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Compare the Top EDI Software as of October 2025

What is EDI Software?

EDI (Electronic Data Interchange) software is software that automates the exchange of business documents, such as invoices, purchase orders, and shipping notices, between companies in standardized electronic formats. It eliminates the need for manual data entry, reducing errors and improving the speed and accuracy of business transactions. EDI providers offer platforms and services that facilitate this seamless data exchange, integrating with existing ERP systems and ensuring compliance with industry standards. These providers also offer support for different communication protocols and data formats, enabling businesses to connect with various trading partners efficiently. By using EDI software and working with EDI providers, companies can streamline their supply chain operations, enhance collaboration, and reduce operational costs. Compare and read user reviews of the best EDI software currently available using the table below. This list is updated regularly.

  • 1
    Service Center

    Service Center

    Office Ally

    Service Center by Office Ally is a trusted Revenue Cycle Management and patient payments platform used by more than 80,000 healthcare providers and health services organizations, which process more than 950 million transactions annually. Service Center is a cost-effective solution enabling providers to control their revenue cycle. With a user-friendly interface, Service Center helps providers check and verify patients’ eligibility and benefits, submit, correct, and check the status of their claims online, and receive remittance advice. Accepting standard ANSI formats, data entry and pipe-delimited formats, Service Center helps streamline administrative tasks and create more efficient workflows for providers.
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    Starting Price: $0
  • 2
    Iguana

    Iguana

    iNTERFACEWARE

    Iguana, iNTERFACEWARE's development-based integration platform, is the only tool you need to build fully custom interfaces, quickly and reliably. Connect all message formats: HL7, FHIR, X12, JSON and more. With over two decades in the business and thousands of installs globally, Iguana is the world's most trusted integration engine.
  • 3
    SERENEDI

    SERENEDI

    Chiapas EDI Technologies

    SERENEDI is a third generation middleware solution for any sized business for their 5010 healthcare EDI integration workflows. Running on Windows and Unix servers, our software is capable of instantly rendering compliant transactions to and from Oracle and SQL Server database tables, CSV and XML. PowerShell Core-based automation, user-expandable SNIP integrity rules engine, a developer studio and Next Business Day support round out the product.
    Starting Price: $3000 / year
  • 4
    Stedi

    Stedi

    Stedi

    Stedi is the only clearinghouse built on modern APIs, while supporting both real-time and batch EDI processes. It enables health techs and incumbents to exchange mission-critical transactions - from eligibility to claims and remits. With a security-first cloud infrastructure, built-in payer redundancy via 3,400+ route connections, and market-leading sub-10-minute support response times, Stedi provides reliability and responsiveness to avoid billing outages and reduce denials.
    Starting Price: $2,000 per month
  • 5
    NetDirector

    NetDirector

    NetDirector

    NetDirector is a leading provider of cloud-based data and document exchange solutions, offering integration-platform-as-a-service models that improve efficiency through automation and one-to-many integration while reducing associated costs. Their services cater to various industries, including mortgage banking and healthcare. In mortgage banking, NetDirector provides data integration, SCRA military search, bankruptcy PACER suite, SSN finder, death search, invoice management, eRecording, name and address search, document request, eFiling, redaction service, and AI extract services. For healthcare, they offer data and document integration with a universal API and integrations. Additional healthcare services include automated patient payments, PDF to DICOM conversion, controlled substance database integration, and health data storage. NetDirector's solutions are designed to streamline operations, enhance data accuracy, and ensure compliance with industry standards.
    Starting Price: $495 per month
  • 6
    eMEDIX

    eMEDIX

    CompuGroup Medical US

    eMEDIX Reimbursement Solutions is an in-house claims clearinghouse and electronic data interchange partner designed to help healthcare organizations overcome payment challenges. The platform offers comprehensive claims management, denial prevention and recovery, improved patient access, and streamlined enrollment processes. With a 99.5% clean claims rate, surpassing the industry's best practice of 95%, eMEDIX ensures efficient claims processing and faster reimbursements. The system automates claim monitoring, streamlines attachments, and provides an easy-to-use dashboard for consolidating claims data. eMEDIX is compatible with various practice management solutions and electronic health record vendors, making it a versatile choice for healthcare providers seeking to enhance their revenue cycle management.
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