MA50804B1 - Nouveaux antagonistes des récepteurs de bradykinine b2 - Google Patents
Nouveaux antagonistes des récepteurs de bradykinine b2Info
- Publication number
- MA50804B1 MA50804B1 MA50804A MA50804A MA50804B1 MA 50804 B1 MA50804 B1 MA 50804B1 MA 50804 A MA50804 A MA 50804A MA 50804 A MA50804 A MA 50804A MA 50804 B1 MA50804 B1 MA 50804B1
- Authority
- MA
- Morocco
- Prior art keywords
- receptor antagonists
- compound
- bradykinin
- novel bradykinin
- novel
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne un composé de formule générale (i), qui agit en tant qu'antagoniste du récepteur b2 de la bradykinine (bk) b2 ; une composition pharmaceutique contenant un ou plusieurs composés selon l'invention ; une préparation combinée contenant au moins un composé selon l'invention et au moins un autre ingrédient pharmaceutique actif ; ainsi que des utilisations dudit ou desdits composés, y compris l'utilisation en tant que médicament.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17203675 | 2017-11-24 | ||
| PCT/EP2018/082338 WO2019101906A1 (fr) | 2017-11-24 | 2018-11-23 | Nouveaux antagonistes du récepteur b2 de la bradykinine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA50804A MA50804A (fr) | 2020-09-30 |
| MA50804B1 true MA50804B1 (fr) | 2022-05-31 |
Family
ID=60473364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA50804A MA50804B1 (fr) | 2017-11-24 | 2018-11-23 | Nouveaux antagonistes des récepteurs de bradykinine b2 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10836748B2 (fr) |
| EP (2) | EP3998259A1 (fr) |
| JP (2) | JP7164619B2 (fr) |
| KR (1) | KR102413321B1 (fr) |
| CN (1) | CN111433196B (fr) |
| AR (1) | AR113839A1 (fr) |
| AU (1) | AU2018371186B2 (fr) |
| CA (1) | CA3082948A1 (fr) |
| CY (1) | CY1125348T1 (fr) |
| DK (1) | DK3713928T3 (fr) |
| EA (1) | EA202091256A1 (fr) |
| ES (1) | ES2908409T3 (fr) |
| HR (1) | HRP20220429T1 (fr) |
| HU (1) | HUE058217T2 (fr) |
| IL (1) | IL274883B2 (fr) |
| LT (1) | LT3713928T (fr) |
| MA (1) | MA50804B1 (fr) |
| MX (1) | MX2020005287A (fr) |
| PH (1) | PH12020550683A1 (fr) |
| PL (1) | PL3713928T3 (fr) |
| PT (1) | PT3713928T (fr) |
| RS (1) | RS63087B1 (fr) |
| SG (1) | SG11202004653TA (fr) |
| SI (1) | SI3713928T1 (fr) |
| SM (1) | SMT202200154T1 (fr) |
| TW (1) | TWI768156B (fr) |
| UY (1) | UY37981A (fr) |
| WO (1) | WO2019101906A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3713928T1 (sl) | 2017-11-24 | 2022-09-30 | Pharvaris Netherlands B.V. | Novi antagonisti receptorja bradikinina B2 |
| AR118982A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| AR118983A1 (es) * | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| CN116685353A (zh) * | 2020-11-12 | 2023-09-01 | 法瓦里斯有限责任公司 | 血管性水肿的预防和治疗 |
| EP4380929A1 (fr) | 2021-08-05 | 2024-06-12 | Pharvaris GmbH | Forme solide d'un antagoniste du récepteur b2 de la bradykinine |
| EP4203919B1 (fr) * | 2021-08-05 | 2024-01-31 | Pharvaris GmbH | Composition à base de lipides pour l'administration par voie orale d'antagonistes des récepteurs b2 de la bradykinine |
| CA3250835A1 (fr) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Composition solide comprenant des antagonistes du récepteur b2 de la bradykinine solubilisés |
| US20250268887A1 (en) | 2022-03-25 | 2025-08-28 | Pharvaris Gmbh | Therapeutic uses of bradykinin b2-receptor antagonists |
| TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| KR970707098A (ko) | 1994-10-27 | 1997-12-01 | 후지야마 아키라 | 브라디키닌 길항제로서 피리도피리미돈, 퀴놀린 및 융합된 N-헤테로사이클(Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists) |
| FR2737892B1 (fr) | 1995-08-17 | 1997-10-24 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique |
| GB9602029D0 (en) | 1996-02-01 | 1996-04-03 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
| DE19609827A1 (de) | 1996-03-13 | 1997-09-18 | Hoechst Ag | Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten |
| DE19610784A1 (de) | 1996-03-19 | 1997-09-25 | Hoechst Ag | Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE19612067A1 (de) | 1996-03-27 | 1997-10-02 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen |
| AUPN952696A0 (en) | 1996-04-29 | 1996-05-23 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
| DE19712960A1 (de) | 1997-03-27 | 1998-10-01 | Hoechst Ag | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
| WO1999064039A1 (fr) | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Antagonistes de bradykinine |
| US6509468B1 (en) | 1998-10-21 | 2003-01-21 | Fujisawa Pharmaceutical Co., Ltd. | Vitreous form of known bradykinin antagonist |
| FR2790260B1 (fr) | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
| GB9913079D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| US6509366B2 (en) | 2000-01-18 | 2003-01-21 | Neurogen Corporation | Substituted imidazoles as selective modulators of Bradykinin B2 receptors |
| CA2364178C (fr) | 2000-12-05 | 2006-01-10 | Yasuhiro Katsu | N-benzenesulfonyl-l-prolines utilisees comme antagonistes de la bradykinine |
| CA2481855A1 (fr) | 2002-04-10 | 2003-10-23 | Ortho-Mcneil Pharmaceutical, Inc. | Nouveaux derives heteroarylalkylamide utiles en tant que modulateurs du recepteur de la bradykinine |
| ITMI20021247A1 (it) | 2002-06-07 | 2003-12-09 | Menarini Ricerche Spa | Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche |
| ITMI20041963A1 (it) | 2004-10-15 | 2005-01-15 | Luso Farmaco Inst | "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche" |
| EP1741444A1 (fr) | 2005-07-05 | 2007-01-10 | Jerini AG | Antagonistes de kinine pour traiter le dysfonctionnement de la vessie |
| TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽ｂ２受體調節劑 |
| AR073304A1 (es) * | 2008-09-22 | 2010-10-28 | Jerini Ag | Moduladores del receptor de bradiquinina b2 de molecula pequena |
| AU2014244592A1 (en) | 2013-03-14 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Methods of treating B2-bradykinin receptor mediated angioedema |
| SI3713928T1 (sl) | 2017-11-24 | 2022-09-30 | Pharvaris Netherlands B.V. | Novi antagonisti receptorja bradikinina B2 |
-
2018
- 2018-11-23 SI SI201830628T patent/SI3713928T1/sl unknown
- 2018-11-23 SG SG11202004653TA patent/SG11202004653TA/en unknown
- 2018-11-23 EP EP21213719.4A patent/EP3998259A1/fr active Pending
- 2018-11-23 RS RS20220335A patent/RS63087B1/sr unknown
- 2018-11-23 WO PCT/EP2018/082338 patent/WO2019101906A1/fr not_active Ceased
- 2018-11-23 KR KR1020207017972A patent/KR102413321B1/ko active Active
- 2018-11-23 HU HUE18818992A patent/HUE058217T2/hu unknown
- 2018-11-23 CA CA3082948A patent/CA3082948A1/fr active Pending
- 2018-11-23 JP JP2020545875A patent/JP7164619B2/ja active Active
- 2018-11-23 MX MX2020005287A patent/MX2020005287A/es unknown
- 2018-11-23 IL IL274883A patent/IL274883B2/en unknown
- 2018-11-23 AR ARP180103444A patent/AR113839A1/es unknown
- 2018-11-23 DK DK18818992.2T patent/DK3713928T3/da active
- 2018-11-23 EP EP18818992.2A patent/EP3713928B1/fr active Active
- 2018-11-23 LT LTEPPCT/EP2018/082338T patent/LT3713928T/lt unknown
- 2018-11-23 HR HRP20220429TT patent/HRP20220429T1/hr unknown
- 2018-11-23 CN CN201880076162.XA patent/CN111433196B/zh active Active
- 2018-11-23 PL PL18818992T patent/PL3713928T3/pl unknown
- 2018-11-23 UY UY0001037981A patent/UY37981A/es active IP Right Grant
- 2018-11-23 AU AU2018371186A patent/AU2018371186B2/en active Active
- 2018-11-23 MA MA50804A patent/MA50804B1/fr unknown
- 2018-11-23 SM SM20220154T patent/SMT202200154T1/it unknown
- 2018-11-23 TW TW107141872A patent/TWI768156B/zh active
- 2018-11-23 ES ES18818992T patent/ES2908409T3/es active Active
- 2018-11-23 EA EA202091256A patent/EA202091256A1/ru unknown
- 2018-11-23 PT PT188189922T patent/PT3713928T/pt unknown
-
2020
- 2020-04-28 US US16/861,131 patent/US10836748B2/en active Active
- 2020-05-21 PH PH12020550683A patent/PH12020550683A1/en unknown
- 2020-09-25 US US17/033,347 patent/US11261173B2/en active Active
-
2022
- 2022-01-18 US US17/578,161 patent/US11820756B2/en active Active
- 2022-04-11 CY CY20221100272T patent/CY1125348T1/el unknown
- 2022-10-20 JP JP2022168473A patent/JP2023002701A/ja active Pending
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