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MX2007004426A - Procesos para preparar telmisartan. - Google Patents

Procesos para preparar telmisartan.

Info

Publication number
MX2007004426A
MX2007004426A MX2007004426A MX2007004426A MX2007004426A MX 2007004426 A MX2007004426 A MX 2007004426A MX 2007004426 A MX2007004426 A MX 2007004426A MX 2007004426 A MX2007004426 A MX 2007004426A MX 2007004426 A MX2007004426 A MX 2007004426A
Authority
MX
Mexico
Prior art keywords
telmisartan
alkyl ester
preparing
preparing telmisartan
hydrolyzed
Prior art date
Application number
MX2007004426A
Other languages
English (en)
Inventor
Nurit Perlman
Eyal Gilboa
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of MX2007004426A publication Critical patent/MX2007004426A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan procesos para preparar alquilester de telmisartan y telmisartan utilizando solventes organicos ambientalmente inocuos que se extraen facilmente de la mezcla de la reaccion, caracterizado porque el alquilester de telmisartan se aisla e hidroliza para formar telmisartan o el telmisartan se prepara utilizando una sintesis en un recipiente de reaccion unico.
MX2007004426A 2004-10-15 2005-10-13 Procesos para preparar telmisartan. MX2007004426A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61956304P 2004-10-15 2004-10-15
PCT/US2005/037001 WO2006044648A1 (en) 2004-10-15 2005-10-13 Process for preparing telmisartan

Publications (1)

Publication Number Publication Date
MX2007004426A true MX2007004426A (es) 2007-06-14

Family

ID=35649417

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004426A MX2007004426A (es) 2004-10-15 2005-10-13 Procesos para preparar telmisartan.

Country Status (9)

Country Link
US (2) US7501448B2 (es)
EP (1) EP1699765A1 (es)
JP (1) JP2008503595A (es)
KR (2) KR20070061583A (es)
CN (1) CN101039917A (es)
CA (1) CA2581723A1 (es)
IL (1) IL182067A0 (es)
MX (1) MX2007004426A (es)
WO (1) WO2006044648A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1699765A1 (en) * 2004-10-15 2006-09-13 Teva Pharmaceutical Industries Ltd Process for preparing telmisartan
CA2645893A1 (en) * 2006-03-17 2007-09-27 Cipla Limited Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-tr1azol-1-yl)methyl] benzonitrile and 4-[1-(1h-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
US7858611B2 (en) 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
WO2007134136A2 (en) * 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
CZ302272B6 (cs) * 2007-07-09 2011-01-19 Zentiva, A. S. Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
US8410285B2 (en) 2008-03-20 2013-04-02 Lek Pharmaceuticals D.D. 2′-halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
EP2103609A1 (en) * 2008-03-20 2009-09-23 Lek Pharmaceuticals D.D. Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
WO2009123483A1 (en) 2008-03-31 2009-10-08 Zaklady Farmaceutyczne Polpharma Sa Process for preparation of telmisartan
EP2149566A1 (en) 2008-07-15 2010-02-03 Chemo Ibérica, S.A. A process for the preparation of telmisartan
EP2305650A1 (en) 2009-09-21 2011-04-06 Chemo Ibérica, S.A. Novel process for the preparation of telmisartan
JP5711888B2 (ja) * 2010-01-26 2015-05-07 株式会社Ｄｎｐファインケミカル宇都宮 テルミサルタンアルキルエステルの製造法
KR20110094751A (ko) * 2010-02-17 2011-08-24 동화약품주식회사 텔미사탄의 개선된 제조방법
WO2012028925A2 (en) 2010-09-03 2012-03-08 Ogene Systems (I) Pvt Ltd An improved process for the preparation of telmisartan
EA025946B1 (ru) 2010-10-27 2017-02-28 Крка, Товарна Здравил, Д. Д., Ново Место Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
ITMI20102416A1 (it) * 2010-12-27 2012-06-28 Chemelectiva S R L Intermedio per la preparazione di un principio attivo e processo per la sua preparazione
CN102267949A (zh) * 2011-06-14 2011-12-07 张长利 替米沙坦制备新工艺
KR101607661B1 (ko) * 2013-12-24 2016-03-31 주식회사 파마코스텍 텔미사르탄의 신규 제조 방법
WO2016089845A1 (en) * 2014-12-01 2016-06-09 Virginia Commonwealth University A convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
CN104610161A (zh) * 2015-01-05 2015-05-13 河南师范大学 一种替米沙坦的制备方法
KR20160112732A (ko) * 2015-03-20 2016-09-28 크리스탈지노믹스(주) 텔미사르탄 칼륨염을 포함하는 약제학적 조성물 및 그 제조방법
CN106008357A (zh) * 2016-06-14 2016-10-12 浙江华海药业股份有限公司 一种替米沙坦的新杂质及其合成方法
EP4479035A1 (en) * 2022-02-17 2024-12-25 Woolsey Pharmaceuticals, Inc. Taste-masking oral formulations of fasudil

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Also Published As

Publication number Publication date
CA2581723A1 (en) 2006-04-27
US7501448B2 (en) 2009-03-10
KR20070061583A (ko) 2007-06-13
JP2008503595A (ja) 2008-02-07
WO2006044648A1 (en) 2006-04-27
IL182067A0 (en) 2007-07-24
CN101039917A (zh) 2007-09-19
US20090124814A1 (en) 2009-05-14
KR20080112424A (ko) 2008-12-24
US20060094883A1 (en) 2006-05-04
EP1699765A1 (en) 2006-09-13

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