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MA29341B1 - Nouveaux composes - Google Patents

Nouveaux composes

Info

Publication number
MA29341B1
MA29341B1 MA30237A MA30237A MA29341B1 MA 29341 B1 MA29341 B1 MA 29341B1 MA 30237 A MA30237 A MA 30237A MA 30237 A MA30237 A MA 30237A MA 29341 B1 MA29341 B1 MA 29341B1
Authority
MA
Morocco
Prior art keywords
new compounds
compounds
compositions
novel
pyridoyl
Prior art date
Application number
MA30237A
Other languages
English (en)
Inventor
James Francis Callahan
Jeffrey C Boehm
Anthony William James Cooper
Stefano Livia
Neysa Nevins
Zehong Wan
Beth A Norton
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA29341B1 publication Critical patent/MA29341B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX COMPOSÉS SUBSTITUÉS COMPRENANT UNE 8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE TRISUBSTITUÉE EN POSITION 2, 4 ET 8, DES COMPOSITIONS COMPORTANT CES NOUVEAUX COMPOSÉS, AINSI QUE L'UTILISATION DE CES COMPOSÉS ET DE CES COMPOSITIONS À DES FINS DE TRAITEMENT EN TANT QU'INHIBITEURS DE LA KINASE CSBP/RK/P38.
MA30237A 2005-03-25 2007-09-24 Nouveaux composes MA29341B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66531505P 2005-03-25 2005-03-25

Publications (1)

Publication Number Publication Date
MA29341B1 true MA29341B1 (fr) 2008-03-03

Family

ID=37053943

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30237A MA29341B1 (fr) 2005-03-25 2007-09-24 Nouveaux composes

Country Status (24)

Country Link
US (3) US8207176B2 (fr)
EP (3) EP1868611B1 (fr)
JP (1) JP5037487B2 (fr)
KR (1) KR101235497B1 (fr)
CN (4) CN102746299A (fr)
AR (1) AR053346A1 (fr)
AU (1) AU2006229993B2 (fr)
BR (1) BRPI0609437A2 (fr)
CA (1) CA2602553C (fr)
EA (1) EA012875B1 (fr)
ES (2) ES2398246T3 (fr)
IL (1) IL185870A (fr)
MA (1) MA29341B1 (fr)
MX (1) MX2007011856A (fr)
MY (2) MY145343A (fr)
NO (1) NO20075275L (fr)
NZ (1) NZ561237A (fr)
PE (2) PE20100737A1 (fr)
SG (1) SG166771A1 (fr)
TW (1) TWI389690B (fr)
UA (1) UA95444C2 (fr)
UY (1) UY29440A1 (fr)
WO (1) WO2006104915A2 (fr)
ZA (1) ZA200707564B (fr)

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US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CN1847229B (zh) * 2000-10-23 2011-05-04 史密丝克莱恩比彻姆公司 2，4，8-三取代-8H-吡啶并[2，3-d]嘧啶-7-酮化合物
EP1499320B1 (fr) * 2002-04-19 2007-08-22 Smithkline Beecham Corporation Nouveaux composes
PE20061193A1 (es) * 2005-03-25 2006-12-02 Glaxo Group Ltd DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
CN101495475A (zh) * 2005-03-25 2009-07-29 葛兰素集团有限公司 制备吡啶并[2,3-d]嘧啶-7-酮和3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物的方法
EP1868612A4 (fr) * 2005-03-25 2010-03-24 Glaxo Group Ltd Nouveaux composes
UY29440A1 (es) 2005-03-25 2006-10-02 Glaxo Group Ltd Nuevos compuestos
EP2034838A4 (fr) * 2006-06-16 2012-01-04 Glaxo Group Ltd Nouveaux composés
JP2009542818A (ja) * 2006-06-16 2009-12-03 グラクソ グループ リミテッド 新規化合物
GB0621830D0 (en) * 2006-11-02 2006-12-13 Chroma Therapeutics Ltd Inhibitors of p38 mitogen-activated protein kinase
EP1992344A1 (fr) 2007-05-18 2008-11-19 Institut Curie P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
WO2012158197A2 (fr) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Composés utiles en tant que modulateurs akt/pkb et leurs utilisations
PL2748147T3 (pl) * 2011-08-25 2018-01-31 St Jude Childrens Res Hospital Podstawione 2-alkilo-1-okso-n-fenylo-3-heteroarylo-1,2,3,4- tetrahydroizochinolino-4-karboksamidy do terapii przeciwmalarycznych
KR20200067170A (ko) 2017-10-05 2020-06-11 풀크럼 쎄러퓨틱스, 인코포레이티드 FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

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CN102746301A (zh) 2012-10-24
TWI389690B (zh) 2013-03-21
SG166771A1 (en) 2010-12-29
CN101258148A (zh) 2008-09-03
US8354416B2 (en) 2013-01-15
IL185870A0 (en) 2008-01-06
AU2006229993B2 (en) 2011-05-19
EA012875B1 (ru) 2009-12-30
US20060235029A1 (en) 2006-10-19
CN102746299A (zh) 2012-10-24
PE20061351A1 (es) 2007-01-14
EP1868611A2 (fr) 2007-12-26
US8207176B2 (en) 2012-06-26
IL185870A (en) 2013-06-27
NZ561237A (en) 2011-02-25
EA200702071A1 (ru) 2008-02-28
NO20075275L (no) 2007-12-27
WO2006104915A3 (fr) 2007-11-22
JP2008534513A (ja) 2008-08-28
JP5037487B2 (ja) 2012-09-26
UA95444C2 (ru) 2011-08-10
EP2436686A1 (fr) 2012-04-04
HK1111422A1 (en) 2008-08-08
US20090069318A1 (en) 2009-03-12
UY29440A1 (es) 2006-10-02
TW200714281A (en) 2007-04-16
CA2602553C (fr) 2013-04-30
BRPI0609437A2 (pt) 2010-04-06
ES2398246T3 (es) 2013-03-14
US7678801B2 (en) 2010-03-16
CA2602553A1 (fr) 2006-10-05
EP1868611A4 (fr) 2009-05-27
ES2426251T3 (es) 2013-10-22
WO2006104915A2 (fr) 2006-10-05
EP2447266A1 (fr) 2012-05-02
PE20100737A1 (es) 2010-11-27
KR20070113255A (ko) 2007-11-28
AR053346A1 (es) 2007-05-02
MY145343A (en) 2012-01-31
WO2006104915A9 (fr) 2008-01-03
EP1868611B1 (fr) 2012-11-14
US20090156597A1 (en) 2009-06-18
KR101235497B1 (ko) 2013-02-20
MY145281A (en) 2012-01-13
EP2447266B1 (fr) 2013-06-12
ZA200707564B (en) 2008-10-29
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CN102746300A (zh) 2012-10-24
AU2006229993A1 (en) 2006-10-05

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