[go: up one dir, main page]

MA39033A1 - Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations - Google Patents

Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations

Info

Publication number
MA39033A1
MA39033A1 MA39033A MA39033A MA39033A1 MA 39033 A1 MA39033 A1 MA 39033A1 MA 39033 A MA39033 A MA 39033A MA 39033 A MA39033 A MA 39033A MA 39033 A1 MA39033 A1 MA 39033A1
Authority
MA
Morocco
Prior art keywords
solid forms
hydroxypyridine
chlorophenyl
carbonyl
amino
Prior art date
Application number
MA39033A
Other languages
English (en)
Inventor
James Densmore Copp
Ann W Newman
Anne Luong
Original Assignee
Akebia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akebia Therapeutics Inc filed Critical Akebia Therapeutics Inc
Publication of MA39033A1 publication Critical patent/MA39033A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des formes solides comprenant de l'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2- carbonyl] amino} acétique, des compositions comprenant ces formes solides, des procédés de fabrication de ces formes solides, et leurs procédés d'utilisation dans le traitement de divers troubles et/ou maladies.
MA39033A 2013-11-15 2014-11-14 Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations MA39033A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361904803P 2013-11-15 2013-11-15
PCT/US2014/065631 WO2015073779A1 (fr) 2013-11-15 2014-11-14 Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations

Publications (1)

Publication Number Publication Date
MA39033A1 true MA39033A1 (fr) 2017-11-30

Family

ID=53058045

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39033A MA39033A1 (fr) 2013-11-15 2014-11-14 Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations

Country Status (24)

Country Link
US (7) US9701636B2 (fr)
EP (2) EP3068394A4 (fr)
JP (5) JP2016537365A (fr)
KR (2) KR102381295B1 (fr)
CN (2) CN105916502A (fr)
AR (2) AR099354A1 (fr)
AU (4) AU2014348523B2 (fr)
BR (1) BR112016011065B1 (fr)
CA (1) CA2930128A1 (fr)
CL (1) CL2016001150A1 (fr)
CR (2) CR20200220A (fr)
DO (1) DOP2016000109A (fr)
IL (2) IL245634A0 (fr)
MA (1) MA39033A1 (fr)
MX (3) MX383715B (fr)
MY (1) MY180626A (fr)
PE (1) PE20160945A1 (fr)
PH (2) PH12021551124A1 (fr)
RU (2) RU2021125455A (fr)
SA (1) SA516371129B1 (fr)
SG (2) SG10201803862UA (fr)
TW (5) TWI846166B (fr)
WO (1) WO2015073779A1 (fr)
ZA (3) ZA201603189B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3357911T (lt) 2006-06-26 2022-08-10 Akebia Therapeutics Inc. Prolilo hidroksilazės inhibitoriai ir naudojimo būdai
NO2686520T3 (fr) 2011-06-06 2018-03-17
SG11201509998WA (en) 2013-06-13 2016-01-28 Akebia Therapeutics Inc Compositions and methods for treating anemia
RU2021125455A (ru) 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения
WO2015112831A1 (fr) * 2014-01-23 2015-07-30 Akebia Therapeutics, Inc. Compositions et méthodes de traitement de maladies oculaires
BR112017015852A2 (pt) * 2015-01-23 2018-03-27 Akebia Therapeutics Inc forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1
TWI794725B (zh) 2015-04-01 2023-03-01 美商阿克比治療有限公司 用於治療貧血之組合物及方法
CN105837502A (zh) * 2016-04-05 2016-08-10 湖南欧亚生物有限公司 一种Vadadustat的合成方法
WO2018108101A1 (fr) 2016-12-13 2018-06-21 苏州科睿思制药有限公司 Nouvelles formes cristallines d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl]amino} acétique et leur procédé de préparation
WO2019028150A1 (fr) 2017-08-01 2019-02-07 Akebia Therapeutics, Inc. Compositions destinées à être utilisées dans des méthodes de traitement des hémoglobinopathies
EP3790863A1 (fr) 2018-05-09 2021-03-17 Akebia Therapeutics Inc. Procédé de préparation d'acide 2-[[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino]acétique
WO2020075199A1 (fr) 2018-10-12 2020-04-16 Mylan Laboratories Limited Formes polymorphes de vadadustat
US11970450B2 (en) 2018-11-28 2024-04-30 Sandoz Ag Multi-component crystals of an orally available HIF prolyl hydroxylase inhibitor
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
IT202000014116A1 (it) 2020-06-12 2021-12-12 Olon Spa Nuovo composto cristallino di vadadustat
CN111825606A (zh) * 2020-06-17 2020-10-27 上海希迈医药科技有限公司 一种伐度司他晶型及其制备方法
PH12022553525A1 (en) * 2020-06-19 2024-06-24 Akebia Therapeutics Inc Modulation of drug-drug interactions of vadadustat
GB202011431D0 (en) * 2020-07-23 2020-09-09 Johnson Matthey Plc Polymorphs of vadadustat and methods for preparing the polymorphs
CN114105866A (zh) * 2020-08-26 2022-03-01 广东东阳光药业有限公司 一种低氧诱导因子脯氨酰羟化酶抑制剂的晶型及其制备方法
CN114105867A (zh) * 2020-09-01 2022-03-01 广东东阳光药业有限公司 一种低氧诱导因子脯氨酰羟化酶抑制剂的晶型及其制备方法
WO2022048613A1 (fr) * 2020-09-04 2022-03-10 广东东阳光药业有限公司 Forme cristalline d'un inhibiteur de la prolyl hydroxylase du facteur inductible par l'hypoxie et son procédé de préparation
JP2024503377A (ja) 2021-01-08 2024-01-25 アケビア セラピューティクス インコーポレイテッド バダデュスタットを使用した治療方法
WO2022179967A1 (fr) 2021-02-23 2022-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Vadadustat pour le traitement de la covid-19 chez un sujet hospitalisé
WO2022187142A1 (fr) * 2021-03-01 2022-09-09 Akebia Therapeutics, Inc. Modulation d'interactions médicamenteuses du vadadustat

Family Cites Families (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894920A (en) 1971-12-21 1975-07-15 Sagami Chem Res Process for preparing alkyl-substituted 3,6-dihydro-o-dioxin derivatives
US4016287A (en) 1972-07-17 1977-04-05 Boehringer Ingelheim Gmbh Dermatological compositions containing an acylamino-carboxylic acid or an alkyl ester thereof
JPH03502535A (ja) 1988-07-25 1991-06-13 フセソユズニ　クルガンスキ　ナウチニ　ツェントル“ボススタノビテルナヤ　トラフマトロギア　イ　オルトペディア” 手の形成的復元のための伸延装置
TW219933B (fr) 1990-02-26 1994-02-01 Lilly Co Eli
US5405613A (en) 1991-12-11 1995-04-11 Creative Nutrition Canada Corp. Vitamin/mineral composition
TW352384B (en) 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
DE4219158A1 (de) 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ATE149486T1 (de) 1993-11-02 1997-03-15 Hoechst Ag Substituierte heterocyclische carbonsäureamide, ihre herstellung und ihre verwendung als arzneimittel
ATE149485T1 (de) 1993-11-02 1997-03-15 Hoechst Ag Substituierte heterocyclische carbonsäureamidester, ihre herstellung und ihre verwendung als arzneimittel
TW406076B (en) 1993-12-30 2000-09-21 Hoechst Ag Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
DE4410480A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carbonsäureesteramide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4410423A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carbonsäureamide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
IL135495A (en) 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid
JPH09221476A (ja) 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
AU5762896A (en) 1996-04-30 1997-11-19 Hoechst Aktiengesellschaft 3-alkoxypyridine-2-carboxylic acid amide esters, their preparation and the ir use as drugs
DE19620041A1 (de) 1996-05-17 1998-01-29 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE19650215A1 (de) 1996-12-04 1998-06-10 Hoechst Ag 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
US6420427B1 (en) 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
DE19746287A1 (de) 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
BR9909086A (pt) 1998-03-23 2001-09-04 Aventis Pharm Prod Inc Derivados de piperidinila e n-amidinopiperidinila
IL141423A (en) 1998-08-27 2005-09-25 Teva Pharma Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
US6500987B1 (en) 1998-11-27 2002-12-31 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs
WO2000032551A1 (fr) 1998-11-27 2000-06-08 Teva Pharmaceutical Industries Ltd. Polymorphes de chlorhydrate de sertraline
US6159379A (en) 1999-05-04 2000-12-12 Baker Hughes Incorporated Organic ammonium salts for the removal of water soluble organics in produced water
JP2001048786A (ja) 1999-08-05 2001-02-20 Yamanouchi Pharmaceut Co Ltd 三環式ヘテロアリール誘導体
SI20816A (sl) 1999-08-11 2002-08-31 Teva Pharmaceutical Industries Ltd. Polimorfi torsemid-a
SK286789B6 (sk) 1999-11-17 2009-05-07 Teva Pharmaceutical Industries Ltd. Kryštalická forma atorvastatínu vápenatého alebo jeho hydrátu, spôsob jej prípravy a farmaceutická kompozícia s jej obsahom
IL150187A0 (en) 1999-12-14 2002-12-01 Biogal Pharmaceutical Co Ltd Novel forms of pravastatin sodium
HUP0204091A3 (en) 1999-12-16 2003-05-28 Teva Pharma Processes for preparing clarithromycin polymorphs and novel polymorph iv and pharmaceutical composition containing them and their use
CZ20022000A3 (cs) 1999-12-16 2003-02-12 Teva Pharmaceuticals Industries Ltd. Způsoby přípravy a nová krystalická forma leflunomidu
IL150332A0 (en) 1999-12-21 2002-12-01 Teva Pharma Novel sertraline hydrochloride polymorphs, processes for preparing them, compositions containing them and methods of using them
CA2396079A1 (fr) 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. Formation, identification et analyse a productivites elevees de formes solides diverses
EP1280535B1 (fr) 2000-01-11 2005-02-09 Teva Pharmaceutical Industries Ltd. Procedes de preparation de formes polymorphes de clarithromycine
US6589758B1 (en) 2000-05-19 2003-07-08 Amgen Inc. Crystal of a kinase-ligand complex and methods of use
SK2242003A3 (en) 2000-07-27 2003-10-07 Teva Pharma Crystalline and pure modafinil, and process of preparing the same
US20020183553A1 (en) 2000-10-19 2002-12-05 Ben-Zion Dolitzky Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
US20020143211A1 (en) 2000-10-19 2002-10-03 Ben-Zion Dolitzky Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochlorid, processes for preparing thereof
JP2004525083A (ja) 2000-10-30 2004-08-19 テバ ファーマシューティカル インダストリーズ リミティド 塩酸オンダンセトロンの新規結晶及び溶媒和物形態並びにその製法
SK6592003A3 (en) 2000-11-03 2004-01-08 Teva Pharma Atorvastatin hemi-calcium form VII
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
DE02718948T1 (de) 2001-02-12 2004-07-08 Teva Pharmaceutical Industries Ltd. Neue kristallformen von oxcarbazepin und verfahren zu deren herstellung
US6849718B2 (en) 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
EP1379630B1 (fr) 2001-03-21 2012-09-26 Isis Innovation Limited Procedes, methodes et dispositifs concernant l'hydroxylase de l'hif
AU2002305162A1 (en) 2001-04-09 2002-10-21 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
PL374176A1 (en) 2001-08-01 2005-10-03 Biogal Gyogyszergyar Rt Process for purifying n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process
EP1436295A4 (fr) 2001-09-07 2007-07-11 Teva Pharma Formes cristallines de chlorhydrate de valacyclovir
ES2272781T5 (es) 2001-10-03 2010-04-06 Teva Pharmaceutical Industries Ltd. Preparacion de levofloxacino hemihidratado.
US6566088B1 (en) 2001-10-04 2003-05-20 Board Of Regents, The University Of Texas System Prolyl-4-hydroxylases
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
AU2002357701A1 (en) 2001-11-08 2003-05-19 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine base
HUP0501067A2 (en) 2001-11-14 2006-02-28 Teva Pharma Amorphous and crystalline forms of losartan potassium and process for their preparation
WO2003047531A2 (fr) 2001-12-04 2003-06-12 Biogal Gyogyszergyar Rt Preparation de l'orlistat et de formes cristallines de l'orlistat
EP1463823B1 (fr) 2001-12-06 2013-03-06 Fibrogen, Inc. Methodes permettant d'augmenter l'erythropoietine endogene (epo)
WO2003051362A2 (fr) 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphes d'hydrogenosulfate de clopidogrel
KR20040075857A (ko) 2001-12-28 2004-08-30 비오갈 기오기스제르갸르 알티. 결정질 및 비결정질 무피로신 칼슘의 제조 방법
WO2003059807A2 (fr) 2002-01-15 2003-07-24 Teva Pharmaceutical Industries Ltd. Corps solides cristallins de carvedilol, et leurs procedes d'elaboration
PL372303A1 (en) 2002-02-15 2005-07-11 Teva Pharmaceutical Industries Ltd. Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation, as well as novel processes for preparing atorvastatin hemi-calcium forms i, viii and ix
AU2003235435A1 (en) 2002-03-20 2003-10-08 Teva Pharmaceutical Industries Ltd. Crystalline forms of quetiapine hemifumarate
IL164153A0 (en) 2002-03-27 2005-12-18 Teval Pharmaceutical Ind Ltd Lansoprazole polymorphs and processes for preparation thereof
KR20040101447A (ko) 2002-04-11 2004-12-02 테바 파마슈티컬 인더스트리즈 리미티드 리세드로네이트 나트륨의 신규한 동질이상체 및유사동질이상체
WO2003093217A1 (fr) 2002-04-29 2003-11-13 Teva Pharmaceutical Industries Ltd. Procedes pour preparer une forme ii polymorphe d'hydrochlorure de sertraline, preparations pharmaceutiques et procedes d'administration
CA2483532A1 (fr) 2002-04-30 2003-11-13 Biogal Gyogyszergyar Rt. Nouvelles formes cristallines d'ondansetron, procedes de preparation correspondant, compositions pharmaceutiques contenant ces nouvelles formes et procedes de traitement de la nausee au moyen des ces nouvelles formes
AU2003232113A1 (en) 2002-05-10 2003-11-11 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of gatifloxacin
AU2003248657A1 (en) 2002-06-10 2003-12-22 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
CN1674902A (zh) 2002-06-14 2005-09-28 特瓦制药工业有限公司 新晶型的加替沙星
WO2004009532A1 (fr) 2002-07-18 2004-01-29 Teva Pharmaceutical Industries Ltd. Formes polymorphes de nateglinide
US7534913B2 (en) 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US20040022764A1 (en) * 2002-07-31 2004-02-05 Hanan Polansky Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease
WO2004012739A1 (fr) 2002-08-06 2004-02-12 Teva Pharmaceutical Industries Ltd. Nouvelles formes cristallines de gatifloxacine
US20040097528A1 (en) 2002-08-26 2004-05-20 Ben-Zion Dolitzky Crystalline solid famciclovir forms I, II, III and preparation thereof
US20050043329A1 (en) 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
CA2508871C (fr) 2002-11-28 2008-09-09 Teva Pharmaceutical Industries Ltd. Forme cristalline f de sel d'hemi-calcium d'astorvastatine
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
AU2003300874A1 (en) 2002-12-12 2004-07-09 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin and processes for preparation
WO2004058773A1 (fr) 2002-12-24 2004-07-15 Teva Pharmaceutical Industries Ltd. Nouvelles formes cristallines d'olanzapine, procedes pour les preparer et procede pour preparer des formes cristallines d'olanzapine connues
WO2004080961A2 (fr) 2003-03-12 2004-09-23 Teva Pharmaceutical Industries Ltd. Formes solides cristallines et amorphes de pantoprazole et procedes de preparation de ces formes
ES2232332T3 (es) 2003-03-12 2007-08-16 Teva Pharmaceutical Industries Ltd Composiciones farmaceuticas estables de desloratadina.
DE602004013405T2 (de) 2003-03-17 2009-05-07 Teva Pharmaceutical Industries Ltd. Polymorphe formen von valsartan
US7452991B2 (en) 2003-05-15 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Aztreonam β polymorph with very low residual solvent content
TW200510414A (en) 2003-06-02 2005-03-16 Teva Pharma Novel crystalline forms of valacyclovir hydrochloride
KR20060015750A (ko) 2003-06-03 2006-02-20 테바 파마슈티컬 인더스트리즈 리미티드 지프라시돈 ＨＣｌ의 다형 형태 및 그 제조 방법
DK1644336T3 (da) 2003-06-06 2011-05-09 Fibrogen Inc Nitrogenholdige heteroarylforbindelser og deres anvendelse til forøgelse af endogent erythropoietin
US7368468B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
CA2529820A1 (fr) 2003-06-18 2004-12-29 Teva Pharmaceutical Industries Ltd Formes cristallines de sodium de fluvastatine, leurs procedes de preparation, compositions les contenant et procedes d'utilisation correspondants
GB0314129D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
EP1612212A1 (fr) 2003-07-03 2006-01-04 Teva Pharmaceutical Industries Ltd Formes cristallines d'acide zoledronique et de ses sels de sodium, sel de sodium de preparation de ceux-ci
EP1601658A1 (fr) 2003-11-24 2005-12-07 Teva Pharmaceutical Industries Limited Sels d'ammonium cristallins de la rosuvastatine
TW200529850A (en) 2003-12-16 2005-09-16 Teva Pharma Methods of preparing aripiprazole crystalline forms
JP2007514000A (ja) 2003-12-16 2007-05-31 テバ ファーマシューティカル インダストリーズ リミティド テガセロッド塩基及びその塩の多形現象形
CN1934108A (zh) 2003-12-18 2007-03-21 特瓦制药工业有限公司 齐拉西酮碱的多晶型b2
MXPA06008584A (es) 2004-01-30 2007-04-16 Teva Pharma Polimorfos de acido libre de montelukast.
EP1709002A2 (fr) 2004-01-30 2006-10-11 Teva Pharmaceutical Industries Ltd. Montelukast de sodium polymorphe
CA2555294A1 (fr) 2004-02-11 2005-08-25 Marina Yu Etinger Polymorphes de candesartan cilexetil
JPWO2005108370A1 (ja) 2004-04-16 2008-03-21 味の素株式会社 ベンゼン化合物
MXPA06012281A (es) 2004-04-26 2007-07-18 Teva Pharma Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion.
KR20080086937A (ko) 2004-05-07 2008-09-26 테바 파마슈티컬 인더스트리즈 리미티드 나테글리나이드의 다형태
CN101072777A (zh) 2004-05-18 2007-11-14 特瓦制药工业有限公司 用于制备结晶固体泛昔洛韦的干燥方法
TW200609199A (en) 2004-05-20 2006-03-16 Teva Pharm Fine Chemicals Srl Levalbuterol hydrochloride polymorph b
MX2007000087A (es) 2004-06-23 2007-11-06 Teva Pharma Acido ibandronico solido y cristalino.
CA2572054A1 (fr) 2004-06-29 2006-01-12 Teva Pharmaceutical Industries Ltd. Forme cristalline iv de linezolide
MX2007000093A (es) 2004-07-01 2007-06-14 Teva Pharma Formas cristalinas de 1,24(s)-dihidroxi vitamina d2.
EP1699773A2 (fr) 2004-07-20 2006-09-13 Ceva Gyogyszergyar R Szv Nytarsasag Procede pour la preparation de mycophenolate sodique cristalline
CA2568629A1 (fr) 2004-07-22 2006-02-23 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphes du chlorhydrate d'atomoxetine
CN101027282A (zh) 2004-07-22 2007-08-29 特瓦制药工业有限公司 阿托伐他汀半钙的新晶形及其制备方法
EP1930011B1 (fr) 2004-08-23 2011-08-17 Teva Pharmaceutical Industries Ltd Forme cristalline de ibandronate de sodium
US20060154957A1 (en) 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
JP2008514641A (ja) 2004-09-28 2008-05-08 テバ ファーマシューティカル インダストリーズ リミティド 結晶形フェキソフェナジン、およびその調製方法
EP1799216A2 (fr) 2004-11-02 2007-06-27 Teva Pharmaceutical Industries Ltd Formes cristallines de tadalafil et leurs procedes de preparation
JP2008516001A (ja) 2004-11-03 2008-05-15 テバ ファーマシューティカル インダストリーズ リミティド 非晶質、および多形のフォームのテルミサルタン・ナトリウム
EP1812428A2 (fr) 2004-11-19 2007-08-01 Teva Pharmaceutical Industries Ltd Formes cristallines de zolmitriptan
WO2006060615A1 (fr) 2004-12-01 2006-06-08 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Pimecrolimus amorphe non hygroscopique pulverulent
JP2007526251A (ja) 2004-12-03 2007-09-13 テバ ファーマシューティカル インダストリーズ リミティド エゼチミベ多形体
US7462743B2 (en) 2005-01-11 2008-12-09 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of memantine hydrochloride
WO2006081515A2 (fr) 2005-01-27 2006-08-03 Teva Pharmaceutical Industries Ltd. Polymorphes d'hydrochlorure de duloxetine
WO2006084210A2 (fr) 2005-02-04 2006-08-10 Regents Of The University Of California, San Diego Composes modulant le hif et methodes d'utilisation associees
EP1866295A2 (fr) 2005-02-24 2007-12-19 Teva Pharmaceutical Industries Ltd Procedes de preparation d'intermediaire linezolid
AU2006216695A1 (en) 2005-02-24 2006-08-31 Teva Pharmaceutical Industries, Ltd. Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof
US7399871B2 (en) 2005-03-08 2008-07-15 Teva Pharmaceutical Industries Ltd. Crystal forms of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate and the preparation thereof
WO2006098834A2 (fr) 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Formes cristallines de mesylate de ziprasidone
US7417165B2 (en) 2005-04-06 2008-08-26 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
DE102005019712A1 (de) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
JP4750184B2 (ja) 2005-05-23 2011-08-17 キャドバリー アダムス ユーエスエー エルエルシー 味覚増強組成物並びに味覚増強組成物を含有する、食用菓子製品及びチューインガム製品
ES2334260T3 (es) 2005-05-23 2010-03-08 Teva Pharmaceutical Industries Ltd. Procedimientos para la preparacion de la forma i cristalina de clorhidrato de cinacalcet.
EP1904480A2 (fr) 2005-05-23 2008-04-02 Novartis Pharma AG Formes cristalline et autres de sels d'acide lactique 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one
AU2006254897A1 (en) 2005-06-06 2006-12-14 Fibrogen, Inc. Improved treatment for anemia using a HIF-alpha stabilising agent
US20070100165A1 (en) 2005-06-09 2007-05-03 Ronen Borochovitz Process for preparation of sertraline hydrochloride form I
EP1781611A1 (fr) 2005-06-09 2007-05-09 Teva Pharmaceutical Industries Ltd. Formes cristallines du carvedilol et leurs procedes de preparation
KR20080028918A (ko) 2005-06-15 2008-04-02 피브로겐, 인크. 암의 치료를 위한 화합물과 방법
KR20070062504A (ko) 2005-06-22 2007-06-15 테바 파마슈티컬 인더스트리즈 리미티드 테가세로드 말레이트의 다형태
WO2007033216A2 (fr) 2005-09-12 2007-03-22 Beth Israel Deaconess Medical Center Procedes et compositions pour le traitement et le diagnostic de maladies caracterisees par la fuite vasculaire, l'hypotension, ou un etat procoagulant
WO2007038571A2 (fr) 2005-09-26 2007-04-05 Smithkline Beecham Corporation Antagonistes de la prolyl-hydroxylase
WO2007038676A2 (fr) 2005-09-28 2007-04-05 Teva Pharmaceutical Industries Ltd. Formes polymorphiques de ladostigil tartrate
US20090176726A1 (en) 2005-10-11 2009-07-09 Fisher David E Methods for treating mitf-related disorders
SI1937642T1 (sl) 2005-10-19 2015-01-30 Teva Pharmaceutical Industries Ltd. Kristali natrijevega lakvinimoda in postopek za njihovo pripravo
EP1943256A2 (fr) 2005-10-31 2008-07-16 Teva Pharmaceutical Industries Ltd. Formes cristallines d'un sel de potassium de cefdinir
EP1828208A2 (fr) 2005-10-31 2007-09-05 Teva Pharmaceutical Industries Ltd Formes cristalline du sel de cesium de cefdinir
WO2007059307A2 (fr) 2005-11-15 2007-05-24 Teva Pharmaceutical Industries Ltd. Formes amorphes et cristallines de telithromycine
US7563930B2 (en) 2005-11-22 2009-07-21 Teva Pharmaceutical Industries Ltd Crystal forms of Cinacalcet HCI and processes for their preparation
WO2007070359A2 (fr) 2005-12-09 2007-06-21 Amgen Inc. Composes a base de quinolone presentant une activite inhibitrice de prolyle hydroxylase, et leurs compositions et utilisations
CN101370774A (zh) 2005-12-13 2009-02-18 特瓦制药工业有限公司 阿托伐他汀半钙的晶形及其制备方法
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
TW200734339A (en) 2006-01-05 2007-09-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Forms of dolasetron mesylate and processes for their preparation
CN101400690A (zh) 2006-01-09 2009-04-01 英国技术集团国际有限公司 低氧诱导因子-1调节剂和相关用途
WO2007082899A1 (fr) 2006-01-17 2007-07-26 Vib Vzw Inhibiteurs de la prolyl-hydroxylase 1 pour le traitement de la degenerescence des muscles du squelette
US20070208072A1 (en) 2006-01-18 2007-09-06 Gustavo Frenkel Maleate salt of tegaserod and crystalline forms thereof
TW200738709A (en) 2006-01-19 2007-10-16 Osi Pharm Inc Fused heterobicyclic kinase inhibitors
JP4801451B2 (ja) 2006-01-19 2011-10-26 株式会社日立ハイテクノロジーズ 走査電子顕微鏡等に用いる電子銃の制御装置及び制御方法
ITMI20060179A1 (it) 2006-02-02 2007-08-03 Abiogen Pharma Spa Procedimento per la risoluzione di miscele racemiche e complesso diastereoisomerico di un agente risolvente e di unantiomero di interesse
EP1986994A2 (fr) 2006-02-21 2008-11-05 Teva Pharmaceutical Industries Ltd Nouvelles formes cristallines d'armodafinil et leur preparation
EP1904444A2 (fr) 2006-02-27 2008-04-02 Teva Pharmaceutical Industries Ltd Nouvelles formes de fluvastatine sodique et leur préparation
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
PE20071020A1 (es) 2006-03-07 2007-12-11 Smithkline Beecham Corp Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa
US20080027223A1 (en) 2006-03-23 2008-01-31 Teva Pharmaceutical Industries Ltd. Polymorphs of eszopiclone malate
US20090176825A1 (en) 2006-05-16 2009-07-09 Fitch Duke M Prolyl hydroxylase inhibitors
US20070293575A1 (en) 2006-06-15 2007-12-20 Fibrogen, Inc. Compounds and methods for treatment of cancer-related anemia
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
LT3357911T (lt) * 2006-06-26 2022-08-10 Akebia Therapeutics Inc. Prolilo hidroksilazės inhibitoriai ir naudojimo būdai
TW200845994A (en) 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: prolyl hydroxylase inhibitors
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
WO2008130508A1 (fr) 2007-04-18 2008-10-30 Amgen Inc. Dérivés d'indanone qui inhibent la prolyle hydroxylase
AU2008241503A1 (en) 2007-04-18 2008-10-30 Merck Sharp & Dohme Corp. Novel 1,8-naphthyridine compounds
EP2150251B9 (fr) 2007-05-04 2013-02-27 Amgen, Inc Derives de la thienopyridine et de la thiazolopyridine qui inhibent l'activite prolyle hydroxylase
EP2160187B1 (fr) 2007-05-16 2013-05-22 Merck Sharp & Dohme Corp. Spiroindalones
TW200908984A (en) 2007-08-07 2009-03-01 Piramal Life Sciences Ltd Pyridyl derivatives, their preparation and use
EP2188295A4 (fr) 2007-08-10 2011-11-16 Crystalgenomics Inc Dérivés de pyridine et leurs procédés d'utilisation
WO2009039323A1 (fr) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Inhibiteurs de la prolyl hydroxylase
WO2009039321A1 (fr) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Inhibiteurs de la prolyl hydroxylase
WO2009043093A1 (fr) 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Inhibition de hif
WO2009049112A1 (fr) 2007-10-10 2009-04-16 Smithkline Beecham Corporation Inhibiteurs de la prolyl hydroxylase
CN101918444A (zh) 2007-11-08 2010-12-15 健泰科生物技术公司 抗因子b抗体及其用途
WO2009067790A1 (fr) 2007-11-26 2009-06-04 Uti Limited Partnership STIMULATION DU FACTEUR 1α INDUCTIBLE PAR L'HYPOXIE (HIF-1α) POUR LE TRAITEMENT DE LA MALADIE ASSOCIÉE À CLOSTRIDIUM DIFFICILE (MACD), POUR LA MOTILITÉ INTESTINALE ET POUR DÉTECTER UNE INFECTION
CN101983384A (zh) 2007-11-30 2011-03-02 葛兰素史密斯克莱有限责任公司 脯氨酰羟化酶抑制剂
EP2224926A4 (fr) 2007-11-30 2010-12-01 Glaxosmithkline Llc Inhibiteurs de prolyl hydroxylases
WO2009073669A1 (fr) 2007-12-03 2009-06-11 Fibrogen, Inc. Dérivés d'isoxazolopyridine destinés à être utilisés dans le traitement d'états à médiation par hif
US20100298324A1 (en) 2007-12-19 2010-11-25 Smith Kline Beecham Corporation Prolyl Hydroxylase Inhibitors
WO2009086592A1 (fr) 2008-01-04 2009-07-16 Garvan Institute Of Medical Research Procédé d'augmentation du métabolisme
US8952160B2 (en) 2008-01-11 2015-02-10 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
JP2014522410A (ja) 2011-06-06 2014-09-04 アケビア セラピューティクス インコーポレイテッド がん治療のための方法として低酸素誘導因子−２αを安定化するための、化合物および組成物
NO2686520T3 (fr) 2011-06-06 2018-03-17
CN104024227B8 (zh) * 2011-07-22 2025-07-29 北京贝美拓新药研发有限公司 抑制脯氨酸羟化酶活性的化合物的晶型及其应用
US8772895B2 (en) 2011-11-28 2014-07-08 Taiwan Semiconductor Manufacturing Company, Ltd. Dark current reduction for back side illuminated image sensor
EP2637274B1 (fr) 2012-03-05 2022-05-04 Vetco Gray Scandinavia AS Agencement de terminaison de câble électrique
SG11201509998WA (en) 2013-06-13 2016-01-28 Akebia Therapeutics Inc Compositions and methods for treating anemia
RU2021125455A (ru) * 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения
WO2015112831A1 (fr) 2014-01-23 2015-07-30 Akebia Therapeutics, Inc. Compositions et méthodes de traitement de maladies oculaires
BR112017015852A2 (pt) 2015-01-23 2018-03-27 Akebia Therapeutics Inc forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1
WO2016153996A1 (fr) 2015-03-20 2016-09-29 Akebia Therapeutics, Inc. Inhibiteurs de l'enzyme prolyl hydroxylase du facteur inductible par hypoxie enrichis en deutérium
TWI794725B (zh) 2015-04-01 2023-03-01 美商阿克比治療有限公司 用於治療貧血之組合物及方法
WO2018108101A1 (fr) 2016-12-13 2018-06-21 苏州科睿思制药有限公司 Nouvelles formes cristallines d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl]amino} acétique et leur procédé de préparation
EP3790863A1 (fr) 2018-05-09 2021-03-17 Akebia Therapeutics Inc. Procédé de préparation d'acide 2-[[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino]acétique
WO2021087144A1 (fr) 2019-10-31 2021-05-06 Akebia Therapeutics, Inc. Méthodes thérapeutiques à l'aide de vadadustat
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Also Published As

Publication number Publication date
TW202126300A (zh) 2021-07-16
JP2025011163A (ja) 2025-01-23
TW202335670A (zh) 2023-09-16
WO2015073779A1 (fr) 2015-05-21
MX383715B (es) 2025-03-14
ZA201603189B (en) 2019-11-27
BR112016011065B1 (pt) 2022-10-25
US9701636B2 (en) 2017-07-11
US11065237B2 (en) 2021-07-20
US10596158B2 (en) 2020-03-24
AR099354A1 (es) 2016-07-20
TWI846166B (zh) 2024-06-21
AU2014348523A1 (en) 2016-06-09
US20200345711A1 (en) 2020-11-05
AU2019202144A1 (en) 2019-04-18
CL2016001150A1 (es) 2016-12-09
US20190290624A1 (en) 2019-09-26
BR112016011065A8 (pt) 2020-04-22
MX2016006271A (es) 2017-05-04
CN114890943A (zh) 2022-08-12
DOP2016000109A (es) 2016-08-31
IL245634A0 (en) 2016-06-30
US20170258773A1 (en) 2017-09-14
US9987262B2 (en) 2018-06-05
KR102381295B1 (ko) 2022-03-31
NZ719970A (en) 2022-03-25
US10149842B2 (en) 2018-12-11
US11690836B2 (en) 2023-07-04
TW201946625A (zh) 2019-12-16
TW202435877A (zh) 2024-09-16
US12419877B2 (en) 2025-09-23
MX2021007268A (es) 2021-07-15
EP3068394A4 (fr) 2017-04-26
PH12016500866A1 (en) 2016-06-20
IL281648A (en) 2021-05-31
US20150141467A1 (en) 2015-05-21
AU2022259767B2 (en) 2024-08-15
SG10201803862UA (en) 2018-06-28
RU2016123382A (ru) 2017-12-20
KR20160083118A (ko) 2016-07-11
JP2022176961A (ja) 2022-11-30
AR128483A2 (es) 2024-05-15
PE20160945A1 (es) 2016-09-26
PH12021551124A1 (en) 2024-04-29
TWI788702B (zh) 2023-01-01
AU2020294308A1 (en) 2021-02-18
TWI665190B (zh) 2019-07-11
CR20200220A (es) 2020-11-18
ZA202004764B (en) 2025-10-29
NZ759132A (en) 2022-03-25
US20180280365A1 (en) 2018-10-04
CN105916502A (zh) 2016-08-31
SG10202012791TA (en) 2021-01-28
KR20220042498A (ko) 2022-04-05
CR20160222U (es) 2016-08-26
EP3068394A1 (fr) 2016-09-21
TW201605801A (zh) 2016-02-16
US20220040159A1 (en) 2022-02-10
KR102495018B1 (ko) 2023-02-06
AU2022259767A1 (en) 2022-12-01
JP2019167353A (ja) 2019-10-03
MX2021001169A (es) 2023-02-10
ZA201905255B (en) 2020-11-25
JP2016537365A (ja) 2016-12-01
AU2020294308B2 (en) 2022-08-11
AU2014348523B2 (en) 2019-01-03
TWI902264B (zh) 2025-10-21
US20240122910A1 (en) 2024-04-18
CA2930128A1 (fr) 2015-05-21
EP3578546A1 (fr) 2019-12-11
SA516371129B1 (ar) 2019-07-28
BR112016011065A2 (pt) 2017-08-08
JP2020183408A (ja) 2020-11-12
RU2021125455A (ru) 2021-10-05
AU2019202144B2 (en) 2020-10-08
MY180626A (en) 2020-12-03

Similar Documents

Publication Publication Date Title
MA39033A1 (fr) Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations
TN2019000099A1 (fr) Anticorps anti-lag-3 et compositions
WO2018229236A3 (fr) Compositions comprenant des souches bactériennes
FR3028753B1 (fr) Gel aqueux ou hydroalcoolique de phyllosilicates synthetiques a titre d'agent viscosant, matifiant et/ou homogeneisant d'application
MA32226B1 (fr) Compositions et leurs procedes de preparation et d'utilisation
HK1206362A1 (zh) 硫代氨基磷酸酯核苷酸前藥的固體形式
BR112015010663A2 (pt) formas de dosagem de ruxolitinib de liberação sustentada
MA42376B1 (fr) Dérivés d'oxopyridine substitués
MA34765B1 (fr) Antagonistes des récepteurs de l'acide lysophosphatidique et utilisations de ceux-ci
EP3463304A4 (fr) Compositions comprenant du cannabidiol et de l'acide hyaluronique pour le traitement de maladies inflammatoires des articulations
EP2536406A4 (fr) Bismuth-thiols comme antiseptiques destinés à des utilisations biomédicales, comprenant le traitement de biofilms bactériens et d'autres utilisations
FR3021970B1 (fr) Anticorps dirige contre la galectine 9 et inhibiteur de l'activite suppressive des lymphocytes t regulateurs
BR112015016315A2 (pt) fluoro-[1,3]oxazinas como inibidores de bace1
MA38349A1 (fr) Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)
MA47356B1 (fr) Dérivés d'isochromène utiles en tant qu'inhibiteurs des phosphoinositide 3-kinases
MA38060A1 (fr) Imidazo[1,2-a]pyridincarboxamides amino-substitués et leur utilisation
EP2968470A4 (fr) Protéines de substance d'inhibition mullerienne (mis) modifiées et leurs utilisations pour le traitement de maladies
MA38925A1 (fr) Dérivés de phénylalanine substitués
CA3010708A1 (fr) Procedes d'administration d'hepcidine
MA38369B1 (fr) Peptides et compositions pour le traitement d'une lesion de l'articulation
BR112015022849A2 (pt) sais de adição de base de nitroxolina e usos dos mesmos
EP3758716A4 (fr) Formulations pour le traitement du reflux acide comprenant de l'alginate de sodium
MA39447B1 (fr) Pirlindole ou ses sels pharmaceutiquement acceptables pour une utilisation en médecine
EP3344071A4 (fr) Compositions combinées pour réguler des niveaux de glycémie, l'hépatoprotection, et pour la prévention et le traitement d'états médicaux associés
MX2023005875A (es) Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol-2,5-diona.