ZA9811531B - Novel process for the preparation of cyclosporin derivatives - Google Patents

Novel process for the preparation of cyclosporin derivatives

Info

Publication number: ZA9811531B
Authority: ZA; South Africa
Prior art keywords: preparation; novel process; cyclosporin derivatives; cyclosporin; derivatives
Prior art date: 1997-12-19

Application number

ZA9811531A

Inventor

Serge Mignani

Michel Evers

Jean-Claude Barriere

Georges Bashiardes

Jean-Christophe Carry

Bruno Filoche

Guy Amouret

Antonio Guerreiro

Christian Viskov

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-19

Filing date

1998-12-15

Publication date

1999-06-15

1998-12-15 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1999-06-15 Publication of ZA9811531B publication Critical patent/ZA9811531B/en

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Cephalosporin Compounds (AREA)

ZA9811531A 1997-12-19 1998-12-15 Novel process for the preparation of cyclosporin derivatives ZA9811531B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9716189A FR2772768B1 (en)	1997-12-19	1997-12-19	NOVEL PROCESS FOR THE PREPARATION OF CYCLOSPORIN DERIVATIVES

Publications (1)

Publication Number	Publication Date
ZA9811531B true ZA9811531B (en)	1999-06-15

Family

ID=9514865

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9811531A ZA9811531B (en)	1997-12-19	1998-12-15	Novel process for the preparation of cyclosporin derivatives

Country Status (15)

Country	Link
EP (1)	EP1040121B1 (en)
JP (1)	JP3980269B2 (en)
AR (1)	AR014136A1 (en)
AT (1)	ATE271563T1 (en)
AU (1)	AU1764099A (en)
DE (1)	DE69825179T2 (en)
DK (1)	DK1040121T3 (en)
ES (1)	ES2224454T3 (en)
FR (1)	FR2772768B1 (en)
MA (1)	MA26585A1 (en)
PE (1)	PE20020526A1 (en)
PT (1)	PT1040121E (en)
TN (1)	TNSN98231A1 (en)
WO (1)	WO1999032512A1 (en)
ZA (1)	ZA9811531B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8329658B2 (en)	2005-09-30	2012-12-11	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
US8536114B2 (en)	2008-12-31	2013-09-17	Scynexis, Inc.	Macrocycles
US8551952B2 (en)	2006-05-19	2013-10-08	Scynexis, Inc.	Methods for the treatment and prevention of ocular disorders

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2780061B1 (en) *	1998-06-22	2001-09-07	Rhone Poulenc Rorer Sa	NOVEL PROCESS FOR THE PREPARATION OF CYCLOSPORIN DERIVATIVES
ES2266564T3 (en)	2001-10-19	2007-03-01	Isotechnika Inc.	SYNTHESIS OF CYCLOPORINE ANALOGS.
KR20040039622A (en) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	Use of 3-position cyclosporin derivatives for hair growth
WO2004082629A2 (en)	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
EP1804823A4 (en)	2004-09-29	2010-06-09	Amr Technology Inc	Novel cyclosporin analogues and their pharmaceutical uses
JP2008514701A (en)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	Cyclosporine alkyne analogs and their pharmaceutical use
US7196161B2 (en)	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7361636B2 (en)	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
NZ567262A (en)	2005-09-30	2011-12-22	Scynexis Inc	Cyclosporin derivatives and their use for the treatment and prevention of hepatitis C infection
US7576057B2 (en)	2006-11-20	2009-08-18	Scynexis, Inc.	Cyclic peptides
WO2010002428A2 (en)	2008-06-06	2010-01-07	Scynexis, Inc.	Novel macrocyclic peptides
EP2435065A1 (en) *	2009-05-27	2012-04-04	Allergan, Inc.	Cyclosporin derivatives for treating inflammatory diseases and conditions
WO2011082289A1 (en)	2009-12-30	2011-07-07	Scynexis Inc.	Cyclosporine analogues
EP2627663B1 (en) *	2010-10-12	2018-02-21	Allergan, Inc.	Cyclosporin analogs
PL2651965T3 (en)	2010-12-15	2019-04-30	Contravir Pharmaceuticals Inc	Cyclosporine analogue molecules modified at amino acid 1 and 3
WO2020037530A1 (en) *	2018-08-22	2020-02-27	Waterstone Pharmaceuticals (Wuhan) Co., Ltd.	Crystalline form of compound and uses thereof in medicine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (en) *	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
PL324531A1 (en) *	1995-07-17	1998-06-08	Chem Ag C	Derivatives of cyclosporin effective against hiv virus

1997
- 1997-12-19 FR FR9716189A patent/FR2772768B1/en not_active Expired - Fee Related
1998
- 1998-12-15 ZA ZA9811531A patent/ZA9811531B/en unknown
- 1998-12-15 MA MA25395A patent/MA26585A1/en unknown
- 1998-12-16 DE DE69825179T patent/DE69825179T2/en not_active Expired - Lifetime
- 1998-12-16 JP JP2000525449A patent/JP3980269B2/en not_active Expired - Fee Related
- 1998-12-16 DK DK98962475T patent/DK1040121T3/en active
- 1998-12-16 PT PT98962475T patent/PT1040121E/en unknown
- 1998-12-16 AU AU17640/99A patent/AU1764099A/en not_active Abandoned
- 1998-12-16 AT AT98962475T patent/ATE271563T1/en active
- 1998-12-16 ES ES98962475T patent/ES2224454T3/en not_active Expired - Lifetime
- 1998-12-16 WO PCT/FR1998/002745 patent/WO1999032512A1/en not_active Ceased
- 1998-12-16 EP EP98962475A patent/EP1040121B1/en not_active Expired - Lifetime
- 1998-12-17 TN TNTNSN98231A patent/TNSN98231A1/en unknown
- 1998-12-18 AR ARP980106479A patent/AR014136A1/en unknown
2000
- 2000-11-23 PE PE2000001248A patent/PE20020526A1/en not_active Application Discontinuation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8329658B2 (en)	2005-09-30	2012-12-11	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
US8551952B2 (en)	2006-05-19	2013-10-08	Scynexis, Inc.	Methods for the treatment and prevention of ocular disorders
US8536114B2 (en)	2008-12-31	2013-09-17	Scynexis, Inc.	Macrocycles

Also Published As

Publication number	Publication date
MA26585A1 (en)	2004-12-20
DE69825179D1 (en)	2004-08-26
FR2772768A1 (en)	1999-06-25
PE20020526A1 (en)	2002-07-10
PT1040121E (en)	2004-11-30
FR2772768B1 (en)	2000-01-14
EP1040121B1 (en)	2004-07-21
ATE271563T1 (en)	2004-08-15
AU1764099A (en)	1999-07-12
DK1040121T3 (en)	2004-11-29
EP1040121A1 (en)	2000-10-04
ES2224454T3 (en)	2005-03-01
DE69825179T2 (en)	2005-09-08
JP2002502803A (en)	2002-01-29
JP3980269B2 (en)	2007-09-26
TNSN98231A1 (en)	2005-03-15
AR014136A1 (en)	2001-02-07
WO1999032512A1 (en)	1999-07-01

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