MEP10109A - Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof - Google Patents
Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereofInfo
- Publication number
- MEP10109A MEP10109A MEP-101/09A MEP10109A MEP10109A ME P10109 A MEP10109 A ME P10109A ME P10109 A MEP10109 A ME P10109A ME P10109 A MEP10109 A ME P10109A
- Authority
- ME
- Montenegro
- Prior art keywords
- alkyl
- pyridin
- thi
- therapeutic use
- pyrrolizine
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 125000002152 1H-pyrrolizinyl group Chemical class C1(C=CN2C=CC=C12)* 0.000 title 1
- GDRVFDDBLLKWRI-UHFFFAOYSA-N 4H-quinolizine Chemical compound C1=CC=CN2CC=CC=C21 GDRVFDDBLLKWRI-UHFFFAOYSA-N 0.000 title 1
- HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical compound C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 title 1
- -1 price Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0608348A FR2906251B1 (fr) | 2006-09-22 | 2006-09-22 | Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique |
| PCT/FR2007/001545 WO2008037881A2 (fr) | 2006-09-22 | 2007-09-21 | Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP10109A true MEP10109A (en) | 2011-12-20 |
Family
ID=37897398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-101/09A MEP10109A (en) | 2006-09-22 | 2007-09-21 | Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7776880B2 (zh) |
| EP (1) | EP2077837A2 (zh) |
| JP (1) | JP2010504311A (zh) |
| KR (1) | KR20090080947A (zh) |
| CN (1) | CN101573113A (zh) |
| AR (1) | AR062896A1 (zh) |
| AU (1) | AU2007301880A1 (zh) |
| BR (1) | BRPI0717100A2 (zh) |
| CA (1) | CA2663080A1 (zh) |
| CL (1) | CL2007002732A1 (zh) |
| CO (1) | CO6160309A2 (zh) |
| CR (1) | CR10658A (zh) |
| EA (1) | EA015974B1 (zh) |
| FR (1) | FR2906251B1 (zh) |
| GT (1) | GT200900061A (zh) |
| HN (1) | HN2009000504A (zh) |
| IL (1) | IL197500A0 (zh) |
| MA (1) | MA30790B1 (zh) |
| ME (1) | MEP10109A (zh) |
| MX (1) | MX2009003083A (zh) |
| NO (1) | NO20091351L (zh) |
| NZ (1) | NZ575573A (zh) |
| PE (1) | PE20081376A1 (zh) |
| SV (1) | SV2009003191A (zh) |
| TN (1) | TN2009000082A1 (zh) |
| TW (1) | TW200819455A (zh) |
| UY (1) | UY30604A1 (zh) |
| WO (1) | WO2008037881A2 (zh) |
| ZA (1) | ZA200901850B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2842804B1 (fr) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861074B1 (fr) * | 2003-10-17 | 2006-04-07 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| WO2010087762A1 (en) * | 2009-01-28 | 2010-08-05 | Astrazeneca Ab | 2-aza-bicyclo[2.2.1]heptane compounds and uses thereof |
| AR075182A1 (es) * | 2009-01-28 | 2011-03-16 | Astrazeneca Ab | Compuestos 2-aza-biciclo (2.2.2) octano y sus usos |
| US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| US8143273B2 (en) * | 2010-06-22 | 2012-03-27 | Hoffman-La Roche Inc. | Quinolizidine and indolizidine derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3801636A (en) * | 1971-08-13 | 1974-04-02 | Abbott Lab | 3,4,5-tri-substituted cinnamides |
| US4409225A (en) * | 1981-03-16 | 1983-10-11 | Beecham Group Limited | Substituted benzamides |
| AU2491092A (en) * | 1991-09-12 | 1993-04-05 | Smithkline Beecham Plc | Azabicyclic compounds as 5-ht4 receptor antagonists |
| CZ284456B6 (cs) | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| WO2002024695A2 (en) * | 2000-09-22 | 2002-03-28 | Ortho Mcneil Pharmaceutical, Inc. | Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines |
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
| FR2861073B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
-
2006
- 2006-09-22 FR FR0608348A patent/FR2906251B1/fr not_active Expired - Fee Related
-
2007
- 2007-09-13 TW TW096134256A patent/TW200819455A/zh unknown
- 2007-09-19 AR ARP070104135A patent/AR062896A1/es unknown
- 2007-09-20 PE PE2007001267A patent/PE20081376A1/es not_active Application Discontinuation
- 2007-09-21 MX MX2009003083A patent/MX2009003083A/es active IP Right Grant
- 2007-09-21 ZA ZA200901850A patent/ZA200901850B/xx unknown
- 2007-09-21 KR KR1020097008124A patent/KR20090080947A/ko not_active Withdrawn
- 2007-09-21 EP EP07848274A patent/EP2077837A2/fr not_active Withdrawn
- 2007-09-21 AU AU2007301880A patent/AU2007301880A1/en not_active Abandoned
- 2007-09-21 CA CA002663080A patent/CA2663080A1/fr not_active Abandoned
- 2007-09-21 BR BRPI0717100-5A patent/BRPI0717100A2/pt not_active IP Right Cessation
- 2007-09-21 EA EA200970312A patent/EA015974B1/ru not_active IP Right Cessation
- 2007-09-21 NZ NZ575573A patent/NZ575573A/en not_active IP Right Cessation
- 2007-09-21 ME MEP-101/09A patent/MEP10109A/xx unknown
- 2007-09-21 CN CNA2007800392487A patent/CN101573113A/zh active Pending
- 2007-09-21 WO PCT/FR2007/001545 patent/WO2008037881A2/fr not_active Ceased
- 2007-09-21 UY UY30604A patent/UY30604A1/es not_active Application Discontinuation
- 2007-09-21 JP JP2009528756A patent/JP2010504311A/ja not_active Withdrawn
- 2007-09-21 CL CL200702732A patent/CL2007002732A1/es unknown
-
2009
- 2009-03-09 IL IL197500A patent/IL197500A0/en unknown
- 2009-03-10 TN TN2009000082A patent/TN2009000082A1/fr unknown
- 2009-03-11 CR CR10658A patent/CR10658A/es not_active Application Discontinuation
- 2009-03-16 GT GT200900061A patent/GT200900061A/es unknown
- 2009-03-18 HN HN2009000504A patent/HN2009000504A/es unknown
- 2009-03-19 SV SV2009003191A patent/SV2009003191A/es active IP Right Grant
- 2009-03-19 US US12/407,276 patent/US7776880B2/en not_active Expired - Fee Related
- 2009-03-19 CO CO09028765A patent/CO6160309A2/es unknown
- 2009-04-01 NO NO20091351A patent/NO20091351L/no not_active Application Discontinuation
- 2009-04-16 MA MA31786A patent/MA30790B1/fr unknown
-
2010
- 2010-06-30 US US12/827,614 patent/US20100267766A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7776880B2 (en) | 2010-08-17 |
| NZ575573A (en) | 2011-12-22 |
| UY30604A1 (es) | 2008-05-02 |
| FR2906251A1 (fr) | 2008-03-28 |
| MA30790B1 (fr) | 2009-10-01 |
| TN2009000082A1 (en) | 2010-08-19 |
| KR20090080947A (ko) | 2009-07-27 |
| US20100267766A1 (en) | 2010-10-21 |
| HN2009000504A (es) | 2011-10-20 |
| PE20081376A1 (es) | 2008-11-07 |
| MX2009003083A (es) | 2009-04-02 |
| WO2008037881A2 (fr) | 2008-04-03 |
| US20090258899A1 (en) | 2009-10-15 |
| AR062896A1 (es) | 2008-12-10 |
| IL197500A0 (en) | 2009-12-24 |
| FR2906251B1 (fr) | 2008-11-07 |
| EA015974B1 (ru) | 2012-01-30 |
| NO20091351L (no) | 2009-06-22 |
| JP2010504311A (ja) | 2010-02-12 |
| ZA200901850B (en) | 2010-06-30 |
| CR10658A (es) | 2009-06-24 |
| CL2007002732A1 (es) | 2008-04-18 |
| AU2007301880A1 (en) | 2008-04-03 |
| TW200819455A (en) | 2008-05-01 |
| GT200900061A (es) | 2010-06-21 |
| CN101573113A (zh) | 2009-11-04 |
| BRPI0717100A2 (pt) | 2013-10-15 |
| CO6160309A2 (es) | 2010-05-20 |
| SV2009003191A (es) | 2009-10-27 |
| WO2008037881A3 (fr) | 2008-05-22 |
| EA200970312A1 (ru) | 2009-12-30 |
| CA2663080A1 (fr) | 2008-04-03 |
| EP2077837A2 (fr) | 2009-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MEP10109A (en) | Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof | |
| MX2010006341A (es) | Indoles y su uso terapeutico. | |
| PE20090290A1 (es) | Derivados de pirrolopiridina como inhibidores de bace | |
| BRPI0910871A2 (pt) | derivados espirocíclicos como inibidores de histona desacetilase | |
| AR082638A1 (es) | Derivados de tetrahidropiran utiles como pesticidas | |
| CO6251283A2 (es) | Pirimidil ciclopentanos como inhibidores de proteina cinasa akt | |
| HRP20140705T1 (hr) | Spoj triazolopiridina i njegovo djelovanje kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina | |
| PE20160523A1 (es) | Derivados de arilo o heteroarilo como inhibidores de moleculas pequenas de fibrosis | |
| AR095422A1 (es) | Compuestos de piperidina sustituidos y su uso como moduladores de receptores de orexina | |
| PE20110843A1 (es) | Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica | |
| DK2197860T3 (da) | Nye forbindelser som adenosin-A1-receptorantagonister | |
| AR089889A1 (es) | Compuestos fungicidas de pirimidina | |
| HRP20120857T1 (hr) | Derivati 4-(n-azacikloalkil) anilida kao modulatori kalijevog kanala | |
| AR089884A1 (es) | Compuestos fungicidas de pirimidina | |
| AR089887A1 (es) | Compuestos fungicidas de pirimidina | |
| AR089880A1 (es) | Compuestos fungicidas de pirimidina | |
| EA201600270A1 (ru) | N-ацилимино гетероциклические соединения | |
| AR089881A1 (es) | Compuestos fungicidas de pirimidina | |
| SE0101767D0 (sv) | Novel compounds | |
| AR089885A1 (es) | Compuestos fungicidas de pirimidina | |
| TNSN08521A1 (en) | Phenylpentadienoyl derivatives and their use as par 1 antagonists | |
| FR2970964B1 (fr) | Nouveaux derives d'azacoumarines presentant une activite inhibitrice des pompes mdr | |
| DOP2009000040A (es) | Derivados de pirrolizina, indolizina y quinolizina, su preparacion y su aplicacion en terapeutica | |
| SE0101772D0 (sv) | Novel compounds | |
| HRPK20080507B3 (en) | Substituted morpholine and thiomorpholine derivates |