MA32385B1 - Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un derive d'indolinone - Google Patents
Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un derive d'indolinoneInfo
- Publication number
- MA32385B1 MA32385B1 MA33402A MA33402A MA32385B1 MA 32385 B1 MA32385 B1 MA 32385B1 MA 33402 A MA33402 A MA 33402A MA 33402 A MA33402 A MA 33402A MA 32385 B1 MA32385 B1 MA 32385B1
- Authority
- MA
- Morocco
- Prior art keywords
- capsule
- dosage form
- pharmaceutical dosage
- suspension formulation
- indolinone derivative
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000002775 capsule Substances 0.000 title 1
- 239000002552 dosage form Substances 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne une formulation en suspension dont le principe actif est le 3-z-[1-(4- (n-((4-méthyl-pipérazin-1-yl)-méthylcarbonyl)-n-méthyl-amino)-anilino)-1-phényl-méthylène]-6- méthoxycarbonyl-2- indolinone-monoéthane-sulphonate. L'invention concerne également, d'une part une forme posologique pharmaceutique en capsule contenant ladite formulation en suspension, d'autre part un procédé d'élaboration de ladite formulation en suspension, mais aussi un procédé d'élaboration de ladite capsule comprenant ladite formulation en suspension, et également le matériau d'enveloppe de la capsule.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08157748 | 2008-06-06 | ||
| PCT/EP2009/056878 WO2009147212A1 (fr) | 2008-06-06 | 2009-06-04 | Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un dérivé d'indolinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32385B1 true MA32385B1 (fr) | 2011-06-01 |
Family
ID=40911908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33402A MA32385B1 (fr) | 2008-06-06 | 2010-12-06 | Forme posologique pharmaceutique en capsule comprenant une formulation en suspension d'un derive d'indolinone |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US20110301177A1 (fr) |
| EP (1) | EP2299987B1 (fr) |
| JP (2) | JP5661031B2 (fr) |
| KR (2) | KR20170020557A (fr) |
| CN (2) | CN105193720B (fr) |
| AR (1) | AR072059A1 (fr) |
| AU (1) | AU2009254548B2 (fr) |
| BR (1) | BRPI0913434B8 (fr) |
| CA (1) | CA2726267C (fr) |
| CL (1) | CL2010001279A1 (fr) |
| CO (1) | CO6280467A2 (fr) |
| CY (1) | CY1120533T1 (fr) |
| DK (1) | DK2299987T3 (fr) |
| EA (1) | EA029996B1 (fr) |
| EC (1) | ECSP10010660A (fr) |
| ES (1) | ES2669469T3 (fr) |
| HR (1) | HRP20180709T1 (fr) |
| HU (1) | HUE039187T2 (fr) |
| IL (1) | IL208954A (fr) |
| LT (1) | LT2299987T (fr) |
| MA (1) | MA32385B1 (fr) |
| MX (2) | MX359229B (fr) |
| MY (1) | MY158930A (fr) |
| NO (1) | NO2299987T3 (fr) |
| NZ (1) | NZ603162A (fr) |
| PE (1) | PE20100254A1 (fr) |
| PL (1) | PL2299987T3 (fr) |
| PT (1) | PT2299987T (fr) |
| RS (1) | RS57142B1 (fr) |
| SI (1) | SI2299987T1 (fr) |
| TW (1) | TW201002691A (fr) |
| UA (1) | UA104590C2 (fr) |
| UY (1) | UY31879A (fr) |
| WO (1) | WO2009147212A1 (fr) |
| ZA (1) | ZA201007636B (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA107560C2 (uk) * | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| PE20100254A1 (es) | 2008-06-06 | 2010-04-21 | Boehringer Ingelheim Int | Forma de dosificacion farmaceutica en capsula que comprende una formulacion en suspension de un derivado de indolinona |
| PL2575784T3 (pl) | 2010-06-02 | 2019-03-29 | Astellas Deutschland Gmbh | Doustne postaci dawkowania bendamustyny |
| JO3659B1 (ar) * | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| GB201020032D0 (en) * | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| EP2900261A1 (fr) | 2012-09-28 | 2015-08-05 | Boehringer Ingelheim International GmbH | Combinaisons pharmaceutiques comprenant des liants doubles angiopoïétine-2/dll4 et des agents anti-vegf-r |
| US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
| CA3172586C (fr) | 2013-07-31 | 2025-10-14 | Avalyn Pharma Inc. | Composes d'imatinib en aerosol et utilisations connexes |
| US20150209360A1 (en) * | 2014-01-30 | 2015-07-30 | Orbz, Llc | Oral caffeine delivery composition |
| CN114504562A (zh) * | 2015-03-13 | 2022-05-17 | 江苏豪森药业集团有限公司 | 含有吲哚满酮衍生物混悬液的胶囊制剂及其制备方法 |
| EP3302379B1 (fr) | 2015-06-06 | 2023-11-22 | Cloudbreak Therapeutics, LLC | Compositions et méthodes pour le traitement du ptérygion |
| CN107019697A (zh) * | 2016-02-02 | 2017-08-08 | 瑞阳(苏州)生物科技有限公司 | 预防或治疗纤维化疾病的药物组合物及其应用 |
| KR102408596B1 (ko) | 2016-06-02 | 2022-06-13 | 에이디에스 테라퓨틱스 엘엘씨 | 비정상적 신생혈관이 있는 안구 질환 치료를 위한, 닌테다닙을 사용하는 조성물 및 방법 |
| WO2018080795A1 (fr) * | 2016-10-25 | 2018-05-03 | Glykon Technologies Group, Llc | Composés d'acide hydroxycitrique et administration de liquide en capsule |
| CN108066343A (zh) * | 2016-11-08 | 2018-05-25 | 瑞阳(苏州)生物科技有限公司 | 一种预防或治疗肾纤维化疾病的药物 |
| WO2018108669A1 (fr) | 2016-12-12 | 2018-06-21 | Boehringer Ingelheim International Gmbh | Nintédanib destiné à être utilisé dans des méthodes de traitement de maladies pulmonaires interstitielles par co-administration d'olodatérol |
| JP2020512364A (ja) | 2017-03-28 | 2020-04-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 筋ジストロフィーの処置方法において使用するためのニンテダニブ |
| CN107184549B (zh) * | 2017-04-11 | 2020-11-20 | 江苏大学 | 一种尼达尼布自微乳制剂和其制成的软胶囊及制备方法 |
| SI3700529T1 (sl) | 2017-10-23 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Nova kombinacija zdravilnih učinkovin za zdravljenje progresivnih fibroznih intersticijskih pljučnih bolezni (PF-ILD) |
| WO2019106692A1 (fr) * | 2017-11-29 | 2019-06-06 | Sun Pharmaceutical Industries Limited | Suspension orale de nintedanib esylate |
| MD3761980T2 (ro) | 2018-03-07 | 2024-09-30 | Pliant Therapeutics Inc | Compuși de aminoacid și metodele utilizare |
| TWI787523B (zh) | 2018-06-15 | 2022-12-21 | 漢達生技醫藥股份有限公司 | 達沙替尼十二烷基硫酸鹽之結晶 |
| EP3849516A2 (fr) * | 2018-09-13 | 2021-07-21 | FTF Pharma Private Limited | Suspensions pharmaceutiques chimiothérapeutiques de dosage perorale |
| WO2020079706A1 (fr) * | 2018-10-15 | 2020-04-23 | Cipla Limited | Formulation pharmaceutique |
| CN112386580B (zh) * | 2019-08-13 | 2022-07-08 | 齐鲁制药有限公司 | 具有改善的溶出度和稳定性的尼达尼布药物制剂、制备方法及其应用 |
| BR112022010891A2 (pt) | 2019-12-04 | 2022-08-16 | Idorsia Pharmaceuticals Ltd | Combinação de um antagonista do receptor lpa1 de azetidina com agentes antifibróticos |
| EP4125890A1 (fr) | 2020-04-01 | 2023-02-08 | Boehringer Ingelheim International GmbH | Utilisation de biomarqueurs dans le traitement d'états fibrotiques |
| EP4098246A1 (fr) | 2021-05-31 | 2022-12-07 | Lotus Pharmaceutical Co., Ltd. | Formulation de nintedanib |
| CA3234791A1 (fr) * | 2021-10-14 | 2023-04-20 | Eric Lefebvre | Inhibiteurs de l'integrine et leurs utilisations en combinaison avec d'autres agents |
| CN114404382B (zh) * | 2022-01-24 | 2023-05-12 | 南京康川济医药科技有限公司 | 乙磺酸尼达尼布软胶囊及其制备方法 |
| CN119630395A (zh) | 2022-02-28 | 2025-03-14 | 努福米克斯技术有限公司 | 用于治疗特发性肺纤维化的组合物和方法 |
| WO2024037982A1 (fr) | 2022-08-16 | 2024-02-22 | Boehringer Ingelheim International Gmbh | Formulations pharmaceutiques de nintédanib pour utilisation intraoculaire |
| KR20250174793A (ko) | 2024-06-05 | 2025-12-15 | 영진약품 주식회사 | 닌테다닙 또는 이의 약학적으로 허용가능한 염을 포함하는 개선된 용출률을 갖는 신규한 정제 및 이의 제조방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2870062A (en) | 1956-04-27 | 1959-01-20 | Scherer Corp R P | Gelatin composition for capsules |
| GB8305693D0 (en) | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
| DE3579384D1 (de) | 1984-07-24 | 1990-10-04 | Scherer Gmbh R P | Oxytetracyclin-hc1-weichgelatinekapseln und verfahren zu ihrer herstellung. |
| GB9313329D0 (en) * | 1993-06-28 | 1993-08-11 | Scherer Ltd R P | Softgel capsule shell compositions |
| DE19603402A1 (de) | 1995-02-24 | 1996-08-29 | Basf Ag | Weichgelatinekapseln |
| US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| DE60221238T2 (de) * | 2001-05-01 | 2007-10-31 | Pfizer Products Inc., Groton | Herstellungsverfahren für niedrig dosierte pharmazeutische zusammensetzung |
| DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| US20060293260A1 (en) * | 2005-05-24 | 2006-12-28 | Wyeth | Useful high load concentrate compositions for control of ecto-and endo-parasites |
| US20090306101A1 (en) | 2005-11-11 | 2009-12-10 | Flavio Solca | Combination treatment of cancer comprising egfr/her2 inhibitors |
| PE20100254A1 (es) | 2008-06-06 | 2010-04-21 | Boehringer Ingelheim Int | Forma de dosificacion farmaceutica en capsula que comprende una formulacion en suspension de un derivado de indolinona |
| UA107560C2 (uk) | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| HUE037291T2 (hu) | 2008-06-06 | 2018-08-28 | Boehringer Ingelheim Int | Gyógyászati kombináció |
| JP2012515184A (ja) | 2009-01-14 | 2012-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 大腸がんの治療方法 |
| US8802384B2 (en) | 2009-03-12 | 2014-08-12 | Boehringer Ingelheim International Gmbh | Method or system using biomarkers for the monitoring of a treatment |
| WO2010130757A1 (fr) * | 2009-05-14 | 2010-11-18 | Boehringer Ingelheim International Gmbh | Nouvelle polytherapie destinee a traiter les maladies oncologiques et fibrotiques |
-
2009
- 2009-06-04 PE PE2009000782A patent/PE20100254A1/es not_active Application Discontinuation
- 2009-06-04 SI SI200931833T patent/SI2299987T1/en unknown
- 2009-06-04 KR KR1020177004310A patent/KR20170020557A/ko not_active Withdrawn
- 2009-06-04 NO NO09757593A patent/NO2299987T3/no unknown
- 2009-06-04 WO PCT/EP2009/056878 patent/WO2009147212A1/fr not_active Ceased
- 2009-06-04 DK DK09757593.0T patent/DK2299987T3/en active
- 2009-06-04 MX MX2014006908A patent/MX359229B/es unknown
- 2009-06-04 PT PT97575930T patent/PT2299987T/pt unknown
- 2009-06-04 ES ES09757593.0T patent/ES2669469T3/es active Active
- 2009-06-04 US US12/995,869 patent/US20110301177A1/en not_active Abandoned
- 2009-06-04 AU AU2009254548A patent/AU2009254548B2/en active Active
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