MA31541B1 - Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine - Google Patents
Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbineInfo
- Publication number
- MA31541B1 MA31541B1 MA32551A MA32551A MA31541B1 MA 31541 B1 MA31541 B1 MA 31541B1 MA 32551 A MA32551 A MA 32551A MA 32551 A MA32551 A MA 32551A MA 31541 B1 MA31541 B1 MA 31541B1
- Authority
- MA
- Morocco
- Prior art keywords
- pharmaceutical composition
- phenorolpenes
- soluble salt
- stable pharmaceutical
- vinorelbine
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 2
- GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 abstract 2
- 229960002066 vinorelbine Drugs 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000007903 gelatin capsule Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- CILBMBUYJCWATM-HGBQGYOLSA-N vinorelbine D-tartrate Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O.OC(=O)[C@@H](O)[C@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-HGBQGYOLSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention porte sur une composition pharmaceutique stable comprenant un sel de vinorelbine soluble dans l'eau et au moins un diluant et un lubrifiant, caractérisé par le fait qu'il apparaît sous une forme solide destiné à une administration orale. Le sel de vinorelbine soluble dans l'eau est avantageusement le ditartrate de vinorelbine. La composition pharmaceutique apparaît de manière avantageuse sous forme de capsule de gélatine ou de comprimé.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0756425A FR2918567B1 (fr) | 2007-07-11 | 2007-07-11 | Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine. |
| PCT/EP2008/058896 WO2009007389A1 (fr) | 2007-07-11 | 2008-07-09 | Composition pharmaceutique stable d'un sel de vinorelbine soluble dans l'eau |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA31541B1 true MA31541B1 (fr) | 2010-07-01 |
Family
ID=38846787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA32551A MA31541B1 (fr) | 2007-07-11 | 2010-01-25 | Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20100196465A1 (fr) |
| EP (1) | EP2175855B1 (fr) |
| JP (1) | JP5774308B2 (fr) |
| KR (1) | KR20100045439A (fr) |
| CN (1) | CN101730534A (fr) |
| AR (1) | AR067498A1 (fr) |
| AU (1) | AU2008274224A1 (fr) |
| BR (1) | BRPI0814224A2 (fr) |
| CA (1) | CA2695040A1 (fr) |
| DK (1) | DK2175855T3 (fr) |
| ES (1) | ES2733113T3 (fr) |
| FR (1) | FR2918567B1 (fr) |
| HU (1) | HUE044165T2 (fr) |
| MA (1) | MA31541B1 (fr) |
| NZ (1) | NZ583039A (fr) |
| PL (1) | PL2175855T3 (fr) |
| RU (1) | RU2476208C2 (fr) |
| TN (1) | TN2010000012A1 (fr) |
| TR (1) | TR201909405T4 (fr) |
| TW (1) | TW200914017A (fr) |
| WO (1) | WO2009007389A1 (fr) |
| ZA (1) | ZA201000337B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267179B (zh) * | 2014-07-08 | 2020-04-03 | 东曜药业有限公司 | 包含水溶性长春瑞滨盐的稳定的固体药物组合物及其制备方法 |
| CN108779129A (zh) * | 2016-03-09 | 2018-11-09 | 赛比亚斯药业股份公司 | 长春瑞滨单酒石酸盐及其药物用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879541A (en) * | 1970-03-03 | 1975-04-22 | Bayer Ag | Antihyperglycemic methods and compositions |
| US4551177A (en) * | 1984-04-23 | 1985-11-05 | National Starch And Chemical Corporation | Compressible starches as binders for tablets or capsules |
| FR2707988B1 (fr) * | 1993-07-21 | 1995-10-13 | Pf Medicament | Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant. |
| FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
| FR2761990B1 (fr) * | 1997-04-10 | 1999-06-25 | Pf Medicament | Derives halogenes antimitotiques d'alcaloides de vinca |
| WO1999059573A1 (fr) * | 1998-05-15 | 1999-11-25 | Warner-Lambert Company | Preparations pharmaceutiques stabilisees de derives d'acide gamma-aminobutyrique et procede de fabrication associe |
| US6242003B1 (en) * | 2000-04-13 | 2001-06-05 | Novartis Ag | Organic compounds |
| CZ20002567A3 (cs) * | 2000-07-11 | 2001-12-12 | Léčiva, A.S. | Tableta vyrobitelná přímým tabletováním, obsahující aktivní látku kyselinu 4-amino-1-hydroxybutyliden-1,1-bisfosfonovou, a způsob její výroby |
| ATE508738T1 (de) * | 2001-01-12 | 2011-05-15 | Sun Pharma Advanced Res Co Ltd | System zur beabstandeten abgabe von arzneimitteln |
| RU2297221C2 (ru) * | 2002-04-26 | 2007-04-20 | Ф.Хоффманн-Ля Рош Аг | Фармацевтическая композиция, включающая ингибитор липазы и глюкоманнан |
| JP2003321349A (ja) * | 2002-05-08 | 2003-11-11 | Capsugel Japan Inc | イカスミ色素含有インクによる硬質カプセルへの印刷 |
| US6890558B2 (en) * | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| EP1530459B1 (fr) * | 2002-05-31 | 2010-03-31 | R.P. Scherer Technologies, LLC | Composition pharmaceutique orale pour capsules souples contenant de la vinorelbine et procede de traitement correspondant |
| US20030138430A1 (en) * | 2002-09-20 | 2003-07-24 | Stimmel Julie Beth | Pharmaceutical comprising an agent that blocks the cell cycle and an antibody |
| DE10351448A1 (de) * | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
| FR2863891B1 (fr) * | 2003-12-23 | 2006-03-24 | Pf Medicament | Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation |
| US20060147518A1 (en) * | 2004-12-30 | 2006-07-06 | Pierre Fabre Medicament | Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it |
| MX2007008059A (es) * | 2004-12-30 | 2007-07-17 | Pf Medicament | Dispersion solida estable de un derivado de alcaloide de pervinca y procedimiento para fabricarlo. |
-
2007
- 2007-07-11 FR FR0756425A patent/FR2918567B1/fr active Active
-
2008
- 2008-07-08 TW TW097125672A patent/TW200914017A/zh unknown
- 2008-07-09 WO PCT/EP2008/058896 patent/WO2009007389A1/fr not_active Ceased
- 2008-07-09 AU AU2008274224A patent/AU2008274224A1/en not_active Abandoned
- 2008-07-09 PL PL08786003T patent/PL2175855T3/pl unknown
- 2008-07-09 DK DK08786003.7T patent/DK2175855T3/da active
- 2008-07-09 JP JP2010515501A patent/JP5774308B2/ja active Active
- 2008-07-09 KR KR1020107001419A patent/KR20100045439A/ko not_active Ceased
- 2008-07-09 HU HUE08786003 patent/HUE044165T2/hu unknown
- 2008-07-09 RU RU2010103935/15A patent/RU2476208C2/ru not_active IP Right Cessation
- 2008-07-09 CN CN200880024035A patent/CN101730534A/zh active Pending
- 2008-07-09 US US12/668,372 patent/US20100196465A1/en not_active Abandoned
- 2008-07-09 ES ES08786003T patent/ES2733113T3/es active Active
- 2008-07-09 NZ NZ583039A patent/NZ583039A/en not_active IP Right Cessation
- 2008-07-09 EP EP08786003.7A patent/EP2175855B1/fr active Active
- 2008-07-09 CA CA2695040A patent/CA2695040A1/fr not_active Abandoned
- 2008-07-09 BR BRPI0814224-6A2A patent/BRPI0814224A2/pt not_active IP Right Cessation
- 2008-07-09 TR TR2019/09405T patent/TR201909405T4/tr unknown
- 2008-07-10 AR ARP080102966A patent/AR067498A1/es not_active Application Discontinuation
-
2010
- 2010-01-08 TN TNP2010000012A patent/TN2010000012A1/fr unknown
- 2010-01-18 ZA ZA201000337A patent/ZA201000337B/xx unknown
- 2010-01-25 MA MA32551A patent/MA31541B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100045439A (ko) | 2010-05-03 |
| AU2008274224A1 (en) | 2009-01-15 |
| TR201909405T4 (tr) | 2019-07-22 |
| US20100196465A1 (en) | 2010-08-05 |
| TN2010000012A1 (en) | 2011-09-26 |
| NZ583039A (en) | 2012-06-29 |
| BRPI0814224A2 (pt) | 2015-01-06 |
| PL2175855T3 (pl) | 2019-10-31 |
| DK2175855T3 (da) | 2019-07-01 |
| EP2175855B1 (fr) | 2019-04-10 |
| TW200914017A (en) | 2009-04-01 |
| RU2010103935A (ru) | 2011-08-20 |
| HUE044165T2 (hu) | 2019-10-28 |
| JP2010533140A (ja) | 2010-10-21 |
| JP5774308B2 (ja) | 2015-09-09 |
| WO2009007389A1 (fr) | 2009-01-15 |
| FR2918567A1 (fr) | 2009-01-16 |
| ES2733113T3 (es) | 2019-11-27 |
| CN101730534A (zh) | 2010-06-09 |
| CA2695040A1 (fr) | 2009-01-15 |
| FR2918567B1 (fr) | 2012-08-03 |
| AR067498A1 (es) | 2009-10-14 |
| RU2476208C2 (ru) | 2013-02-27 |
| EP2175855A1 (fr) | 2010-04-21 |
| ZA201000337B (en) | 2010-09-29 |
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