[go: up one dir, main page]

MA45517B1 - Molécules de liaison inhibant la croissance de cancer - Google Patents

Molécules de liaison inhibant la croissance de cancer

Info

Publication number
MA45517B1
MA45517B1 MA45517A MA45517A MA45517B1 MA 45517 B1 MA45517 B1 MA 45517B1 MA 45517 A MA45517 A MA 45517A MA 45517 A MA45517 A MA 45517A MA 45517 B1 MA45517 B1 MA 45517B1
Authority
MA
Morocco
Prior art keywords
binding molecules
growth inhibitor
cancer growth
membrane
inhibitor binding
Prior art date
Application number
MA45517A
Other languages
English (en)
Other versions
MA45517A (fr
Inventor
Mark Throsby
Ton Logtenberg
Johannes Carolus Clevers
Robert Gerhardus Jacob Vries
Eduard Batlle
Bram Herpers
Original Assignee
Merus Nv
Koninklijke Nederlandse Akademie Van Wetenschappen
Ocello B V
Inst Catalana Recerca Estudis Avancats
Fundacio Inst De Recerca Biomedica Irb Barcelona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus Nv, Koninklijke Nederlandse Akademie Van Wetenschappen, Ocello B V, Inst Catalana Recerca Estudis Avancats, Fundacio Inst De Recerca Biomedica Irb Barcelona filed Critical Merus Nv
Publication of MA45517A publication Critical patent/MA45517A/fr
Publication of MA45517B1 publication Critical patent/MA45517B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des moyens et des procédés pour inhiber la croissance d'un cancer. Les moyens, dans certains modes de réalisation, comprennent des protéines et des anticorps qui se lient à une partie extracellulaire d'un membre de la famille du récepteur du facteur de croissance épidermique (egf) associé à la membrane et à une partie extracellulaire d'un élément d'une voie de signalisation wnt associé à la membrane. L'invention concerne en outre diverses cellules et tests qui sont utiles pour produire des protéines, des anticorps et des cellules.
MA45517A 2015-10-23 2016-10-21 Molécules de liaison inhibant la croissance de cancer MA45517B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15191343 2015-10-23
EP16168647 2016-05-06
PCT/NL2016/050726 WO2017069628A2 (fr) 2015-10-23 2016-10-21 Molécules de liaison inhibant la croissance de cancer

Publications (2)

Publication Number Publication Date
MA45517A MA45517A (fr) 2018-08-29
MA45517B1 true MA45517B1 (fr) 2021-04-30

Family

ID=57190021

Family Applications (2)

Application Number Title Priority Date Filing Date
MA45517A MA45517B1 (fr) 2015-10-23 2016-10-21 Molécules de liaison inhibant la croissance de cancer
MA054760A MA54760A (fr) 2015-10-23 2016-10-21 Molécules de liaison qui inhibent la croissance d'un cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA054760A MA54760A (fr) 2015-10-23 2016-10-21 Molécules de liaison qui inhibent la croissance d'un cancer

Country Status (26)

Country Link
US (2) US11939394B2 (fr)
EP (2) EP3365373B1 (fr)
JP (3) JP7296728B2 (fr)
KR (2) KR102877714B1 (fr)
CN (2) CN115925944A (fr)
AU (2) AU2016340764B2 (fr)
BR (1) BR112018008068A2 (fr)
CA (1) CA3002957A1 (fr)
CY (1) CY1124108T1 (fr)
DK (1) DK3365373T3 (fr)
EA (1) EA201890866A1 (fr)
ES (1) ES2865482T3 (fr)
HR (1) HRP20210483T1 (fr)
HU (1) HUE055222T2 (fr)
LT (1) LT3365373T (fr)
MA (2) MA45517B1 (fr)
MD (1) MD3365373T2 (fr)
MX (2) MX389547B (fr)
NZ (1) NZ742290A (fr)
PL (1) PL3365373T3 (fr)
RS (1) RS61800B1 (fr)
SG (1) SG11201803359VA (fr)
SI (1) SI3365373T1 (fr)
SM (1) SMT202100230T1 (fr)
WO (1) WO2017069628A2 (fr)
ZA (1) ZA201802758B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2941030C (fr) 2014-02-28 2025-05-13 Merus N.V. Anticorps qui se lient à l'egfr et à l'erbb3
CA2944649C (fr) * 2014-04-04 2022-06-21 Bionomics, Inc. Anticorps humanises qui se lient a lgr5
EP3365373B1 (fr) * 2015-10-23 2021-03-10 Merus N.V. Molécules de liaison inhibant la croissance de cancer
KR20180138205A (ko) 2016-03-22 2018-12-28 바이오노믹스 리미티드 항-lgr5 단클론성 항체의 투여
AU2018207440B2 (en) * 2017-01-11 2022-06-02 The Board Of Trustees Of The Leland Stanford Junior University R-spondin (RSPO) surrogate molecules
CA3050133A1 (fr) * 2017-01-26 2018-08-02 Surrozen, Inc. Molecules d'amelioration de signal wnt specifiques au tissu et leurs utilisations
EP3600411A1 (fr) * 2017-03-31 2020-02-05 Merus N.V. Anticorps pour le traitement de tumeurs positives erbb-2/erbb-3
KR102905513B1 (ko) 2017-03-31 2026-01-02 메뤼스 엔.페. NRG1 융합 유전자를 가지는 세포를 치료하기 위한 ErbB-2 및 ErbB-3 결합 이중특이적 항체
JP7296891B2 (ja) 2017-05-17 2023-06-23 メルス ナムローゼ フェンノートシャップ 乳癌のためのＥｒｂＢ－２／ＥｒｂＢ－３二重特異性抗体と内分泌療法との組み合わせ
IL271832B2 (en) * 2017-07-06 2025-07-01 Merus Nv Bispecific anti pd1-anti tim3 antibodies and uses thereof
CA3068933A1 (fr) * 2017-07-06 2019-01-10 Merus N.V. Anticorps qui modulent une activite biologique exprimee par une cellule
FI3665198T3 (fi) 2017-08-09 2025-04-25 Merus Nv EGFR:ää ja cMET:tä sitovia vasta-aineita
KR20200139189A (ko) * 2018-03-30 2020-12-11 메뤼스 엔.페. 다가 항체
WO2020014271A1 (fr) * 2018-07-09 2020-01-16 Surrozen, Inc. Molécules d'amélioration de signaux wnt spécifiques au tissu et leurs utilisations
AU2019416324A1 (en) * 2018-12-27 2021-07-22 H. Lee Moffitt Cancer Center And Research Institute Inc. Bispecific antibody for membrane clearance of target receptors
BR112021013009A2 (pt) * 2018-12-31 2021-09-14 Merus N.V. Domínios de ligação mistos
US20220380440A1 (en) 2018-12-31 2022-12-01 Merus N.V. Truncated multivalent multimers
CA3130248A1 (fr) * 2019-02-14 2020-08-20 Merus N.V. Combinaisons de fractions de liaison se liant a egfr, her2 et her3
CN114426578B (zh) * 2019-02-14 2025-03-21 美勒斯公司 结合egfr、her2及her3的结合部分的组合
PH12021552030A1 (en) 2019-02-26 2022-08-15 Janssen Biotech Inc Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies
TW202509079A (zh) * 2019-04-04 2025-03-01 日商小野藥品工業股份有限公司 雙特異性抗體
WO2020230091A1 (fr) 2019-05-14 2020-11-19 Janssen Biotech, Inc. Polythérapies avec des anticorps anti-egfr/c-met bispécifiques et des inhibiteurs de tyrosine kinase egfr de troisième génération
MX2022002096A (es) 2019-08-19 2022-03-17 Merus Nv Tratamiento del cancer con una combinacion de un anticuerpo que se une al receptor 5 acoplado a la proteina g que contiene repeticiones ricas en leucina (lgr5) y al receptor del factor de crecimiento epidermico (egfr) y un inhibidor de topoisomerasa i.
CA3159745A1 (fr) * 2019-11-01 2021-05-06 The Regents Of The University Of California Degradation de proteines de surface a l'aide d'un agent de liaison bispecifique
JOP20220184A1 (ar) 2020-02-12 2023-01-30 Janssen Biotech Inc علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14
JP2023517010A (ja) * 2020-03-05 2023-04-21 ユーエムセー・ユトレヒト・ホールディング・ベー・フェー タンパク質分解を標的とする膜ユビキチンリガーゼ
KR20230005281A (ko) * 2020-04-24 2023-01-09 메뤼스 엔.페. Lgr5 및 egfr에 결합하는 항체를 사용하는 암의 치료
EP4168442A1 (fr) * 2020-06-18 2023-04-26 UMC Utrecht Holding B.V. Procédé de criblage pour des combinaisons efficaces de ligase e3 cible
CN113862326B (zh) * 2020-09-08 2024-07-05 复旦大学 KREMEN1和/或ASGR1作为药物靶点在治疗SARS-CoV-2感染中的应用
JP7714992B2 (ja) * 2020-10-02 2025-07-30 小野薬品工業株式会社 二重特異性抗体を有効成分として含む医薬組成物
KR20230109668A (ko) 2020-11-16 2023-07-20 서로젠 오퍼레이팅, 인크. 간-특이적 Wnt 신호 증강 분자 및 그의 용도
TW202237656A (zh) * 2020-12-15 2022-10-01 荷蘭商美勒斯公司 利用結合ｌｇｒ５與ｅｇｆｒ之抗體治療癌症
WO2022131918A1 (fr) 2020-12-18 2022-06-23 Merus N.V. Composition d'anticorps
CN114853889B (zh) * 2021-02-03 2024-03-01 中国科学院动物研究所 针对人gpr48的单克隆抗体及其应用
CA3211727A1 (fr) * 2021-03-31 2022-10-06 Merus N.V. Nouveaux domaines de liaison a pd-1
CN113307882B (zh) * 2021-05-12 2022-12-20 东北大学 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物
CN118055949A (zh) 2021-10-06 2024-05-17 美勒斯公司 使用至少结合egfr的抗体治疗免疫检查点抑制剂治疗的具高egfr表达的癌症
WO2024136658A1 (fr) 2022-12-23 2024-06-27 Merus N.V. Traitement combiné de cancers à l'aide d'un anticorps qui se lie au moins à egfr et à un inhibiteur de point de contrôle immunitaire
IL321816A (en) 2022-12-28 2025-08-01 Merus Nv Treatment of cancer with a combination of an antibody that binds egfr and cytotoxic drugs
CN116082510B (zh) * 2023-03-07 2023-12-05 四川尚锐生物医药有限公司 一种单克隆抗体或其抗原结合片段及其抗肿瘤的用途

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4801687A (en) 1986-10-27 1989-01-31 Bioprobe International, Inc. Monoclonal antibody purification process using protein A
NZ226694A (en) 1987-10-28 1994-04-27 Oncogen Human immunoglobulin produced by recombinant dna techniques
US5151504A (en) 1989-11-17 1992-09-29 E. R. Squibb & Sons, Inc. Method for purification of monoclonal antibodies
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
JP3502093B2 (ja) 1991-07-15 2004-03-02 ザ・ウエルカム・ファウンデーション・リミテッド 抗体の製造
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
DE29706518U1 (de) 1997-04-11 1997-05-22 E. Missel GmbH & Co., 70374 Stuttgart Trägersystem für Bade-, Dusch- oder Whirlwannen
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
JP4213224B2 (ja) 1997-05-02 2009-01-21 ジェネンテック，インコーポレーテッド ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
SI1161548T2 (sl) 1999-04-15 2010-02-26 Crucell Holland Bv Priprava rekombinantnega proteina v humani celici z uporabo sekvenc, ki kodirajo adenovirusni E1 protein
DE29915950U1 (de) 1999-09-10 1999-12-30 CMW Automation GmbH, 65594 Runkel Vorrichtung zum Elektrolytbefüllen der Zellen eines Akkumulators
US20070111201A1 (en) 2001-04-30 2007-05-17 Benjamin Doranz Reverse transfection of cell arrays for structural and functional analyses of proteins
EP1600510B1 (fr) 2001-07-04 2007-03-28 Chromagenics B.V. Séquences d'ADN avec une activité Anti-repressor
US7332580B2 (en) 2002-04-05 2008-02-19 The Regents Of The University Of California Bispecific single chain Fv antibody molecules and methods of use thereof
WO2003107218A1 (fr) 2002-05-31 2003-12-24 セレスター・レキシコ・サイエンシズ株式会社 Dispositif de prediction d'interactions
CN100480260C (zh) 2002-07-18 2009-04-22 克鲁塞尔荷兰公司 抗体混合物的重组生产
MXPA05006724A (es) 2003-01-07 2005-09-08 Symphogen As Metodo para producir proteinas policlonales recombinantes.
NZ543635A (en) 2003-06-25 2008-05-30 Crucell Holland Bv Human C-type lectin: a suitable target molecule for binding molecules, particularly immunoconjugates, in the diagnosis, prevention and/or treatment of myeloid neoplastic diseases such as AML and CML
SG10201606980VA (en) 2004-06-03 2016-10-28 Novimmune Sa Anti-cd3 antibodies and methods of use thereof
JP2008511337A (ja) 2004-09-02 2008-04-17 ジェネンテック・インコーポレーテッド ヘテロ多量体分子
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
JP2008531557A (ja) 2005-02-23 2008-08-14 メリマック ファーマシューティカルズ インコーポレーティッド 生物活性を調節するための二重特異性結合剤
US20060212956A1 (en) 2005-03-14 2006-09-21 Genentech, Inc. Animal model of ligand activated HER2 expressing tumors
CN101198698B (zh) 2005-03-31 2014-03-19 中外制药株式会社 通过调节多肽缔合制备多肽的方法
DK1999154T3 (da) 2006-03-24 2012-12-03 Merck Patent Gmbh Fremstillede heterodimere proteindomæner
EP2035456A1 (fr) 2006-06-22 2009-03-18 Novo Nordisk A/S Production d'anticorps bispécifiques
PL2059533T3 (pl) 2006-08-30 2013-04-30 Genentech Inc Przeciwciała wieloswoiste
US8290739B2 (en) 2006-10-20 2012-10-16 Amfit, Inc. Method for determining relative mobility of regions of an object
EP2091975A4 (fr) 2006-11-21 2013-05-22 Univ California Anticorps de la famille anti-egfr, anticorps de la famille anti-egfr bispécifiques et leurs procédés d'utilisation
ES2631727T3 (es) 2007-02-16 2017-09-04 Merrimack Pharmaceuticals, Inc. Anticuerpos contra el ErbB3 y usos de los mismos
WO2008119353A1 (fr) 2007-03-29 2008-10-09 Genmab A/S Anticorps bispécifiques et procédés de production de ceux-ci
EP2155788B1 (fr) 2007-04-03 2012-06-27 Micromet AG Éléments de liaison bispécifiques spécifiques d'espèces croisées
US7705103B2 (en) 2007-06-22 2010-04-27 3M Innovative Properties Company Polydiorganosiloxane polyoxamide copolymers
EP3424529A1 (fr) 2007-07-02 2019-01-09 Oncomed Pharmaceuticals, Inc. Compositions et procédés de traitement et de diagnostic du cancer
EP2211903A4 (fr) 2007-10-17 2011-07-06 Nuvelo Inc Anticorps anti-cll-1
WO2009086197A1 (fr) 2007-12-20 2009-07-09 Monogram Biosciences, Inc. Procédés de diagnostic du her-2
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
AU2009204501B2 (en) 2008-01-07 2015-02-12 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
CA2715043C (fr) 2008-02-05 2021-02-16 Zymeworks Inc. Procedes de determination de residus correles dans une proteine ou autre biopolymere mettant en oeuvre la dynamique moleculaire
CA2729095C (fr) 2008-06-27 2018-12-04 Merus B.V. Methode de production d'un mammifere murin transgenique
US8663640B2 (en) 2008-08-29 2014-03-04 Symphogen A/S Methods using recombinant anti-epidermal growth factor receptor antibody compositions
JP5677972B2 (ja) 2008-11-18 2015-02-25 メリマック ファーマシューティカルズ インコーポレーティッド ヒト血清アルブミンリンカーおよびそのコンジュゲート
EP2387711B1 (fr) 2009-01-15 2015-04-22 Laboratory Corporation of America Holdings Procédés permettant de déterminer la réponse d'un patient par mesure de her-3
EP2389392A1 (fr) 2009-01-26 2011-11-30 Genmab A/S Procédés pour produire des mélanges d'anticorps
AU2010226453B2 (en) 2009-03-20 2013-11-21 Genentech, Inc. Bispecific anti-HER antibodies
WO2010129304A2 (fr) 2009-04-27 2010-11-11 Oncomed Pharmaceuticals, Inc. Procédé de fabrication de molécules hétéromultimères
MY164121A (en) 2009-06-26 2017-11-30 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
SG178509A1 (en) 2009-08-21 2012-04-27 Merrimack Pharmaceuticals Inc Antibodies against the ectodomain of erbb3 and uses thereof
WO2011028952A1 (fr) 2009-09-02 2011-03-10 Xencor, Inc. Compositions et procédés pour une co-liaison bivalente et monovalente simultanée d'antigènes
WO2011056124A1 (fr) 2009-11-04 2011-05-12 Affibody Ab Polypeptides de liaison de her3
US20130185821A1 (en) 2010-02-08 2013-07-18 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
PL2501817T5 (pl) 2010-02-08 2021-08-16 Regeneron Pharmaceuticals, Inc. Mysz o wspólnym łańcuchu lekkim
JP6022444B2 (ja) 2010-05-14 2016-11-09 ライナット ニューロサイエンス コーポレイション ヘテロ二量体タンパク質ならびにそれを生産および精製するための方法
ES2537207T3 (es) 2010-08-16 2015-06-03 Novimmune S.A. Métodos para la generación de anticuerpos multiespecíficos y multivalentes
BR112013004012B1 (pt) 2010-08-20 2021-03-23 Novartis Ag Anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo ao receptor her3, seu uso e composição farmacêutica
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
US9155802B2 (en) 2010-11-01 2015-10-13 Symphogen A/S Pan-HER antibody composition
HUE047228T2 (hu) 2010-11-05 2020-04-28 Zymeworks Inc Stabil heterodimer antitest-kialakítás az FC doménben mutációval
US20140056898A1 (en) 2011-02-24 2014-02-27 Bo Zhang Combination therapies comprising anti-erbb3 agents
MX2013010444A (es) 2011-03-15 2014-03-21 Merrimack Pharmaceuticals Inc Superar la resistencia a inhibidores de la via erbb.
KR20200052383A (ko) 2011-03-25 2020-05-14 아이크노스 사이언스 에스. 아. 헤테로 이량체 면역글로불린
GB201106395D0 (en) * 2011-04-14 2011-06-01 Hubrecht Inst Compounds
PL2707391T3 (pl) 2011-05-13 2018-04-30 Gamamabs Pharma Przeciwciała przeciwko her3
AU2012274461A1 (en) 2011-06-20 2014-01-16 Kyowa Hakko Kirin Co., Ltd. Anti-erbB3 antibody
CN106167526A (zh) * 2011-07-15 2016-11-30 昂考梅德药品有限公司 Rspo结合剂和其应用
US9567827B2 (en) 2013-07-15 2017-02-14 Downhole Technology, Llc Downhole tool and method of use
CA2791109C (fr) 2011-09-26 2021-02-16 Merus B.V. Generation de molecules de liaison
MX357391B (es) 2011-09-30 2018-07-06 Regeneron Pharma Anticuerpos anti-erbb3 y usos de los mismos.
ES2745684T3 (es) 2011-11-23 2020-03-03 Medimmune Llc Moléculas de unión específicas para HER3 y usos de las mismas
UY34488A (es) 2011-12-05 2013-07-31 Novartis Ag Anticuerpos dirigidos al receptor de factor de crecimiento epidérmico 3 (her3) dirigidos contra el dominio iii y dominio iv del her3
WO2013084147A2 (fr) 2011-12-05 2013-06-13 Novartis Ag Anticorps dirigés contre le récepteur 3 du facteur de croissance épidermique (her3)
CN102448183A (zh) 2012-01-18 2012-05-09 大唐移动通信设备有限公司 一种Uu接口重配置方法及设备
WO2013134686A1 (fr) 2012-03-09 2013-09-12 Promega Corporation Détecteurs de ph
AU2013240261A1 (en) 2012-03-27 2014-09-18 Genentech, Inc. Diagnosis and treatments relating to HER3 inhibitors
AR090549A1 (es) 2012-03-30 2014-11-19 Genentech Inc Anticuerpos anti-lgr5 e inmunoconjugados
WO2013157953A1 (fr) 2012-04-20 2013-10-24 Merus B.V. Procédés et moyens de production de molécules de type ig
TW201843172A (zh) 2012-06-25 2018-12-16 美商再生元醫藥公司 抗－ｅｇｆｒ抗體及其用途
PT2900694T (pt) 2012-09-27 2018-11-13 Merus Nv Anticorpos de igg biespecíficos como ativadores de células t
US10093740B2 (en) 2012-10-15 2018-10-09 Universitat Zurich Bispecific HER2 ligands for cancer therapy
ES2700231T3 (es) * 2012-11-21 2019-02-14 Janssen Biotech Inc Anticuerpos de EGFR/c-Met biespecíficos
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US20160319034A1 (en) * 2013-03-14 2016-11-03 Oncomed Pharmaceuticals, Inc. Met-binding agents and uses thereof
JP6402173B2 (ja) 2013-04-05 2018-10-10 ラボラトリー コーポレイション オブ アメリカ ホールディングス Ｈｅｒ３の検出に基づく癌の診断、予後予測、および処置を容易にするためのシステムおよび方法
WO2014182970A1 (fr) 2013-05-08 2014-11-13 Zymeworks Inc. Constructions de liaison aux antigènes her2 et her3 bispécifiques
US9879081B2 (en) 2013-06-25 2018-01-30 Samsung Electronics Co., Ltd. Protein complex, bispecific antibody including the protein complex, and method of preparation thereof
US9551208B2 (en) 2013-08-26 2017-01-24 Halliburton Energy Services, Inc. Identifying uncertainty associated with a stimulated reservoir volume (SRV) calculation
WO2015066543A1 (fr) 2013-11-01 2015-05-07 Board Of Regents, The University Of Texas System Ciblage de her2 et her3 avec des anticorps bispécifiques dans des cellules cancéreuses
HRP20240939T1 (hr) * 2013-12-17 2024-10-25 Genentech, Inc. Anti-cd3 protutijela i metode uporabe
ES3006007T3 (en) 2014-02-28 2025-03-17 Merus Nv Antibody that binds erbb-2 and erbb-3
CA2941030C (fr) 2014-02-28 2025-05-13 Merus N.V. Anticorps qui se lient à l'egfr et à l'erbb3
AU2015229591B2 (en) * 2014-03-11 2020-10-22 Regeneron Pharmaceuticals, Inc. Anti-EGFRvlll antibodies and uses thereof
CA2944649C (fr) 2014-04-04 2022-06-21 Bionomics, Inc. Anticorps humanises qui se lient a lgr5
MA41123A (fr) 2014-12-02 2017-10-10 Oncomed Pharm Inc Polythérapie pour le traitement du cancer
US10383945B2 (en) * 2015-02-18 2019-08-20 The United States of America as Represented by the Department of Verterans Affairs Methods for DNA-dependent targeting of a cell permeant antibody
EA201890028A1 (ru) 2015-07-10 2018-08-31 Мерус Н.В. Антитело, связывающее cd3 человека
EP3365373B1 (fr) * 2015-10-23 2021-03-10 Merus N.V. Molécules de liaison inhibant la croissance de cancer
WO2017109706A1 (fr) * 2015-12-22 2017-06-29 Novartis Ag Méthodes de traitement ou d'amélioration de troubles métaboliques à l'aide du facteur-15 de croissance et de différenciation (gdf-15)
EP3600411A1 (fr) 2017-03-31 2020-02-05 Merus N.V. Anticorps pour le traitement de tumeurs positives erbb-2/erbb-3
KR102905513B1 (ko) 2017-03-31 2026-01-02 메뤼스 엔.페. NRG1 융합 유전자를 가지는 세포를 치료하기 위한 ErbB-2 및 ErbB-3 결합 이중특이적 항체
JP7296891B2 (ja) 2017-05-17 2023-06-23 メルス ナムローゼ フェンノートシャップ 乳癌のためのＥｒｂＢ－２／ＥｒｂＢ－３二重特異性抗体と内分泌療法との組み合わせ
FI3665198T3 (fi) 2017-08-09 2025-04-25 Merus Nv EGFR:ää ja cMET:tä sitovia vasta-aineita
WO2020140084A1 (fr) * 2018-12-27 2020-07-02 Gigagen, Inc. Protéines de liaison anti-ctla-4 et méthodes d'utilisation de celles-ci

Also Published As

Publication number Publication date
MA45517A (fr) 2018-08-29
ES2865482T3 (es) 2021-10-15
EA201890866A1 (ru) 2018-09-28
MX2022000302A (es) 2022-02-03
WO2017069628A9 (fr) 2017-10-26
CN108602888B (zh) 2022-10-04
EP3365373A2 (fr) 2018-08-29
JP2023008754A (ja) 2023-01-19
BR112018008068A2 (en) 2018-11-13
ZA201802758B (en) 2020-08-26
SG11201803359VA (en) 2018-05-30
HRP20210483T1 (hr) 2021-07-09
NZ759325A (en) 2025-05-30
DK3365373T3 (da) 2021-04-06
CN108602888A (zh) 2018-09-28
CN115925944A (zh) 2023-04-07
AU2023222928A1 (en) 2023-09-21
JP7296728B2 (ja) 2023-06-23
NZ742290A (en) 2019-11-29
WO2017069628A2 (fr) 2017-04-27
JP2019500405A (ja) 2019-01-10
HUE055222T2 (hu) 2021-11-29
PL3365373T3 (pl) 2021-08-23
MX2018004988A (es) 2018-11-09
RS61800B1 (sr) 2021-06-30
WO2017069628A3 (fr) 2017-09-08
KR20250157457A (ko) 2025-11-04
EP3912998A3 (fr) 2022-02-23
HK1253914A1 (en) 2019-07-05
KR20180100305A (ko) 2018-09-10
CY1124108T1 (el) 2022-05-27
MA54760A (fr) 2022-04-13
MX389547B (es) 2025-03-20
US20180312604A1 (en) 2018-11-01
CA3002957A1 (fr) 2017-04-27
KR102877714B1 (ko) 2025-10-29
EP3912998A2 (fr) 2021-11-24
AU2016340764B2 (en) 2023-06-01
JP2024023445A (ja) 2024-02-21
SMT202100230T1 (it) 2021-07-12
LT3365373T (lt) 2021-05-25
US11939394B2 (en) 2024-03-26
SI3365373T1 (sl) 2021-08-31
EP3365373B1 (fr) 2021-03-10
US20240343824A1 (en) 2024-10-17
MD3365373T2 (ro) 2021-08-31
AU2016340764A1 (en) 2018-05-17

Similar Documents

Publication Publication Date Title
MA45517B1 (fr) Molécules de liaison inhibant la croissance de cancer
CU20120095A7 (es) Antagonistas de pcsk9
NI200900081U (es) Anticuerpos agonistas de trkb y sus usos.
MA42530B1 (fr) Constructions d'anticorps bispécifiques se liant à dll3 et à cd3
CR20160206A (es) Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento C5
EA201170030A1 (ru) Il-6-опосредованная иммунотерапия
ECSP099027A (es) Anticuerpos anti-dll4 y métodos que los usan
PA8807601A1 (es) Moleculas de union al receptor ox40 humano
CR11691A (es) Anticuerpos monoclonales contra la proteína rgm a y sus usos
EA201891066A1 (ru) Антитела к ror1
CR20150088A (es) Anticuerpos anti-notch1 nrr
MA43028B1 (fr) Anticorps bispécifiques pour pd1 et tim3
MA38498B1 (fr) Protéines de liaison anti-lag-3
CL2012003245A1 (es) Proteína de unión a antígeno aislada que se une a linfopoyetina estromal tímica (tslp); composición que comprende una proteína de unión a antígeno que une tslp correspondiente a un anticuerpo humano anti-tslp.
ECSP11011417A (es) Anticuerpos anti-fgfr3 y métodos que los utilizan
MX2010004726A (es) Antigeno asociado con artritis reumatoide.
CO6721041A2 (es) Anticuerpo anti-pcsk9 y métodos de uso
CR10069A (es) Anticuerpos anti-ox40l y métodos que los utilizan referencia cruzada con solicitudes relacionadas
NO20083397L (no) Anti-EphB4-antistoffer og fremgangsmater for anvendelse av disse
AR073140A1 (es) Anticuerpos anti-il-23r disenados
DE602007012836D1 (de) Cd86- und cd80-rezeptorkonkurrenztests
DE602005015559D1 (de) Pharmakodynamische tests mit durchflusszytometrie
PH12021553121A1 (en) Novel cthrc1-specific antibody and use thereof
MX2021004684A (es) Anticuerpos especificos para apoj glucosilada y usos de los mismos.
MA42186A1 (fr) Protéines de liaison d'antigène qui activent le récepteur de la leptine