MA50438B1 - Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci - Google Patents
Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ciInfo
- Publication number
- MA50438B1 MA50438B1 MA50438A MA50438A MA50438B1 MA 50438 B1 MA50438 B1 MA 50438B1 MA 50438 A MA50438 A MA 50438A MA 50438 A MA50438 A MA 50438A MA 50438 B1 MA50438 B1 MA 50438B1
- Authority
- MA
- Morocco
- Prior art keywords
- prodrugs
- triazol
- carboxamide
- trifluoro
- chlorophenyl
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- OSVUKJSOVIXPMR-ZDUSSCGKSA-N 5-[[3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-1,2,4-triazol-1-yl]methyl]-2-(3-chloropyridin-2-yl)-1,2,4-triazole-3-carboxamide Chemical compound ClC1=CC=C(C=C1)C1=NN(C(N1C[C@@H](C(F)(F)F)O)=O)CC1=NN(C(=N1)C(=O)N)C1=NC=CC=C1Cl OSVUKJSOVIXPMR-ZDUSSCGKSA-N 0.000 abstract 1
- YPJGHBRCKDZNEG-HNNXBMFYSA-N 5-[[3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-1,2,4-triazol-1-yl]methyl]-2-[2-(trifluoromethyl)phenyl]-1,2,4-triazole-3-carboxamide Chemical compound NC(=O)C1=NC(CN2N=C(N(C[C@H](O)C(F)(F)F)C2=O)C2=CC=C(Cl)C=C2)=NN1C1=C(C=CC=C1)C(F)(F)F YPJGHBRCKDZNEG-HNNXBMFYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000027032 Renal vascular disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000015670 renal artery disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des promédicaments de 3-({3-(4-chlorophényl)-5-oxo-4-[(2s)-3,3,3-trifluoro- 2-hydroxypropyl] -4,5-dihydro- 1h-1,2,4-triazol-1-yl jméthyl)-1- [3-(trifluorométhyl)-pyridin-2-yl] - 1h-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophényl)-5-oxo-4-[(2s)-3,3,3-trifluoro-2- hydroxypropyl] -4,5-dihydro- 1h-1,2,4-triazol-1-yl} méthyl)-1- [2-(trifluorométhyl)-phényl] -1h- 1,2,4-triazole-5-carboxamide et 3-({3-(4-chlorophényl)-5-oxo-4-[(2s)-3,3,3-trifluoro-2- hydroxypropyl] -4,5-dihydro-1h-1,2,4-triazol-1-yl} méthyl)-1-(3-chloropyridin-2-yl)-1h-1,2,4- triazole-5-carboxamide, des procédés pour la préparation de tels composés, des compositions pharmaceutiques contenant de tels composés, et l'utilisation de tels composés ou compositions pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de maladies rénales et cardiovasculaires.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17197935 | 2017-10-24 | ||
| PCT/EP2018/078364 WO2019081292A1 (fr) | 2017-10-24 | 2018-10-17 | Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA50438A MA50438A (fr) | 2020-09-02 |
| MA50438B1 true MA50438B1 (fr) | 2022-03-31 |
Family
ID=60162099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA50438A MA50438B1 (fr) | 2017-10-24 | 2018-10-17 | Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US11298367B2 (fr) |
| EP (1) | EP3700913B1 (fr) |
| JP (1) | JP2021500365A (fr) |
| KR (1) | KR20200069361A (fr) |
| CN (1) | CN111225921A (fr) |
| AR (1) | AR113791A1 (fr) |
| AU (1) | AU2018356352A1 (fr) |
| BR (1) | BR112020007983A2 (fr) |
| CA (1) | CA3079767A1 (fr) |
| CL (1) | CL2020001076A1 (fr) |
| CO (1) | CO2020004945A2 (fr) |
| CR (1) | CR20200176A (fr) |
| CU (1) | CU24604B1 (fr) |
| CY (1) | CY1124938T1 (fr) |
| DK (1) | DK3700913T3 (fr) |
| DO (1) | DOP2020000076A (fr) |
| EA (1) | EA202091025A1 (fr) |
| EC (1) | ECSP20023056A (fr) |
| ES (1) | ES2906305T3 (fr) |
| HR (1) | HRP20220060T1 (fr) |
| HU (1) | HUE057278T2 (fr) |
| IL (1) | IL273949A (fr) |
| JO (1) | JOP20200099A1 (fr) |
| LT (1) | LT3700913T (fr) |
| MA (1) | MA50438B1 (fr) |
| MX (1) | MX2020004191A (fr) |
| NI (1) | NI202000030A (fr) |
| PE (1) | PE20210394A1 (fr) |
| PH (1) | PH12020550473A1 (fr) |
| PL (1) | PL3700913T3 (fr) |
| PT (1) | PT3700913T (fr) |
| RS (1) | RS62984B1 (fr) |
| SG (1) | SG11202003049WA (fr) |
| SI (1) | SI3700913T1 (fr) |
| TW (1) | TW201932117A (fr) |
| UA (1) | UA126456C2 (fr) |
| UY (1) | UY37948A (fr) |
| WO (1) | WO2019081292A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021259852A1 (fr) | 2020-06-25 | 2021-12-30 | Bayer Aktiengesellschaft | Procédé de préparation de dérivés de 5-(alcoxycarbonyle)-et de 5- (carboxamide)-1-aryl-1,2,4-triazole |
| WO2022112213A1 (fr) | 2020-11-30 | 2022-06-02 | Bayer Aktiengesellschaft | Formes cristallines de 3-[[3-(4-chlorophényl)-5-oxo-4-((2s)-3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1h-1,2,4-triazol-1-yl]méthyl]-1-[3- (trifluorométhyl)pyridin-2-yl]-1h-1,2,4-triazole-5-carboxamide |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| WO2005063754A1 (fr) | 2003-12-22 | 2005-07-14 | Pfizer Limited | Derives de triazole utiles comme antagonistes de la vasopressine |
| EP1742932A1 (fr) | 2004-04-28 | 2007-01-17 | Pfizer Limited | Derives 3-heterocyclyl-4-phenyl-triazole comme inhibiteurs de la vasopressine par recepteur |
| CL2008003301A1 (es) * | 2007-11-06 | 2009-10-16 | Astrazeneca Ab | Compuestos derivados de 3,4-dihidropirazina-2-carboxamida, inhibidores de la elastasa de neutrofilos humanos; composiciones farmacéuticas; procesos de preparación de compuestos y composición farmacéutica; y uso en el tratamiento de síndrome de dificultad respiratoria de los adultos, fibrosis quística, cáncer, entre otras. |
| DE102010001064A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| AR076542A1 (es) * | 2009-05-22 | 2011-06-22 | Merck Sharp & Dohme | Antagonistas del receptor de orexina de isonicotinamida |
| US9187466B2 (en) | 2010-02-27 | 2015-11-17 | Bayer Intellectual Property Gmbh | Bisaryl-bonded aryltriazolones and use thereof |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| JP6114189B2 (ja) | 2010-07-09 | 2017-04-12 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 縮合ピリミジンおよびトリアジンならびに心血管障害の処置および／または予防のためのその使用 |
| DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| DE102010043379A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung |
| EP2675440B1 (fr) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Inhibiteurs de cystéine protéases, les cathepsines |
| AR098031A1 (es) * | 2013-10-16 | 2016-04-27 | Bayer Cropscience Ag | Combinaciones de compuestos activos que comprenden un derivado de (tio)carboxamida y un compuesto fungicida |
| BR112017009204A2 (pt) | 2014-11-03 | 2018-07-03 | Bayer Pharma Aktiengesellschaft | Derivados de feniltriazol hidroxialquil- substituído e usos dos mesmos |
| UY36571A (es) * | 2015-03-05 | 2016-09-30 | Bayer Cropscience Ag | Combinaciones de compuestos activos |
| US20190119251A1 (en) | 2016-05-03 | 2019-04-25 | Bayer Pharma Aktiengesellschaft | Amide-substituted aryltriazole derivatives and uses thereof |
| EP3452457B1 (fr) | 2016-05-03 | 2020-03-18 | Bayer Pharma Aktiengesellschaft | Dérivés de phényltriazole à substitution oxoalkyle et utilisations associées |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| WO2017191107A1 (fr) * | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | Dérivés de phényltriazole substitués par amides et utilisations associées |
| WO2017191114A1 (fr) | 2016-05-03 | 2017-11-09 | Bayer Aktiengesellschaft | Dérivés d'hétéroaryltriazole substitués par hydroxyalkyle et utilisations associées |
| WO2017191112A1 (fr) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | Dérivés d'aryltriazole à substitution fluoroalkyle et utilisations desdits dérivés |
| EP3529244A1 (fr) | 2016-10-20 | 2019-08-28 | Bayer Pharma Aktiengesellschaft | Dérivés de triazole substitués par hydroxyalkyle et utilisations associées |
-
2018
- 2018-10-17 WO PCT/EP2018/078364 patent/WO2019081292A1/fr not_active Ceased
- 2018-10-17 HU HUE18785394A patent/HUE057278T2/hu unknown
- 2018-10-17 LT LTEPPCT/EP2018/078364T patent/LT3700913T/lt unknown
- 2018-10-17 MX MX2020004191A patent/MX2020004191A/es unknown
- 2018-10-17 DK DK18785394.0T patent/DK3700913T3/da active
- 2018-10-17 KR KR1020207014412A patent/KR20200069361A/ko not_active Withdrawn
- 2018-10-17 PL PL18785394T patent/PL3700913T3/pl unknown
- 2018-10-17 ES ES18785394T patent/ES2906305T3/es active Active
- 2018-10-17 CA CA3079767A patent/CA3079767A1/fr not_active Abandoned
- 2018-10-17 BR BR112020007983-9A patent/BR112020007983A2/pt not_active Application Discontinuation
- 2018-10-17 JO JOP/2020/0099A patent/JOP20200099A1/ar unknown
- 2018-10-17 HR HRP20220060TT patent/HRP20220060T1/hr unknown
- 2018-10-17 CU CU2020000040A patent/CU24604B1/es unknown
- 2018-10-17 RS RS20220036A patent/RS62984B1/sr unknown
- 2018-10-17 MA MA50438A patent/MA50438B1/fr unknown
- 2018-10-17 PT PT187853940T patent/PT3700913T/pt unknown
- 2018-10-17 CR CR20200176A patent/CR20200176A/es unknown
- 2018-10-17 SG SG11202003049WA patent/SG11202003049WA/en unknown
- 2018-10-17 CN CN201880068846.5A patent/CN111225921A/zh active Pending
- 2018-10-17 EA EA202091025A patent/EA202091025A1/ru unknown
- 2018-10-17 US US16/758,742 patent/US11298367B2/en active Active
- 2018-10-17 SI SI201830540T patent/SI3700913T1/sl unknown
- 2018-10-17 PE PE2020000813A patent/PE20210394A1/es unknown
- 2018-10-17 UA UAA202003139A patent/UA126456C2/uk unknown
- 2018-10-17 EP EP18785394.0A patent/EP3700913B1/fr active Active
- 2018-10-17 AU AU2018356352A patent/AU2018356352A1/en not_active Abandoned
- 2018-10-17 JP JP2020522855A patent/JP2021500365A/ja active Pending
- 2018-10-22 TW TW107137148A patent/TW201932117A/zh unknown
- 2018-10-24 AR ARP180103099A patent/AR113791A1/es not_active Application Discontinuation
- 2018-10-24 UY UY0001037948A patent/UY37948A/es not_active Application Discontinuation
-
2020
- 2020-04-13 IL IL273949A patent/IL273949A/en unknown
- 2020-04-21 EC ECSENADI202023056A patent/ECSP20023056A/es unknown
- 2020-04-22 CL CL2020001076A patent/CL2020001076A1/es unknown
- 2020-04-22 PH PH12020550473A patent/PH12020550473A1/en unknown
- 2020-04-22 CO CONC2020/0004945A patent/CO2020004945A2/es unknown
- 2020-04-23 NI NI202000030A patent/NI202000030A/es unknown
- 2020-05-06 DO DO2020000076A patent/DOP2020000076A/es unknown
-
2022
- 2022-02-01 CY CY20221100084T patent/CY1124938T1/el unknown
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