MX2007005170A - Composiciones catalizadoras y su uso en el desenriquecimiento de substratos enantiomericamente enriquecidos. - Google Patents
Composiciones catalizadoras y su uso en el desenriquecimiento de substratos enantiomericamente enriquecidos.Info
- Publication number
- MX2007005170A MX2007005170A MX2007005170A MX2007005170A MX2007005170A MX 2007005170 A MX2007005170 A MX 2007005170A MX 2007005170 A MX2007005170 A MX 2007005170A MX 2007005170 A MX2007005170 A MX 2007005170A MX 2007005170 A MX2007005170 A MX 2007005170A
- Authority
- MX
- Mexico
- Prior art keywords
- enantiomerically enriched
- heteroatom
- enantiomer
- carbon
- optionally substituted
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 239000003054 catalyst Substances 0.000 title abstract 3
- 239000000758 substrate Substances 0.000 title abstract 3
- 230000000536 complexating effect Effects 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 229910052723 transition metal Inorganic materials 0.000 abstract 2
- 150000003624 transition metals Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 abstract 1
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 abstract 1
- -1 halide salt Chemical class 0.000 abstract 1
- 150000004820 halides Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se provee un procedimiento para el desenriquecimiento de composiciones enantiomericamente enriquecidas que comprende hacer reaccionar una composicion enantiomericamente enriquecida que comprende por lo menos un primer enantiomero o diastereomero de un substrato que comprende un enlace carbono-heteroatomo, en donde el carbono es un centro quiral y el heteroatomo es un heteroatomo del grupo V, en presencia de un sistema catalizador y opcionalmente un promotor de reaccion para dar una composicion de producto que comprende primeros y segundos enantiomeros o diastereomeros del substrato que tiene un enlace carbono-heteroatomo, la relacion del segundo al primer enantiomero o diastereomero en la composicion del producto es mayor a la relacion del segundo al primer enantiomero o diastereomero en la composicion enantiomericamente enriquecida; los sistemas catalizadores preferidos incluyen un complejo de haluro de metal de transicion de la formula MnXpYr en donde M es un metal de transicion; X es un haluro; Y es un grupo neutro formador de complejos de hidrocarbilo opcionalmente sustituido, un grupo neutro formador de complejos de hidrocarbilo perhalogenado opcionalmente sustituido, o un grupo formador de complejos de ciclopentadienilo opcionalmente sustituido; y n, p y r son numeros enteros; el promotor de reaccion es preferiblemente una sal haluro.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0424002A GB0424002D0 (en) | 2004-10-29 | 2004-10-29 | Process |
| GB0507960A GB0507960D0 (en) | 2005-04-20 | 2005-04-20 | Process |
| PCT/GB2005/004176 WO2006046059A1 (en) | 2004-10-29 | 2005-10-27 | Catalyst compositions and their use in the de-enrichment of enantiomerically enriched substrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007005170A true MX2007005170A (es) | 2007-07-04 |
Family
ID=35654376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007005170A MX2007005170A (es) | 2004-10-29 | 2005-10-27 | Composiciones catalizadoras y su uso en el desenriquecimiento de substratos enantiomericamente enriquecidos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090163719A1 (es) |
| EP (1) | EP1809585A1 (es) |
| JP (1) | JP2008517989A (es) |
| KR (1) | KR20070068415A (es) |
| BR (1) | BRPI0517248A (es) |
| CA (1) | CA2583489A1 (es) |
| IL (1) | IL182590A0 (es) |
| MX (1) | MX2007005170A (es) |
| WO (1) | WO2006046059A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009019412A1 (en) * | 2007-08-09 | 2009-02-12 | Npil Pharmaceuticals (Uk) Limited | Racemisation process for obtaining (1s,4s) n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (sertraline) |
| GB2464101A (en) * | 2008-10-01 | 2010-04-07 | Npil Pharmaceuticals | A dynamic thermodynamic resolution process for amines using an iridium catalyst |
| JP6269499B2 (ja) * | 2012-11-02 | 2018-01-31 | 住友化学株式会社 | 化合物のラセミ体の製造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69635874T2 (de) * | 1995-12-06 | 2006-12-14 | Japan Science And Technology Agency, Kawaguchi | Verfahren zur Herstellung von optisch aktiven Alkoholen |
| DE10062729A1 (de) * | 2000-12-15 | 2002-06-20 | Basf Ag | Verfahren zur Racemisierung von optisch aktiven Aminen |
-
2005
- 2005-10-27 US US11/577,912 patent/US20090163719A1/en not_active Abandoned
- 2005-10-27 EP EP05804254A patent/EP1809585A1/en not_active Withdrawn
- 2005-10-27 CA CA002583489A patent/CA2583489A1/en not_active Abandoned
- 2005-10-27 WO PCT/GB2005/004176 patent/WO2006046059A1/en not_active Ceased
- 2005-10-27 MX MX2007005170A patent/MX2007005170A/es unknown
- 2005-10-27 JP JP2007538511A patent/JP2008517989A/ja not_active Withdrawn
- 2005-10-27 KR KR1020077009334A patent/KR20070068415A/ko not_active Withdrawn
- 2005-10-27 BR BRPI0517248-9A patent/BRPI0517248A/pt not_active IP Right Cessation
-
2007
- 2007-04-16 IL IL182590A patent/IL182590A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1809585A1 (en) | 2007-07-25 |
| US20090163719A1 (en) | 2009-06-25 |
| BRPI0517248A (pt) | 2008-10-07 |
| WO2006046059A1 (en) | 2006-05-04 |
| CA2583489A1 (en) | 2006-05-04 |
| JP2008517989A (ja) | 2008-05-29 |
| KR20070068415A (ko) | 2007-06-29 |
| IL182590A0 (en) | 2007-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of company name or juridical status |