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MA30435B1 - Inhibiteurs de protéase de type nitrile spirocyclique - Google Patents

Inhibiteurs de protéase de type nitrile spirocyclique

Info

Publication number
MA30435B1
MA30435B1 MA31426A MA31426A MA30435B1 MA 30435 B1 MA30435 B1 MA 30435B1 MA 31426 A MA31426 A MA 31426A MA 31426 A MA31426 A MA 31426A MA 30435 B1 MA30435 B1 MA 30435B1
Authority
MA
Morocco
Prior art keywords
spirocyclic
nitrile
protease inhibitors
medicaments
formula
Prior art date
Application number
MA31426A
Other languages
English (en)
Inventor
Manfred Schudok
Michael Wagner
Armin Bauer
Anna Kohlmann
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA30435B1 publication Critical patent/MA30435B1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract

L'INVENTION CONCERNE DES COMPOSÉS SPIRO HÉTÉROCYCLIQUES SUBSTITUÉS DE FORMULE (I), LESQUELS INHIBENT LA CATHEPSINE, AINSI QU'UN PROCÉDÉ DE PRODUCTION ASSOCIÉ ET LEUR UTILISATION COMME MÉDICAMENTS.
MA31426A 2006-06-01 2008-11-28 Inhibiteurs de protéase de type nitrile spirocyclique MA30435B1 (fr)

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WO2012119941A1 (fr) 2011-03-04 2012-09-13 Prozymex A/S Composés de peptidylnitrile à titre d'inhibiteurs de peptidases
CN103304571B (zh) * 2012-03-06 2018-02-16 凯惠科技发展(上海)有限公司 螺环化合物、其制备方法、中间体、药物组合物和应用
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CA2960916C (fr) * 2014-09-12 2023-03-07 Boehringer Ingelheim International Gmbh Inhibiteurs spirocycliques de la cathepsine c
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
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UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
US10709692B2 (en) * 2015-12-04 2020-07-14 Denali Therapeutics Inc. Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1)
CN110386932A (zh) 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
EP3946332A1 (fr) 2019-04-05 2022-02-09 Université de Bretagne Occidentale Inhibiteurs du récepteur 2 activé par une protéase pour le traitement d'une neuropathie sensorielle induite par une intoxication neurotoxique marine
WO2021147882A1 (fr) * 2020-01-21 2021-07-29 深圳信立泰药业股份有限公司 Inhibiteur de la cathepsine k dérivé du dibenzofurane, son procédé de préparation et son utilisation médicale

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BRPI0711723A2 (pt) 2011-11-29
HN2008001723A (es) 2010-12-27
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JO2741B1 (en) 2014-03-15
TW200817418A (en) 2008-04-16
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MX341849B (es) 2016-09-05
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US20120015933A1 (en) 2012-01-19
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IL195519A (en) 2012-12-31
US20140073662A1 (en) 2014-03-13
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WO2007137738A1 (fr) 2007-12-06
DOP2007000107A (es) 2007-12-15
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