MA40224B1 - Anticorps se liant aux protofibrilles ass améliorés - Google Patents
Anticorps se liant aux protofibrilles ass améliorésInfo
- Publication number
- MA40224B1 MA40224B1 MA40224A MA40224A MA40224B1 MA 40224 B1 MA40224 B1 MA 40224B1 MA 40224 A MA40224 A MA 40224A MA 40224 A MA40224 A MA 40224A MA 40224 B1 MA40224 B1 MA 40224B1
- Authority
- MA
- Morocco
- Prior art keywords
- protofibrils
- ass
- enhanced
- antibodies binding
- antibodies
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
La présente invention concerne le peptide bêta amyloïde (aß) et, plus spécifiquement, des anticorps se liant à des protofibrilles aß et leur utilisation à des fins thérapeutiques et/ou pour le traitement prophylactique de la maladie d'alzheimer et d'autres troubles associés à l'agrégation des protéines aß. En outre, l'invention peut se rapporter au diagnostic de telles maladies, ainsi qu'au suivi de la progression de la maladie grâce à l'utilisation des anticorps de l'invention. En outre, l'invention peut se rapporter à un usage vétérinaire des anticorps de l'invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462022952P | 2014-07-10 | 2014-07-10 | |
| PCT/EP2015/065633 WO2016005466A2 (fr) | 2014-07-10 | 2015-07-08 | Anticorps se liant aux protofibrilles ass améliorés |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA40224A MA40224A (fr) | 2017-05-17 |
| MA40224B1 true MA40224B1 (fr) | 2021-05-31 |
Family
ID=53673920
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40224A MA40224B1 (fr) | 2014-07-10 | 2015-07-08 | Anticorps se liant aux protofibrilles ass améliorés |
| MA053887A MA53887A (fr) | 2014-07-10 | 2015-07-08 | Anticorps à liaison protofibrille a-bêta améliorée |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA053887A MA53887A (fr) | 2014-07-10 | 2015-07-08 | Anticorps à liaison protofibrille a-bêta améliorée |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9573994B2 (fr) |
| EP (2) | EP3865510A3 (fr) |
| JP (1) | JP6628786B2 (fr) |
| KR (2) | KR102763164B1 (fr) |
| CN (2) | CN112390881B (fr) |
| AR (1) | AR101130A1 (fr) |
| AU (1) | AU2015286707B2 (fr) |
| CA (1) | CA2951990C (fr) |
| CL (1) | CL2017000053A1 (fr) |
| CO (1) | CO2017000346A2 (fr) |
| CY (1) | CY1124563T1 (fr) |
| DK (1) | DK3166970T3 (fr) |
| ES (1) | ES2865112T3 (fr) |
| HR (1) | HRP20210680T1 (fr) |
| HU (1) | HUE053809T2 (fr) |
| IL (2) | IL282823B2 (fr) |
| JO (1) | JO3537B1 (fr) |
| LT (1) | LT3166970T (fr) |
| MA (2) | MA40224B1 (fr) |
| MX (1) | MX379241B (fr) |
| MY (1) | MY184890A (fr) |
| PE (1) | PE20170768A1 (fr) |
| PH (1) | PH12017500032B1 (fr) |
| PL (1) | PL3166970T3 (fr) |
| PT (1) | PT3166970T (fr) |
| RS (1) | RS61717B1 (fr) |
| RU (1) | RU2700104C2 (fr) |
| SG (1) | SG11201610734RA (fr) |
| SI (1) | SI3166970T1 (fr) |
| SM (1) | SMT202100263T1 (fr) |
| TW (1) | TWI678376B (fr) |
| UA (1) | UA121550C2 (fr) |
| WO (1) | WO2016005466A2 (fr) |
| ZA (1) | ZA201706272B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017013599A1 (fr) | 2015-07-21 | 2017-01-26 | Bioarctic Neuroscience Ab | Procédé de traitement d'une lésion cérébrale traumatique ciblant des peptides agrégés |
| WO2018011353A1 (fr) | 2016-07-14 | 2018-01-18 | Bioarctic Ab | Protéine d'apport du cerveau |
| SG10201913049QA (en) * | 2016-10-27 | 2020-02-27 | Eisai R&D Man Co Ltd | Composition comprising an anti-abeta protofibril antibody and a beta-secretase bace1 inhibitor for the treatment of alzheimer's disease |
| WO2019023247A1 (fr) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | Traitement du cancer par blocage de l'interaction de tim-3 et de son ligand |
| EP3762031A4 (fr) * | 2018-03-08 | 2021-12-22 | Phanes Therapeutics, Inc. | Anticorps anti-claudine 18.2 et leurs utilisations |
| CN112805031A (zh) | 2018-07-24 | 2021-05-14 | 卫材R&D管理有限公司 | 阿尔茨海默病的治疗及预防方法 |
| CN116063505B (zh) | 2019-01-30 | 2024-05-03 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| EP4157338A4 (fr) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | Méthodes de traitement de maladies inflammatoires par blocage de la galectine-3 |
| TW202216760A (zh) | 2020-07-23 | 2022-05-01 | 愛爾蘭商歐薩爾普羅席納有限公司 | 抗類澱粉β (ABETA)抗體 |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (fr) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anticorps anti-amyloïde bêta et leurs utilisations |
| US20250163135A1 (en) | 2021-07-09 | 2025-05-22 | Eisai R&D Management Co., Ltd. | Biomarkers for alzheimer's disease treatment |
| WO2023034230A1 (fr) | 2021-08-30 | 2023-03-09 | Eisai R&D Mangement Co., Ltd. | Formulations sous-cutanées d'anticorps protofibrille anti-abêta et leurs méthodes d'utilisation |
| EP4473009A1 (fr) | 2022-02-02 | 2024-12-11 | Eisai R&D Management Co., Ltd. | Méthodes de traitement utilisant le niveau de p-tau181 |
| CN114578066B (zh) * | 2022-05-07 | 2022-08-19 | 北京第一生物化学药业有限公司 | 检测β-淀粉样蛋白的产品和方法 |
| US12084492B2 (en) | 2023-01-20 | 2024-09-10 | Mabwell Therapeutics, Inc. | Anti-amyloid beta protofibril/oligomer antibodies and uses thereof |
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| US5231000A (en) | 1987-10-08 | 1993-07-27 | The Mclean Hospital | Antibodies to A4 amyloid peptide |
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| US5753624A (en) | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
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| CA2191101C (fr) | 1994-05-25 | 2001-08-07 | Ellis L. Kline | Compositions et procedes de traitement de maladies a formation de plaque |
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