MA48594B1 - Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a - Google Patents
Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba aInfo
- Publication number
- MA48594B1 MA48594B1 MA48594A MA48594A MA48594B1 MA 48594 B1 MA48594 B1 MA 48594B1 MA 48594 A MA48594 A MA 48594A MA 48594 A MA48594 A MA 48594A MA 48594 B1 MA48594 B1 MA 48594B1
- Authority
- MA
- Morocco
- Prior art keywords
- alpha5
- gaba
- pam
- ether derivatives
- new
- Prior art date
Links
- LRJJZSXDNXHKQV-UHFFFAOYSA-N 3-(1,2-oxazol-3-yloxy)-1,2-oxazole Chemical class C1=CON=C1OC=1C=CON=1 LRJJZSXDNXHKQV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
L'invention porte sur de nouveaux composés répondant à la formule générale (i), dans laquelle r1, r2, r3, r4, r5, r6, x, y, et z sont tels que décrits dans la description. L'invention porte également sur des compositions comprenant ces composés et sur leurs procédés d'utilisation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16202889 | 2016-12-08 | ||
| PCT/EP2017/081768 WO2018104419A1 (fr) | 2016-12-08 | 2017-12-07 | Nouveaux dérivés d'éther isoxazolyle en tant que gaba a alpha5 pam |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA48594A MA48594A (fr) | 2021-04-28 |
| MA48594B1 true MA48594B1 (fr) | 2022-05-31 |
Family
ID=57530563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA48594A MA48594B1 (fr) | 2016-12-08 | 2017-12-07 | Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US11091471B2 (fr) |
| EP (1) | EP3551627B1 (fr) |
| JP (1) | JP7084405B2 (fr) |
| KR (1) | KR102564643B1 (fr) |
| CN (2) | CN117285525A (fr) |
| AR (1) | AR110498A1 (fr) |
| AU (1) | AU2017373734B2 (fr) |
| BR (1) | BR112019006571A2 (fr) |
| CA (1) | CA3040024A1 (fr) |
| CL (1) | CL2019001458A1 (fr) |
| CO (1) | CO2019002692A2 (fr) |
| CR (1) | CR20190268A (fr) |
| DK (1) | DK3551627T3 (fr) |
| ES (1) | ES2910110T3 (fr) |
| HR (1) | HRP20220468T1 (fr) |
| HU (1) | HUE058355T2 (fr) |
| IL (1) | IL267054B (fr) |
| LT (1) | LT3551627T (fr) |
| MA (1) | MA48594B1 (fr) |
| MX (1) | MX388725B (fr) |
| MY (1) | MY200641A (fr) |
| PE (1) | PE20191156A1 (fr) |
| PH (1) | PH12019500664B1 (fr) |
| PL (1) | PL3551627T3 (fr) |
| PT (1) | PT3551627T (fr) |
| RS (1) | RS63106B1 (fr) |
| SI (1) | SI3551627T1 (fr) |
| TW (1) | TWI642666B (fr) |
| UA (1) | UA125524C2 (fr) |
| WO (1) | WO2018104419A1 (fr) |
| ZA (1) | ZA201902225B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20220468T1 (hr) | 2016-12-08 | 2022-05-27 | F. Hoffmann - La Roche Ag | Novi derivati izoksazolil etera kao gaba a alpha5 pam |
| WO2019238633A1 (fr) | 2018-06-13 | 2019-12-19 | F. Hoffmann-La Roche Ag | Nouveaux dérivés d'isoxazolyle éther en tant que gaba a alpha5 pam |
| BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
| HU231223B1 (hu) * | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| TWI901650B (zh) * | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| US20240043418A1 (en) * | 2020-03-26 | 2024-02-08 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| KR20240005848A (ko) | 2021-05-05 | 2024-01-12 | 유니버시티 칼리지 카디프 컨설턴츠 리미티드 | 인지 장애의 치료에 유용한 헤테로아릴 화합물 |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
| CN119343344A (zh) | 2022-06-20 | 2025-01-21 | 豪夫迈·罗氏有限公司 | 6-((5-甲基-3-(6-甲基吡啶-3-基)异噁唑-4-基)甲氧基)-n-(四氢吡喃-4-基)哒嗪-3-甲酰胺的结晶形式 |
| KR20250092192A (ko) | 2022-10-25 | 2025-06-23 | 에프. 호프만-라 로슈 아게 | 알로가바트 제조 방법 |
| WO2024223450A1 (fr) | 2023-04-24 | 2024-10-31 | F. Hoffmann-La Roche Ag | Comprimé comprenant du 6-((5-méthyl-3-(6-méthylpyridin-3-yl)isoxazol-4-yl)méthoxy)-n-(tétrahydrapyran-4-yl)pyridazine-3-carboxamide |
| WO2024251133A1 (fr) * | 2023-06-05 | 2024-12-12 | 武汉人福创新药物研发中心有限公司 | COMPOSÉ HÉTÉROCYCLIQUE EN TANT QUE MODULATEUR DU RÉCEPTEUR α5-GABAA ET SON UTILISATION |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100015648A (ko) | 2007-04-18 | 2010-02-12 | 아스트라제네카 아베 | 양성 알로스테릭 ｇａｂａｂ 수용체 조절제 효과를 갖는 크산틴 화합물 |
| AU2008333326B2 (en) | 2007-12-04 | 2013-05-30 | F. Hoffmann-La Roche Ag | Isoxazolo-pyridine derivatives |
| US7943619B2 (en) * | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| AU2010244553A1 (en) | 2009-05-05 | 2011-12-01 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives |
| KR20130083927A (ko) | 2010-11-05 | 2013-07-23 | 에프. 호프만-라 로슈 아게 | 중추 신경계 질환의 치료를 위한 활성 약학 화합물의 용도 |
| LT2755963T (lt) * | 2011-09-15 | 2020-01-27 | F. Hoffmann-La Roche Ag | Nauji dihidrochinolin-2-ono dariniai |
| CN107922409A (zh) | 2015-08-17 | 2018-04-17 | 鲁宾有限公司 | 作为parp抑制剂的杂芳基衍生物 |
| HUE063388T2 (hu) | 2016-01-08 | 2024-01-28 | Arcus Biosciences Inc | Ekto-5'-nukleotidáz modulátorok és ezek alkalmazása |
| WO2017120422A1 (fr) | 2016-01-08 | 2017-07-13 | Celgene Corporation | Composés antiprolifératifs, leurs compositions pharmaceutiques et leurs utilisations |
| HRP20220468T1 (hr) | 2016-12-08 | 2022-05-27 | F. Hoffmann - La Roche Ag | Novi derivati izoksazolil etera kao gaba a alpha5 pam |
-
2017
- 2017-12-07 HR HRP20220468TT patent/HRP20220468T1/hr unknown
- 2017-12-07 KR KR1020197016011A patent/KR102564643B1/ko active Active
- 2017-12-07 AR ARP170103429A patent/AR110498A1/es active IP Right Grant
- 2017-12-07 PT PT178166302T patent/PT3551627T/pt unknown
- 2017-12-07 CN CN202311216893.9A patent/CN117285525A/zh active Pending
- 2017-12-07 MY MYPI2019001529A patent/MY200641A/en unknown
- 2017-12-07 TW TW106142872A patent/TWI642666B/zh active
- 2017-12-07 MA MA48594A patent/MA48594B1/fr unknown
- 2017-12-07 PE PE2019001006A patent/PE20191156A1/es unknown
- 2017-12-07 RS RS20220321A patent/RS63106B1/sr unknown
- 2017-12-07 CN CN201780069758.2A patent/CN109923113B/zh active Active
- 2017-12-07 HU HUE17816630A patent/HUE058355T2/hu unknown
- 2017-12-07 BR BR112019006571-7A patent/BR112019006571A2/pt active Search and Examination
- 2017-12-07 ES ES17816630T patent/ES2910110T3/es active Active
- 2017-12-07 DK DK17816630.2T patent/DK3551627T3/da active
- 2017-12-07 PL PL17816630T patent/PL3551627T3/pl unknown
- 2017-12-07 AU AU2017373734A patent/AU2017373734B2/en active Active
- 2017-12-07 EP EP17816630.2A patent/EP3551627B1/fr active Active
- 2017-12-07 LT LTEPPCT/EP2017/081768T patent/LT3551627T/lt unknown
- 2017-12-07 MX MX2019006696A patent/MX388725B/es unknown
- 2017-12-07 CR CR20190268A patent/CR20190268A/es unknown
- 2017-12-07 UA UAA201907047A patent/UA125524C2/uk unknown
- 2017-12-07 PH PH1/2019/500664A patent/PH12019500664B1/en unknown
- 2017-12-07 WO PCT/EP2017/081768 patent/WO2018104419A1/fr not_active Ceased
- 2017-12-07 SI SI201731124T patent/SI3551627T1/sl unknown
- 2017-12-07 JP JP2019530755A patent/JP7084405B2/ja active Active
- 2017-12-07 CA CA3040024A patent/CA3040024A1/fr active Pending
-
2019
- 2019-03-26 CO CONC2019/0002692A patent/CO2019002692A2/es unknown
- 2019-04-09 ZA ZA2019/02225A patent/ZA201902225B/en unknown
- 2019-05-29 CL CL2019001458A patent/CL2019001458A1/es unknown
- 2019-06-03 IL IL267054A patent/IL267054B/en unknown
- 2019-06-05 US US16/432,584 patent/US11091471B2/en active Active
-
2021
- 2021-07-16 US US17/378,410 patent/US20220411415A1/en not_active Abandoned
-
2024
- 2024-02-28 US US18/590,606 patent/US20240279218A1/en active Pending
Also Published As
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