Category: Mental Health Page 1 of 8

I have the GG (val/val) variant in SNP rs4680, which corresponds with high COMT enzyme activity. COMT breaks down dopamine in the part of the brain related to higher cognitive and executive function. People with my COMT genetic variant tend to have a hard time sustaining attention and motivation in low-stakes situations. We tend to do a little better when the stakes are a bit higher and intense, like hand-to-hand combat or downhill racing.

I did well in school, but paying attention during lectures was always difficult. My mind would constantly wander. By my third year in college I’d come up with systems (mainly active note-taking/idea synthesis during class) that allowed me to excel. But the first fifteen years of school were a struggle in terms of paying attention and retaining information, even if it didn’t look that way from the outside.

After I graduated, I soon learned that most jobs were pure torture for me. Sustaining my attention for eight hours a day was too difficult and too boring. I decided early on that a 40+ hour workweek would ruin me. I needed to find an alternative. I settled on computer programming because I could do it part time, at my own pace, on my own schedule. I could then use the rest of my time to make beats, write fiction, play games, spend time with friend and family, or just let my mind wander.

Obviously my personality isn’t the result of a single genetic variant. But I’ve learned that maintaining a high level of motivation and attention for long periods of time requires a few “tricks”. Since ~40% of the global population has the same rs4680 COMT variant, maybe you find yourself in the same boat.

• Goal-setting. Mostly self-explanatory. I go back and forth on exact goal-setting methods, but currently I’m liking three month horizons for my main goals, with monthly sub-goals. The key to using goals is to enjoy the process, and not hang your happiness hat on completing the goal or not. Set an ambitious but doable goal that can be achieved with concrete consistent actions. Allow yourself to be happy while pursuing the goal. If you achieve it, pat yourself on the back, give yourself a treat, then set another goal. If you don’t, analyze the game and iterate your strategy.
• Supplements. Lithium orotate up to 5mg daily to balance neurotransmitter health and stave off depression and anxiety. Fish oil for brain cell membrane permeability. Tyrosine up to 500mg/day for a direct dopamine boost. Collagen and other sources of glycine to support deep sleep and brain recovery.
• Clean(ish) living. Too much alcohol, sugar, and refined carbs blunts motivation. Exercise amps it up. You don’t have to be a monk.
• Death-framing. What’s important if I hold the reality of my own mortality in mind? Will I regret not getting those extra billable hours? More likely I’ll regret never attempting a particular writing or music project, or not visiting a friend, or not doing something fun with my family.

That’s about it. Hope that helps you, rs4680 G/G or whatever kind of mutant you are!