MX2007004274A - Quinazolinilmetilentiazolinonas como inhibidores de cdk1. - Google Patents
Quinazolinilmetilentiazolinonas como inhibidores de cdk1.Info
- Publication number
- MX2007004274A MX2007004274A MX2007004274A MX2007004274A MX2007004274A MX 2007004274 A MX2007004274 A MX 2007004274A MX 2007004274 A MX2007004274 A MX 2007004274A MX 2007004274 A MX2007004274 A MX 2007004274A MX 2007004274 A MX2007004274 A MX 2007004274A
- Authority
- MX
- Mexico
- Prior art keywords
- quinazolinylmethylene
- thiazolinones
- cdk1 inhibitors
- cdk1
- inhibitors
- Prior art date
Links
- GSARZVBHESRRSV-UHFFFAOYSA-N 5-(quinazolin-2-ylmethylidene)-1,3-thiazol-2-one Chemical class N1=C(N=CC2=CC=CC=C12)C=C1C=NC(S1)=O GSARZVBHESRRSV-UHFFFAOYSA-N 0.000 title 1
- 101150012716 CDK1 gene Proteins 0.000 title 1
- 101100059559 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) nimX gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102100032857 Cyclin-dependent kinase 1 Human genes 0.000 abstract 1
- 101710106279 Cyclin-dependent kinase 1 Proteins 0.000 abstract 1
- ZOIBXNQXBKZCJC-UHFFFAOYSA-N S1C(N=CC1)=O.N1=CN=CC2=CC=CC=C12 Chemical class S1C(N=CC1)=O.N1=CN=CC2=CC=CC=C12 ZOIBXNQXBKZCJC-UHFFFAOYSA-N 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion describe los derivados de quinazolin-tiazolinona de la formula (1), en donde Rl, R3, R4, X y n tienen los significados como se definen en la presente, los cuales demuestran actividad antiproliferativa de CDK1 y son utiles como agentes anti-cancerosos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61861204P | 2004-10-14 | 2004-10-14 | |
| US68107905P | 2005-05-13 | 2005-05-13 | |
| PCT/EP2005/010703 WO2006040050A1 (en) | 2004-10-14 | 2005-10-05 | Quinazolinylmethylene thiazolinones as cdk1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007004274A true MX2007004274A (es) | 2007-05-16 |
Family
ID=35810865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007004274A MX2007004274A (es) | 2004-10-14 | 2005-10-05 | Quinazolinilmetilentiazolinonas como inhibidores de cdk1. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7501428B2 (es) |
| EP (1) | EP1802614A1 (es) |
| JP (1) | JP2008516904A (es) |
| KR (1) | KR100890533B1 (es) |
| CN (1) | CN101039939B (es) |
| AU (1) | AU2005293832A1 (es) |
| BR (1) | BRPI0518164A (es) |
| CA (1) | CA2583311A1 (es) |
| MX (1) | MX2007004274A (es) |
| RU (1) | RU2405782C2 (es) |
| WO (1) | WO2006040050A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080034436A (ko) * | 2005-07-21 | 2008-04-21 | 베타게논 에이비 | 암 치료에 사용되는 티아졸 유도체 및 유사체 |
| TW200745066A (en) | 2005-09-16 | 2007-12-16 | Torrent Pharmaceuticals Ltd | Novel PTP1B inhibitors |
| WO2008065409A2 (en) * | 2006-12-01 | 2008-06-05 | Betagenon Ab | Combination for use in the treatment of cancer, comprising tamoxifen or an aromatase inhibitor |
| WO2010086613A1 (en) | 2009-01-30 | 2010-08-05 | Betagenon Ab | Compounds useful as inhibitors as ampk |
| RU2521390C1 (ru) * | 2013-03-14 | 2014-06-27 | Общество с ограниченной ответственностью "Тиацен" | Производное роданина и средство для профилактики опухолевых заболеваний |
| WO2014141082A1 (ru) | 2013-03-14 | 2014-09-18 | Общество с ограниченной ответственностью "Тиацен" | Cредство для профилактики и/или лечения опухолевых заболеваний |
| WO2022113003A1 (en) | 2020-11-27 | 2022-06-02 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| WO2022149057A1 (en) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU679859B2 (en) * | 1994-06-14 | 1997-07-10 | Dainippon Sumitomo Pharma Co., Ltd. | Novel compound, process for producing the same, and antitumor agent |
| US6407124B1 (en) * | 1998-06-18 | 2002-06-18 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| EA011807B1 (ru) * | 2002-07-10 | 2009-06-30 | Лаборатуар Сероно Са | Азолидинонвинильные производные конденсированного бензола |
| AU2003255529B2 (en) | 2002-07-10 | 2008-11-20 | Laboratoires Serono Sa | Use of compounds for increasing spermatozoa motility |
| ATE411302T1 (de) * | 2002-11-22 | 2008-10-15 | Smithkline Beecham Corp | Thiazolidin-4-ones um hyak3 proteinen zu hemmen |
| ES2328146T3 (es) * | 2003-07-28 | 2009-11-10 | Merck Serono Sa | 2-imino-4-(tio)oxo-5-policiclovinilazolinas para su uso como inhibidores de p13 quinasas. |
-
2005
- 2005-10-05 RU RU2007117766/04A patent/RU2405782C2/ru not_active IP Right Cessation
- 2005-10-05 JP JP2007536045A patent/JP2008516904A/ja active Pending
- 2005-10-05 CA CA002583311A patent/CA2583311A1/en not_active Abandoned
- 2005-10-05 BR BRPI0518164-0A patent/BRPI0518164A/pt not_active IP Right Cessation
- 2005-10-05 US US11/244,028 patent/US7501428B2/en not_active Expired - Fee Related
- 2005-10-05 AU AU2005293832A patent/AU2005293832A1/en not_active Abandoned
- 2005-10-05 CN CN2005800349026A patent/CN101039939B/zh not_active Expired - Fee Related
- 2005-10-05 KR KR1020077008501A patent/KR100890533B1/ko not_active Expired - Fee Related
- 2005-10-05 MX MX2007004274A patent/MX2007004274A/es active IP Right Grant
- 2005-10-05 EP EP05794407A patent/EP1802614A1/en not_active Withdrawn
- 2005-10-05 WO PCT/EP2005/010703 patent/WO2006040050A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006040050A1 (en) | 2006-04-20 |
| CA2583311A1 (en) | 2006-04-20 |
| US7501428B2 (en) | 2009-03-10 |
| AU2005293832A1 (en) | 2006-04-20 |
| RU2007117766A (ru) | 2008-11-20 |
| EP1802614A1 (en) | 2007-07-04 |
| US20060084804A1 (en) | 2006-04-20 |
| JP2008516904A (ja) | 2008-05-22 |
| BRPI0518164A (pt) | 2008-11-04 |
| CN101039939A (zh) | 2007-09-19 |
| RU2405782C2 (ru) | 2010-12-10 |
| KR20070053343A (ko) | 2007-05-23 |
| KR100890533B1 (ko) | 2009-03-27 |
| CN101039939B (zh) | 2010-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |