MA34726B1 - Prévention des effets secondaires provoqués par des domaines de liaison spécifiques de cd3 - Google Patents
Prévention des effets secondaires provoqués par des domaines de liaison spécifiques de cd3Info
- Publication number
- MA34726B1 MA34726B1 MA35999A MA35999A MA34726B1 MA 34726 B1 MA34726 B1 MA 34726B1 MA 35999 A MA35999 A MA 35999A MA 35999 A MA35999 A MA 35999A MA 34726 B1 MA34726 B1 MA 34726B1
- Authority
- MA
- Morocco
- Prior art keywords
- side effects
- effects caused
- specific
- preventing side
- linkage domains
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 239000003862 glucocorticoid Substances 0.000 abstract 4
- 230000006872 improvement Effects 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Materials For Medical Uses (AREA)
- Developing Agents For Electrophotography (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
L'invention concerne un glucocorticoïde (GC) s'utilisant dans l'amélioration, le traitement thérapeutique ou prophylactique d'effets secondaires neurologiques/psychiatriques provoqués par un domaine de liaison de CD3. Elle concerne aussi des trousses comprenant un GC, un domaine de liaison de CD3 et un mode d'emploi qui indique que le GC est destiné à être utilisé pour traiter, améliorer et/ou traiter de manière prophylactique des effets secondaires provoqués par un domaine de liaison de CD3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41222910P | 2010-11-10 | 2010-11-10 | |
| PCT/EP2011/068862 WO2012062596A1 (fr) | 2010-11-10 | 2011-10-27 | Prévention des effets secondaires provoqués par des domaines de liaison spécifiques de cd3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA34726B1 true MA34726B1 (fr) | 2013-12-03 |
Family
ID=45044532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA35999A MA34726B1 (fr) | 2010-11-10 | 2013-06-10 | Prévention des effets secondaires provoqués par des domaines de liaison spécifiques de cd3 |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10130638B2 (fr) |
| EP (3) | EP3228315B1 (fr) |
| JP (2) | JP6023717B2 (fr) |
| KR (1) | KR101891845B1 (fr) |
| CN (2) | CN103533943B (fr) |
| AU (3) | AU2011328393B2 (fr) |
| CA (1) | CA2816668C (fr) |
| CL (1) | CL2013001287A1 (fr) |
| CR (1) | CR20130278A (fr) |
| CY (1) | CY1118894T1 (fr) |
| DK (1) | DK2637670T4 (fr) |
| EA (1) | EA026075B1 (fr) |
| ES (2) | ES2627538T5 (fr) |
| FI (1) | FI2637670T4 (fr) |
| HR (1) | HRP20170814T4 (fr) |
| HU (1) | HUE032782T2 (fr) |
| IL (2) | IL226268B (fr) |
| LT (1) | LT2637670T (fr) |
| MA (1) | MA34726B1 (fr) |
| ME (1) | ME02722B (fr) |
| MY (1) | MY173177A (fr) |
| NZ (1) | NZ610034A (fr) |
| PH (1) | PH12013500940A1 (fr) |
| PL (1) | PL2637670T5 (fr) |
| PT (1) | PT2637670T (fr) |
| RS (1) | RS55995B2 (fr) |
| SG (2) | SG190174A1 (fr) |
| SI (1) | SI2637670T2 (fr) |
| SM (1) | SMT201700250T1 (fr) |
| TN (1) | TN2013000250A1 (fr) |
| UA (1) | UA113397C2 (fr) |
| WO (1) | WO2012062596A1 (fr) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1874821B1 (fr) | 2005-04-26 | 2013-04-17 | Trion Pharma Gmbh | Combinaison d'anticorps et de glucocorticoides destinee au traitement du cancer |
| KR101891845B1 (ko) | 2010-11-10 | 2018-08-24 | 암젠 리서치 (뮌헨) 게엠베하 | Cd3-특이적 결합 도메인에 의해 유발된 악영향의 예방 |
| EP3753572A1 (fr) * | 2011-04-28 | 2020-12-23 | Amgen Research (Munich) GmbH | Régime posologique pour l'administration d'un anticorps bispécifique cd19xcd3 à des patients à risque d'éventuels effets indésirables |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US10738132B2 (en) | 2013-01-14 | 2020-08-11 | Xencor, Inc. | Heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| JO3529B1 (ar) * | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| EP3421495A3 (fr) | 2013-03-15 | 2019-05-15 | Xencor, Inc. | Modulation de cellules t avec des anticorps bispécifiques et des fusions fc |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| CN111138543B (zh) * | 2013-03-15 | 2024-06-11 | Xencor股份有限公司 | 异二聚体蛋白 |
| EP3192812B1 (fr) | 2013-12-17 | 2020-05-27 | Genentech, Inc. | Anticorps anti-cd3 et leurs utilisations |
| LT3122781T (lt) | 2014-03-28 | 2020-03-25 | Xencor, Inc. | Bispecifiniai antikūnai, kurie jungiasi prie cd38 ir cd3 |
| BR112017004802A2 (pt) | 2014-09-12 | 2017-12-12 | Genentech Inc | anticorpos anti-cll-1 e imunoconjugados |
| TN2017000223A1 (en) | 2014-11-26 | 2018-10-19 | Xencor Inc | Heterodimeric antibodies that bind cd3 and tumor antigens |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| IL252467B (en) | 2014-11-26 | 2022-06-01 | Xencor Inc | Heterodimeric antibodies that bind cd3 and cd38 |
| PT3227336T (pt) | 2014-12-05 | 2019-09-09 | Hoffmann La Roche | Anticorpos anti-cd79b e métodos de utilização |
| US10428155B2 (en) | 2014-12-22 | 2019-10-01 | Xencor, Inc. | Trispecific antibodies |
| US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
| HUE063270T2 (hu) | 2015-06-16 | 2024-01-28 | Hoffmann La Roche | Az FcRH5 elleni humanizált és affinitásérett antitestek és alkalmazási eljárások |
| EP3310378B1 (fr) | 2015-06-16 | 2024-01-24 | F. Hoffmann-La Roche AG | Anticorps anti-c1 et leurs procédés d'utilisation |
| CN108137706A (zh) | 2015-07-15 | 2018-06-08 | 酵活有限公司 | 药物缀合的双特异性抗原结合构建体 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
| EA039859B1 (ru) * | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
| CN106810611A (zh) * | 2015-11-30 | 2017-06-09 | 中国科学院深圳先进技术研究院 | 抗cMet和CD3特异性双靶向抗体及其制备方法和应用、含该双靶向抗体表达盒的微环DNA及应用 |
| CN106810610A (zh) * | 2015-11-30 | 2017-06-09 | 中国科学院深圳先进技术研究院 | 抗EpCAM和CD3特异性双靶向抗体及其制备方法和应用、含该双靶向抗体表达盒的微环DNA及应用 |
| KR20180085800A (ko) | 2015-12-07 | 2018-07-27 | 젠코어 인코포레이티드 | Cd3 및 psma에 결합하는 이종이합체성 항체 |
| MA43959A (fr) | 2016-02-03 | 2018-12-12 | Amgen Res Munich Gmbh | Constructions d'anticorps impliquant des cellules t bispécifiques psma et cd3 |
| MA45255A (fr) | 2016-06-14 | 2019-04-17 | Xencor Inc | Anticorps inhibiteurs de points de contrôle bispécifiques |
| CA3029328A1 (fr) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Anticorps heterodimeriques qui se lient au recepteur 2 de la somatostatine |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| JP7142630B2 (ja) | 2016-10-14 | 2022-09-27 | ゼンコア インコーポレイテッド | IL15/IL15Rαヘテロ二量体FC-融合タンパク質 |
| CA3042435A1 (fr) | 2016-11-15 | 2018-05-24 | Genentech, Inc. | Dosage pour le traitement avec des anticorps bispecifiques anti-cd20/anti-cd3 |
| MA46963A (fr) * | 2016-12-03 | 2019-10-09 | Juno Therapeutics Inc | Méthodes pour déterminer le dosage de céllules car-t |
| KR20180090600A (ko) | 2017-02-03 | 2018-08-13 | 주식회사 대유위니아 | 전기밥솥 |
| EP4353818A3 (fr) | 2017-02-27 | 2024-06-19 | Juno Therapeutics, Inc. | Compositions, articles manufacturés et procédés associés au dosage en thérapie cellulaire |
| EP3409322A1 (fr) * | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Procédés de traitement |
| AU2018291497A1 (en) | 2017-06-30 | 2020-01-16 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains |
| WO2019046233A1 (fr) * | 2017-08-30 | 2019-03-07 | Bristol-Myers Squibb Company | Procédé de surveillance de réponses pharmacodynamiques médiées par l'administration in vivo de glucocorticoïdes |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| US11312770B2 (en) | 2017-11-08 | 2022-04-26 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| JP7765181B2 (ja) | 2017-12-19 | 2025-11-06 | ゼンコア インコーポレイテッド | 改変されたil-2 fc融合タンパク質 |
| CR20200391A (es) | 2018-02-08 | 2020-10-19 | Genentech Inc | Moléculas biespecíficas de unión al antígeno y métodos de uso |
| US10982006B2 (en) | 2018-04-04 | 2021-04-20 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| CN112867734A (zh) | 2018-04-18 | 2021-05-28 | Xencor股份有限公司 | 包含IL-15/IL-15Ra Fc融合蛋白和PD-1抗原结合结构域的靶向PD-1的异源二聚体融合蛋白及其用途 |
| CA3097741A1 (fr) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Proteines de fusion heterodimeres ciblant tim-3 contenant des proteines de fusion fc d'il-15/il-15ra et domaines de liaison a l'antigene de tim-3 |
| AU2019355971B2 (en) | 2018-10-03 | 2025-05-08 | Xencor, Inc. | IL-12 heterodimeric Fc-fusion proteins |
| BR112021016955A2 (pt) | 2019-03-01 | 2021-11-23 | Xencor Inc | Composição, composição de ácido nucleico, composição de vetor de expressão, vetor de expressão, célula hospedeira, métodos de produção de um domínio de ligação de membro de família 3 de pirofosfatase/fosfodiesterase de ectonucleotídeo e de tratamento de um câncer, anticorpo anti-enpp3, e, anticorpo heterodimérico |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| KR20250156861A (ko) | 2019-05-21 | 2025-11-03 | 노파르티스 아게 | Cd19 결합 분자 및 이의 용도 |
| RU2738802C1 (ru) * | 2019-08-21 | 2020-12-17 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Определяющие комплементарность участки для связывания cd3 и содержащая их биспецифическая антигенсвязывающая молекула |
| EP4072584B1 (fr) | 2019-12-13 | 2026-01-28 | Genentech, Inc. | Anti-ly6g6d anticorps et methodes pour utilisation |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| CA3182445A1 (fr) | 2020-06-11 | 2021-12-16 | Francisco Leon | Procedes et compositions de prevention du diabete de type 1 |
| KR20230166150A (ko) | 2020-08-19 | 2023-12-06 | 젠코어 인코포레이티드 | 항-cd28 조성물 |
| CA3196539A1 (fr) | 2020-11-04 | 2022-05-12 | Chi-Chung Li | Dosage pour le traitement avec des anticorps bispecifiques anti-cd20/anti-cd3 |
| US12516118B2 (en) | 2020-11-04 | 2026-01-06 | Genentech, Inc. | Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies and anti-CD79b antibody drug conjugates |
| JP7716473B2 (ja) | 2020-11-04 | 2025-07-31 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体の皮下投薬 |
| US11739144B2 (en) | 2021-03-09 | 2023-08-29 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and CLDN6 |
| KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | 젠코어 인코포레이티드 | Cd3 및 gpc3에 결합하는 이종이량체 항체 |
| WO2022216702A1 (fr) * | 2021-04-06 | 2022-10-13 | Memorial Sloan-Kettering Cancer Center | Polythérapie avec dexaméthasone et lymphocytes t spécifiques d'une tumeur mettant en contact des anticorps multispécifiques pour le traitement du cancer |
| BR112023023775A2 (pt) | 2021-05-14 | 2024-02-20 | Genentech Inc | Métodos para tratar um indivíduo com um distúrbio proliferativo de células positivas para cd20 e para tratar uma população de indivíduos com um distúrbio proliferativo de células positivas para cd20 |
| WO2023057650A1 (fr) | 2021-10-10 | 2023-04-13 | Centre Hospitalier Universitaire Vaudois (Chuv) | Procédé de prédiction d'effets secondaires de médicaments et de vaccins |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3853515T3 (de) | 1987-05-21 | 2005-08-25 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung. |
| CA2326389C (fr) | 1998-04-21 | 2007-01-23 | Micromet Gesellschaft Fur Biomedizinische Forschung Mbh | Polypeptides specifiques a cd19 et cd3 et leurs utilisations |
| US20070224191A1 (en) | 2002-12-05 | 2007-09-27 | Pdl Biopharma, Inc. | Methods of treatment of Ulcerative Colitis and Crohn's disease with anti-CD3 antibodies |
| CA2522586C (fr) | 2003-05-31 | 2017-02-21 | Micromet Ag | Compositions pharmaceutiques comprenant des constructions d'anticorps anti-cd3, anti-cd19 bispecifiques pour le traitement de troubles associes aux lymphocytes b |
| EP1874821B1 (fr) | 2005-04-26 | 2013-04-17 | Trion Pharma Gmbh | Combinaison d'anticorps et de glucocorticoides destinee au traitement du cancer |
| CN101331151A (zh) * | 2005-12-16 | 2008-12-24 | 麦克罗梅特股份公司 | 治疗肿瘤性疾病的方式和方法 |
| CA2633594C (fr) | 2005-12-16 | 2021-10-26 | Micromet Ag | Moyens et procedes pour le traitement de maladies tumorales |
| KR101626988B1 (ko) | 2007-04-03 | 2016-06-02 | 암젠 리서치 (뮌헨) 게엠베하 | 종간 특이적 이중특이적인 결합제들 |
| PT2520590T (pt) | 2007-04-03 | 2018-11-14 | Amgen Res Munich Gmbh | Domínio de ligação específico de espécies cruzadas |
| CN103694350B (zh) | 2007-04-03 | 2018-04-24 | 安进研发(慕尼黑)股份有限公司 | 跨物种特异性CD3-ε结合结构域 |
| US9308257B2 (en) | 2007-11-28 | 2016-04-12 | Medimmune, Llc | Protein formulation |
| EP2982696B1 (fr) * | 2008-11-07 | 2019-03-27 | Amgen Research (Munich) GmbH | Traitement de la leucémie lymphoblastique aiguë |
| KR102406407B1 (ko) | 2009-10-27 | 2022-06-08 | 암젠 리서치 (뮌헨) 게엠베하 | CD19xCD3 이중특이적 항체를 투여하는 투약 용법 |
| WO2012055961A1 (fr) | 2010-10-27 | 2012-05-03 | Micromet Gmbh | Moyens et méthodes de traitement du lymphome b diffus à grandes cellules |
| KR101891845B1 (ko) | 2010-11-10 | 2018-08-24 | 암젠 리서치 (뮌헨) 게엠베하 | Cd3-특이적 결합 도메인에 의해 유발된 악영향의 예방 |
-
2011
- 2011-10-27 KR KR1020137014669A patent/KR101891845B1/ko active Active
- 2011-10-27 SG SG2013034731A patent/SG190174A1/en unknown
- 2011-10-27 LT LTEP11788077.3T patent/LT2637670T/lt unknown
- 2011-10-27 US US13/884,497 patent/US10130638B2/en active Active
- 2011-10-27 ME MEP-2017-104A patent/ME02722B/fr unknown
- 2011-10-27 PL PL11788077.3T patent/PL2637670T5/pl unknown
- 2011-10-27 JP JP2013538125A patent/JP6023717B2/ja active Active
- 2011-10-27 RS RS20170458A patent/RS55995B2/sr unknown
- 2011-10-27 CA CA2816668A patent/CA2816668C/fr active Active
- 2011-10-27 MY MYPI2013001611A patent/MY173177A/en unknown
- 2011-10-27 CN CN201180064622.5A patent/CN103533943B/zh active Active
- 2011-10-27 EP EP17159560.6A patent/EP3228315B1/fr active Active
- 2011-10-27 WO PCT/EP2011/068862 patent/WO2012062596A1/fr not_active Ceased
- 2011-10-27 FI FIEP11788077.3T patent/FI2637670T4/fi active
- 2011-10-27 AU AU2011328393A patent/AU2011328393B2/en active Active
- 2011-10-27 PH PH1/2013/500940A patent/PH12013500940A1/en unknown
- 2011-10-27 EA EA201390621A patent/EA026075B1/ru not_active IP Right Cessation
- 2011-10-27 PT PT117880773T patent/PT2637670T/pt unknown
- 2011-10-27 ES ES11788077T patent/ES2627538T5/es active Active
- 2011-10-27 EP EP20209362.1A patent/EP3831386A1/fr active Pending
- 2011-10-27 DK DK11788077.3T patent/DK2637670T4/da active
- 2011-10-27 ES ES17159560T patent/ES2842937T3/es active Active
- 2011-10-27 NZ NZ610034A patent/NZ610034A/en unknown
- 2011-10-27 UA UAA201307130A patent/UA113397C2/uk unknown
- 2011-10-27 HU HUE11788077A patent/HUE032782T2/en unknown
- 2011-10-27 SG SG10201508789TA patent/SG10201508789TA/en unknown
- 2011-10-27 EP EP11788077.3A patent/EP2637670B2/fr active Active
- 2011-10-27 SI SI201131196T patent/SI2637670T2/sl unknown
- 2011-10-27 CN CN201810044039.1A patent/CN108403702A/zh active Pending
- 2011-10-27 HR HRP20170814TT patent/HRP20170814T4/hr unknown
- 2011-10-27 SM SM20170250T patent/SMT201700250T1/it unknown
-
2013
- 2013-05-09 IL IL226268A patent/IL226268B/en active IP Right Grant
- 2013-05-09 CL CL2013001287A patent/CL2013001287A1/es unknown
- 2013-06-10 MA MA35999A patent/MA34726B1/fr unknown
- 2013-06-10 TN TNP2013000250A patent/TN2013000250A1/fr unknown
- 2013-06-10 CR CR20130278A patent/CR20130278A/es unknown
-
2016
- 2016-07-06 JP JP2016133918A patent/JP6189491B2/ja active Active
-
2017
- 2017-03-29 AU AU2017202079A patent/AU2017202079B2/en active Active
- 2017-05-08 CY CY20171100491T patent/CY1118894T1/el unknown
-
2018
- 2018-01-25 IL IL257164A patent/IL257164B/en active IP Right Grant
- 2018-02-07 AU AU2018200915A patent/AU2018200915B2/en active Active
- 2018-10-11 US US16/157,985 patent/US11633408B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA34726B1 (fr) | Prévention des effets secondaires provoqués par des domaines de liaison spécifiques de cd3 | |
| MA40454B1 (fr) | Gamma-dicétones pour le traitement et la prévention des rides et du vieillissement de la peau | |
| MA38144A1 (fr) | Compositions et procédés pour le traitement de protéinopathies | |
| FR3028753B1 (fr) | Gel aqueux ou hydroalcoolique de phyllosilicates synthetiques a titre d'agent viscosant, matifiant et/ou homogeneisant d'application | |
| NO20091926L (no) | Anti-Notch3-agonist-antistoffer og deres anvendelse ved behandlingen av Notch3-relaterte sykdommer | |
| FR2934782B1 (fr) | Kit pour le traitement des onychomycoses. | |
| MA32131B1 (fr) | Antagonistes aminoalkylbiphényle n, n' disubstitués des récepteurs d2 de la prostaglandine | |
| EA201000603A1 (ru) | ПРИМЕНЕНИЕ АНТИТЕЛ К TrkB ДЛЯ ЛЕЧЕНИЯ РЕСПИРАТОРНЫХ НАРУШЕНИЙ | |
| EA201100239A1 (ru) | Композиции, одновалетные в отношении связывания cd28, и способы их применения | |
| CA2820681C (fr) | Utilisation de lymphocytes t modifies par un recepteur chimerique d'antigenes chimerique pour traiter le cancer | |
| MA31862B1 (fr) | Anticorps anti-mésothéline et leurs utilisations | |
| EA201301293A1 (ru) | Применение антител и фрагментов антител против cgrp для профилактики или ингибирования светобоязни или отвращения к свету у субъектов, нуждающихся в этом, в особенности страдающих мигренью | |
| MA33607B1 (fr) | Molécules de liaison bispécifiques pour une thérapie anti-angiogénique | |
| MX2020009260A (es) | Uso de moleculas de union a semaforina-4d para el tratamiento de trastornos neurodegenerativos. | |
| EA201300471A1 (ru) | Замещенные 6-аминоникотинамиды в качестве модуляторов kcnq2/3 | |
| EP1796669A4 (fr) | Aminopiperidines utilisees comme inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete | |
| MA30632B1 (fr) | Anticorps humanisé | |
| MA31117B1 (fr) | Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes | |
| ATE503754T1 (de) | 1h-indol-3-carbonsäure-chinuclidin-4- ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit | |
| MA38478A1 (fr) | Anticorps anti-pac1 humains | |
| MA38810B1 (fr) | Inhibiteurs de rorc2 méthodes d'utilisation associées | |
| FR2959128B1 (fr) | Utilisation cosmetique d'un lysat de bifidobacterium species pour le traitement des odeurs corporelles | |
| FR3103706B1 (fr) | Composition cosmétique triphasique | |
| MA62935B1 (fr) | Méthodes de traitement ou de prévention de l'amyotrophie spinale | |
| MA56998B1 (fr) | Traitement de symptômes induits par le cycle menstruel |