MC2326A1 - Antagonistes d'un nonapeptide de la bombesine - Google Patents

Antagonistes d'un nonapeptide de la bombesine

Info

Publication number: MC2326A1
Authority: MC; Monaco
Prior art keywords: phenyl; alkyl; hydrogen; 10alkyl; nonapeptide
Prior art date: 1990-11-29

Application number

MC912326D

Other languages

English (en)

French (fr)

Inventor

Schally Andrew V Mm

Ren Zhi Cai

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-29

Filing date

1991-11-15

Publication date

1994-01-18

1991-11-15 Application filed by Univ Tulane filed Critical Univ Tulane

1994-01-18 Publication of MC2326A1 publication Critical patent/MC2326A1/xx

Links

XXFIWKDBCZWORZ-YQZUKWOLSA-N (2s)-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[(2s)-1-[[(2s)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl] Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(N)=O)C(C)C)C1=CN=CN1 XXFIWKDBCZWORZ-YQZUKWOLSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
108010016438 bombesin nonapeptide Proteins 0.000 title 1
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
150000002431 hydrogen Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
239000002790 bombesin antagonist Substances 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MC912326D 1990-11-29 1991-11-15 Antagonistes d'un nonapeptide de la bombesine MC2326A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/619,747 US5244883A (en)	1990-11-29	1990-11-29	Nonapeptide bombesin antagonists

Publications (1)

Publication Number	Publication Date
MC2326A1 true MC2326A1 (fr)	1994-01-18

Family

ID=24483142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MC912326D MC2326A1 (fr)	1990-11-29	1991-11-15	Antagonistes d'un nonapeptide de la bombesine

Country Status (26)

Country	Link
US (1)	US5244883A (xx)
EP (1)	EP0559756B1 (xx)
JP (1)	JPH06503090A (xx)
KR (1)	KR100225679B1 (xx)
AT (1)	ATE120760T1 (xx)
AU (1)	AU657723B2 (xx)
CA (1)	CA2097192C (xx)
CZ (1)	CZ281533B6 (xx)
DE (1)	DE69108738T2 (xx)
DK (1)	DK0559756T3 (xx)
ES (1)	ES2072137T3 (xx)
FI (1)	FI104253B1 (xx)
GR (1)	GR3015866T3 (xx)
HU (2)	HU213114B (xx)
IE (1)	IE62722B1 (xx)
LV (1)	LV5794B4 (xx)
MC (1)	MC2326A1 (xx)
NO (1)	NO311362B1 (xx)
NZ (1)	NZ240628A (xx)
PL (1)	PL169498B1 (xx)
PT (1)	PT99667B (xx)
RU (1)	RU2115659C1 (xx)
SK (1)	SK283541B6 (xx)
WO (1)	WO1992009626A1 (xx)
YU (1)	YU48751B (xx)
ZA (1)	ZA919387B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5877277A (en)	1987-09-24	1999-03-02	Biomeasure, Inc.	Octapeptide bombesin analogs
US5723578A (en) *	1987-09-24	1998-03-03	The Administrators Of Tulane Educational Fund	Peptide analogs of bombesin
CA2042027A1 (en) *	1989-09-15	1991-03-16	Arthur E. Bogden	Treatment of colon cancer
US5162336A (en) *	1990-06-21	1992-11-10	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
US5834433A (en) *	1990-07-26	1998-11-10	Merrell Pharmaceuticals Inc.	Compounds and pharmaceutical uses of peptides of bombesin and GRP
US5369094A (en) *	1990-11-29	1994-11-29	The Administrators Of The Tulane Educational Fund	Polypeptide bombesin antagonists
FI943638A0 (fi) *	1992-02-07	1994-08-05	Merrell Dow Pharma	Bombesiinin fenyylialaniinianalogeja
US5620955A (en) *	1993-06-18	1997-04-15	Peptide Technologies Corporation	Bombesin receptor antagonists and uses thereof
DE4320201A1 (de) *	1993-06-18	1995-01-12	Asta Medica Ag	Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5997870A (en) *	1994-06-03	1999-12-07	Ludwig Institute For Cancer Research	Isolated peptides which bind to HLA-B44 Molecules
US5650395A (en) *	1995-03-13	1997-07-22	Hurel; Steven	Treatment of pulmonary hypertension
US5972895A (en) *	1996-12-11	1999-10-26	A. Glenn Braswell	Composition and method for increasing growth hormone levels
EP0977579B1 (en)	1997-04-22	2009-03-11	Curator Of The University Of Missouri	Gastrin receptor-avid peptide conjugates
RU2153623C1 (ru) *	1999-04-20	2000-07-27	Сысун Виктор Викторович	Светосигнальный огонь кругового обзора
JP4294959B2 (ja) *	2001-03-06	2009-07-15	ウニベルシタ・デグリ・ストゥッディ・ディ・フェラーラ	髄様甲状腺癌の増殖を変調させる方法
US7922998B2 (en) *	2003-01-13	2011-04-12	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
DE60328226D1 (de) *	2003-01-13	2009-08-13	Bracco Imaging Spa	Verbesserte linker für radiopharmazeutische verbindungen
US20060239923A1 (en) *	2003-01-13	2006-10-26	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US8420050B2 (en) *	2003-01-13	2013-04-16	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7611692B2 (en) *	2003-01-13	2009-11-03	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7850947B2 (en)	2003-01-13	2010-12-14	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7226577B2 (en) *	2003-01-13	2007-06-05	Bracco Imaging, S. P. A.	Gastrin releasing peptide compounds
US7795385B2 (en) *	2004-12-17	2010-09-14	Bexar Global, Inc.	Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
US8101580B2 (en)	2005-04-21	2012-01-24	Astellas Pharma Inc.	Therapeutic agent for irritable bowel syndrome
US8557776B2 (en)	2006-09-08	2013-10-15	Bayer Pharma AG	Compounds and methods for 18F labeled agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4839465A (en) *	1987-01-20	1989-06-13	Sterling Drug Inc.	Di-(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides and process for preparation thereof
JP2795449B2 (ja) *	1987-09-24	1998-09-10	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ペプチド
GB8808768D0 (en) *	1988-04-14	1988-05-18	Erba Carlo Spa	Peptide ligands for bombesin receptors
GR1000608B (el) *	1988-07-21	1992-08-31	Erba Carlo Spa	Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
HU208439B (en) *	1988-10-14	1993-10-28	Univ Tulane	Process for producing pharmaceutical peptides

1990
- 1990-11-29 US US07/619,747 patent/US5244883A/en not_active Expired - Lifetime
1991
- 1991-11-15 AT AT92900740T patent/ATE120760T1/de not_active IP Right Cessation
- 1991-11-15 HU HU9301567A patent/HU213114B/hu unknown
- 1991-11-15 DE DE69108738T patent/DE69108738T2/de not_active Expired - Fee Related
- 1991-11-15 JP JP4501946A patent/JPH06503090A/ja active Granted
- 1991-11-15 WO PCT/US1991/008534 patent/WO1992009626A1/en not_active Ceased
- 1991-11-15 AU AU90645/91A patent/AU657723B2/en not_active Ceased
- 1991-11-15 KR KR1019930701620A patent/KR100225679B1/ko not_active Expired - Fee Related
- 1991-11-15 RU RU93041053A patent/RU2115659C1/ru not_active IP Right Cessation
- 1991-11-15 PL PL91300477A patent/PL169498B1/pl not_active IP Right Cessation
- 1991-11-15 CZ CS931006A patent/CZ281533B6/cs not_active IP Right Cessation
- 1991-11-15 DK DK92900740.9T patent/DK0559756T3/da active
- 1991-11-15 CA CA002097192A patent/CA2097192C/en not_active Expired - Fee Related
- 1991-11-15 ES ES92900740T patent/ES2072137T3/es not_active Expired - Lifetime
- 1991-11-15 EP EP92900740A patent/EP0559756B1/en not_active Expired - Lifetime
- 1991-11-15 SK SK551-93A patent/SK283541B6/sk unknown
- 1991-11-15 MC MC912326D patent/MC2326A1/xx unknown
- 1991-11-18 NZ NZ24062891A patent/NZ240628A/en not_active IP Right Cessation
- 1991-11-22 YU YU183491A patent/YU48751B/sh unknown
- 1991-11-28 ZA ZA919387A patent/ZA919387B/xx unknown
- 1991-11-28 IE IE414091A patent/IE62722B1/en not_active IP Right Cessation
- 1991-11-29 PT PT99667A patent/PT99667B/pt not_active IP Right Cessation
1993
- 1993-05-28 NO NO19931977A patent/NO311362B1/no unknown
- 1993-05-28 FI FI932457A patent/FI104253B1/fi not_active IP Right Cessation
1995
- 1995-04-19 GR GR950400995T patent/GR3015866T3/el unknown
- 1995-06-27 HU HU95P/P00466P patent/HU211603A9/hu unknown
1996
- 1996-07-22 LV LV960305A patent/LV5794B4/xx unknown

Also Published As

Publication number	Publication date
HU211603A9 (en)	1995-12-28
PT99667B (pt)	1999-05-31
HUT64566A (en)	1994-01-28
NO931977L (no)	1993-05-28
DE69108738T2 (de)	1995-08-17
IE62722B1 (en)	1995-02-22
EP0559756B1 (en)	1995-04-05
WO1992009626A1 (en)	1992-06-11
DK0559756T3 (da)	1995-06-19
ES2072137T3 (es)	1995-07-01
AU657723B2 (en)	1995-03-23
IE914140A1 (en)	1992-06-03
FI932457A0 (fi)	1993-05-28
NO311362B1 (no)	2001-11-19
AU9064591A (en)	1992-06-25
PT99667A (pt)	1992-10-30
RU2115659C1 (ru)	1998-07-20
JPH06503090A (ja)	1994-04-07
CA2097192A1 (en)	1992-05-30
DE69108738D1 (de)	1995-05-11
GR3015866T3 (en)	1995-07-31
FI104253B (fi)	1999-12-15
YU48751B (sh)	1999-09-27
YU183491A (sh)	1994-11-15
ZA919387B (en)	1992-09-30
NZ240628A (en)	1994-07-26
HU9301567D0 (en)	1993-09-28
HU213114B (en)	1997-02-28
LV5794B4 (lv)	1997-08-20
LV5794A4 (lv)	1997-02-20
ATE120760T1 (de)	1995-04-15
PL169498B1 (pl)	1996-07-31
CZ281533B6 (cs)	1996-10-16
CZ100693A3 (en)	1994-03-16
SK283541B6 (sk)	2003-09-11
FI104253B1 (fi)	1999-12-15
US5244883A (en)	1993-09-14
NO931977D0 (no)	1993-05-28
KR100225679B1 (ko)	1999-10-15
KR930702386A (ko)	1993-09-08
FI932457A7 (fi)	1993-05-28
SK55193A3 (en)	1993-10-06
EP0559756A1 (en)	1993-09-15
CA2097192C (en)	2002-01-01

Publication	Publication Date	Title
MC2326A1 (fr)	1994-01-18	Antagonistes d'un nonapeptide de la bombesine
SE9604341D0 (sv)	1996-11-26	Hepta-peptide oxytocin analogue
TW363064B (en)	1999-07-01	Novel inhibitors of bone reabsorption and antagonists of vitronectin receptors
UA72917C2 (en)	2005-05-16	Cyclic carbamates derivatives, pharmaceutical composition containing said derivatives of cyclic carbamates and active ingredients as modulators of the progesterone receptor
HUP0100669A2 (hu)	2001-08-28	Szerin proteázokat gátló peptidszármazékok és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
DE3881592D1 (de)	1993-07-15	Lhrh antagonisten, deren herstellung und entsprechende pharmazeutische zubereitungen.
NO20006282D0 (no)	2000-12-11	Nye cyklosporiner
ES8105698A1 (es)	1981-06-16	Procedimiento para la obtencion de octapeptidos ciclicos
CY1111740T1 (el)	2015-10-07	Συζευγματα πεπτιδιων ν- και/ή c-τελικως τροποποιημενα μεσω βραχεων αλυσων φορτισμενων πεπτιδιων
CA2060034A1 (en)	1992-07-26	Tumour growth-inhibiting somatostatin analogues, pharmaceutical compositions containing them and process for preparing same
RU94045881A (ru)	1996-09-10	Производные пептидов, способ получения, фармацевтическая композиция, способ лечения
ATE254121T1 (de)	2003-11-15	Heterocyclische verbindungen als bradykinin antagonisten
NO944293D0 (no)	1994-11-10	Bombesin antagonist-polypeptider
JPH01113353A (ja)	1989-05-02	抗高血圧剤としてのα−アミノアシルβ−アミノアシルアミノジオール
HUP9702509A2 (hu)	1999-06-28	Kondenzált heterociklusos vegyületek aminocsoportjukon szubsztituált származékai, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
CY1107990T1 (el)	2013-09-04	Τριπεπτιδια και παραγωγα τριπεπτιδιων για τη θepαπεια νευροεκφυλιστικων ασθενειων
GB927714A (en)	1963-06-06	New cyclic octapeptides
AR002715A1 (es)	1998-04-29	Derivados de piperazina y piperazinona heterociclos substituidos particularmente utiles como antagonistas de los receptores de taquikinina,composicion farmaceutica que incluye uno de dichos derivados, uso de dichos compuestos en la preparacion de las composiciones y procedimiento para la preparacion de los derivados
HU181402B (en)	1983-07-28	Process for preparing new peptides with psychopharmacological activity
ATE46347T1 (de)	1989-09-15	Immunostimulierende peptide.
NO931091L (no)	1993-03-24	Analoger av sykloinopeptid a og anvendelse derav