ZA9711051B - Benzodioxole benzofuran dihydrobenzofuran and benzodioxane melatonergic agents - Google Patents
Benzodioxole benzofuran dihydrobenzofuran and benzodioxane melatonergic agentsInfo
- Publication number
- ZA9711051B ZA9711051B ZA9711051A ZA9711051A ZA9711051B ZA 9711051 B ZA9711051 B ZA 9711051B ZA 9711051 A ZA9711051 A ZA 9711051A ZA 9711051 A ZA9711051 A ZA 9711051A ZA 9711051 B ZA9711051 B ZA 9711051B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzodioxane
- benzodioxole
- dihydrobenzofuran
- benzofuran
- melatonergic agents
- Prior art date
Links
- YJTSGJMQDKJSGA-UHFFFAOYSA-N O1CCC2=C1C=CC=C2.O2C=CC1=C2C=CC=C1.O1COC2=C1C=CC=C2 Chemical compound O1CCC2=C1C=CC=C2.O2C=CC1=C2C=CC=C1.O1COC2=C1C=CC=C2 YJTSGJMQDKJSGA-UHFFFAOYSA-N 0.000 title 1
- LYKMMUBOEFYJQG-UHFFFAOYSA-N piperoxan Chemical compound C1OC2=CC=CC=C2OC1CN1CCCCC1 LYKMMUBOEFYJQG-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3268996P | 1996-12-10 | 1996-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA9711051B true ZA9711051B (en) | 1999-06-09 |
Family
ID=21866306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9711051A ZA9711051B (en) | 1996-12-10 | 1997-12-09 | Benzodioxole benzofuran dihydrobenzofuran and benzodioxane melatonergic agents |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US5856529A (hu) |
| EP (1) | EP1027043B1 (hu) |
| JP (1) | JP4290765B2 (hu) |
| KR (1) | KR100499106B1 (hu) |
| CN (1) | CN1152679C (hu) |
| AR (1) | AR010346A1 (hu) |
| AT (1) | ATE281833T1 (hu) |
| AU (1) | AU719994B2 (hu) |
| BR (1) | BR9713690B1 (hu) |
| CA (1) | CA2274183C (hu) |
| CY (1) | CY2501B1 (hu) |
| CZ (1) | CZ297673B6 (hu) |
| DE (1) | DE69731562T2 (hu) |
| DK (1) | DK1027043T3 (hu) |
| ES (1) | ES2230626T3 (hu) |
| HU (1) | HU226524B1 (hu) |
| IL (1) | IL129999A (hu) |
| NO (1) | NO321450B1 (hu) |
| NZ (1) | NZ335910A (hu) |
| PL (1) | PL190499B1 (hu) |
| PT (1) | PT1027043E (hu) |
| RU (1) | RU2190609C2 (hu) |
| TW (1) | TW476758B (hu) |
| WO (1) | WO1998025606A1 (hu) |
| ZA (1) | ZA9711051B (hu) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9614347D0 (en) * | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
| US6160134A (en) * | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
| CA2334299A1 (en) | 1998-06-05 | 1999-12-09 | Pierre Dextraze | Heterocyclic cis cyclopropane derivatives as melatonergic agents |
| ES2213022T3 (es) * | 1999-06-30 | 2004-08-16 | Bristol-Myers Squibb Company | Derivados de aminopirrolidina heterociclicos utiles como agentes melatonergicos. |
| MXPA03010435A (es) | 2001-05-15 | 2004-03-09 | Hoffmann La Roche | Derivados de oxazol acido carboxilico sustituidos para uso como activadores de proliferacion del peroximosa(ppar-alfa y gama) en el tratamiento de diabetes. |
| US6569894B1 (en) | 2001-10-04 | 2003-05-27 | Bristol-Myers Squibb Company | Arylalkylbenzofuran derivatives as melatonergic agents |
| JP2005505586A (ja) * | 2001-10-04 | 2005-02-24 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体 |
| US6737431B2 (en) | 2002-03-12 | 2004-05-18 | Bristol-Myers Squibb Company | Benzoxazole derivatives as novel melatonergic agents |
| DE60316290T2 (de) * | 2002-07-03 | 2008-06-12 | F. Hoffmann-La Roche Ag | Oxazolderivate und deren verwendung als insulinsensibilisatoren |
| ES2350340T3 (es) * | 2002-08-30 | 2011-01-21 | F. Hoffmann-La Roche Ag | Nuevos compuestos de 2-aril-tiazol como agonistas de pparalfa y ppargamma. |
| PL375878A1 (en) * | 2002-09-12 | 2005-12-12 | F.Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| BR0316556A (pt) * | 2002-11-25 | 2005-10-04 | Hoffmann La Roche | Compostos, processo para a preparação de um composto, composição farmacêutica que compreende esse composto, sua utilização e método para o tratamento e/ou profilaxia de enfermidades que são moduladas por agonistas ppar(alfa) e/ou ppary |
| US7177737B2 (en) * | 2002-12-17 | 2007-02-13 | Evolution Robotics, Inc. | Systems and methods for correction of drift via global localization with a visual landmark |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| KR101571163B1 (ko) * | 2006-05-22 | 2015-11-23 | 반다 파마슈티칼즈, 인코퍼레이티드. | 멜라토닌 효능제 치료 |
| MX2008014840A (es) * | 2006-05-22 | 2008-12-05 | Vanda Pharmaceuticals Inc | Tratamiento de trastornos depresivos. |
| JP5289308B2 (ja) | 2007-04-26 | 2013-09-11 | 武田薬品工業株式会社 | 二環性化合物およびその医薬用途 |
| US7964430B2 (en) * | 2007-05-23 | 2011-06-21 | Applied Materials, Inc. | Silicon layer on a laser transparent conductive oxide layer suitable for use in solar cell applications |
| EP2195462B1 (en) * | 2007-09-13 | 2013-06-12 | Vanda Pharmaceuticals Inc. | Prediction of sleep parameter and response to sleep-inducing compound based on per3 vntr genotype |
| US20120136050A1 (en) | 2009-07-16 | 2012-05-31 | Vanda Pharmaceuticals Inc. | Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia |
| EP2287159A1 (en) * | 2009-07-29 | 2011-02-23 | V.Mane Fils | New bicyclic dioxanes, their preparation and their use as organoleptic compounds |
| RU2571414C2 (ru) * | 2010-09-22 | 2015-12-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Циклопропановые соединения |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| US8785492B2 (en) | 2012-01-26 | 2014-07-22 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| BR112014028446A2 (pt) * | 2012-05-18 | 2017-10-24 | Vanda Pharmaceuticals Inc | composto isolado, composição farmacêutica, método de tratamento ou prevenção de pelo menos um de doenças, distúrbios ou condições seguintes, e, método de tratamento ou prevenção de um distúrbio de ritmo circadiano ou distúrbio com um componente circadiano em um indivíduo |
| EP2884275A4 (en) * | 2012-07-10 | 2016-04-13 | Astellas Pharma Inc | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF STRESS-RELATED HARNINE CONTINENCE OR MIXED INCONTINENCE AND METHOD FOR SCREENING COMPOUNDS FOR INTRODUCTION TO THIS PHARMACEUTICAL COMPOSITION |
| AR091699A1 (es) | 2012-07-10 | 2015-02-25 | Astellas Pharma Inc | Derivado de indol carboxamida |
| AU2013361459A1 (en) | 2012-12-18 | 2015-07-02 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| US9643947B2 (en) | 2013-08-28 | 2017-05-09 | Northwestern University | 7-membered fused heterocycles and methods of their synthesis |
| WO2015047113A1 (en) * | 2013-09-30 | 2015-04-02 | Polfarmex S.A. | Novel substituted n, n-dimethylaminoalkyl ethers of isoflavanone oximes as η1-receptor antagonists |
| US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
| US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
| WO2015117048A1 (en) | 2014-01-31 | 2015-08-06 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| EP3105212A1 (en) * | 2014-02-12 | 2016-12-21 | Vanda Pharmaceuticals Inc. | Highly purified pharmaceutical grade tasimelteon |
| US12304896B2 (en) | 2014-12-04 | 2025-05-20 | Vanda Pharmaceuticals Inc. | Highly purified pharmaceutical grade tasimelteon |
| EP3188727B1 (en) | 2014-09-02 | 2022-11-09 | Vanda Pharmaceuticals Inc. | Tasimelteon for treating smith-magenis syndrome |
| CN104327022B (zh) * | 2014-10-17 | 2015-12-02 | 苏州明锐医药科技有限公司 | 他司美琼的制备方法 |
| CN104402849B (zh) * | 2014-11-11 | 2016-11-09 | 苏州莱克施德药业有限公司 | 他司美琼中间体的新制备工艺 |
| CN106588841B (zh) * | 2015-10-19 | 2019-01-25 | 富乐马鸿凯（大连）医药有限公司 | 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法 |
| JP7576905B2 (ja) | 2016-05-06 | 2024-11-01 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | バレリアン組成物及び関連方法 |
| CN105949153B (zh) * | 2016-05-10 | 2018-03-02 | 浙江工业大学 | 一种他司美琼的合成方法 |
| CN107365288A (zh) * | 2016-05-12 | 2017-11-21 | 浙江京新药业股份有限公司 | 他司美琼的晶型 |
| US9944616B2 (en) | 2016-06-08 | 2018-04-17 | Apotex Inc. | Processes for the preparation of Tasimelteon and intermediates thereof |
| CN106543119B (zh) * | 2016-09-22 | 2019-07-26 | 浙江工业大学 | 一种光学纯他司美琼的制备方法 |
| BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
| WO2018149940A1 (en) | 2017-02-17 | 2018-08-23 | Quimica Sintetica, S. A. | Process for the preparation of enantiomerically enriched dihydrobenzofurans and intermediate compounds obtained in the process |
| EP3661494B8 (en) | 2017-08-02 | 2023-11-22 | Vanda Pharmaceuticals Inc. | Use of tasimelteon for the treatment of affective disorders in majority black african patients |
| RU2020131941A (ru) | 2018-03-04 | 2022-04-05 | Ванда Фармасьютиклз Инк. | Лечение расстройств тасимелтеоном |
| US20210353586A1 (en) * | 2018-09-12 | 2021-11-18 | Vanda Pharmaceuticals Inc. | Improving Sleep or Post-Sleep Performance |
| US12479819B2 (en) | 2019-05-15 | 2025-11-25 | Eisai R&D Management Co., Ltd. | Method and compound useful in preparation of orexin-2 receptor antagonist, and lemborexant having few impurities |
| US20220347150A1 (en) | 2019-06-29 | 2022-11-03 | Vanda Pharmaceuticals Inc. | Tasimelteon use in treating sleep aberrations |
| EP4072542A1 (en) | 2019-12-13 | 2022-10-19 | Vanda Pharmaceuticals Inc. | Liquid tasimelteon formulations and methods of use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071875A (en) * | 1989-09-25 | 1991-12-10 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2667316B1 (fr) * | 1990-10-02 | 1994-09-16 | Roussel Uclaf | Nouveaux derives du benzofuranne, leur procede de preparation et leur application comme pesticides. |
| FR2674524B1 (fr) * | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2680507B1 (fr) * | 1991-08-23 | 1993-10-08 | Adir Cie | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2689124A1 (fr) * | 1992-03-27 | 1993-10-01 | Adir | Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5449683A (en) * | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
| FR2696453B1 (fr) * | 1992-10-02 | 1994-12-23 | Adir | Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent. |
| GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| GB9407919D0 (en) * | 1994-04-21 | 1994-06-15 | Glaxo Group Ltd | Chemical compounds |
| FR2725985B1 (fr) * | 1994-10-21 | 1996-11-15 | Adir | Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5633218A (en) * | 1995-05-24 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Herbicidal benzodioxoles and benzodioxanes |
| US5596019A (en) * | 1995-06-07 | 1997-01-21 | Bristol-Myers Squibb Company | N-acyl-cycloalkylamine derivatives as melatonergics |
| CA2176854A1 (en) * | 1995-06-07 | 1996-12-08 | Daniel J. Keavy | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics |
| PT901483E (pt) * | 1996-05-14 | 2003-11-28 | Glaxo Group Ltd | Benzofuranos e benzopiranos como agentes cronobiologicos |
-
1997
- 1997-12-09 TW TW086118524A patent/TW476758B/zh active
- 1997-12-09 CN CNB971804443A patent/CN1152679C/zh not_active Expired - Lifetime
- 1997-12-09 ES ES97952354T patent/ES2230626T3/es not_active Expired - Lifetime
- 1997-12-09 KR KR10-1999-7005148A patent/KR100499106B1/ko not_active Expired - Lifetime
- 1997-12-09 HU HU0000695A patent/HU226524B1/hu unknown
- 1997-12-09 ZA ZA9711051A patent/ZA9711051B/xx unknown
- 1997-12-09 DE DE69731562T patent/DE69731562T2/de not_active Expired - Lifetime
- 1997-12-09 AT AT97952354T patent/ATE281833T1/de active
- 1997-12-09 AU AU55985/98A patent/AU719994B2/en not_active Expired
- 1997-12-09 PT PT97952354T patent/PT1027043E/pt unknown
- 1997-12-09 CA CA002274183A patent/CA2274183C/en not_active Expired - Lifetime
- 1997-12-09 CZ CZ0199199A patent/CZ297673B6/cs not_active IP Right Cessation
- 1997-12-09 RU RU99115102/04A patent/RU2190609C2/ru active
- 1997-12-09 BR BRPI9713690-5A patent/BR9713690B1/pt not_active IP Right Cessation
- 1997-12-09 DK DK97952354T patent/DK1027043T3/da active
- 1997-12-09 JP JP52692198A patent/JP4290765B2/ja not_active Expired - Lifetime
- 1997-12-09 PL PL97333950A patent/PL190499B1/pl unknown
- 1997-12-09 EP EP97952354A patent/EP1027043B1/en not_active Expired - Lifetime
- 1997-12-09 US US08/987,478 patent/US5856529A/en not_active Expired - Lifetime
- 1997-12-09 WO PCT/US1997/022627 patent/WO1998025606A1/en not_active Ceased
- 1997-12-09 IL IL12999997A patent/IL129999A/en not_active IP Right Cessation
- 1997-12-09 NZ NZ335910A patent/NZ335910A/xx not_active IP Right Cessation
- 1997-12-10 AR ARP970105795A patent/AR010346A1/es active IP Right Grant
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1998
- 1998-10-09 US US09/169,784 patent/US5981571A/en not_active Expired - Lifetime
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1999
- 1999-06-09 NO NO19992804A patent/NO321450B1/no not_active IP Right Cessation
- 1999-07-13 US US09/352,560 patent/US6060506A/en not_active Expired - Lifetime
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2005
- 2005-01-31 CY CY0500008A patent/CY2501B1/xx unknown
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