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MA42294B1 - Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers - Google Patents

Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers

Info

Publication number
MA42294B1
MA42294B1 MA42294A MA42294A MA42294B1 MA 42294 B1 MA42294 B1 MA 42294B1 MA 42294 A MA42294 A MA 42294A MA 42294 A MA42294 A MA 42294A MA 42294 B1 MA42294 B1 MA 42294B1
Authority
MA
Morocco
Prior art keywords
peptides
combination
cells
present
cancers
Prior art date
Application number
MA42294A
Other languages
English (en)
Other versions
MA42294A (fr
Inventor
Toni Weinschenk
Jens Fritsche
Andrea Mahr
Harpreet Singh
Oliver Schoor
Helen Hörzer
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1511546.2A external-priority patent/GB201511546D0/en
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MA42294A publication Critical patent/MA42294A/fr
Publication of MA42294B1 publication Critical patent/MA42294B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

La présente invention concerne des peptides, des protéines, des acides nucléiques et des cellules destinés à être utilisés dans des procédés immunothérapeutiques. La présente invention concerne en particulier l'immunothérapie du cancer. La présente invention porte en outre sur des épitopes peptidiques tumoraux de cellules t, seuls ou combinés à d'autres peptides tumoraux, qui peuvent par exemple servir en tant que principes actifs pharmaceutiques de compositions de vaccin qui stimulent des réponses immunitaires antitumorales, ou sur la stimulation ex vivo des cellules t et leur transfert aux patients. Des peptides liés aux molécules du complexe majeur d'histocompatibilité (cmh), ou des peptides tels quels, peuvent également être des cibles d'anticorps, des récepteurs de cellules t solubles, et d'autres molécules de liaison.
MA42294A 2015-07-01 2016-06-29 Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers MA42294B1 (fr)

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US201562187507P 2015-07-01 2015-07-01
GBGB1511546.2A GB201511546D0 (en) 2015-07-01 2015-07-01 Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
PCT/EP2016/065166 WO2017001491A2 (fr) 2015-07-01 2016-06-29 Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers

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MA42294B1 true MA42294B1 (fr) 2020-11-30

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MA42294A MA42294B1 (fr) 2015-07-01 2016-06-29 Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1258386A1 (zh) 2015-10-05 2019-11-08 Immatics Biotechnologies Gmbh 用於小细胞肺癌和其他癌症免疫治疗的肽和肽组合物
GB201521746D0 (en) 2015-12-10 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers
GB201604490D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
EP3727467A4 (fr) * 2017-12-22 2021-12-01 Centivax, Inc. Compositions du complexe majeur d'histocompatibilité (cmh) et procédés d'utilisation correspondants
CN110531077B (zh) * 2018-05-25 2023-07-07 荣昌生物制药(烟台)股份有限公司 间皮素免疫组化检测试剂盒
CN110835623B (zh) * 2018-08-15 2022-08-30 复旦大学附属肿瘤医院 一种原发性铂耐药的人卵巢癌细胞系fdovl、其制备方法和应用
CN109633156B (zh) * 2018-12-19 2022-02-22 湖南中南大学湘雅口腔医院 生物标志物在评估口腔鳞癌危险程度中的应用
CN109856400B (zh) * 2019-01-22 2022-02-01 上海交通大学医学院附属仁济医院 神经酰胺c24作为生物标记物在诊断胆囊癌中的用途
CN110018316B (zh) * 2019-04-16 2022-04-05 福建师范大学 Ddx20在制备肾透明细胞癌术后预后评估试剂盒中的应用
CN110412273B (zh) * 2019-06-26 2022-09-09 四川大学华西医院 Caap1自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
CN112409449B (zh) * 2019-08-19 2023-12-15 辽宁中健医药科技有限公司 Hla-a0201限定性kif15特异性抗肿瘤ctl优势表位肽及应用
GB201915598D0 (en) * 2019-10-28 2019-12-11 Univ Bradford Methods for determining the invasive and/or metastic potential of a tumour
WO2021119554A1 (fr) * 2019-12-12 2021-06-17 Kumquat Biosciences Inc. Compositions et procédés pour potentialiser l'activité immunitaire
CN113105528B (zh) * 2020-01-13 2023-12-08 辽宁中健医药科技有限公司 一条肿瘤相关抗原ctl表位肽及其应用
US20230201166A1 (en) * 2020-03-18 2023-06-29 Dana-Farber Cancer Institute, Inc. Methods for treating cancer by inhibiting carm1
CN112595849B (zh) * 2020-06-01 2023-05-26 郑州大学第一附属医院 用于早期食管癌筛查的血清学检测标志物及其应用
WO2022009052A2 (fr) 2020-07-06 2022-01-13 Janssen Biotech, Inc. Néo-antigènes prostatiques et leurs utilisations
CN112216388A (zh) * 2020-09-29 2021-01-12 北京大学第三医院（北京大学第三临床医学院） 一种子宫内膜异位症相关卵巢癌的风险预测模型和风险预测系统
CN112691195B (zh) * 2021-02-02 2023-03-14 黑龙江省科学院高技术研究院 Prpf8表达抑制剂在制备治疗肺癌的药物中的应用
CN113041342A (zh) * 2021-03-24 2021-06-29 深圳先进技术研究院 一种纳米人工抗原呈递细胞及其制备方法和应用
CN113209313B (zh) * 2021-06-25 2025-08-26 华中科技大学同济医学院附属同济医院 Tgfbr2在制备卵巢功能保护药物方面中的应用
CN116144765A (zh) * 2021-11-19 2023-05-23 中国医学科学院药物研究所 生物标志物plxnc1在结直肠癌诊断、治疗和预后预测中的应用
CN114592006A (zh) * 2022-04-29 2022-06-07 昆明理工大学 Memo1基因的新用途
CN114875030A (zh) * 2022-06-06 2022-08-09 中国水产科学研究院黑龙江水产研究所 虹鳟ccne1基因的dsRNA及其应用
CN114751961B (zh) * 2022-06-14 2022-09-20 中山大学孙逸仙纪念医院 circ0005199-173aa蛋白及其在制备食管癌诊断产品中的应用
CN117805381B (zh) * 2024-02-29 2024-05-28 首都医科大学附属北京积水潭医院 检测Gasdermin蛋白家族的物质在制备检测骨肉瘤的产品中的应用
CN119318708B (zh) * 2024-10-15 2025-10-10 中国科学技术大学 Eya3作为靶点在宫颈癌治疗中的应用
CN120966999B (zh) * 2025-10-22 2026-01-09 宁波大学 Klhl14基因在制备结肠癌、5-fu耐受结肠癌诊断试剂中的应用

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440859A (en) 1977-05-27 1984-04-03 The Regents Of The University Of California Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
LU88258I2 (fr) 1978-12-22 1994-02-03
US4530901A (en) 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4678751A (en) 1981-09-25 1987-07-07 Genentech, Inc. Hybrid human leukocyte interferons
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4582800A (en) 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4677063A (en) 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4810648A (en) 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
US4897445A (en) 1986-06-27 1990-01-30 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
DK0703925T3 (da) 1993-06-03 1999-12-06 Therapeutic Antibodies Inc Fremstilling af antistoffragmenter
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
ES2203782T3 (es) 1996-01-17 2004-04-16 Imperial College Innovations Limited Inmunoterapia que utiliza linfocitos t citotoxicos (ctl).
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6858710B2 (en) 1998-12-17 2005-02-22 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US20020119158A1 (en) 1998-12-17 2002-08-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
WO2001047944A2 (fr) 1999-12-28 2001-07-05 Curagen Corporation Acides nucleiques contenant des polymorphismes mononucleotidiques et procedes d'utilisation correspondants
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
JP2004503213A (ja) 2000-03-27 2004-02-05 テクニオン　リサーチ　アンド　ディベロップメント　ファウンデーション　リミテッド １本鎖クラスｉ主要組織適合性複合体、それをコードする構築物およびそれを生成する方法
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
CN101712721A (zh) 2000-06-05 2010-05-26 阿尔托生物科学有限公司 T细胞受体融合物及共轭物以及其使用方法
WO2003020884A2 (fr) 2001-08-14 2003-03-13 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Procede de generation rapide de cellules dentritique matures
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
US20030223994A1 (en) 2002-02-20 2003-12-04 Hoogenboom Henricus Renerus Jacobus Mattheus MHC-peptide complex binding ligands
DE10225144A1 (de) 2002-05-29 2003-12-18 Immatics Biotechnologies Gmbh An MHC-Moleküle bindende Tumor-assoziierte Peptide
US20070073047A1 (en) 2002-06-10 2007-03-29 Biogen Idec Ma Inc. Genes overexpressed by ovarian cancer and their use in developing novel therapeutics
CA2491017A1 (fr) 2002-07-03 2004-01-15 Immunogen, Inc. Anticorps contre muc1 et muc16 non liberees et leurs utilisations
CA2501870C (fr) 2002-10-09 2013-07-02 Avidex Limited Recepteurs de lymphocytes t de recombinaison a chaine unique
WO2004044004A2 (fr) 2002-11-09 2004-05-27 Avidex Limited Presentation de recepteurs pour l'antigene des lymphocytes t
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
US7348007B2 (en) 2004-02-09 2008-03-25 Ludwig Institute For Cancer Research Mage C2 antigenic peptides and uses thereof
DE102004026135A1 (de) 2004-05-25 2006-01-05 Immatics Biotechnologies Gmbh An MHC-Moleküle bindende Tumor-assoziierte Peptide
AU2005282489A1 (en) * 2004-09-08 2006-03-16 Cornell Research Foundation, Inc. Cancer-testis antigens
US8404803B2 (en) 2005-03-31 2013-03-26 Chugai Seiyaku Kabushiki Kaisha Cancer-associated antigen analogue peptides and uses thereof
JP4962687B2 (ja) 2005-08-30 2012-06-27 Ｎｏｋ株式会社 密封構造
SI1760089T1 (sl) 2005-09-05 2009-12-31 Immatics Biotechnologies Gmbh S tumorjem povezani peptidi, ki se veĹľejo na molekule humanega levkocitnega antigena (HLA) razreda I ali II in ustrezno cepivo proti raku
EP1806359B1 (fr) 2005-09-05 2010-03-17 Immatics Biotechnologies GmbH Peptides associeés a des tumeurs et se liantes a des différentes antigènes d'histocompatibilité (HLA) de classe II
CA2655933C (fr) 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Sequences de polynucleotides et de polypeptides impliquees dans le cancer
WO2008127285A2 (fr) * 2006-10-05 2008-10-23 The Board Of Trustees Of The University Of Arkansas Peptides cibles pour immunothérapie du cancer des ovaires
AU2007350900A1 (en) 2007-04-05 2008-10-16 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring and treatment of ovarian cancer
MX2010001086A (es) 2007-07-27 2010-04-09 Immatics Biotechnologies Gmbh Nueva inmunoterapia contra tumores neuronales y cerebrales.
EA018456B1 (ru) 2007-07-27 2013-08-30 Имматикс Байотекнолоджиз Гмбх Новые иммуногенные эпитопы для иммунотерапии
UA103882C2 (uk) 2007-07-27 2013-12-10 Імматікс Біотекнолоджіс Гмбх Композиція пухлино-асоційованих пептидів та відповідна протиракова вакцина
CA2705486C (fr) 2007-11-19 2019-04-02 Celera Corporation Marqueurs de cancer du poumon et leurs utilisations
US20090263574A1 (en) 2008-04-21 2009-10-22 Quinn Daniel E Method of restoring an article
SI2119726T2 (en) * 2008-05-14 2018-03-30 Immatics Biotechnologies Gmbh New and powerful Class II MHC peptides derived from survivin and neurocane
EP3093351B1 (fr) * 2008-07-09 2018-04-18 Celera Corporation Polymorphismes génétiques associés à des maladies cardiovasculaires, procédés de détection et utilisations associées
US20100029748A1 (en) 2008-08-04 2010-02-04 Sloan-Kettering Institute For Cancer Research Metastasis Promoting Genes and Proteins
PT2172211E (pt) 2008-10-01 2015-03-09 Immatics Biotechnologies Gmbh Composição de peptídeos associados a tumores e vacina anti -cancro relacionada para o tratamento de glioblastoma (gbm) e outros tipos de câncer
WO2010088688A2 (fr) 2009-02-02 2010-08-05 Biotheranostics, Inc. Diagnostic de cancer du sein in situ et invasif
US20120053080A1 (en) 2009-03-09 2012-03-01 Juan Cui Protein markers identification for gastric cancer diagnosis
GB201004551D0 (en) 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
WO2013040142A2 (fr) 2011-09-16 2013-03-21 Iogenetics, Llc Procédés bio-informatiques de détermination de liaisons peptidiques
PT2552959T (pt) 2010-03-26 2017-04-21 Memorial Sloan Kettering Cancer Center Anticorpos para muc16 e métodos de utilização dos mesmos
GB201006360D0 (en) 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
EP2569626B1 (fr) 2010-05-11 2019-11-27 Veracyte, Inc. Méthodes et compositions utilisées dans le cadre du diagnostic de maladies
GB201009222D0 (en) 2010-06-02 2010-07-21 Immatics Biotechnologies Gmbh Improved cancer therapy based on tumour associated antigens derived from cyclin D1
CN102372773B (zh) 2010-08-11 2013-06-05 中国科学院生物物理研究所 人膀胱癌肿瘤标志物及其抗体和应用
EP2632955A1 (fr) 2010-10-26 2013-09-04 Technion Research & Development Foundation Ltd. Anticorps qui se lient à des ligands de récepteurs de lymphocytes t solubles
BR112013031019A2 (pt) 2011-06-02 2017-03-21 Almac Diagnostics Ltd teste diagnóstico molecular para câncer
US20140228233A1 (en) 2011-06-07 2014-08-14 Traci Pawlowski Circulating biomarkers for cancer
WO2013057586A1 (fr) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions et procédés de production de récepteurs solubles des lymphocytes t
JP6368243B2 (ja) 2011-11-11 2018-08-08 フレッド ハッチンソン キャンサー リサーチ センター がんのためのサイクリンａ１に標的化されたｔ細胞免疫療法
GB201201511D0 (en) * 2012-01-30 2012-03-14 Univ Leuven Kath Modified epitopes for boosting CD4+ T-cell responses
US9688991B2 (en) 2012-07-13 2017-06-27 Albert Einstein College Of Medicine, Inc. Aptamer-targetted antigen delivery
US20150226744A1 (en) 2012-09-17 2015-08-13 Ait Austrian Institute Of Technology Gmbh Colon Cancer Diagnostic Method and Means
EP2917388B1 (fr) 2012-11-08 2016-10-05 Roche Diagnostics GmbH Acides nucléiques codant pour des polypeptides chimériques pour criblage de banque
EP2808392A1 (fr) 2013-05-28 2014-12-03 Rheinische Friedrich-Wilhelms-Universität Bonn Aptamères et utilisation de ces aptamères dans le diagnostic et le traitement du cancer
TWI777196B (zh) 2013-08-05 2022-09-11 德商伊瑪提克斯生物科技有限公司 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（五）
JP6622222B2 (ja) 2014-05-28 2019-12-18 ノノ インコーポレイテッド Ｔａｔ−ＮＲ２Ｂ９ｃの塩化物塩
US10317402B2 (en) 2014-12-03 2019-06-11 Verik Bio, Inc. Identification, selection and use of high curative potential T cell epitopes
GB201507030D0 (en) 2015-04-24 2015-06-10 Immatics Biotechnologies Gmbh Immunotherapy against lung cancers, in particular NSCLC
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers

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US20220119470A1 (en) 2022-04-21
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