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MX2007005169A - Procedimiento para el desenriquecimiento de substratos enantiomericamente enriquecidos. - Google Patents

Procedimiento para el desenriquecimiento de substratos enantiomericamente enriquecidos.

Info

Publication number
MX2007005169A
MX2007005169A MX2007005169A MX2007005169A MX2007005169A MX 2007005169 A MX2007005169 A MX 2007005169A MX 2007005169 A MX2007005169 A MX 2007005169A MX 2007005169 A MX2007005169 A MX 2007005169A MX 2007005169 A MX2007005169 A MX 2007005169A
Authority
MX
Mexico
Prior art keywords
optionally substituted
enantiomerically enriched
heteroatom
optionally
enantiomer
Prior art date
Application number
MX2007005169A
Other languages
English (en)
Inventor
Andrew John Blacker
Matthew John Stirling
Original Assignee
Avecia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Pharmaceuticals Ltd filed Critical Avecia Pharmaceuticals Ltd
Publication of MX2007005169A publication Critical patent/MX2007005169A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B31/00—Reduction in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se provee un procedimiento para el desenriquecimiento de composiciones enantiomericamente enriquecidas que comprende hacer reaccionar una composicion enantiomericamente enriquecida que comprende por lo menos un primer enantiomero o diastereomero de un substrato que comprende un enlace carbono-heteroatomo, en donde el carbono es un centro quiral y el heteroatomo es un heteroatomo del grupo VI, en la presencia de un sistema catalizador y opcionalmente un promotor de reaccion para dar una composicion de producto que comprende primeros y segundos enantiomeros o diastereomeros del substrato que tiene un enlace carbono-heteroatomo, la relacion de segundo a primer enantiomero o diastereomero en la composicion de producto es mayor que la relacion de segundo a primer enantiomero o diastereomero en la composicion enantiomericamente enriquecida. Substratos preferidos incluyen compuestos de Formula (I) (ver Formula (1)) en donde X representa O, S; R1, R2 cada uno representa independientemente un hidrocarbilo opcionalmente substituido, un hidrocarbilo perthalogenado, un grupo heterociclico opcionalmente substituido; o R1 y R2 se unen opcionalmente a fin de formar un anillo(s) opcionalmente substituido; con la condicion de que R1, R2 se seleccionan de tal manera que * es un centro quiral. En un procedimiento preferido se puede obtener un compuesto de Formula (2) (ver Formula (2)) en donde: X representa O, S; R1, R2 cada uno representa independientemente un hidrocarbilo opcionalmente substituido, un hidrocarbilo perthalogenado, un grupo heterociclico opcionalmente substituido; o R1 y R2 se unen opcionalmente a fin de formar un anillo(s) opcionalmente substituido; con la condicion de que R1, R2 son diferentes.
MX2007005169A 2004-10-29 2005-10-27 Procedimiento para el desenriquecimiento de substratos enantiomericamente enriquecidos. MX2007005169A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0424000.8A GB0424000D0 (en) 2004-10-29 2004-10-29 Process
PCT/GB2005/004179 WO2006046062A1 (en) 2004-10-29 2005-10-27 Process for the de-enrichment of enantiomerically enriched substrates

Publications (1)

Publication Number Publication Date
MX2007005169A true MX2007005169A (es) 2007-07-04

Family

ID=33515740

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007005169A MX2007005169A (es) 2004-10-29 2005-10-27 Procedimiento para el desenriquecimiento de substratos enantiomericamente enriquecidos.

Country Status (11)

Country Link
EP (1) EP1809586A1 (es)
JP (1) JP2008517990A (es)
KR (1) KR20070068428A (es)
CN (1) CN101052604A (es)
BR (1) BRPI0517243A (es)
CA (1) CA2583821A1 (es)
GB (1) GB0424000D0 (es)
IL (1) IL182589A0 (es)
MX (1) MX2007005169A (es)
WO (1) WO2006046062A1 (es)
ZA (1) ZA200702979B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5212109B2 (ja) * 2006-11-10 2013-06-19 和光純薬工業株式会社 金属触媒担持炭素−エチレンジアミン複合体及びその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476964A (en) * 1994-11-21 1995-12-19 Uop Continuous racemization of benzylic alcohols, ethers, and esters by solid acid catalyst
DE69635874T2 (de) * 1995-12-06 2006-12-14 Japan Science And Technology Agency, Kawaguchi Verfahren zur Herstellung von optisch aktiven Alkoholen
CA2165125A1 (en) * 1995-12-13 1997-06-14 David W. House Continuous process for racemization of benzylic alcohols, ethers, and esters by solid acid catalyst
GB0029356D0 (en) * 2000-12-01 2001-01-17 Avecia Ltd Transfer hydrogenation
DE10062729A1 (de) * 2000-12-15 2002-06-20 Basf Ag Verfahren zur Racemisierung von optisch aktiven Aminen
DE10133783A1 (de) * 2001-07-16 2003-02-06 Degussa Verfahren zur Racemisierung von Alkoholen

Also Published As

Publication number Publication date
GB0424000D0 (en) 2004-12-01
BRPI0517243A (pt) 2008-10-07
CN101052604A (zh) 2007-10-10
EP1809586A1 (en) 2007-07-25
IL182589A0 (en) 2007-07-24
JP2008517990A (ja) 2008-05-29
ZA200702979B (en) 2008-08-27
WO2006046062A1 (en) 2006-05-04
KR20070068428A (ko) 2007-06-29
CA2583821A1 (en) 2006-05-04

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