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ZA9811068B - Solution-phase site-specific preparation of GRF-PEG conjugates - Google Patents

Solution-phase site-specific preparation of GRF-PEG conjugates

Info

Publication number
ZA9811068B
ZA9811068B ZA9811068A ZA9811068A ZA9811068B ZA 9811068 B ZA9811068 B ZA 9811068B ZA 9811068 A ZA9811068 A ZA 9811068A ZA 9811068 A ZA9811068 A ZA 9811068A ZA 9811068 B ZA9811068 B ZA 9811068B
Authority
ZA
South Africa
Prior art keywords
grf
solution
specific preparation
peg conjugates
phase site
Prior art date
Application number
ZA9811068A
Other languages
English (en)
Inventor
Francesco Maria Veronese
Paolo Caliceti
Oddone Schiavon
Original Assignee
Applied Research System Ars Ho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research System Ars Ho filed Critical Applied Research System Ars Ho
Publication of ZA9811068B publication Critical patent/ZA9811068B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ZA9811068A 1997-12-03 1998-12-03 Solution-phase site-specific preparation of GRF-PEG conjugates ZA9811068B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97121264A EP0922446A1 (en) 1997-12-03 1997-12-03 Solution-phase site-specific preparation of GRF-PEG conjugates

Publications (1)

Publication Number Publication Date
ZA9811068B true ZA9811068B (en) 1999-06-28

Family

ID=8227732

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9811068A ZA9811068B (en) 1997-12-03 1998-12-03 Solution-phase site-specific preparation of GRF-PEG conjugates

Country Status (29)

Country Link
US (3) US6528485B1 (et)
EP (2) EP0922446A1 (et)
JP (2) JP2001524505A (et)
KR (1) KR100561768B1 (et)
CN (1) CN1149967C (et)
AR (1) AR017780A1 (et)
AT (1) ATE236607T1 (et)
AU (1) AU755285B2 (et)
BG (1) BG64815B1 (et)
BR (1) BR9815159A (et)
CA (1) CA2312004C (et)
DE (1) DE69813291T2 (et)
DK (1) DK1037587T3 (et)
EA (1) EA004269B1 (et)
EE (1) EE200000319A (et)
ES (1) ES2194376T3 (et)
HU (1) HUP0100507A3 (et)
IL (2) IL136551A0 (et)
NO (1) NO327238B1 (et)
NZ (1) NZ504570A (et)
PL (1) PL192082B1 (et)
PT (1) PT1037587E (et)
SI (1) SI1037587T1 (et)
SK (1) SK8242000A3 (et)
TR (1) TR200001615T2 (et)
TW (1) TWI254641B (et)
UA (1) UA73716C2 (et)
WO (1) WO1999027897A1 (et)
ZA (1) ZA9811068B (et)

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US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
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GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
CN100357313C (zh) * 2003-01-18 2007-12-26 派格斯菲尔有限公司 非靶位点胺基被保护的肽,其制备方法以及使用该肽制备特异性地结合的peg肽的方法
AU2004259727A1 (en) * 2003-07-15 2005-02-03 Barros Research Institute Compositions and methods for immunotherapy of cancer and infectious diseases.
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CA2554755A1 (en) * 2004-01-28 2005-08-11 Cytimmune Sciences, Inc. Functionalized colloidal metal compositions and methods
CN100355784C (zh) * 2004-02-12 2007-12-19 江苏恒瑞医药股份有限公司 聚乙二醇修饰α－干扰素1b的制备方法
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US20070238656A1 (en) * 2006-04-10 2007-10-11 Eastman Kodak Company Functionalized poly(ethylene glycol)
AU2007248680C1 (en) 2006-05-02 2014-01-23 Allozyne, Inc. Non-natural amino acid substituted polypeptides
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
KR101304081B1 (ko) * 2006-08-04 2013-09-05 프로롱 파마슈티컬스, 엘엘씨 수식된 에리스로포이에틴
US20080083154A1 (en) * 2006-10-05 2008-04-10 Timothy M Gregory Bait retention fish hook
RU2345608C2 (ru) * 2007-01-09 2009-02-10 Государственное образовательное учреждение высшего профессионального образования "Северо-Кавказский государственный технический университет" Вареная колбаса с использованием pse свинины и способ ее производства
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
CA2700378A1 (en) * 2007-09-21 2009-03-29 Cytimmune Sciences, Inc. Nanotherapeutic colloidal metal compositions and methods
US7960145B2 (en) * 2007-11-08 2011-06-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
BRPI0921640A2 (pt) * 2008-11-04 2019-09-24 Janssen Pharmaceutica Nv agonistas peptídicos do crhr2 e usos do mesmo
PL2408800T3 (pl) * 2009-03-20 2016-11-30 Sposób wytwarzania koniugatu miejscowo-specyficznego, fizjologicznie aktywnego polipeptydu
EP2421547A1 (en) * 2009-04-20 2012-02-29 Theratechnologies Inc. Use of (hexenoyl trans-3)hgrf(1-44)nh2 and ritonavir in combination therapy
EP2421548A4 (en) * 2009-04-20 2012-09-26 Theratechnologies Inc USE OF (HEXENOYL TRANS-3) HGRF (1-44) NH2 AND SIMVASTATIN IN COMBINED TREATMENT
US10370245B2 (en) 2009-06-22 2019-08-06 Sanford-Burnham Medical Research Institute Methods and compositions using peptides and proteins with C-terminal elements
EP2496248A2 (en) * 2009-11-04 2012-09-12 Janssen Pharmaceutica, N.V. Method for treating heart failure with stresscopin-like peptides
WO2012118778A1 (en) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Truncated car peptides and methods and compositions using truncated car peptides
US8361964B2 (en) 2011-04-21 2013-01-29 Theratechnologies Inc. Growth hormone releasing factor (GRF) analogs and uses thereof
AU2012262488A1 (en) 2011-05-31 2014-01-16 Airware, Inc. Re-calibration of AB NDIR gas sensors
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US10064940B2 (en) 2013-12-11 2018-09-04 Siva Therapeutics Inc. Multifunctional radiation delivery apparatus and method
EP3303378B1 (en) 2015-05-28 2021-04-21 Institut National de la Recherche Scientifique Inhibitors of prototypic galectin dimerization and uses thereof
RU2748576C2 (ru) * 2016-04-19 2021-05-27 Гриффон Фармасьютикалз Интернешнл Са. Пэгилированные биологически активные пептиды и их применение
CN110317826B (zh) * 2019-05-22 2020-11-10 中国农业大学 调控PvGRF9含量或活性的物质在调控植物茎生长发育中的应用
CA3162011A1 (en) 2019-12-19 2021-06-24 Rodolphe SORET Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies
WO2021133407A1 (en) 2019-12-27 2021-07-01 Compagnie Generale Des Etablissements Michelin Rubber mix with high specific surface area and high structure acetylene carbon black
WO2022165039A1 (en) 2021-01-28 2022-08-04 Talem Therapeutics Llc Anti-sars-cov-2 spike glycoprotein antibodies and the therapeutic use thereof
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EP0400472B1 (en) * 1989-05-27 1996-04-03 Sumitomo Pharmaceuticals Company, Limited Process for preparing polyethylene glycol derivatives and modified protein.
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FR2687681B1 (fr) * 1992-02-20 1995-10-13 Transgene Sa Conjugues polyethyleneglycol-hirudine, leur procede de preparation et leur emploi pour le traitement des thromboses.
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Also Published As

Publication number Publication date
AU755285B2 (en) 2002-12-05
NO20002664D0 (no) 2000-05-24
JP2010024245A (ja) 2010-02-04
JP5431874B2 (ja) 2014-03-05
CN1149967C (zh) 2004-05-19
KR20010032494A (ko) 2001-04-25
BG104484A (bg) 2000-12-29
PL341139A1 (en) 2001-03-26
CA2312004A1 (en) 1999-06-10
JP2001524505A (ja) 2001-12-04
CN1280483A (zh) 2001-01-17
IL136551A0 (en) 2001-06-14
HUP0100507A2 (hu) 2001-08-28
ATE236607T1 (de) 2003-04-15
AU1563399A (en) 1999-06-16
PL192082B1 (pl) 2006-08-31
EP0922446A1 (en) 1999-06-16
NO20002664L (no) 2000-07-13
US6869932B2 (en) 2005-03-22
EA200000601A1 (ru) 2000-12-25
US20040029794A1 (en) 2004-02-12
WO1999027897A9 (en) 1999-09-30
US20050159353A1 (en) 2005-07-21
WO1999027897A1 (en) 1999-06-10
CA2312004C (en) 2009-05-19
NZ504570A (en) 2003-10-31
SK8242000A3 (en) 2001-01-18
EP1037587A1 (en) 2000-09-27
US6528485B1 (en) 2003-03-04
HUP0100507A3 (en) 2001-11-28
IL136551A (en) 2008-12-29
DK1037587T3 (da) 2003-07-28
TR200001615T2 (tr) 2000-12-21
EA004269B1 (ru) 2004-02-26
SI1037587T1 (en) 2003-08-31
NO327238B1 (no) 2009-05-18
EP1037587B1 (en) 2003-04-09
BR9815159A (pt) 2000-10-10
AR017780A1 (es) 2001-10-24
BG64815B1 (bg) 2006-05-31
KR100561768B1 (ko) 2006-03-16
DE69813291D1 (de) 2003-05-15
TWI254641B (en) 2006-05-11
EE200000319A (et) 2001-08-15
HK1034203A1 (en) 2001-10-19
DE69813291T2 (de) 2003-11-13
US7317002B2 (en) 2008-01-08
UA73716C2 (en) 2005-09-15
PT1037587E (pt) 2003-08-29
ES2194376T3 (es) 2003-11-16

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