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MA51146B1 - Composés hétérocycliques bicycliques substitués utilisés en tant qu'inhibiteurs de prmt5 - Google Patents

Composés hétérocycliques bicycliques substitués utilisés en tant qu'inhibiteurs de prmt5

Info

Publication number
MA51146B1
MA51146B1 MA51146A MA51146A MA51146B1 MA 51146 B1 MA51146 B1 MA 51146B1 MA 51146 A MA51146 A MA 51146A MA 51146 A MA51146 A MA 51146A MA 51146 B1 MA51146 B1 MA 51146B1
Authority
MA
Morocco
Prior art keywords
heterocyclic compounds
substituted heterocyclic
compounds used
prmt5 inhibitors
bicyclic substituted
Prior art date
Application number
MA51146A
Other languages
English (en)
Other versions
MA51146A (fr
Inventor
Venkata Palle
Rajender Kamboj
Dipak Lagad
Sanjeev Kulkarni
Prathap Nair
Ganesh Gudade
Sachin Sethi
Chetan Pawar
Mahadeo Tryambake
Chaitanya Kulkarni
Anil Hajare
Balasaheb Gore
Milind Sindkhedkar
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Priority claimed from PCT/IB2018/060015 external-priority patent/WO2019116302A1/fr
Publication of MA51146A publication Critical patent/MA51146A/fr
Publication of MA51146B1 publication Critical patent/MA51146B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés hétérocycliques bicycliques substitués de formule (i), des sels pharmaceutiquement acceptables de ceux-ci et des compositions pharmaceutiques pour le traitement de maladies, de troubles ou d'états pathologiques associés à la surexpression de l'enzyme prmt5. L'invention concerne également des méthodes de traitement de maladies, de troubles ou d'états pathologiques associés à la surexpression de l'enzyme prmt5.
MA51146A 2017-12-13 2018-12-13 Composés hétérocycliques bicycliques substitués utilisés en tant qu'inhibiteurs de prmt5 MA51146B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201721044886 2017-12-13
PCT/IB2018/060015 WO2019116302A1 (fr) 2017-12-13 2018-12-13 Composés hétérocycliques bicycliques substitués utilisés en tant qu'inhibiteurs de prmt5

Publications (2)

Publication Number Publication Date
MA51146A MA51146A (fr) 2021-03-24
MA51146B1 true MA51146B1 (fr) 2022-10-31

Family

ID=83995765

Family Applications (1)

Application Number Title Priority Date Filing Date
MA51146A MA51146B1 (fr) 2017-12-13 2018-12-13 Composés hétérocycliques bicycliques substitués utilisés en tant qu'inhibiteurs de prmt5

Country Status (1)

Country Link
MA (1) MA51146B1 (fr)

Also Published As

Publication number Publication date
MA51146A (fr) 2021-03-24

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