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MX2007004593A - Anticuerpo anti-glipican 3 que tiene cadena de azucar modificada. - Google Patents

Anticuerpo anti-glipican 3 que tiene cadena de azucar modificada.

Info

Publication number
MX2007004593A
MX2007004593A MX2007004593A MX2007004593A MX2007004593A MX 2007004593 A MX2007004593 A MX 2007004593A MX 2007004593 A MX2007004593 A MX 2007004593A MX 2007004593 A MX2007004593 A MX 2007004593A MX 2007004593 A MX2007004593 A MX 2007004593A
Authority
MX
Mexico
Prior art keywords
antibody
glypican
sugar chain
modified sugar
fucose
Prior art date
Application number
MX2007004593A
Other languages
English (en)
Inventor
Kiyotaka Nakano
Megumi Tanaka
Izumi Sugo
Takahiro Ishiguro
Masamichi Sugimoto
Shigeyuki Iijima
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2007004593A publication Critical patent/MX2007004593A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se proporciona un anticuerpo anti-glipican 3 con cadenas de azucar modificadas, mas especificamente, un anticuerpo anti-glipican 3, carente de fucosa. El anticuerpo anti-glipican 3 con cadenas de azucar modificadas de la presente invencion se puede producir por un proceso que consiste en introducir un acido nucleico que codifica un anticuerpo anti-glipican 3 dentro de las celulas hospederas con capacidad reducida de adicionar fucosa, tales como celulas YB2/0 y celulas carentes de un transportador de fucosa. El anticuerpo anti-glipican 3 con las cadenas de azucar modificadas de la presente invencion tiene un alto nivel de actividad citotoxica y por lo tanto es eficaz como inhibidor del crecimiento celular tal como un agente anticancer.
MX2007004593A 2004-10-26 2005-10-26 Anticuerpo anti-glipican 3 que tiene cadena de azucar modificada. MX2007004593A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004311356 2004-10-26
PCT/JP2005/020057 WO2006046751A1 (ja) 2004-10-26 2005-10-26 糖鎖改変抗グリピカン３抗体

Publications (1)

Publication Number Publication Date
MX2007004593A true MX2007004593A (es) 2007-06-22

Family

ID=36227980

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004593A MX2007004593A (es) 2004-10-26 2005-10-26 Anticuerpo anti-glipican 3 que tiene cadena de azucar modificada.

Country Status (19)

Country Link
US (2) US7867734B2 (es)
EP (1) EP1816140A4 (es)
JP (1) JP4794457B2 (es)
KR (1) KR101296931B1 (es)
CN (1) CN101068836B (es)
AU (1) AU2005297772B2 (es)
BR (1) BRPI0518279A2 (es)
CA (1) CA2585196C (es)
CR (1) CR9151A (es)
IL (1) IL182662A (es)
MA (1) MA29025B1 (es)
MX (1) MX2007004593A (es)
NO (1) NO20072366L (es)
NZ (1) NZ554940A (es)
RU (1) RU2451030C2 (es)
TW (1) TWI468514B (es)
UA (1) UA93488C2 (es)
WO (1) WO2006046751A1 (es)
ZA (1) ZA200703888B (es)

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Also Published As

Publication number Publication date
CN101068836A (zh) 2007-11-07
EP1816140A1 (en) 2007-08-08
KR20070070222A (ko) 2007-07-03
MA29025B1 (fr) 2007-11-01
CA2585196A1 (en) 2006-05-04
US20080124330A1 (en) 2008-05-29
RU2007119579A (ru) 2008-12-10
JP4794457B2 (ja) 2011-10-19
TWI468514B (zh) 2015-01-11
RU2451030C2 (ru) 2012-05-20
NZ554940A (en) 2010-04-30
AU2005297772B2 (en) 2011-06-23
UA93488C2 (uk) 2011-02-25
HK1110335A1 (en) 2008-07-11
EP1816140A4 (en) 2009-09-02
TW200621980A (en) 2006-07-01
JPWO2006046751A1 (ja) 2008-05-22
CA2585196C (en) 2015-01-06
WO2006046751A1 (ja) 2006-05-04
CR9151A (es) 2008-03-18
ZA200703888B (en) 2009-11-25
BRPI0518279A2 (pt) 2008-11-11
KR101296931B1 (ko) 2013-08-14
IL182662A (en) 2014-09-30
CN101068836B (zh) 2013-08-14
IL182662A0 (en) 2007-09-20
US7867734B2 (en) 2011-01-11
AU2005297772A1 (en) 2006-05-04
NO20072366L (no) 2007-06-21
US20110033452A1 (en) 2011-02-10

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