Expired - Fee Related
-
2006
- 2006-03-02 BR BRPI0607567-3A patent/BRPI0607567A2/pt not_active IP Right Cessation
- 2006-03-02 RU RU2007136027/04A patent/RU2007136027A/ru not_active Application Discontinuation
- 2006-03-02 ES ES06726008T patent/ES2336823T3/es active Active
- 2006-03-02 JP JP2007557542A patent/JP5269420B2/ja not_active Expired - Fee Related
- 2006-03-02 EP EP06726008A patent/EP1856065B1/fr active Active
- 2006-03-02 CA CA002599848A patent/CA2599848A1/fr not_active Abandoned
- 2006-03-02 US US11/885,630 patent/US7713971B2/en not_active Expired - Fee Related
- 2006-03-02 AR ARP060100797A patent/AR053155A1/es unknown
- 2006-03-02 WO PCT/FR2006/000469 patent/WO2006092507A1/fr not_active Ceased
- 2006-03-02 KR KR1020077022414A patent/KR20070112230A/ko not_active Abandoned
- 2006-03-02 PL PL06726008T patent/PL1856065T3/pl unknown
- 2006-03-02 MX MX2007010787A patent/MX2007010787A/es active IP Right Grant
- 2006-03-02 AT AT06726008T patent/ATE448211T1/de not_active IP Right Cessation
- 2006-03-02 PT PT06726008T patent/PT1856065E/pt unknown
- 2006-03-02 TW TW095107034A patent/TW200643016A/zh unknown
- 2006-03-02 AU AU2006219802A patent/AU2006219802A1/en not_active Abandoned
- 2006-03-02 DE DE602006010337T patent/DE602006010337D1/de active Active
- 2006-03-02 CN CNA2006800114913A patent/CN101155790A/zh active Pending
- 2006-03-03 MY MYPI20060914A patent/MY140662A/en unknown
-
2007
- 2007-08-29 IL IL185586A patent/IL185586A0/en unknown
- 2007-08-30 NI NI200700224A patent/NI200700224A/es unknown
- 2007-08-31 TN TNP2007000335A patent/TNSN07335A1/fr unknown
- 2007-09-04 CR CR9366A patent/CR9366A/es not_active Application Discontinuation
- 2007-09-10 ZA ZA200707730A patent/ZA200707730B/en unknown
- 2007-09-25 MA MA30243A patent/MA29343B1/fr unknown
- 2007-09-25 NO NO20074881A patent/NO20074881L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20074881L (no) | 2007-11-27 |
| CA2599848A1 (fr) | 2006-09-08 |
| KR20070112230A (ko) | 2007-11-22 |
| NI200700224A (es) | 2008-03-27 |
| ES2336823T3 (es) | 2010-04-16 |
| TW200643016A (en) | 2006-12-16 |
| CR9366A (es) | 2008-02-12 |
| US20080167313A1 (en) | 2008-07-10 |
| EP1856065B1 (fr) | 2009-11-11 |
| PL1856065T3 (pl) | 2010-04-30 |
| JP2008531662A (ja) | 2008-08-14 |
| AU2006219802A1 (en) | 2006-09-08 |
| WO2006092507A1 (fr) | 2006-09-08 |
| EP1856065A1 (fr) | 2007-11-21 |
| IL185586A0 (en) | 2008-01-06 |
| AR053155A1 (es) | 2007-04-25 |
| DE602006010337D1 (de) | 2009-12-24 |
| CN101155790A (zh) | 2008-04-02 |
| ZA200707730B (en) | 2008-05-28 |
| MY140662A (en) | 2010-01-15 |
| MA29343B1 (fr) | 2008-03-03 |
| RU2007136027A (ru) | 2009-04-10 |
| US7713971B2 (en) | 2010-05-11 |
| FR2882750B1 (fr) | 2007-05-11 |
| WO2006092507A8 (fr) | 2007-11-01 |
| FR2882750A1 (fr) | 2006-09-08 |
| ATE448211T1 (de) | 2009-11-15 |
| PT1856065E (pt) | 2010-02-10 |
| JP5269420B2 (ja) | 2013-08-21 |
| TNSN07335A1 (fr) | 2008-12-31 |
| BRPI0607567A2 (pt) | 2011-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |